4LT5

Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005506	molecular_function	iron ion binding
A	0010385	molecular_function	double-stranded methylated DNA binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0070579	molecular_function	DNA 5-methylcytosine dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 401

Chain	Residue
A	HIS229
A	ASP231
A	HIS279
A	OGA413
A	HOH414

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 402

Chain	Residue
A	TYR252
A	GLU254

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 403

Chain	Residue
A	ASN248
A	ASN245
A	PHE246

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 404

Chain	Residue
A	ASN175
A	ASN175
A	SER179
A	SER179
A	TYR201
A	TYR201
A	LEU207
A	LEU207

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 405

Chain	Residue
A	ASN80

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 406

Chain	Residue
A	ILE235
A	THR236

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 407

Chain	Residue
A	GLU129
A	ASN245
A	ASN245
A	GLY287
A	GLY287
A	TRP288

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 408

Chain	Residue
A	ASP138

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 409

Chain	Residue
A	GLN76
A	SER77
A	HOH549

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 410

Chain	Residue
A	PRO117
A	LYS118
A	HOH528

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 411

Chain	Residue
A	SER186
A	SER187
A	ARG188

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 412

Chain	Residue
A	PRO172
A	ASN175
A	TYR201
A	TYR201
A	ASN205
A	ASN205
A	HOH560
A	HOH560

---

site_id	BC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE OGA A 413

Chain	Residue
A	ASN214
A	ARG224
A	ILE225
A	HIS229
A	ASP231
A	LEU240
A	TYR242
A	LEU253
A	HIS279
A	VAL281
A	ARG289
A	VAL293
A	MN401
A	HOH508

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 101

Chain	Residue
C	DC22
C	DA23

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 102

Chain	Residue
B	DG9
C	DA19
C	DG21
C	HOH207

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24390346","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26323320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24390346","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26323320","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24390346","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26323320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24390346","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26323320","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"24390346","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26323320","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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