Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KF6

Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 8:0 Ceramide-1-Phosphate (8:0-C1P)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005543	molecular_function	phospholipid binding
A	0005634	cellular_component	nucleus
A	0005640	cellular_component	nuclear outer membrane
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0010008	cellular_component	endosome membrane
A	0010507	biological_process	negative regulation of autophagy
A	0016020	cellular_component	membrane
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0035627	biological_process	ceramide transport
A	0046836	biological_process	glycolipid transport
A	0120009	biological_process	intermembrane lipid transfer
A	0120013	molecular_function	lipid transfer activity
A	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
A	1902387	molecular_function	ceramide 1-phosphate binding
A	1902388	molecular_function	ceramide 1-phosphate transfer activity
A	1902389	biological_process	ceramide 1-phosphate transport
B	0005543	molecular_function	phospholipid binding
B	0005634	cellular_component	nucleus
B	0005640	cellular_component	nuclear outer membrane
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0010008	cellular_component	endosome membrane
B	0010507	biological_process	negative regulation of autophagy
B	0016020	cellular_component	membrane
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0035627	biological_process	ceramide transport
B	0046836	biological_process	glycolipid transport
B	0120009	biological_process	intermembrane lipid transfer
B	0120013	molecular_function	lipid transfer activity
B	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
B	1902387	molecular_function	ceramide 1-phosphate binding
B	1902388	molecular_function	ceramide 1-phosphate transfer activity
B	1902389	biological_process	ceramide 1-phosphate transport
C	0005543	molecular_function	phospholipid binding
C	0005634	cellular_component	nucleus
C	0005640	cellular_component	nuclear outer membrane
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0010008	cellular_component	endosome membrane
C	0010507	biological_process	negative regulation of autophagy
C	0016020	cellular_component	membrane
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0035627	biological_process	ceramide transport
C	0046836	biological_process	glycolipid transport
C	0120009	biological_process	intermembrane lipid transfer
C	0120013	molecular_function	lipid transfer activity
C	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
C	1902387	molecular_function	ceramide 1-phosphate binding
C	1902388	molecular_function	ceramide 1-phosphate transfer activity
C	1902389	biological_process	ceramide 1-phosphate transport
D	0005543	molecular_function	phospholipid binding
D	0005634	cellular_component	nucleus
D	0005640	cellular_component	nuclear outer membrane
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0010008	cellular_component	endosome membrane
D	0010507	biological_process	negative regulation of autophagy
D	0016020	cellular_component	membrane
D	0032691	biological_process	negative regulation of interleukin-1 beta production
D	0035627	biological_process	ceramide transport
D	0046836	biological_process	glycolipid transport
D	0120009	biological_process	intermembrane lipid transfer
D	0120013	molecular_function	lipid transfer activity
D	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
D	1902387	molecular_function	ceramide 1-phosphate binding
D	1902388	molecular_function	ceramide 1-phosphate transfer activity
D	1902389	biological_process	ceramide 1-phosphate transport
E	0005543	molecular_function	phospholipid binding
E	0005634	cellular_component	nucleus
E	0005640	cellular_component	nuclear outer membrane
E	0005737	cellular_component	cytoplasm
E	0005768	cellular_component	endosome
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006869	biological_process	lipid transport
E	0008289	molecular_function	lipid binding
E	0010008	cellular_component	endosome membrane
E	0010507	biological_process	negative regulation of autophagy
E	0016020	cellular_component	membrane
E	0032691	biological_process	negative regulation of interleukin-1 beta production
E	0035627	biological_process	ceramide transport
E	0046836	biological_process	glycolipid transport
E	0120009	biological_process	intermembrane lipid transfer
E	0120013	molecular_function	lipid transfer activity
E	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
E	1902387	molecular_function	ceramide 1-phosphate binding
E	1902388	molecular_function	ceramide 1-phosphate transfer activity
E	1902389	biological_process	ceramide 1-phosphate transport
F	0005543	molecular_function	phospholipid binding
F	0005634	cellular_component	nucleus
F	0005640	cellular_component	nuclear outer membrane
F	0005737	cellular_component	cytoplasm
F	0005768	cellular_component	endosome
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006869	biological_process	lipid transport
F	0008289	molecular_function	lipid binding
F	0010008	cellular_component	endosome membrane
F	0010507	biological_process	negative regulation of autophagy
F	0016020	cellular_component	membrane
F	0032691	biological_process	negative regulation of interleukin-1 beta production
F	0035627	biological_process	ceramide transport
F	0046836	biological_process	glycolipid transport
F	0120009	biological_process	intermembrane lipid transfer
F	0120013	molecular_function	lipid transfer activity
F	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
F	1902387	molecular_function	ceramide 1-phosphate binding
F	1902388	molecular_function	ceramide 1-phosphate transfer activity
F	1902389	biological_process	ceramide 1-phosphate transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1T9 A 301

Chain	Residue
A	ILE53
A	VAL153
D	TRP152
A	ASP56
A	LYS60
A	ARG106
A	ARG110
A	ALA114
A	TRP117
A	LEU146
A	HIS150

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1T9 B 301

Chain	Residue
B	ILE53
B	ASP56
B	LYS60
B	ARG106
B	ARG110
B	HIS150
B	ALA157
F	TRP152

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1T9 C 301

Chain	Residue
A	TRP152
A	ARG156
C	ILE53
C	ASP56
C	LYS60
C	ARG106
C	ARG110
C	HIS150
C	VAL153

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1T9 D 301

Chain	Residue
C	TRP152
C	ARG156
D	ILE53
D	ASP56
D	LYS60
D	ARG106
D	ARG110
D	HIS150

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1T9 E 301

Chain	Residue
B	TRP152
E	ILE53
E	ASP56
E	VAL57
E	LYS60
E	ARG106
E	ARG110
E	TRP117
E	TYR142
E	LEU146
E	HIS150

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1T9 F 301

Chain	Residue
E	TRP152
E	ARG156
F	ASP56
F	LYS60
F	ARG106
F	ARG110
F	HIS150

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23863933","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)