4LKM
Crystal structure of Plk1 Polo-box domain in complex with PL-74
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 701 |
| Chain | Residue |
| A | THR517 |
| A | ARG518 |
| A | SER519 |
| A | TYR582 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 5PV B -1 |
| Chain | Residue |
| C | LEU463 |
| A | TYR421 |
| A | ARG599 |
| C | TYR445 |
| C | SER450 |
| C | TYR462 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LYT B 102 |
| Chain | Residue |
| A | TYR417 |
| A | TYR485 |
| B | 5PV-1 |
| C | THR464 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 201 |
| Chain | Residue |
| A | PHE535 |
| A | HIS538 |
| B | HIS3 |
| B | SER4 |
| B | TPO5 |
| B | HOH306 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 701 |
| Chain | Residue |
| C | THR517 |
| C | ARG518 |
| C | SER519 |
| C | TYR582 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 301 |
| Chain | Residue |
| A | HOH814 |
| C | TRP414 |
| C | PHE535 |
| D | HIS3 |
| D | SER4 |
| D | TPO5 |
| D | HOH406 |
| site_id | AC7 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR CHAIN B OF PL-74 |
| Chain | Residue |
| A | LYS413 |
| A | TRP414 |
| A | VAL415 |
| A | ASP416 |
| A | TYR417 |
| A | TYR485 |
| A | HIS489 |
| A | LEU490 |
| A | LEU491 |
| A | ARG516 |
| A | HIS538 |
| A | LYS540 |
| A | HOH843 |
| B | GOL201 |
| B | HOH306 |
| B | HOH303 |
| B | HOH305 |
| B | HOH308 |
| B | HOH304 |
| B | HOH301 |
| C | HOH809 |
| C | SER466 |
| C | HOH817 |
| C | HOH834 |
| site_id | AC8 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR CHAIN D OF PL-74 |
| Chain | Residue |
| A | GLU399 |
| A | TYR570 |
| A | HOH893 |
| C | LYS413 |
| C | TRP414 |
| C | VAL415 |
| C | ASP416 |
| C | TYR417 |
| C | TYR485 |
| C | HIS489 |
| C | LEU490 |
| C | LEU491 |
| C | ARG516 |
| C | HIS538 |
| C | LYS540 |
| C | HOH848 |
| D | HOH406 |
| D | HOH402 |
| D | HOH403 |
| D | HOH404 |
| D | HOH408 |
| D | HOH410 |
| D | HOH411 |
| D | GOL301 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 156 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 164 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
