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4KAX

Crystal structure of the Grp1 PH domain in complex with Arf6-GTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0001889biological_processliver development
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006886biological_processintracellular protein transport
A0007155biological_processcell adhesion
A0007399biological_processnervous system development
A0010975biological_processregulation of neuron projection development
A0010976biological_processpositive regulation of neuron projection development
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030139cellular_componentendocytic vesicle
A0030154biological_processcell differentiation
A0030496cellular_componentmidbody
A0030838biological_processpositive regulation of actin filament polymerization
A0030866biological_processcortical actin cytoskeleton organization
A0031527cellular_componentfilopodium membrane
A0031901cellular_componentearly endosome membrane
A0031996molecular_functionthioesterase binding
A0032154cellular_componentcleavage furrow
A0032456biological_processendocytic recycling
A0034394biological_processprotein localization to cell surface
A0035020biological_processregulation of Rac protein signal transduction
A0035591molecular_functionsignaling adaptor activity
A0036010biological_processprotein localization to endosome
A0042995cellular_componentcell projection
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048488biological_processsynaptic vesicle endocytosis
A0050714biological_processpositive regulation of protein secretion
A0051301biological_processcell division
A0051489biological_processregulation of filopodium assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060998biological_processregulation of dendritic spine development
A0070062cellular_componentextracellular exosome
A0072659biological_processprotein localization to plasma membrane
A0090162biological_processestablishment of epithelial cell polarity
A0090543cellular_componentFlemming body
A0097178biological_processruffle assembly
A0097284biological_processhepatocyte apoptotic process
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099562biological_processmaintenance of postsynaptic density structure
A0120183biological_processpositive regulation of focal adhesion disassembly
A1902217biological_processerythrocyte apoptotic process
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903438biological_processpositive regulation of mitotic cytokinetic process
A1905345biological_processprotein localization to cleavage furrow
A1905606biological_processregulation of presynapse assembly
A1990090biological_processcellular response to nerve growth factor stimulus
A2000009biological_processnegative regulation of protein localization to cell surface
A2000171biological_processnegative regulation of dendrite development
Functional Information from PDB Data
site_idAC1
Number of Residues28
DetailsBINDING SITE FOR RESIDUE GTP A 201
ChainResidue
AASP22
AGLY66
AASN122
ALYS123
AASP125
ALEU126
ACYS155
AALA156
AMG202
AHOH311
AHOH314
AALA23
AHOH323
AHOH329
AHOH340
AHOH342
AHOH353
AHOH354
AHOH355
AHOH388
AHOH414
AALA24
AGLY25
ALYS26
ATHR27
ATHR28
ATHR41
ATHR44

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 202
ChainResidue
ATHR27
ATHR44
AGTP201
AHOH354
AHOH355

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE CIT A 203
ChainResidue
ALYS34
ATHR51
ATHR53
ALYS55
ALYS58
AGOL204
AHOH349
AHOH371
AHOH389
AHOH420
BALA396
BASN397

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 204
ChainResidue
ALEU33
ALYS34
AVAL52
ATHR53
ALYS55
ATYR163
ACIT203
AHOH341
AHOH344

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 205
ChainResidue
AHIS76
ATHR79
AHOH359
AHOH364
BGLY348
BHOH1281

site_idAC6
Number of Residues25
DetailsBINDING SITE FOR RESIDUE 4IP B 1101
ChainResidue
BLYS273
BGLY275
BGLY276
BARG277
BVAL278
BTHR280
BLYS282
BARG284
BTYR295
BARG305
BLYS343
BASN354
BHIS355
BHOH1201
BHOH1211
BHOH1215
BHOH1221
BHOH1226
BHOH1247
BHOH1252
BHOH1263
BHOH1293
BHOH1301
BHOH1305
BHOH1356

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1102
ChainResidue
AASP94
BTRP281
BASP320
BARG322
BARG359
BHOH1265
BHOH1272
BHOH1275

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1103
ChainResidue
ALYS69
BPHE263
BASN264
BASP266
BTHR289
BASP290

site_idAC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1104
ChainResidue
BTHR259
BTRP285
BILE287
BTHR299
BASP301
BHOH1358
BHOH1374
BHOH1387

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING:
ChainResidueDetails
BLYS273
ATHR41
AASP63
AASN122
ACYS155

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:23940353
ChainResidueDetails
BTRP285
BPHE296
BGLY306
BHIS355

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PDB entries from 2024-07-24

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