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4KVG

Crystal structure of RIAM RA-PH domains in complex with GTP bound Rap1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0007399biological_processnervous system development
A0010008cellular_componentendosome membrane
A0010976biological_processpositive regulation of neuron projection development
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030033biological_processmicrovillus assembly
A0030054cellular_componentcell junction
A0031267molecular_functionsmall GTPase binding
A0032045cellular_componentguanyl-nucleotide exchange factor complex
A0032486biological_processRap protein signal transduction
A0035579cellular_componentspecific granule membrane
A0038180biological_processnerve growth factor signaling pathway
A0043005cellular_componentneuron projection
A0043547biological_processpositive regulation of GTPase activity
A0044877molecular_functionprotein-containing complex binding
A0045860biological_processpositive regulation of protein kinase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0061028biological_processestablishment of endothelial barrier
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071320biological_processcellular response to cAMP
A0072659biological_processprotein localization to plasma membrane
A0097225cellular_componentsperm midpiece
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A1901888biological_processregulation of cell junction assembly
A1990090biological_processcellular response to nerve growth factor stimulus
A2000301biological_processnegative regulation of synaptic vesicle exocytosis
A2001214biological_processpositive regulation of vasculogenesis
B0007165biological_processsignal transduction
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007264biological_processsmall GTPase-mediated signal transduction
C0007399biological_processnervous system development
C0010008cellular_componentendosome membrane
C0010976biological_processpositive regulation of neuron projection development
C0016020cellular_componentmembrane
C0016079biological_processsynaptic vesicle exocytosis
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0030033biological_processmicrovillus assembly
C0030054cellular_componentcell junction
C0031267molecular_functionsmall GTPase binding
C0032045cellular_componentguanyl-nucleotide exchange factor complex
C0032486biological_processRap protein signal transduction
C0035579cellular_componentspecific granule membrane
C0038180biological_processnerve growth factor signaling pathway
C0043005cellular_componentneuron projection
C0043547biological_processpositive regulation of GTPase activity
C0044877molecular_functionprotein-containing complex binding
C0045860biological_processpositive regulation of protein kinase activity
C0048471cellular_componentperinuclear region of cytoplasm
C0061028biological_processestablishment of endothelial barrier
C0070062cellular_componentextracellular exosome
C0070161cellular_componentanchoring junction
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0071320biological_processcellular response to cAMP
C0072659biological_processprotein localization to plasma membrane
C0097225cellular_componentsperm midpiece
C0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C0098793cellular_componentpresynapse
C0098978cellular_componentglutamatergic synapse
C1901888biological_processregulation of cell junction assembly
C1990090biological_processcellular response to nerve growth factor stimulus
C2000301biological_processnegative regulation of synaptic vesicle exocytosis
C2001214biological_processpositive regulation of vasculogenesis
D0007165biological_processsignal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues28
DetailsBINDING SITE FOR RESIDUE GTP A 201
ChainResidue
AVAL12
AGLU30
ATYR32
APRO34
ATHR35
AGLY60
AASN116
ALYS117
AASP119
ALEU120
ASER147
AGLY13
AALA148
ALYS149
AMG202
AHOH305
AHOH308
AHOH358
AHOH387
AHOH412
AHOH413
AVAL14
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 202
ChainResidue
ASER17
ATHR35
AGTP201
AHOH412
AHOH413

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 501
ChainResidue
BPHE306
BCYS307
BTYR427
BASP428
BHOH718
BHOH802
DLYS374

site_idAC4
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GTP C 201
ChainResidue
CGLY13
CVAL14
CGLY15
CLYS16
CSER17
CALA18
CPHE28
CVAL29
CGLU30
CTYR32
CPRO34
CTHR35
CGLY60
CASN116
CLYS117
CASP119
CLEU120
CSER147
CALA148
CLYS149
CMG202
CHOH306
CHOH332
CHOH333

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C 202
ChainResidue
CSER17
CTHR35
CGTP201
CHOH332
CHOH333

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO D 501
ChainResidue
AHOH317
BLYS374
DPHE306
DCYS307
DLYS424
DTYR427
DASP428
DHOH723
DHOH733

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:7791872, ECO:0000269|PubMed:8756332
ChainResidueDetails
AGLY10
AVAL29
AGLY60
AASN116
CGLY10
CVAL29
CGLY60
CASN116

222624

PDB entries from 2024-07-17

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