4LKV

Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0009029	molecular_function	tetraacyldisaccharide 4'-kinase activity
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0009029	molecular_function	tetraacyldisaccharide 4'-kinase activity
B	0009244	biological_process	lipopolysaccharide core region biosynthetic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0009029	molecular_function	tetraacyldisaccharide 4'-kinase activity
C	0009244	biological_process	lipopolysaccharide core region biosynthetic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006629	biological_process	lipid metabolic process
D	0009029	molecular_function	tetraacyldisaccharide 4'-kinase activity
D	0009244	biological_process	lipopolysaccharide core region biosynthetic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EPE A 401

Chain	Residue
A	LYS145

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LP4 A 402

Chain	Residue
A	TYR13
A	ARG72
A	ARG171
A	LP5403

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LP5 A 403

Chain	Residue
A	LP4402
A	ARG72
A	GLU117
A	ARG119
A	HIS143

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LP4 C 401

Chain	Residue
C	VAL46
C	ARG72
C	ARG171
C	LP5402

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LP5 C 402

Chain	Residue
C	ARG72
C	GLU117
C	ARG119
C	GLN142
C	HIS143
C	ARG171
C	LP4401

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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