4LK3
Crystal structure of Human UDP-xylose synthase R236A substitution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0042732 | biological_process | D-xylose metabolic process |
A | 0048040 | molecular_function | UDP-glucuronate decarboxylase activity |
A | 0070403 | molecular_function | NAD+ binding |
B | 0042732 | biological_process | D-xylose metabolic process |
B | 0048040 | molecular_function | UDP-glucuronate decarboxylase activity |
B | 0070403 | molecular_function | NAD+ binding |
C | 0042732 | biological_process | D-xylose metabolic process |
C | 0048040 | molecular_function | UDP-glucuronate decarboxylase activity |
C | 0070403 | molecular_function | NAD+ binding |
D | 0042732 | biological_process | D-xylose metabolic process |
D | 0048040 | molecular_function | UDP-glucuronate decarboxylase activity |
D | 0070403 | molecular_function | NAD+ binding |
E | 0042732 | biological_process | D-xylose metabolic process |
E | 0048040 | molecular_function | UDP-glucuronate decarboxylase activity |
E | 0070403 | molecular_function | NAD+ binding |
F | 0042732 | biological_process | D-xylose metabolic process |
F | 0048040 | molecular_function | UDP-glucuronate decarboxylase activity |
F | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAD A 501 |
Chain | Residue |
A | GLY95 |
A | GLY124 |
A | HIS143 |
A | ASP144 |
A | VAL145 |
A | LEU159 |
A | ALA160 |
A | SER161 |
A | ALA163 |
A | THR178 |
A | ALA200 |
A | ALA97 |
A | SER201 |
A | THR202 |
A | LYS235 |
A | ILE258 |
A | PHE259 |
A | THR261 |
A | HIS267 |
A | GLY98 |
A | PHE99 |
A | VAL100 |
A | ASP119 |
A | ASN120 |
A | PHE122 |
A | THR123 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE UDP A 502 |
Chain | Residue |
A | ARG272 |
A | VAL273 |
A | ASN276 |
A | PHE277 |
A | THR288 |
A | VAL289 |
A | TYR290 |
A | GLN295 |
A | ARG297 |
A | ILE331 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE UGA A 503 |
Chain | Residue |
A | PRO148 |
A | LEU149 |
A | TYR150 |
A | ASN185 |
A | GLY188 |
A | LEU189 |
A | LYS191 |
A | ARG192 |
A | TYR245 |
A | GLN248 |
A | GLU249 |
B | ASN171 |
B | ILE173 |
B | LYS174 |
B | LYS177 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 504 |
Chain | Residue |
A | ARG125 |
A | HIS267 |
A | MET268 |
A | ASN269 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 505 |
Chain | Residue |
A | ARG125 |
A | LYS126 |
A | ARG127 |
F | ARG125 |
F | LYS126 |
F | ARG127 |
site_id | AC6 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NAD B 501 |
Chain | Residue |
B | GLY95 |
B | ALA97 |
B | GLY98 |
B | PHE99 |
B | VAL100 |
B | ASP119 |
B | ASN120 |
B | PHE121 |
B | PHE122 |
B | THR123 |
B | GLY124 |
B | HIS143 |
B | ASP144 |
B | VAL145 |
B | LEU159 |
B | ALA160 |
B | SER161 |
B | PRO162 |
B | ALA163 |
B | THR178 |
B | ALA200 |
B | SER201 |
B | THR202 |
B | LYS235 |
B | ILE258 |
B | PHE259 |
B | THR261 |
B | HIS267 |
B | ARG272 |
B | HOH615 |
site_id | AC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE UDP B 502 |
Chain | Residue |
B | ARG297 |
B | ILE331 |
B | HOH613 |
B | GLY271 |
B | ARG272 |
B | VAL273 |
B | ASN276 |
B | PHE277 |
B | THR288 |
B | TYR290 |
B | GLN295 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UGA B 503 |
Chain | Residue |
A | LYS177 |
B | PRO148 |
B | LEU149 |
B | TYR150 |
B | LEU184 |
B | ASN185 |
B | GLY188 |
B | LEU189 |
B | LYS191 |
B | ARG192 |
B | TYR245 |
B | GLN248 |
B | GLU249 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 504 |
Chain | Residue |
B | ARG125 |
B | HIS267 |
B | MET268 |
B | ASN269 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 505 |
Chain | Residue |
B | ARG125 |
B | LYS126 |
B | ARG127 |
C | ARG125 |
C | LYS126 |
C | ARG127 |
site_id | BC2 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAD C 501 |
Chain | Residue |
C | GLY95 |
C | ALA97 |
C | GLY98 |
C | PHE99 |
C | VAL100 |
C | ASP119 |
C | ASN120 |
C | PHE122 |
C | THR123 |
C | GLY124 |
C | HIS143 |
C | ASP144 |
C | VAL145 |
C | LEU159 |
C | ALA160 |
C | SER161 |
C | PRO162 |
C | THR178 |
C | ALA200 |
C | SER201 |
C | THR202 |
C | LYS235 |
C | ILE258 |
C | THR261 |
C | HIS267 |
C | ARG272 |
C | HOH607 |
C | HOH614 |
site_id | BC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UGA C 502 |
Chain | Residue |
C | PRO148 |
C | LEU149 |
C | TYR150 |
C | LEU184 |
C | ASN185 |
C | GLY188 |
C | LEU189 |
C | LYS191 |
C | ARG192 |
C | TYR245 |
C | GLN248 |
C | GLU249 |
D | LYS177 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE POP C 503 |
Chain | Residue |
C | ARG272 |
C | VAL273 |
C | ARG297 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 504 |
Chain | Residue |
C | ARG125 |
C | HIS267 |
C | MET268 |
C | ASN269 |
site_id | BC6 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAD D 501 |
Chain | Residue |
D | GLY95 |
D | ALA97 |
D | GLY98 |
D | PHE99 |
D | VAL100 |
D | ASP119 |
D | ASN120 |
D | PHE121 |
D | PHE122 |
D | THR123 |
D | GLY124 |
D | HIS143 |
D | ASP144 |
D | VAL145 |
D | LEU159 |
D | SER161 |
D | ALA163 |
D | THR178 |
D | ALA200 |
D | SER201 |
D | THR202 |
D | LYS235 |
D | ILE258 |
D | PHE259 |
D | ASN260 |
D | THR261 |
D | HIS267 |
D | ARG272 |
site_id | BC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE UDP D 502 |
Chain | Residue |
D | ASN260 |
D | ARG272 |
D | VAL273 |
D | ASN276 |
D | THR288 |
D | TYR290 |
D | GLN295 |
D | ARG297 |
D | ILE331 |
site_id | BC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UGA D 503 |
Chain | Residue |
C | ASN171 |
C | LYS177 |
D | PRO148 |
D | LEU149 |
D | TYR150 |
D | ASN185 |
D | GLY188 |
D | LEU189 |
D | LYS191 |
D | ARG192 |
D | TYR245 |
D | GLN248 |
D | GLU249 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 D 504 |
Chain | Residue |
D | ARG125 |
D | LYS126 |
D | ARG127 |
E | ARG125 |
E | LYS126 |
E | ARG127 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 505 |
Chain | Residue |
D | ARG125 |
D | HIS267 |
D | MET268 |
D | ASN269 |
site_id | CC2 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAD E 501 |
Chain | Residue |
E | GLY95 |
E | ALA97 |
E | GLY98 |
E | PHE99 |
E | VAL100 |
E | ASP119 |
E | ASN120 |
E | PHE121 |
E | PHE122 |
E | THR123 |
E | GLY124 |
E | HIS143 |
E | ASP144 |
E | VAL145 |
E | LEU159 |
E | ALA160 |
E | SER161 |
E | THR178 |
E | ALA200 |
E | SER201 |
E | THR202 |
E | LYS235 |
E | ILE258 |
E | THR261 |
E | HIS267 |
E | ARG272 |
site_id | CC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE POP E 502 |
Chain | Residue |
E | ARG297 |
site_id | CC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UGA E 503 |
Chain | Residue |
E | PRO148 |
E | LEU149 |
E | TYR150 |
E | ASN185 |
E | GLY188 |
E | LEU189 |
E | LYS191 |
E | ARG192 |
E | TYR245 |
E | GLN248 |
E | GLU249 |
E | HOH602 |
F | LYS177 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 504 |
Chain | Residue |
E | ARG125 |
E | HIS267 |
E | MET268 |
E | ASN269 |
site_id | CC6 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAD F 501 |
Chain | Residue |
F | GLY95 |
F | ALA97 |
F | GLY98 |
F | PHE99 |
F | VAL100 |
F | ASP119 |
F | ASN120 |
F | PHE121 |
F | PHE122 |
F | THR123 |
F | GLY124 |
F | HIS143 |
F | ASP144 |
F | VAL145 |
F | LEU159 |
F | ALA160 |
F | SER161 |
F | THR178 |
F | SER201 |
F | THR202 |
F | LYS235 |
F | ILE258 |
F | PHE259 |
F | THR261 |
F | HIS267 |
F | ARG272 |
site_id | CC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UGA F 502 |
Chain | Residue |
E | LYS174 |
E | LYS177 |
F | PRO148 |
F | LEU149 |
F | TYR150 |
F | ASN185 |
F | GLY188 |
F | LEU189 |
F | LYS191 |
F | ARG192 |
F | TYR245 |
F | GLN248 |
F | GLU249 |
site_id | CC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE POP F 503 |
Chain | Residue |
F | ASN260 |
F | ARG272 |
F | VAL273 |
F | ARG297 |
F | PHE299 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 F 504 |
Chain | Residue |
F | ARG125 |
F | HIS267 |
F | MET268 |
F | ASN269 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:23656592, ECO:0000269|PubMed:25521717 |
Chain | Residue | Details |
A | TYR231 | |
B | TYR231 | |
C | TYR231 | |
D | TYR231 | |
E | TYR231 | |
F | TYR231 |
site_id | SWS_FT_FI2 |
Number of Residues | 90 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22810237, ECO:0000269|PubMed:25521717, ECO:0007744|PDB:2B69, ECO:0007744|PDB:4LK3, ECO:0007744|PDB:4M55 |
Chain | Residue | Details |
B | ASP119 | |
B | ASN120 | |
B | PHE122 | |
B | THR123 | |
B | GLY124 | |
B | ASP144 | |
B | VAL145 | |
B | LEU159 | |
B | THR178 | |
B | LYS235 | |
B | THR261 | |
B | ARG272 | |
C | GLY98 | |
C | PHE99 | |
C | VAL100 | |
C | ASP119 | |
C | ASN120 | |
C | PHE122 | |
C | THR123 | |
C | GLY124 | |
C | ASP144 | |
C | VAL145 | |
C | LEU159 | |
C | THR178 | |
C | LYS235 | |
C | THR261 | |
C | ARG272 | |
D | GLY98 | |
D | PHE99 | |
D | VAL100 | |
D | ASP119 | |
D | ASN120 | |
D | PHE122 | |
D | THR123 | |
D | GLY124 | |
D | ASP144 | |
D | VAL145 | |
D | LEU159 | |
D | THR178 | |
D | LYS235 | |
D | THR261 | |
D | ARG272 | |
E | GLY98 | |
E | PHE99 | |
E | VAL100 | |
E | ASP119 | |
E | ASN120 | |
E | PHE122 | |
E | THR123 | |
E | GLY124 | |
E | ASP144 | |
E | VAL145 | |
E | LEU159 | |
E | THR178 | |
E | LYS235 | |
E | THR261 | |
E | ARG272 | |
F | GLY98 | |
F | PHE99 | |
F | VAL100 | |
F | ASP119 | |
F | ASN120 | |
F | PHE122 | |
F | THR123 | |
F | GLY124 | |
F | ASP144 | |
F | VAL145 | |
F | LEU159 | |
F | THR178 | |
F | LYS235 | |
F | THR261 | |
F | ARG272 | |
A | GLY98 | |
A | PHE99 | |
A | VAL100 | |
A | ASP119 | |
A | ASN120 | |
A | PHE122 | |
A | THR123 | |
A | GLY124 | |
A | ASP144 | |
A | VAL145 | |
A | LEU159 | |
A | THR178 | |
A | LYS235 | |
A | THR261 | |
A | ARG272 | |
B | GLY98 | |
B | PHE99 | |
B | VAL100 |
site_id | SWS_FT_FI3 |
Number of Residues | 66 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25521717, ECO:0007744|PDB:4LK3 |
Chain | Residue | Details |
C | TYR245 | |
C | GLN248 | |
C | GLU249 | |
D | LEU149 | |
D | TYR150 | |
D | LYS177 | |
D | ASN185 | |
D | GLY188 | |
D | LYS191 | |
D | ARG192 | |
D | ALA200 | |
D | TYR245 | |
D | GLN248 | |
D | GLU249 | |
E | LEU149 | |
E | TYR150 | |
E | LYS177 | |
E | ASN185 | |
E | GLY188 | |
E | LYS191 | |
E | ARG192 | |
E | ALA200 | |
E | TYR245 | |
E | GLN248 | |
E | GLU249 | |
F | LEU149 | |
F | TYR150 | |
F | LYS177 | |
F | ASN185 | |
F | GLY188 | |
F | LYS191 | |
F | ARG192 | |
F | ALA200 | |
F | TYR245 | |
F | GLN248 | |
F | GLU249 | |
A | ALA200 | |
A | TYR245 | |
A | GLN248 | |
A | GLU249 | |
B | LEU149 | |
B | TYR150 | |
B | LYS177 | |
B | ASN185 | |
B | GLY188 | |
B | LYS191 | |
B | ARG192 | |
B | ALA200 | |
B | TYR245 | |
B | GLN248 | |
B | GLU249 | |
C | LEU149 | |
C | TYR150 | |
C | LYS177 | |
C | ASN185 | |
C | GLY188 | |
C | LYS191 | |
C | ARG192 | |
C | ALA200 | |
A | ARG192 | |
A | LEU149 | |
A | TYR150 | |
A | LYS177 | |
A | ASN185 | |
A | GLY188 | |
A | LYS191 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25521717, ECO:0007744|PDB:4M55 |
Chain | Residue | Details |
A | SER161 | |
B | SER161 | |
C | SER161 | |
D | SER161 | |
E | SER161 | |
F | SER161 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22810237, ECO:0007744|PDB:2B69 |
Chain | Residue | Details |
A | TYR231 | |
B | TYR231 | |
C | TYR231 | |
D | TYR231 | |
E | TYR231 | |
F | TYR231 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25521717, ECO:0007744|PDB:4LK3, ECO:0007744|PDB:4M55 |
Chain | Residue | Details |
A | HIS267 | |
B | HIS267 | |
C | HIS267 | |
D | HIS267 | |
E | HIS267 | |
F | HIS267 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
A | THR94 | |
B | THR94 | |
C | THR94 | |
D | THR94 | |
E | THR94 | |
F | THR94 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN316 | |
B | ASN316 | |
C | ASN316 | |
D | ASN316 | |
E | ASN316 | |
F | ASN316 |