4LV8
Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0000045 | biological_process | autophagosome assembly |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002376 | biological_process | immune system process |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0009617 | biological_process | response to bacterium |
| B | 0010506 | biological_process | regulation of autophagy |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019003 | molecular_function | GDP binding |
| B | 0019221 | biological_process | cytokine-mediated signaling pathway |
| B | 0020005 | cellular_component | symbiont-containing vacuole membrane |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0032580 | cellular_component | Golgi cisterna membrane |
| B | 0035458 | biological_process | cellular response to interferon-beta |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042832 | biological_process | defense response to protozoan |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP A 601 |
| Chain | Residue |
| A | ARG241 |
| A | PRO338 |
| A | ALA340 |
| A | ASP343 |
| A | ASP393 |
| A | PHE396 |
| A | MG602 |
| A | EDO603 |
| A | HOH729 |
| A | HOH763 |
| A | HOH863 |
| A | GLY243 |
| A | HOH888 |
| A | HOH897 |
| A | HOH965 |
| A | ASP244 |
| A | ARG245 |
| A | SER246 |
| A | VAL248 |
| A | ALA261 |
| A | LYS263 |
| A | MET337 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 602 |
| Chain | Residue |
| A | ASP393 |
| A | ADP601 |
| A | HOH897 |
| A | HOH965 |
| A | HOH986 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 603 |
| Chain | Residue |
| A | LEU304 |
| A | MET337 |
| A | GLY406 |
| A | ASP407 |
| A | ADP601 |
| A | HOH888 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 604 |
| Chain | Residue |
| A | GLU258 |
| A | ASP259 |
| A | PHE260 |
| A | PRO338 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 605 |
| Chain | Residue |
| A | SER359 |
| A | THR360 |
| A | GLU361 |
| A | ARG417 |
| A | SER436 |
| A | THR437 |
| A | HOH737 |
| A | HOH969 |
| B | ASN215 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 606 |
| Chain | Residue |
| A | ARG196 |
| A | ALA199 |
| A | LEU200 |
| A | LEU240 |
| A | ARG241 |
| A | VAL242 |
| A | HOH807 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 607 |
| Chain | Residue |
| A | ALA377 |
| A | LEU380 |
| A | GLN381 |
| A | HIS442 |
| A | ASP445 |
| A | ALA446 |
| A | LEU516 |
| A | PRO517 |
| A | HOH985 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 601 |
| Chain | Residue |
| A | LEU357 |
| B | THR158 |
| B | ARG182 |
| B | ASN212 |
| B | HOH815 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 602 |
| Chain | Residue |
| A | ARG358 |
| A | SER359 |
| A | THR360 |
| B | ASN212 |
| B | ASN215 |
| B | THR216 |
| B | GLU219 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GDP B 603 |
| Chain | Residue |
| B | GLY79 |
| B | SER80 |
| B | GLY81 |
| B | LYS82 |
| B | SER83 |
| B | SER84 |
| B | THR102 |
| B | LYS184 |
| B | ASP186 |
| B | SER231 |
| B | ASN232 |
| B | LYS233 |
| B | HOH718 |
| B | HOH786 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 604 |
| Chain | Residue |
| B | MET46 |
| B | THR54 |
| B | ASP290 |
| B | LEU291 |
| B | HOH776 |
| B | HOH837 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 605 |
| Chain | Residue |
| B | GLU192 |
| B | THR199 |
| B | ASP201 |
| B | LYS204 |
| B | VAL205 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 606 |
| Chain | Residue |
| B | THR158 |
| B | LYS184 |
| B | SER187 |
| B | ASP188 |
| B | ASN191 |
| B | HOH701 |
| B | HOH816 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 182 |
| Details | Domain: {"description":"IRG-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01053","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(Microbial infection) Phosphothreonine; by ROP18","evidences":[{"source":"PubMed","id":"21203588","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
