4L3Q
Crystal structure of glucokinase-activator complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001678 | biological_process | intracellular glucose homeostasis |
| A | 0004340 | molecular_function | glucokinase activity |
| A | 0004396 | molecular_function | hexokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006007 | biological_process | glucose catabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006110 | biological_process | regulation of glycolytic process |
| A | 0006163 | biological_process | purine nucleotide metabolic process |
| A | 0008865 | molecular_function | fructokinase activity |
| A | 0009749 | biological_process | response to glucose |
| A | 0019158 | molecular_function | mannokinase activity |
| A | 0019318 | biological_process | hexose metabolic process |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0044320 | biological_process | cellular response to leptin stimulus |
| A | 0045721 | biological_process | negative regulation of gluconeogenesis |
| A | 0045725 | biological_process | positive regulation of glycogen biosynthetic process |
| A | 0046496 | biological_process | nicotinamide nucleotide metabolic process |
| A | 0050796 | biological_process | regulation of insulin secretion |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 0061621 | biological_process | canonical glycolysis |
| A | 0070509 | biological_process | calcium ion import |
| A | 0141089 | molecular_function | glucose sensor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00378 |
| Number of Residues | 26 |
| Details | HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPvrhedIDkgiLlnWTKgF |
| Chain | Residue | Details |
| A | LEU146-PHE171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 136 |
| Details | Region: {"description":"Hexokinase small subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 239 |
| Details | Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P19367","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15016359","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22101819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ID8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 592 |
| Chain | Residue | Details |
| A | LYS169 | proton acceptor, proton donor |
| A | ASP205 | metal ligand, proton acceptor, proton donor |
