4M62

Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003094	biological_process	glomerular filtration
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0019731	biological_process	antibacterial humoral response
L	0019814	cellular_component	immunoglobulin complex
L	0070062	cellular_component	extracellular exosome
L	0071748	cellular_component	monomeric IgA immunoglobulin complex
L	0071751	cellular_component	secretory IgA immunoglobulin complex
L	0071756	cellular_component	pentameric IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle
M	0002250	biological_process	adaptive immune response
M	0002376	biological_process	immune system process
M	0003094	biological_process	glomerular filtration
M	0003823	molecular_function	antigen binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0006955	biological_process	immune response
M	0019731	biological_process	antibacterial humoral response
M	0019814	cellular_component	immunoglobulin complex
M	0070062	cellular_component	extracellular exosome
M	0071748	cellular_component	monomeric IgA immunoglobulin complex
M	0071751	cellular_component	secretory IgA immunoglobulin complex
M	0071756	cellular_component	pentameric IgM immunoglobulin complex
M	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 201

Chain	Residue
L	PRO59
L	ASP60
L	ARG61
L	HOH391
L	HOH392

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 202

Chain	Residue
L	HOH316
L	HOH397
L	ARG45
L	PRO59
L	ARG61
L	HOH314

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 M 201

Chain	Residue
M	ARG45
M	PRO59
M	ARG61
M	PHE62
M	HOH302
M	HOH337
M	HOH387

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 S 201

Chain	Residue
I	THR28
I	PHE29
I	SER30
I	HOH281
S	ARG15
S	ARG16
S	HIS17
S	HOH311

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 S 202

Chain	Residue
L	LYS107
L	ARG108
L	LEU109
L	VAL110
S	ARG20
S	SER37
S	HOH337
S	HOH352
S	HOH397

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 T 201

Chain	Residue
H	THR28
H	PHE29
H	SER30
H	HOH300
T	ARG15
T	ARG16
T	HIS17

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 T 202

Chain	Residue
H	HOH214
M	ARG108
M	ARG112
T	HIS17
T	PRO38
T	HOH303
T	HOH304
T	HOH322
T	HOH342
T	HOH390

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 T 203

Chain	Residue
S	ASN29
S	LYS33
S	HOH399
T	LYS33
T	HOH336
T	HOH338
T	HOH412
T	HOH419

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 T 204

Chain	Residue
T	ARG82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Region: {"description":"Framework-1","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	Region: {"description":"Complementarity-determining-1","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	Region: {"description":"Framework-2","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Region: {"description":"Complementarity-determining-2","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	62
Details	Region: {"description":"Framework-3","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Region: {"description":"Complementarity-determining-3","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---