Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CIT A 701 |
| Chain | Residue |
| A | LYS219 |
| A | ARG223 |
| A | ARG473 |
| A | HOH805 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 702 |
| Chain | Residue |
| A | PHE504 |
| A | TYR549 |
| A | LEU550 |
| A | VAL565 |
| A | GLN568 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 703 |
| Chain | Residue |
| A | HIS542 |
| A | CYS572 |
| A | CYS575 |
| A | CYS591 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 704 |
| Chain | Residue |
| A | CYS555 |
| A | CYS558 |
| A | HIS580 |
| A | CYS583 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DHDQDGYISqeEF |
| Chain | Residue | Details |
| A | ASP483-PHE495 | |
| A | ASP510-ILE522 | |
| site_id | PS00479 |
| Number of Residues | 50 |
| Details | ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFqettylkptf.CdnCagfLwgvikqgyr.CkdCgmncHkqCkdlvvfe..C |
| Chain | Residue | Details |
| A | HIS542-CYS591 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 123 |
| Details | Domain: {"description":"N-terminal Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00135","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 231 |
| Details | Domain: {"description":"Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00168","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 50 |
| Details | Zinc finger: {"description":"Phorbol-ester/DAG-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 53 |
| Details | Region: {"description":"Ras exchanger motif region; required for transforming activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"15657177","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15899849","evidenceCode":"ECO:0000269"}]} |
