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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4LK0

Crystal Structure Analysis of the E.coli holoenzyme/T7 Gp2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed RNA polymerase activity
A0006351biological_processDNA-templated transcription
A0046983molecular_functionprotein dimerization activity
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0006351biological_processDNA-templated transcription
B0046983molecular_functionprotein dimerization activity
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed RNA polymerase activity
C0006351biological_processDNA-templated transcription
C0032549molecular_functionribonucleoside binding
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed RNA polymerase activity
D0006351biological_processDNA-templated transcription
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0006351biological_processDNA-templated transcription
F0003677molecular_functionDNA binding
F0003700molecular_functionDNA-binding transcription factor activity
F0006352biological_processDNA-templated transcription initiation
F0006355biological_processregulation of DNA-templated transcription
F0016987molecular_functionsigma factor activity
G0003677molecular_functionDNA binding
G0003899molecular_functionDNA-directed RNA polymerase activity
G0006351biological_processDNA-templated transcription
G0046983molecular_functionprotein dimerization activity
H0003677molecular_functionDNA binding
H0003899molecular_functionDNA-directed RNA polymerase activity
H0006351biological_processDNA-templated transcription
H0046983molecular_functionprotein dimerization activity
I0003677molecular_functionDNA binding
I0003899molecular_functionDNA-directed RNA polymerase activity
I0006351biological_processDNA-templated transcription
I0032549molecular_functionribonucleoside binding
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed RNA polymerase activity
J0006351biological_processDNA-templated transcription
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed RNA polymerase activity
K0006351biological_processDNA-templated transcription
L0003677molecular_functionDNA binding
L0003700molecular_functionDNA-binding transcription factor activity
L0006352biological_processDNA-templated transcription initiation
L0006355biological_processregulation of DNA-templated transcription
L0016987molecular_functionsigma factor activity
M0039653biological_processsymbiont-mediated suppression of host transcription
M0039657biological_processsymbiont-mediated suppression of host gene expression
N0039653biological_processsymbiont-mediated suppression of host transcription
N0039657biological_processsymbiont-mediated suppression of host gene expression
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG D 1501
ChainResidue
DASP460
DASP462
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 1502
ChainResidue
DCYS70
DCYS72
DCYS85
DCYS88
site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 1503
ChainResidue
DCYS898
DCYS814
DCYS888
DCYS895
site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG J 1501
ChainResidue
JASP460
JASP462
site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 1502
ChainResidue
JCYS70
JCYS72
JCYS85
JCYS88
site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 1503
ChainResidue
JCYS814
JCYS888
JCYS895
JCYS898
Functional Information from PROSITE/UniProt
site_idPS00715
Number of Residues14
DetailsSIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnIGLMkAV
ChainResidueDetails
FASP403-VAL416
site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TleEVGkqfdVTrerIrQIEakaLrkL
ChainResidueDetails
FTHR572-LEU598
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV
ChainResidueDetails
CGLY1063-VAL1075
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues38
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues140
DetailsRegion: {"description":"Sigma-70 factor domain-2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues152
DetailsRegion: {"description":"Sigma-70 factor domain-3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues106
DetailsRegion: {"description":"Sigma-70 factor domain-4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues30
DetailsRegion: {"description":"Interaction with anti-sigma factors"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsMotif: {"description":"Interaction with polymerase core subunit RpoC"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsSite: {"description":"Interaction with anti-sigma factors"}
ChainResidueDetails

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PDB entries from 2025-12-10

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