4KAZ
Crystal structure of RNase T in complex with a Y structured DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006396 | biological_process | RNA processing |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008310 | molecular_function | single-stranded DNA 3'-5' DNA exonuclease activity |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016896 | molecular_function | RNA exonuclease activity, producing 5'-phosphomonoesters |
| A | 0031125 | biological_process | rRNA 3'-end processing |
| A | 0034644 | biological_process | cellular response to UV |
| A | 0042780 | biological_process | tRNA 3'-end processing |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043628 | biological_process | regulatory ncRNA 3'-end processing |
| A | 0045004 | biological_process | DNA replication proofreading |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | GLU25 |
| A | HIS181 |
| A | ASP186 |
| A | HOH429 |
| B | DC20 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 101 |
| Chain | Residue |
| B | DC19 |
| B | DC20 |
| A | ASP23 |
| A | HOH409 |
| A | HOH410 |
| A | HOH419 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 174 |
| Details | Domain: {"description":"Exonuclease","evidences":[{"source":"HAMAP-Rule","id":"MF_00157","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00157","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21317904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22718982","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Site: {"description":"Important for substrate binding and specificity"} |
| Chain | Residue | Details |
