4LT5
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0005506 | molecular_function | iron ion binding |
A | 0010385 | molecular_function | double-stranded methylated DNA binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051213 | molecular_function | dioxygenase activity |
A | 0070579 | molecular_function | 5-methylcytosine dioxygenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 401 |
Chain | Residue |
A | HIS229 |
A | ASP231 |
A | HIS279 |
A | OGA413 |
A | HOH414 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 402 |
Chain | Residue |
A | TYR252 |
A | GLU254 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 403 |
Chain | Residue |
A | ASN248 |
A | ASN245 |
A | PHE246 |
site_id | AC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 404 |
Chain | Residue |
A | ASN175 |
A | ASN175 |
A | SER179 |
A | SER179 |
A | TYR201 |
A | TYR201 |
A | LEU207 |
A | LEU207 |
site_id | AC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO A 405 |
Chain | Residue |
A | ASN80 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 406 |
Chain | Residue |
A | ILE235 |
A | THR236 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 407 |
Chain | Residue |
A | GLU129 |
A | ASN245 |
A | ASN245 |
A | GLY287 |
A | GLY287 |
A | TRP288 |
site_id | AC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO A 408 |
Chain | Residue |
A | ASP138 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 409 |
Chain | Residue |
A | GLN76 |
A | SER77 |
A | HOH549 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 410 |
Chain | Residue |
A | PRO117 |
A | LYS118 |
A | HOH528 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 411 |
Chain | Residue |
A | SER186 |
A | SER187 |
A | ARG188 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 412 |
Chain | Residue |
A | PRO172 |
A | ASN175 |
A | TYR201 |
A | TYR201 |
A | ASN205 |
A | ASN205 |
A | HOH560 |
A | HOH560 |
site_id | BC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE OGA A 413 |
Chain | Residue |
A | ASN214 |
A | ARG224 |
A | ILE225 |
A | HIS229 |
A | ASP231 |
A | LEU240 |
A | TYR242 |
A | LEU253 |
A | HIS279 |
A | VAL281 |
A | ARG289 |
A | VAL293 |
A | MN401 |
A | HOH508 |
site_id | BC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO C 101 |
Chain | Residue |
C | DC22 |
C | DA23 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO C 102 |
Chain | Residue |
B | DG9 |
C | DA19 |
C | DG21 |
C | HOH207 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24390346, ECO:0000269|PubMed:26323320, ECO:0007744|PDB:4LT5, ECO:0007744|PDB:5CG8, ECO:0007744|PDB:5CG9 |
Chain | Residue | Details |
A | ASN214 | |
A | ARG224 | |
A | TYR242 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000305|PubMed:24390346, ECO:0000305|PubMed:26323320 |
Chain | Residue | Details |
A | HIS229 | |
A | ASP231 | |
A | HIS279 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000269|PubMed:24390346, ECO:0000269|PubMed:26323320, ECO:0007744|PDB:4LT5, ECO:0007744|PDB:5CG8, ECO:0007744|PDB:5CG9 |
Chain | Residue | Details |
A | ARG289 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24390346, ECO:0000269|PubMed:26323320 |
Chain | Residue | Details |
A | GLN310 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Interaction with DNA => ECO:0000269|PubMed:24390346, ECO:0000269|PubMed:26323320 |
Chain | Residue | Details |
A | SER148 |