Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4K95

Crystal Structure of Parkin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000139cellular_componentGolgi membrane
A0000151cellular_componentubiquitin ligase complex
A0000209biological_processprotein polyubiquitination
A0000266biological_processmitochondrial fission
A0000422biological_processautophagy of mitochondrion
A0000423biological_processmitophagy
A0001664molecular_functionG protein-coupled receptor binding
A0001963biological_processsynaptic transmission, dopaminergic
A0001964biological_processstartle response
A0003714molecular_functiontranscription corepressor activity
A0003779molecular_functionactin binding
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0006511biological_processubiquitin-dependent protein catabolic process
A0006513biological_processprotein monoubiquitination
A0006914biological_processautophagy
A0006979biological_processresponse to oxidative stress
A0006986biological_processresponse to unfolded protein
A0007005biological_processmitochondrion organization
A0007612biological_processlearning
A0007626biological_processlocomotory behavior
A0008013molecular_functionbeta-catenin binding
A0008021cellular_componentsynaptic vesicle
A0008270molecular_functionzinc ion binding
A0008344biological_processadult locomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0009896biological_processpositive regulation of catabolic process
A0010498biological_processproteasomal protein catabolic process
A0010506biological_processregulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010636biological_processpositive regulation of mitochondrial fusion
A0010637biological_processnegative regulation of mitochondrial fusion
A0010821biological_processregulation of mitochondrion organization
A0010918biological_processpositive regulation of mitochondrial membrane potential
A0010994biological_processfree ubiquitin chain polymerization
A0014069cellular_componentpostsynaptic density
A0014850biological_processresponse to muscle activity
A0015631molecular_functiontubulin binding
A0016235cellular_componentaggresome
A0016567biological_processprotein ubiquitination
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0019005cellular_componentSCF ubiquitin ligase complex
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0019901molecular_functionprotein kinase binding
A0022603biological_processregulation of anatomical structure morphogenesis
A0030163biological_processprotein catabolic process
A0030165molecular_functionPDZ domain binding
A0030424cellular_componentaxon
A0030544molecular_functionHsp70 protein binding
A0030672cellular_componentsynaptic vesicle membrane
A0031072molecular_functionheat shock protein binding
A0031396biological_processregulation of protein ubiquitination
A0031624molecular_functionubiquitin conjugating enzyme binding
A0031625molecular_functionubiquitin protein ligase binding
A0031647biological_processregulation of protein stability
A0031648biological_processprotein destabilization
A0032232biological_processnegative regulation of actin filament bundle assembly
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032991cellular_componentprotein-containing complex
A0033132biological_processnegative regulation of glucokinase activity
A0034599biological_processcellular response to oxidative stress
A0034976biological_processresponse to endoplasmic reticulum stress
A0035249biological_processsynaptic transmission, glutamatergic
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042053biological_processregulation of dopamine metabolic process
A0042415biological_processnorepinephrine metabolic process
A0042417biological_processdopamine metabolic process
A0042802molecular_functionidentical protein binding
A0042826molecular_functionhistone deacetylase binding
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043130molecular_functionubiquitin binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043195cellular_componentterminal bouton
A0043274molecular_functionphospholipase binding
A0043524biological_processnegative regulation of neuron apoptotic process
A0043653biological_processmitochondrial fragmentation involved in apoptotic process
A0044314biological_processprotein K27-linked ubiquitination
A0044828biological_processhost-mediated suppression of viral genome replication
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046329biological_processnegative regulation of JNK cascade
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048471cellular_componentperinuclear region of cytoplasm
A0050804biological_processmodulation of chemical synaptic transmission
A0050821biological_processprotein stabilization
A0051087molecular_functionprotein-folding chaperone binding
A0051412biological_processresponse to corticosterone
A0051582biological_processpositive regulation of neurotransmitter uptake
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051646biological_processmitochondrion localization
A0051865biological_processprotein autoubiquitination
A0051881biological_processregulation of mitochondrial membrane potential
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0061630molecular_functionubiquitin protein ligase activity
A0061734biological_processtype 2 mitophagy
A0070050biological_processneuron cellular homeostasis
A0070534biological_processprotein K63-linked ubiquitination
A0070585biological_processprotein localization to mitochondrion
A0070842biological_processaggresome assembly
A0070936biological_processprotein K48-linked ubiquitination
A0070979biological_processprotein K11-linked ubiquitination
A0071287biological_processcellular response to manganese ion
A0080090biological_processregulation of primary metabolic process
A0085020biological_processprotein K6-linked ubiquitination
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090141biological_processpositive regulation of mitochondrial fission
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0090258biological_processnegative regulation of mitochondrial fission
A0090394biological_processnegative regulation of excitatory postsynaptic potential
A0097237biological_processcellular response to toxic substance
A0097602molecular_functioncullin family protein binding
A0097708cellular_componentintracellular vesicle
A0098691cellular_componentdopaminergic synapse
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
A0099073cellular_componentmitochondrion-derived vesicle
A0099074biological_processmitochondrion to lysosome vesicle-mediated transport
A0140251biological_processregulation protein catabolic process at presynapse
A1900242biological_processregulation of synaptic vesicle endocytosis
A1900407biological_processregulation of cellular response to oxidative stress
A1901526biological_processpositive regulation of mitophagy
A1901800biological_processpositive regulation of proteasomal protein catabolic process
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
A1902530biological_processpositive regulation of protein linear polyubiquitination
A1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903530biological_processregulation of secretion by cell
A1903542biological_processnegative regulation of exosomal secretion
A1903861biological_processpositive regulation of dendrite extension
A1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
A1904643biological_processresponse to curcumin
A1904845biological_processcellular response to L-glutamine
A1904881biological_processcellular response to hydrogen sulfide
A1905091biological_processpositive regulation of type 2 mitophagy
A1905232biological_processcellular response to L-glutamate
A1905366biological_processnegative regulation of intralumenal vesicle formation
A1905477biological_processpositive regulation of protein localization to membrane
A1990381molecular_functionubiquitin-specific protease binding
A1990444molecular_functionF-box domain binding
A1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
A2000377biological_processregulation of reactive oxygen species metabolic process
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000139cellular_componentGolgi membrane
B0000151cellular_componentubiquitin ligase complex
B0000209biological_processprotein polyubiquitination
B0000266biological_processmitochondrial fission
B0000422biological_processautophagy of mitochondrion
B0000423biological_processmitophagy
B0001664molecular_functionG protein-coupled receptor binding
B0001963biological_processsynaptic transmission, dopaminergic
B0001964biological_processstartle response
B0003714molecular_functiontranscription corepressor activity
B0003779molecular_functionactin binding
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006351biological_processDNA-templated transcription
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0006914biological_processautophagy
B0006979biological_processresponse to oxidative stress
B0006986biological_processresponse to unfolded protein
B0007005biological_processmitochondrion organization
B0007612biological_processlearning
B0007626biological_processlocomotory behavior
B0008013molecular_functionbeta-catenin binding
B0008021cellular_componentsynaptic vesicle
B0008270molecular_functionzinc ion binding
B0008344biological_processadult locomotory behavior
B0009410biological_processresponse to xenobiotic stimulus
B0009896biological_processpositive regulation of catabolic process
B0010498biological_processproteasomal protein catabolic process
B0010506biological_processregulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010636biological_processpositive regulation of mitochondrial fusion
B0010637biological_processnegative regulation of mitochondrial fusion
B0010821biological_processregulation of mitochondrion organization
B0010918biological_processpositive regulation of mitochondrial membrane potential
B0010994biological_processfree ubiquitin chain polymerization
B0014069cellular_componentpostsynaptic density
B0014850biological_processresponse to muscle activity
B0015631molecular_functiontubulin binding
B0016235cellular_componentaggresome
B0016567biological_processprotein ubiquitination
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0019005cellular_componentSCF ubiquitin ligase complex
B0019899molecular_functionenzyme binding
B0019900molecular_functionkinase binding
B0019901molecular_functionprotein kinase binding
B0022603biological_processregulation of anatomical structure morphogenesis
B0030163biological_processprotein catabolic process
B0030165molecular_functionPDZ domain binding
B0030424cellular_componentaxon
B0030544molecular_functionHsp70 protein binding
B0030672cellular_componentsynaptic vesicle membrane
B0031072molecular_functionheat shock protein binding
B0031396biological_processregulation of protein ubiquitination
B0031624molecular_functionubiquitin conjugating enzyme binding
B0031625molecular_functionubiquitin protein ligase binding
B0031647biological_processregulation of protein stability
B0031648biological_processprotein destabilization
B0032232biological_processnegative regulation of actin filament bundle assembly
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032991cellular_componentprotein-containing complex
B0033132biological_processnegative regulation of glucokinase activity
B0034599biological_processcellular response to oxidative stress
B0034976biological_processresponse to endoplasmic reticulum stress
B0035249biological_processsynaptic transmission, glutamatergic
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042053biological_processregulation of dopamine metabolic process
B0042415biological_processnorepinephrine metabolic process
B0042417biological_processdopamine metabolic process
B0042802molecular_functionidentical protein binding
B0042826molecular_functionhistone deacetylase binding
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043130molecular_functionubiquitin binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043195cellular_componentterminal bouton
B0043274molecular_functionphospholipase binding
B0043524biological_processnegative regulation of neuron apoptotic process
B0043653biological_processmitochondrial fragmentation involved in apoptotic process
B0044314biological_processprotein K27-linked ubiquitination
B0044828biological_processhost-mediated suppression of viral genome replication
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046329biological_processnegative regulation of JNK cascade
B0046676biological_processnegative regulation of insulin secretion
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048471cellular_componentperinuclear region of cytoplasm
B0050804biological_processmodulation of chemical synaptic transmission
B0050821biological_processprotein stabilization
B0051087molecular_functionprotein-folding chaperone binding
B0051412biological_processresponse to corticosterone
B0051582biological_processpositive regulation of neurotransmitter uptake
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051646biological_processmitochondrion localization
B0051865biological_processprotein autoubiquitination
B0051881biological_processregulation of mitochondrial membrane potential
B0051967biological_processnegative regulation of synaptic transmission, glutamatergic
B0061630molecular_functionubiquitin protein ligase activity
B0061734biological_processtype 2 mitophagy
B0070050biological_processneuron cellular homeostasis
B0070534biological_processprotein K63-linked ubiquitination
B0070585biological_processprotein localization to mitochondrion
B0070842biological_processaggresome assembly
B0070936biological_processprotein K48-linked ubiquitination
B0070979biological_processprotein K11-linked ubiquitination
B0071287biological_processcellular response to manganese ion
B0080090biological_processregulation of primary metabolic process
B0085020biological_processprotein K6-linked ubiquitination
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090141biological_processpositive regulation of mitochondrial fission
B0090201biological_processnegative regulation of release of cytochrome c from mitochondria
B0090258biological_processnegative regulation of mitochondrial fission
B0090394biological_processnegative regulation of excitatory postsynaptic potential
B0097237biological_processcellular response to toxic substance
B0097602molecular_functioncullin family protein binding
B0097708cellular_componentintracellular vesicle
B0098691cellular_componentdopaminergic synapse
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
B0099073cellular_componentmitochondrion-derived vesicle
B0099074biological_processmitochondrion to lysosome vesicle-mediated transport
B0140251biological_processregulation protein catabolic process at presynapse
B1900242biological_processregulation of synaptic vesicle endocytosis
B1900407biological_processregulation of cellular response to oxidative stress
B1901526biological_processpositive regulation of mitophagy
B1901800biological_processpositive regulation of proteasomal protein catabolic process
B1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
B1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
B1902530biological_processpositive regulation of protein linear polyubiquitination
B1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
B1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903530biological_processregulation of secretion by cell
B1903542biological_processnegative regulation of exosomal secretion
B1903861biological_processpositive regulation of dendrite extension
B1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
B1904643biological_processresponse to curcumin
B1904845biological_processcellular response to L-glutamine
B1904881biological_processcellular response to hydrogen sulfide
B1905091biological_processpositive regulation of type 2 mitophagy
B1905232biological_processcellular response to L-glutamate
B1905366biological_processnegative regulation of intralumenal vesicle formation
B1905477biological_processpositive regulation of protein localization to membrane
B1990381molecular_functionubiquitin-specific protease binding
B1990444molecular_functionF-box domain binding
B1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
B2000377biological_processregulation of reactive oxygen species metabolic process
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
B2001171biological_processpositive regulation of ATP biosynthetic process
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000139cellular_componentGolgi membrane
C0000151cellular_componentubiquitin ligase complex
C0000209biological_processprotein polyubiquitination
C0000266biological_processmitochondrial fission
C0000422biological_processautophagy of mitochondrion
C0000423biological_processmitophagy
C0001664molecular_functionG protein-coupled receptor binding
C0001963biological_processsynaptic transmission, dopaminergic
C0001964biological_processstartle response
C0003714molecular_functiontranscription corepressor activity
C0003779molecular_functionactin binding
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006511biological_processubiquitin-dependent protein catabolic process
C0006513biological_processprotein monoubiquitination
C0006914biological_processautophagy
C0006979biological_processresponse to oxidative stress
C0006986biological_processresponse to unfolded protein
C0007005biological_processmitochondrion organization
C0007612biological_processlearning
C0007626biological_processlocomotory behavior
C0008013molecular_functionbeta-catenin binding
C0008021cellular_componentsynaptic vesicle
C0008270molecular_functionzinc ion binding
C0008344biological_processadult locomotory behavior
C0009410biological_processresponse to xenobiotic stimulus
C0009896biological_processpositive regulation of catabolic process
C0010498biological_processproteasomal protein catabolic process
C0010506biological_processregulation of autophagy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010636biological_processpositive regulation of mitochondrial fusion
C0010637biological_processnegative regulation of mitochondrial fusion
C0010821biological_processregulation of mitochondrion organization
C0010918biological_processpositive regulation of mitochondrial membrane potential
C0010994biological_processfree ubiquitin chain polymerization
C0014069cellular_componentpostsynaptic density
C0014850biological_processresponse to muscle activity
C0015631molecular_functiontubulin binding
C0016235cellular_componentaggresome
C0016567biological_processprotein ubiquitination
C0016607cellular_componentnuclear speck
C0016740molecular_functiontransferase activity
C0019005cellular_componentSCF ubiquitin ligase complex
C0019899molecular_functionenzyme binding
C0019900molecular_functionkinase binding
C0019901molecular_functionprotein kinase binding
C0022603biological_processregulation of anatomical structure morphogenesis
C0030163biological_processprotein catabolic process
C0030165molecular_functionPDZ domain binding
C0030424cellular_componentaxon
C0030544molecular_functionHsp70 protein binding
C0030672cellular_componentsynaptic vesicle membrane
C0031072molecular_functionheat shock protein binding
C0031396biological_processregulation of protein ubiquitination
C0031624molecular_functionubiquitin conjugating enzyme binding
C0031625molecular_functionubiquitin protein ligase binding
C0031647biological_processregulation of protein stability
C0031648biological_processprotein destabilization
C0032232biological_processnegative regulation of actin filament bundle assembly
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0032991cellular_componentprotein-containing complex
C0033132biological_processnegative regulation of glucokinase activity
C0034599biological_processcellular response to oxidative stress
C0034976biological_processresponse to endoplasmic reticulum stress
C0035249biological_processsynaptic transmission, glutamatergic
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0042053biological_processregulation of dopamine metabolic process
C0042415biological_processnorepinephrine metabolic process
C0042417biological_processdopamine metabolic process
C0042802molecular_functionidentical protein binding
C0042826molecular_functionhistone deacetylase binding
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043130molecular_functionubiquitin binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043195cellular_componentterminal bouton
C0043274molecular_functionphospholipase binding
C0043524biological_processnegative regulation of neuron apoptotic process
C0043653biological_processmitochondrial fragmentation involved in apoptotic process
C0044314biological_processprotein K27-linked ubiquitination
C0044828biological_processhost-mediated suppression of viral genome replication
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046329biological_processnegative regulation of JNK cascade
C0046676biological_processnegative regulation of insulin secretion
C0046872molecular_functionmetal ion binding
C0046928biological_processregulation of neurotransmitter secretion
C0048471cellular_componentperinuclear region of cytoplasm
C0050804biological_processmodulation of chemical synaptic transmission
C0050821biological_processprotein stabilization
C0051087molecular_functionprotein-folding chaperone binding
C0051412biological_processresponse to corticosterone
C0051582biological_processpositive regulation of neurotransmitter uptake
C0051583biological_processdopamine uptake involved in synaptic transmission
C0051646biological_processmitochondrion localization
C0051865biological_processprotein autoubiquitination
C0051881biological_processregulation of mitochondrial membrane potential
C0051967biological_processnegative regulation of synaptic transmission, glutamatergic
C0061630molecular_functionubiquitin protein ligase activity
C0061734biological_processtype 2 mitophagy
C0070050biological_processneuron cellular homeostasis
C0070534biological_processprotein K63-linked ubiquitination
C0070585biological_processprotein localization to mitochondrion
C0070842biological_processaggresome assembly
C0070936biological_processprotein K48-linked ubiquitination
C0070979biological_processprotein K11-linked ubiquitination
C0071287biological_processcellular response to manganese ion
C0080090biological_processregulation of primary metabolic process
C0085020biological_processprotein K6-linked ubiquitination
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090141biological_processpositive regulation of mitochondrial fission
C0090201biological_processnegative regulation of release of cytochrome c from mitochondria
C0090258biological_processnegative regulation of mitochondrial fission
C0090394biological_processnegative regulation of excitatory postsynaptic potential
C0097237biological_processcellular response to toxic substance
C0097602molecular_functioncullin family protein binding
C0097708cellular_componentintracellular vesicle
C0098691cellular_componentdopaminergic synapse
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
C0099073cellular_componentmitochondrion-derived vesicle
C0099074biological_processmitochondrion to lysosome vesicle-mediated transport
C0140251biological_processregulation protein catabolic process at presynapse
C1900242biological_processregulation of synaptic vesicle endocytosis
C1900407biological_processregulation of cellular response to oxidative stress
C1901526biological_processpositive regulation of mitophagy
C1901800biological_processpositive regulation of proteasomal protein catabolic process
C1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
C1902530biological_processpositive regulation of protein linear polyubiquitination
C1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
C1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
C1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
C1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
C1903530biological_processregulation of secretion by cell
C1903542biological_processnegative regulation of exosomal secretion
C1903861biological_processpositive regulation of dendrite extension
C1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
C1904643biological_processresponse to curcumin
C1904845biological_processcellular response to L-glutamine
C1904881biological_processcellular response to hydrogen sulfide
C1905091biological_processpositive regulation of type 2 mitophagy
C1905232biological_processcellular response to L-glutamate
C1905366biological_processnegative regulation of intralumenal vesicle formation
C1905477biological_processpositive regulation of protein localization to membrane
C1990381molecular_functionubiquitin-specific protease binding
C1990444molecular_functionF-box domain binding
C1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
C2000377biological_processregulation of reactive oxygen species metabolic process
C2000378biological_processnegative regulation of reactive oxygen species metabolic process
C2001171biological_processpositive regulation of ATP biosynthetic process
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000139cellular_componentGolgi membrane
D0000151cellular_componentubiquitin ligase complex
D0000209biological_processprotein polyubiquitination
D0000266biological_processmitochondrial fission
D0000422biological_processautophagy of mitochondrion
D0000423biological_processmitophagy
D0001664molecular_functionG protein-coupled receptor binding
D0001963biological_processsynaptic transmission, dopaminergic
D0001964biological_processstartle response
D0003714molecular_functiontranscription corepressor activity
D0003779molecular_functionactin binding
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0006914biological_processautophagy
D0006979biological_processresponse to oxidative stress
D0006986biological_processresponse to unfolded protein
D0007005biological_processmitochondrion organization
D0007612biological_processlearning
D0007626biological_processlocomotory behavior
D0008013molecular_functionbeta-catenin binding
D0008021cellular_componentsynaptic vesicle
D0008270molecular_functionzinc ion binding
D0008344biological_processadult locomotory behavior
D0009410biological_processresponse to xenobiotic stimulus
D0009896biological_processpositive regulation of catabolic process
D0010498biological_processproteasomal protein catabolic process
D0010506biological_processregulation of autophagy
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010636biological_processpositive regulation of mitochondrial fusion
D0010637biological_processnegative regulation of mitochondrial fusion
D0010821biological_processregulation of mitochondrion organization
D0010918biological_processpositive regulation of mitochondrial membrane potential
D0010994biological_processfree ubiquitin chain polymerization
D0014069cellular_componentpostsynaptic density
D0014850biological_processresponse to muscle activity
D0015631molecular_functiontubulin binding
D0016235cellular_componentaggresome
D0016567biological_processprotein ubiquitination
D0016607cellular_componentnuclear speck
D0016740molecular_functiontransferase activity
D0019005cellular_componentSCF ubiquitin ligase complex
D0019899molecular_functionenzyme binding
D0019900molecular_functionkinase binding
D0019901molecular_functionprotein kinase binding
D0022603biological_processregulation of anatomical structure morphogenesis
D0030163biological_processprotein catabolic process
D0030165molecular_functionPDZ domain binding
D0030424cellular_componentaxon
D0030544molecular_functionHsp70 protein binding
D0030672cellular_componentsynaptic vesicle membrane
D0031072molecular_functionheat shock protein binding
D0031396biological_processregulation of protein ubiquitination
D0031624molecular_functionubiquitin conjugating enzyme binding
D0031625molecular_functionubiquitin protein ligase binding
D0031647biological_processregulation of protein stability
D0031648biological_processprotein destabilization
D0032232biological_processnegative regulation of actin filament bundle assembly
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032991cellular_componentprotein-containing complex
D0033132biological_processnegative regulation of glucokinase activity
D0034599biological_processcellular response to oxidative stress
D0034976biological_processresponse to endoplasmic reticulum stress
D0035249biological_processsynaptic transmission, glutamatergic
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0042053biological_processregulation of dopamine metabolic process
D0042415biological_processnorepinephrine metabolic process
D0042417biological_processdopamine metabolic process
D0042802molecular_functionidentical protein binding
D0042826molecular_functionhistone deacetylase binding
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043130molecular_functionubiquitin binding
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043195cellular_componentterminal bouton
D0043274molecular_functionphospholipase binding
D0043524biological_processnegative regulation of neuron apoptotic process
D0043653biological_processmitochondrial fragmentation involved in apoptotic process
D0044314biological_processprotein K27-linked ubiquitination
D0044828biological_processhost-mediated suppression of viral genome replication
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046329biological_processnegative regulation of JNK cascade
D0046676biological_processnegative regulation of insulin secretion
D0046872molecular_functionmetal ion binding
D0046928biological_processregulation of neurotransmitter secretion
D0048471cellular_componentperinuclear region of cytoplasm
D0050804biological_processmodulation of chemical synaptic transmission
D0050821biological_processprotein stabilization
D0051087molecular_functionprotein-folding chaperone binding
D0051412biological_processresponse to corticosterone
D0051582biological_processpositive regulation of neurotransmitter uptake
D0051583biological_processdopamine uptake involved in synaptic transmission
D0051646biological_processmitochondrion localization
D0051865biological_processprotein autoubiquitination
D0051881biological_processregulation of mitochondrial membrane potential
D0051967biological_processnegative regulation of synaptic transmission, glutamatergic
D0061630molecular_functionubiquitin protein ligase activity
D0061734biological_processtype 2 mitophagy
D0070050biological_processneuron cellular homeostasis
D0070534biological_processprotein K63-linked ubiquitination
D0070585biological_processprotein localization to mitochondrion
D0070842biological_processaggresome assembly
D0070936biological_processprotein K48-linked ubiquitination
D0070979biological_processprotein K11-linked ubiquitination
D0071287biological_processcellular response to manganese ion
D0080090biological_processregulation of primary metabolic process
D0085020biological_processprotein K6-linked ubiquitination
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0090141biological_processpositive regulation of mitochondrial fission
D0090201biological_processnegative regulation of release of cytochrome c from mitochondria
D0090258biological_processnegative regulation of mitochondrial fission
D0090394biological_processnegative regulation of excitatory postsynaptic potential
D0097237biological_processcellular response to toxic substance
D0097602molecular_functioncullin family protein binding
D0097708cellular_componentintracellular vesicle
D0098691cellular_componentdopaminergic synapse
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
D0099073cellular_componentmitochondrion-derived vesicle
D0099074biological_processmitochondrion to lysosome vesicle-mediated transport
D0140251biological_processregulation protein catabolic process at presynapse
D1900242biological_processregulation of synaptic vesicle endocytosis
D1900407biological_processregulation of cellular response to oxidative stress
D1901526biological_processpositive regulation of mitophagy
D1901800biological_processpositive regulation of proteasomal protein catabolic process
D1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
D1902530biological_processpositive regulation of protein linear polyubiquitination
D1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
D1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
D1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
D1903530biological_processregulation of secretion by cell
D1903542biological_processnegative regulation of exosomal secretion
D1903861biological_processpositive regulation of dendrite extension
D1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
D1904643biological_processresponse to curcumin
D1904845biological_processcellular response to L-glutamine
D1904881biological_processcellular response to hydrogen sulfide
D1905091biological_processpositive regulation of type 2 mitophagy
D1905232biological_processcellular response to L-glutamate
D1905366biological_processnegative regulation of intralumenal vesicle formation
D1905477biological_processpositive regulation of protein localization to membrane
D1990381molecular_functionubiquitin-specific protease binding
D1990444molecular_functionF-box domain binding
D1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
D2000377biological_processregulation of reactive oxygen species metabolic process
D2000378biological_processnegative regulation of reactive oxygen species metabolic process
D2001171biological_processpositive regulation of ATP biosynthetic process
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0000139cellular_componentGolgi membrane
E0000151cellular_componentubiquitin ligase complex
E0000209biological_processprotein polyubiquitination
E0000266biological_processmitochondrial fission
E0000422biological_processautophagy of mitochondrion
E0000423biological_processmitophagy
E0001664molecular_functionG protein-coupled receptor binding
E0001963biological_processsynaptic transmission, dopaminergic
E0001964biological_processstartle response
E0003714molecular_functiontranscription corepressor activity
E0003779molecular_functionactin binding
E0004842molecular_functionubiquitin-protein transferase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005741cellular_componentmitochondrial outer membrane
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006351biological_processDNA-templated transcription
E0006511biological_processubiquitin-dependent protein catabolic process
E0006513biological_processprotein monoubiquitination
E0006914biological_processautophagy
E0006979biological_processresponse to oxidative stress
E0006986biological_processresponse to unfolded protein
E0007005biological_processmitochondrion organization
E0007612biological_processlearning
E0007626biological_processlocomotory behavior
E0008013molecular_functionbeta-catenin binding
E0008021cellular_componentsynaptic vesicle
E0008270molecular_functionzinc ion binding
E0008344biological_processadult locomotory behavior
E0009410biological_processresponse to xenobiotic stimulus
E0009896biological_processpositive regulation of catabolic process
E0010498biological_processproteasomal protein catabolic process
E0010506biological_processregulation of autophagy
E0010628biological_processpositive regulation of gene expression
E0010629biological_processnegative regulation of gene expression
E0010636biological_processpositive regulation of mitochondrial fusion
E0010637biological_processnegative regulation of mitochondrial fusion
E0010821biological_processregulation of mitochondrion organization
E0010918biological_processpositive regulation of mitochondrial membrane potential
E0010994biological_processfree ubiquitin chain polymerization
E0014069cellular_componentpostsynaptic density
E0014850biological_processresponse to muscle activity
E0015631molecular_functiontubulin binding
E0016235cellular_componentaggresome
E0016567biological_processprotein ubiquitination
E0016607cellular_componentnuclear speck
E0016740molecular_functiontransferase activity
E0019005cellular_componentSCF ubiquitin ligase complex
E0019899molecular_functionenzyme binding
E0019900molecular_functionkinase binding
E0019901molecular_functionprotein kinase binding
E0022603biological_processregulation of anatomical structure morphogenesis
E0030163biological_processprotein catabolic process
E0030165molecular_functionPDZ domain binding
E0030424cellular_componentaxon
E0030544molecular_functionHsp70 protein binding
E0030672cellular_componentsynaptic vesicle membrane
E0031072molecular_functionheat shock protein binding
E0031396biological_processregulation of protein ubiquitination
E0031624molecular_functionubiquitin conjugating enzyme binding
E0031625molecular_functionubiquitin protein ligase binding
E0031647biological_processregulation of protein stability
E0031648biological_processprotein destabilization
E0032232biological_processnegative regulation of actin filament bundle assembly
E0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
E0032991cellular_componentprotein-containing complex
E0033132biological_processnegative regulation of glucokinase activity
E0034599biological_processcellular response to oxidative stress
E0034976biological_processresponse to endoplasmic reticulum stress
E0035249biological_processsynaptic transmission, glutamatergic
E0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
E0042053biological_processregulation of dopamine metabolic process
E0042415biological_processnorepinephrine metabolic process
E0042417biological_processdopamine metabolic process
E0042802molecular_functionidentical protein binding
E0042826molecular_functionhistone deacetylase binding
E0043005cellular_componentneuron projection
E0043025cellular_componentneuronal cell body
E0043065biological_processpositive regulation of apoptotic process
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0043130molecular_functionubiquitin binding
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0043195cellular_componentterminal bouton
E0043274molecular_functionphospholipase binding
E0043524biological_processnegative regulation of neuron apoptotic process
E0043653biological_processmitochondrial fragmentation involved in apoptotic process
E0044314biological_processprotein K27-linked ubiquitination
E0044828biological_processhost-mediated suppression of viral genome replication
E0044877molecular_functionprotein-containing complex binding
E0045202cellular_componentsynapse
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0046329biological_processnegative regulation of JNK cascade
E0046676biological_processnegative regulation of insulin secretion
E0046872molecular_functionmetal ion binding
E0046928biological_processregulation of neurotransmitter secretion
E0048471cellular_componentperinuclear region of cytoplasm
E0050804biological_processmodulation of chemical synaptic transmission
E0050821biological_processprotein stabilization
E0051087molecular_functionprotein-folding chaperone binding
E0051412biological_processresponse to corticosterone
E0051582biological_processpositive regulation of neurotransmitter uptake
E0051583biological_processdopamine uptake involved in synaptic transmission
E0051646biological_processmitochondrion localization
E0051865biological_processprotein autoubiquitination
E0051881biological_processregulation of mitochondrial membrane potential
E0051967biological_processnegative regulation of synaptic transmission, glutamatergic
E0061630molecular_functionubiquitin protein ligase activity
E0061734biological_processtype 2 mitophagy
E0070050biological_processneuron cellular homeostasis
E0070534biological_processprotein K63-linked ubiquitination
E0070585biological_processprotein localization to mitochondrion
E0070842biological_processaggresome assembly
E0070936biological_processprotein K48-linked ubiquitination
E0070979biological_processprotein K11-linked ubiquitination
E0071287biological_processcellular response to manganese ion
E0080090biological_processregulation of primary metabolic process
E0085020biological_processprotein K6-linked ubiquitination
E0090090biological_processnegative regulation of canonical Wnt signaling pathway
E0090141biological_processpositive regulation of mitochondrial fission
E0090201biological_processnegative regulation of release of cytochrome c from mitochondria
E0090258biological_processnegative regulation of mitochondrial fission
E0090394biological_processnegative regulation of excitatory postsynaptic potential
E0097237biological_processcellular response to toxic substance
E0097602molecular_functioncullin family protein binding
E0097708cellular_componentintracellular vesicle
E0098691cellular_componentdopaminergic synapse
E0098793cellular_componentpresynapse
E0098794cellular_componentpostsynapse
E0098978cellular_componentglutamatergic synapse
E0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
E0099073cellular_componentmitochondrion-derived vesicle
E0099074biological_processmitochondrion to lysosome vesicle-mediated transport
E0140251biological_processregulation protein catabolic process at presynapse
E1900242biological_processregulation of synaptic vesicle endocytosis
E1900407biological_processregulation of cellular response to oxidative stress
E1901526biological_processpositive regulation of mitophagy
E1901800biological_processpositive regulation of proteasomal protein catabolic process
E1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
E1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
E1902530biological_processpositive regulation of protein linear polyubiquitination
E1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
E1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
E1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
E1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
E1903530biological_processregulation of secretion by cell
E1903542biological_processnegative regulation of exosomal secretion
E1903861biological_processpositive regulation of dendrite extension
E1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
E1904643biological_processresponse to curcumin
E1904845biological_processcellular response to L-glutamine
E1904881biological_processcellular response to hydrogen sulfide
E1905091biological_processpositive regulation of type 2 mitophagy
E1905232biological_processcellular response to L-glutamate
E1905366biological_processnegative regulation of intralumenal vesicle formation
E1905477biological_processpositive regulation of protein localization to membrane
E1990381molecular_functionubiquitin-specific protease binding
E1990444molecular_functionF-box domain binding
E1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
E2000377biological_processregulation of reactive oxygen species metabolic process
E2000378biological_processnegative regulation of reactive oxygen species metabolic process
E2001171biological_processpositive regulation of ATP biosynthetic process
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000139cellular_componentGolgi membrane
F0000151cellular_componentubiquitin ligase complex
F0000209biological_processprotein polyubiquitination
F0000266biological_processmitochondrial fission
F0000422biological_processautophagy of mitochondrion
F0000423biological_processmitophagy
F0001664molecular_functionG protein-coupled receptor binding
F0001963biological_processsynaptic transmission, dopaminergic
F0001964biological_processstartle response
F0003714molecular_functiontranscription corepressor activity
F0003779molecular_functionactin binding
F0004842molecular_functionubiquitin-protein transferase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005741cellular_componentmitochondrial outer membrane
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0006351biological_processDNA-templated transcription
F0006511biological_processubiquitin-dependent protein catabolic process
F0006513biological_processprotein monoubiquitination
F0006914biological_processautophagy
F0006979biological_processresponse to oxidative stress
F0006986biological_processresponse to unfolded protein
F0007005biological_processmitochondrion organization
F0007612biological_processlearning
F0007626biological_processlocomotory behavior
F0008013molecular_functionbeta-catenin binding
F0008021cellular_componentsynaptic vesicle
F0008270molecular_functionzinc ion binding
F0008344biological_processadult locomotory behavior
F0009410biological_processresponse to xenobiotic stimulus
F0009896biological_processpositive regulation of catabolic process
F0010498biological_processproteasomal protein catabolic process
F0010506biological_processregulation of autophagy
F0010628biological_processpositive regulation of gene expression
F0010629biological_processnegative regulation of gene expression
F0010636biological_processpositive regulation of mitochondrial fusion
F0010637biological_processnegative regulation of mitochondrial fusion
F0010821biological_processregulation of mitochondrion organization
F0010918biological_processpositive regulation of mitochondrial membrane potential
F0010994biological_processfree ubiquitin chain polymerization
F0014069cellular_componentpostsynaptic density
F0014850biological_processresponse to muscle activity
F0015631molecular_functiontubulin binding
F0016235cellular_componentaggresome
F0016567biological_processprotein ubiquitination
F0016607cellular_componentnuclear speck
F0016740molecular_functiontransferase activity
F0019005cellular_componentSCF ubiquitin ligase complex
F0019899molecular_functionenzyme binding
F0019900molecular_functionkinase binding
F0019901molecular_functionprotein kinase binding
F0022603biological_processregulation of anatomical structure morphogenesis
F0030163biological_processprotein catabolic process
F0030165molecular_functionPDZ domain binding
F0030424cellular_componentaxon
F0030544molecular_functionHsp70 protein binding
F0030672cellular_componentsynaptic vesicle membrane
F0031072molecular_functionheat shock protein binding
F0031396biological_processregulation of protein ubiquitination
F0031624molecular_functionubiquitin conjugating enzyme binding
F0031625molecular_functionubiquitin protein ligase binding
F0031647biological_processregulation of protein stability
F0031648biological_processprotein destabilization
F0032232biological_processnegative regulation of actin filament bundle assembly
F0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
F0032991cellular_componentprotein-containing complex
F0033132biological_processnegative regulation of glucokinase activity
F0034599biological_processcellular response to oxidative stress
F0034976biological_processresponse to endoplasmic reticulum stress
F0035249biological_processsynaptic transmission, glutamatergic
F0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
F0042053biological_processregulation of dopamine metabolic process
F0042415biological_processnorepinephrine metabolic process
F0042417biological_processdopamine metabolic process
F0042802molecular_functionidentical protein binding
F0042826molecular_functionhistone deacetylase binding
F0043005cellular_componentneuron projection
F0043025cellular_componentneuronal cell body
F0043065biological_processpositive regulation of apoptotic process
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043130molecular_functionubiquitin binding
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0043195cellular_componentterminal bouton
F0043274molecular_functionphospholipase binding
F0043524biological_processnegative regulation of neuron apoptotic process
F0043653biological_processmitochondrial fragmentation involved in apoptotic process
F0044314biological_processprotein K27-linked ubiquitination
F0044828biological_processhost-mediated suppression of viral genome replication
F0044877molecular_functionprotein-containing complex binding
F0045202cellular_componentsynapse
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046329biological_processnegative regulation of JNK cascade
F0046676biological_processnegative regulation of insulin secretion
F0046872molecular_functionmetal ion binding
F0046928biological_processregulation of neurotransmitter secretion
F0048471cellular_componentperinuclear region of cytoplasm
F0050804biological_processmodulation of chemical synaptic transmission
F0050821biological_processprotein stabilization
F0051087molecular_functionprotein-folding chaperone binding
F0051412biological_processresponse to corticosterone
F0051582biological_processpositive regulation of neurotransmitter uptake
F0051583biological_processdopamine uptake involved in synaptic transmission
F0051646biological_processmitochondrion localization
F0051865biological_processprotein autoubiquitination
F0051881biological_processregulation of mitochondrial membrane potential
F0051967biological_processnegative regulation of synaptic transmission, glutamatergic
F0061630molecular_functionubiquitin protein ligase activity
F0061734biological_processtype 2 mitophagy
F0070050biological_processneuron cellular homeostasis
F0070534biological_processprotein K63-linked ubiquitination
F0070585biological_processprotein localization to mitochondrion
F0070842biological_processaggresome assembly
F0070936biological_processprotein K48-linked ubiquitination
F0070979biological_processprotein K11-linked ubiquitination
F0071287biological_processcellular response to manganese ion
F0080090biological_processregulation of primary metabolic process
F0085020biological_processprotein K6-linked ubiquitination
F0090090biological_processnegative regulation of canonical Wnt signaling pathway
F0090141biological_processpositive regulation of mitochondrial fission
F0090201biological_processnegative regulation of release of cytochrome c from mitochondria
F0090258biological_processnegative regulation of mitochondrial fission
F0090394biological_processnegative regulation of excitatory postsynaptic potential
F0097237biological_processcellular response to toxic substance
F0097602molecular_functioncullin family protein binding
F0097708cellular_componentintracellular vesicle
F0098691cellular_componentdopaminergic synapse
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
F0099073cellular_componentmitochondrion-derived vesicle
F0099074biological_processmitochondrion to lysosome vesicle-mediated transport
F0140251biological_processregulation protein catabolic process at presynapse
F1900242biological_processregulation of synaptic vesicle endocytosis
F1900407biological_processregulation of cellular response to oxidative stress
F1901526biological_processpositive regulation of mitophagy
F1901800biological_processpositive regulation of proteasomal protein catabolic process
F1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
F1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
F1902530biological_processpositive regulation of protein linear polyubiquitination
F1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
F1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
F1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F1903530biological_processregulation of secretion by cell
F1903542biological_processnegative regulation of exosomal secretion
F1903861biological_processpositive regulation of dendrite extension
F1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
F1904643biological_processresponse to curcumin
F1904845biological_processcellular response to L-glutamine
F1904881biological_processcellular response to hydrogen sulfide
F1905091biological_processpositive regulation of type 2 mitophagy
F1905232biological_processcellular response to L-glutamate
F1905366biological_processnegative regulation of intralumenal vesicle formation
F1905477biological_processpositive regulation of protein localization to membrane
F1990381molecular_functionubiquitin-specific protease binding
F1990444molecular_functionF-box domain binding
F1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
F2000377biological_processregulation of reactive oxygen species metabolic process
F2000378biological_processnegative regulation of reactive oxygen species metabolic process
F2001171biological_processpositive regulation of ATP biosynthetic process
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0000139cellular_componentGolgi membrane
G0000151cellular_componentubiquitin ligase complex
G0000209biological_processprotein polyubiquitination
G0000266biological_processmitochondrial fission
G0000422biological_processautophagy of mitochondrion
G0000423biological_processmitophagy
G0001664molecular_functionG protein-coupled receptor binding
G0001963biological_processsynaptic transmission, dopaminergic
G0001964biological_processstartle response
G0003714molecular_functiontranscription corepressor activity
G0003779molecular_functionactin binding
G0004842molecular_functionubiquitin-protein transferase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005741cellular_componentmitochondrial outer membrane
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0006351biological_processDNA-templated transcription
G0006511biological_processubiquitin-dependent protein catabolic process
G0006513biological_processprotein monoubiquitination
G0006914biological_processautophagy
G0006979biological_processresponse to oxidative stress
G0006986biological_processresponse to unfolded protein
G0007005biological_processmitochondrion organization
G0007612biological_processlearning
G0007626biological_processlocomotory behavior
G0008013molecular_functionbeta-catenin binding
G0008021cellular_componentsynaptic vesicle
G0008270molecular_functionzinc ion binding
G0008344biological_processadult locomotory behavior
G0009410biological_processresponse to xenobiotic stimulus
G0009896biological_processpositive regulation of catabolic process
G0010498biological_processproteasomal protein catabolic process
G0010506biological_processregulation of autophagy
G0010628biological_processpositive regulation of gene expression
G0010629biological_processnegative regulation of gene expression
G0010636biological_processpositive regulation of mitochondrial fusion
G0010637biological_processnegative regulation of mitochondrial fusion
G0010821biological_processregulation of mitochondrion organization
G0010918biological_processpositive regulation of mitochondrial membrane potential
G0010994biological_processfree ubiquitin chain polymerization
G0014069cellular_componentpostsynaptic density
G0014850biological_processresponse to muscle activity
G0015631molecular_functiontubulin binding
G0016235cellular_componentaggresome
G0016567biological_processprotein ubiquitination
G0016607cellular_componentnuclear speck
G0016740molecular_functiontransferase activity
G0019005cellular_componentSCF ubiquitin ligase complex
G0019899molecular_functionenzyme binding
G0019900molecular_functionkinase binding
G0019901molecular_functionprotein kinase binding
G0022603biological_processregulation of anatomical structure morphogenesis
G0030163biological_processprotein catabolic process
G0030165molecular_functionPDZ domain binding
G0030424cellular_componentaxon
G0030544molecular_functionHsp70 protein binding
G0030672cellular_componentsynaptic vesicle membrane
G0031072molecular_functionheat shock protein binding
G0031396biological_processregulation of protein ubiquitination
G0031624molecular_functionubiquitin conjugating enzyme binding
G0031625molecular_functionubiquitin protein ligase binding
G0031647biological_processregulation of protein stability
G0031648biological_processprotein destabilization
G0032232biological_processnegative regulation of actin filament bundle assembly
G0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
G0032991cellular_componentprotein-containing complex
G0033132biological_processnegative regulation of glucokinase activity
G0034599biological_processcellular response to oxidative stress
G0034976biological_processresponse to endoplasmic reticulum stress
G0035249biological_processsynaptic transmission, glutamatergic
G0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
G0042053biological_processregulation of dopamine metabolic process
G0042415biological_processnorepinephrine metabolic process
G0042417biological_processdopamine metabolic process
G0042802molecular_functionidentical protein binding
G0042826molecular_functionhistone deacetylase binding
G0043005cellular_componentneuron projection
G0043025cellular_componentneuronal cell body
G0043065biological_processpositive regulation of apoptotic process
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0043130molecular_functionubiquitin binding
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0043195cellular_componentterminal bouton
G0043274molecular_functionphospholipase binding
G0043524biological_processnegative regulation of neuron apoptotic process
G0043653biological_processmitochondrial fragmentation involved in apoptotic process
G0044314biological_processprotein K27-linked ubiquitination
G0044828biological_processhost-mediated suppression of viral genome replication
G0044877molecular_functionprotein-containing complex binding
G0045202cellular_componentsynapse
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0046329biological_processnegative regulation of JNK cascade
G0046676biological_processnegative regulation of insulin secretion
G0046872molecular_functionmetal ion binding
G0046928biological_processregulation of neurotransmitter secretion
G0048471cellular_componentperinuclear region of cytoplasm
G0050804biological_processmodulation of chemical synaptic transmission
G0050821biological_processprotein stabilization
G0051087molecular_functionprotein-folding chaperone binding
G0051412biological_processresponse to corticosterone
G0051582biological_processpositive regulation of neurotransmitter uptake
G0051583biological_processdopamine uptake involved in synaptic transmission
G0051646biological_processmitochondrion localization
G0051865biological_processprotein autoubiquitination
G0051881biological_processregulation of mitochondrial membrane potential
G0051967biological_processnegative regulation of synaptic transmission, glutamatergic
G0061630molecular_functionubiquitin protein ligase activity
G0061734biological_processtype 2 mitophagy
G0070050biological_processneuron cellular homeostasis
G0070534biological_processprotein K63-linked ubiquitination
G0070585biological_processprotein localization to mitochondrion
G0070842biological_processaggresome assembly
G0070936biological_processprotein K48-linked ubiquitination
G0070979biological_processprotein K11-linked ubiquitination
G0071287biological_processcellular response to manganese ion
G0080090biological_processregulation of primary metabolic process
G0085020biological_processprotein K6-linked ubiquitination
G0090090biological_processnegative regulation of canonical Wnt signaling pathway
G0090141biological_processpositive regulation of mitochondrial fission
G0090201biological_processnegative regulation of release of cytochrome c from mitochondria
G0090258biological_processnegative regulation of mitochondrial fission
G0090394biological_processnegative regulation of excitatory postsynaptic potential
G0097237biological_processcellular response to toxic substance
G0097602molecular_functioncullin family protein binding
G0097708cellular_componentintracellular vesicle
G0098691cellular_componentdopaminergic synapse
G0098793cellular_componentpresynapse
G0098794cellular_componentpostsynapse
G0098978cellular_componentglutamatergic synapse
G0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
G0099073cellular_componentmitochondrion-derived vesicle
G0099074biological_processmitochondrion to lysosome vesicle-mediated transport
G0140251biological_processregulation protein catabolic process at presynapse
G1900242biological_processregulation of synaptic vesicle endocytosis
G1900407biological_processregulation of cellular response to oxidative stress
G1901526biological_processpositive regulation of mitophagy
G1901800biological_processpositive regulation of proteasomal protein catabolic process
G1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
G1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
G1902530biological_processpositive regulation of protein linear polyubiquitination
G1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
G1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
G1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
G1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
G1903530biological_processregulation of secretion by cell
G1903542biological_processnegative regulation of exosomal secretion
G1903861biological_processpositive regulation of dendrite extension
G1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
G1904643biological_processresponse to curcumin
G1904845biological_processcellular response to L-glutamine
G1904881biological_processcellular response to hydrogen sulfide
G1905091biological_processpositive regulation of type 2 mitophagy
G1905232biological_processcellular response to L-glutamate
G1905366biological_processnegative regulation of intralumenal vesicle formation
G1905477biological_processpositive regulation of protein localization to membrane
G1990381molecular_functionubiquitin-specific protease binding
G1990444molecular_functionF-box domain binding
G1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
G2000377biological_processregulation of reactive oxygen species metabolic process
G2000378biological_processnegative regulation of reactive oxygen species metabolic process
G2001171biological_processpositive regulation of ATP biosynthetic process
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0000139cellular_componentGolgi membrane
H0000151cellular_componentubiquitin ligase complex
H0000209biological_processprotein polyubiquitination
H0000266biological_processmitochondrial fission
H0000422biological_processautophagy of mitochondrion
H0000423biological_processmitophagy
H0001664molecular_functionG protein-coupled receptor binding
H0001963biological_processsynaptic transmission, dopaminergic
H0001964biological_processstartle response
H0003714molecular_functiontranscription corepressor activity
H0003779molecular_functionactin binding
H0004842molecular_functionubiquitin-protein transferase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005741cellular_componentmitochondrial outer membrane
H0005783cellular_componentendoplasmic reticulum
H0005789cellular_componentendoplasmic reticulum membrane
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0006351biological_processDNA-templated transcription
H0006511biological_processubiquitin-dependent protein catabolic process
H0006513biological_processprotein monoubiquitination
H0006914biological_processautophagy
H0006979biological_processresponse to oxidative stress
H0006986biological_processresponse to unfolded protein
H0007005biological_processmitochondrion organization
H0007612biological_processlearning
H0007626biological_processlocomotory behavior
H0008013molecular_functionbeta-catenin binding
H0008021cellular_componentsynaptic vesicle
H0008270molecular_functionzinc ion binding
H0008344biological_processadult locomotory behavior
H0009410biological_processresponse to xenobiotic stimulus
H0009896biological_processpositive regulation of catabolic process
H0010498biological_processproteasomal protein catabolic process
H0010506biological_processregulation of autophagy
H0010628biological_processpositive regulation of gene expression
H0010629biological_processnegative regulation of gene expression
H0010636biological_processpositive regulation of mitochondrial fusion
H0010637biological_processnegative regulation of mitochondrial fusion
H0010821biological_processregulation of mitochondrion organization
H0010918biological_processpositive regulation of mitochondrial membrane potential
H0010994biological_processfree ubiquitin chain polymerization
H0014069cellular_componentpostsynaptic density
H0014850biological_processresponse to muscle activity
H0015631molecular_functiontubulin binding
H0016235cellular_componentaggresome
H0016567biological_processprotein ubiquitination
H0016607cellular_componentnuclear speck
H0016740molecular_functiontransferase activity
H0019005cellular_componentSCF ubiquitin ligase complex
H0019899molecular_functionenzyme binding
H0019900molecular_functionkinase binding
H0019901molecular_functionprotein kinase binding
H0022603biological_processregulation of anatomical structure morphogenesis
H0030163biological_processprotein catabolic process
H0030165molecular_functionPDZ domain binding
H0030424cellular_componentaxon
H0030544molecular_functionHsp70 protein binding
H0030672cellular_componentsynaptic vesicle membrane
H0031072molecular_functionheat shock protein binding
H0031396biological_processregulation of protein ubiquitination
H0031624molecular_functionubiquitin conjugating enzyme binding
H0031625molecular_functionubiquitin protein ligase binding
H0031647biological_processregulation of protein stability
H0031648biological_processprotein destabilization
H0032232biological_processnegative regulation of actin filament bundle assembly
H0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
H0032991cellular_componentprotein-containing complex
H0033132biological_processnegative regulation of glucokinase activity
H0034599biological_processcellular response to oxidative stress
H0034976biological_processresponse to endoplasmic reticulum stress
H0035249biological_processsynaptic transmission, glutamatergic
H0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
H0042053biological_processregulation of dopamine metabolic process
H0042415biological_processnorepinephrine metabolic process
H0042417biological_processdopamine metabolic process
H0042802molecular_functionidentical protein binding
H0042826molecular_functionhistone deacetylase binding
H0043005cellular_componentneuron projection
H0043025cellular_componentneuronal cell body
H0043065biological_processpositive regulation of apoptotic process
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0043130molecular_functionubiquitin binding
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0043195cellular_componentterminal bouton
H0043274molecular_functionphospholipase binding
H0043524biological_processnegative regulation of neuron apoptotic process
H0043653biological_processmitochondrial fragmentation involved in apoptotic process
H0044314biological_processprotein K27-linked ubiquitination
H0044828biological_processhost-mediated suppression of viral genome replication
H0044877molecular_functionprotein-containing complex binding
H0045202cellular_componentsynapse
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0046329biological_processnegative regulation of JNK cascade
H0046676biological_processnegative regulation of insulin secretion
H0046872molecular_functionmetal ion binding
H0046928biological_processregulation of neurotransmitter secretion
H0048471cellular_componentperinuclear region of cytoplasm
H0050804biological_processmodulation of chemical synaptic transmission
H0050821biological_processprotein stabilization
H0051087molecular_functionprotein-folding chaperone binding
H0051412biological_processresponse to corticosterone
H0051582biological_processpositive regulation of neurotransmitter uptake
H0051583biological_processdopamine uptake involved in synaptic transmission
H0051646biological_processmitochondrion localization
H0051865biological_processprotein autoubiquitination
H0051881biological_processregulation of mitochondrial membrane potential
H0051967biological_processnegative regulation of synaptic transmission, glutamatergic
H0061630molecular_functionubiquitin protein ligase activity
H0061734biological_processtype 2 mitophagy
H0070050biological_processneuron cellular homeostasis
H0070534biological_processprotein K63-linked ubiquitination
H0070585biological_processprotein localization to mitochondrion
H0070842biological_processaggresome assembly
H0070936biological_processprotein K48-linked ubiquitination
H0070979biological_processprotein K11-linked ubiquitination
H0071287biological_processcellular response to manganese ion
H0080090biological_processregulation of primary metabolic process
H0085020biological_processprotein K6-linked ubiquitination
H0090090biological_processnegative regulation of canonical Wnt signaling pathway
H0090141biological_processpositive regulation of mitochondrial fission
H0090201biological_processnegative regulation of release of cytochrome c from mitochondria
H0090258biological_processnegative regulation of mitochondrial fission
H0090394biological_processnegative regulation of excitatory postsynaptic potential
H0097237biological_processcellular response to toxic substance
H0097602molecular_functioncullin family protein binding
H0097708cellular_componentintracellular vesicle
H0098691cellular_componentdopaminergic synapse
H0098793cellular_componentpresynapse
H0098794cellular_componentpostsynapse
H0098978cellular_componentglutamatergic synapse
H0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
H0099073cellular_componentmitochondrion-derived vesicle
H0099074biological_processmitochondrion to lysosome vesicle-mediated transport
H0140251biological_processregulation protein catabolic process at presynapse
H1900242biological_processregulation of synaptic vesicle endocytosis
H1900407biological_processregulation of cellular response to oxidative stress
H1901526biological_processpositive regulation of mitophagy
H1901800biological_processpositive regulation of proteasomal protein catabolic process
H1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
H1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
H1902530biological_processpositive regulation of protein linear polyubiquitination
H1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
H1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
H1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
H1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
H1903530biological_processregulation of secretion by cell
H1903542biological_processnegative regulation of exosomal secretion
H1903861biological_processpositive regulation of dendrite extension
H1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
H1904643biological_processresponse to curcumin
H1904845biological_processcellular response to L-glutamine
H1904881biological_processcellular response to hydrogen sulfide
H1905091biological_processpositive regulation of type 2 mitophagy
H1905232biological_processcellular response to L-glutamate
H1905366biological_processnegative regulation of intralumenal vesicle formation
H1905477biological_processpositive regulation of protein localization to membrane
H1990381molecular_functionubiquitin-specific protease binding
H1990444molecular_functionF-box domain binding
H1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
H2000377biological_processregulation of reactive oxygen species metabolic process
H2000378biological_processnegative regulation of reactive oxygen species metabolic process
H2001171biological_processpositive regulation of ATP biosynthetic process
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0000139cellular_componentGolgi membrane
I0000151cellular_componentubiquitin ligase complex
I0000209biological_processprotein polyubiquitination
I0000266biological_processmitochondrial fission
I0000422biological_processautophagy of mitochondrion
I0000423biological_processmitophagy
I0001664molecular_functionG protein-coupled receptor binding
I0001963biological_processsynaptic transmission, dopaminergic
I0001964biological_processstartle response
I0003714molecular_functiontranscription corepressor activity
I0003779molecular_functionactin binding
I0004842molecular_functionubiquitin-protein transferase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005741cellular_componentmitochondrial outer membrane
I0005783cellular_componentendoplasmic reticulum
I0005789cellular_componentendoplasmic reticulum membrane
I0005794cellular_componentGolgi apparatus
I0005829cellular_componentcytosol
I0006351biological_processDNA-templated transcription
I0006511biological_processubiquitin-dependent protein catabolic process
I0006513biological_processprotein monoubiquitination
I0006914biological_processautophagy
I0006979biological_processresponse to oxidative stress
I0006986biological_processresponse to unfolded protein
I0007005biological_processmitochondrion organization
I0007612biological_processlearning
I0007626biological_processlocomotory behavior
I0008013molecular_functionbeta-catenin binding
I0008021cellular_componentsynaptic vesicle
I0008270molecular_functionzinc ion binding
I0008344biological_processadult locomotory behavior
I0009410biological_processresponse to xenobiotic stimulus
I0009896biological_processpositive regulation of catabolic process
I0010498biological_processproteasomal protein catabolic process
I0010506biological_processregulation of autophagy
I0010628biological_processpositive regulation of gene expression
I0010629biological_processnegative regulation of gene expression
I0010636biological_processpositive regulation of mitochondrial fusion
I0010637biological_processnegative regulation of mitochondrial fusion
I0010821biological_processregulation of mitochondrion organization
I0010918biological_processpositive regulation of mitochondrial membrane potential
I0010994biological_processfree ubiquitin chain polymerization
I0014069cellular_componentpostsynaptic density
I0014850biological_processresponse to muscle activity
I0015631molecular_functiontubulin binding
I0016235cellular_componentaggresome
I0016567biological_processprotein ubiquitination
I0016607cellular_componentnuclear speck
I0016740molecular_functiontransferase activity
I0019005cellular_componentSCF ubiquitin ligase complex
I0019899molecular_functionenzyme binding
I0019900molecular_functionkinase binding
I0019901molecular_functionprotein kinase binding
I0022603biological_processregulation of anatomical structure morphogenesis
I0030163biological_processprotein catabolic process
I0030165molecular_functionPDZ domain binding
I0030424cellular_componentaxon
I0030544molecular_functionHsp70 protein binding
I0030672cellular_componentsynaptic vesicle membrane
I0031072molecular_functionheat shock protein binding
I0031396biological_processregulation of protein ubiquitination
I0031624molecular_functionubiquitin conjugating enzyme binding
I0031625molecular_functionubiquitin protein ligase binding
I0031647biological_processregulation of protein stability
I0031648biological_processprotein destabilization
I0032232biological_processnegative regulation of actin filament bundle assembly
I0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
I0032991cellular_componentprotein-containing complex
I0033132biological_processnegative regulation of glucokinase activity
I0034599biological_processcellular response to oxidative stress
I0034976biological_processresponse to endoplasmic reticulum stress
I0035249biological_processsynaptic transmission, glutamatergic
I0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
I0042053biological_processregulation of dopamine metabolic process
I0042415biological_processnorepinephrine metabolic process
I0042417biological_processdopamine metabolic process
I0042802molecular_functionidentical protein binding
I0042826molecular_functionhistone deacetylase binding
I0043005cellular_componentneuron projection
I0043025cellular_componentneuronal cell body
I0043065biological_processpositive regulation of apoptotic process
I0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
I0043130molecular_functionubiquitin binding
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0043195cellular_componentterminal bouton
I0043274molecular_functionphospholipase binding
I0043524biological_processnegative regulation of neuron apoptotic process
I0043653biological_processmitochondrial fragmentation involved in apoptotic process
I0044314biological_processprotein K27-linked ubiquitination
I0044828biological_processhost-mediated suppression of viral genome replication
I0044877molecular_functionprotein-containing complex binding
I0045202cellular_componentsynapse
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0046329biological_processnegative regulation of JNK cascade
I0046676biological_processnegative regulation of insulin secretion
I0046872molecular_functionmetal ion binding
I0046928biological_processregulation of neurotransmitter secretion
I0048471cellular_componentperinuclear region of cytoplasm
I0050804biological_processmodulation of chemical synaptic transmission
I0050821biological_processprotein stabilization
I0051087molecular_functionprotein-folding chaperone binding
I0051412biological_processresponse to corticosterone
I0051582biological_processpositive regulation of neurotransmitter uptake
I0051583biological_processdopamine uptake involved in synaptic transmission
I0051646biological_processmitochondrion localization
I0051865biological_processprotein autoubiquitination
I0051881biological_processregulation of mitochondrial membrane potential
I0051967biological_processnegative regulation of synaptic transmission, glutamatergic
I0061630molecular_functionubiquitin protein ligase activity
I0061734biological_processtype 2 mitophagy
I0070050biological_processneuron cellular homeostasis
I0070534biological_processprotein K63-linked ubiquitination
I0070585biological_processprotein localization to mitochondrion
I0070842biological_processaggresome assembly
I0070936biological_processprotein K48-linked ubiquitination
I0070979biological_processprotein K11-linked ubiquitination
I0071287biological_processcellular response to manganese ion
I0080090biological_processregulation of primary metabolic process
I0085020biological_processprotein K6-linked ubiquitination
I0090090biological_processnegative regulation of canonical Wnt signaling pathway
I0090141biological_processpositive regulation of mitochondrial fission
I0090201biological_processnegative regulation of release of cytochrome c from mitochondria
I0090258biological_processnegative regulation of mitochondrial fission
I0090394biological_processnegative regulation of excitatory postsynaptic potential
I0097237biological_processcellular response to toxic substance
I0097602molecular_functioncullin family protein binding
I0097708cellular_componentintracellular vesicle
I0098691cellular_componentdopaminergic synapse
I0098793cellular_componentpresynapse
I0098794cellular_componentpostsynapse
I0098978cellular_componentglutamatergic synapse
I0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
I0099073cellular_componentmitochondrion-derived vesicle
I0099074biological_processmitochondrion to lysosome vesicle-mediated transport
I0140251biological_processregulation protein catabolic process at presynapse
I1900242biological_processregulation of synaptic vesicle endocytosis
I1900407biological_processregulation of cellular response to oxidative stress
I1901526biological_processpositive regulation of mitophagy
I1901800biological_processpositive regulation of proteasomal protein catabolic process
I1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
I1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
I1902530biological_processpositive regulation of protein linear polyubiquitination
I1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
I1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
I1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
I1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
I1903530biological_processregulation of secretion by cell
I1903542biological_processnegative regulation of exosomal secretion
I1903861biological_processpositive regulation of dendrite extension
I1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
I1904643biological_processresponse to curcumin
I1904845biological_processcellular response to L-glutamine
I1904881biological_processcellular response to hydrogen sulfide
I1905091biological_processpositive regulation of type 2 mitophagy
I1905232biological_processcellular response to L-glutamate
I1905366biological_processnegative regulation of intralumenal vesicle formation
I1905477biological_processpositive regulation of protein localization to membrane
I1990381molecular_functionubiquitin-specific protease binding
I1990444molecular_functionF-box domain binding
I1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
I2000377biological_processregulation of reactive oxygen species metabolic process
I2000378biological_processnegative regulation of reactive oxygen species metabolic process
I2001171biological_processpositive regulation of ATP biosynthetic process
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0000139cellular_componentGolgi membrane
J0000151cellular_componentubiquitin ligase complex
J0000209biological_processprotein polyubiquitination
J0000266biological_processmitochondrial fission
J0000422biological_processautophagy of mitochondrion
J0000423biological_processmitophagy
J0001664molecular_functionG protein-coupled receptor binding
J0001963biological_processsynaptic transmission, dopaminergic
J0001964biological_processstartle response
J0003714molecular_functiontranscription corepressor activity
J0003779molecular_functionactin binding
J0004842molecular_functionubiquitin-protein transferase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005741cellular_componentmitochondrial outer membrane
J0005783cellular_componentendoplasmic reticulum
J0005789cellular_componentendoplasmic reticulum membrane
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0006351biological_processDNA-templated transcription
J0006511biological_processubiquitin-dependent protein catabolic process
J0006513biological_processprotein monoubiquitination
J0006914biological_processautophagy
J0006979biological_processresponse to oxidative stress
J0006986biological_processresponse to unfolded protein
J0007005biological_processmitochondrion organization
J0007612biological_processlearning
J0007626biological_processlocomotory behavior
J0008013molecular_functionbeta-catenin binding
J0008021cellular_componentsynaptic vesicle
J0008270molecular_functionzinc ion binding
J0008344biological_processadult locomotory behavior
J0009410biological_processresponse to xenobiotic stimulus
J0009896biological_processpositive regulation of catabolic process
J0010498biological_processproteasomal protein catabolic process
J0010506biological_processregulation of autophagy
J0010628biological_processpositive regulation of gene expression
J0010629biological_processnegative regulation of gene expression
J0010636biological_processpositive regulation of mitochondrial fusion
J0010637biological_processnegative regulation of mitochondrial fusion
J0010821biological_processregulation of mitochondrion organization
J0010918biological_processpositive regulation of mitochondrial membrane potential
J0010994biological_processfree ubiquitin chain polymerization
J0014069cellular_componentpostsynaptic density
J0014850biological_processresponse to muscle activity
J0015631molecular_functiontubulin binding
J0016235cellular_componentaggresome
J0016567biological_processprotein ubiquitination
J0016607cellular_componentnuclear speck
J0016740molecular_functiontransferase activity
J0019005cellular_componentSCF ubiquitin ligase complex
J0019899molecular_functionenzyme binding
J0019900molecular_functionkinase binding
J0019901molecular_functionprotein kinase binding
J0022603biological_processregulation of anatomical structure morphogenesis
J0030163biological_processprotein catabolic process
J0030165molecular_functionPDZ domain binding
J0030424cellular_componentaxon
J0030544molecular_functionHsp70 protein binding
J0030672cellular_componentsynaptic vesicle membrane
J0031072molecular_functionheat shock protein binding
J0031396biological_processregulation of protein ubiquitination
J0031624molecular_functionubiquitin conjugating enzyme binding
J0031625molecular_functionubiquitin protein ligase binding
J0031647biological_processregulation of protein stability
J0031648biological_processprotein destabilization
J0032232biological_processnegative regulation of actin filament bundle assembly
J0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
J0032991cellular_componentprotein-containing complex
J0033132biological_processnegative regulation of glucokinase activity
J0034599biological_processcellular response to oxidative stress
J0034976biological_processresponse to endoplasmic reticulum stress
J0035249biological_processsynaptic transmission, glutamatergic
J0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
J0042053biological_processregulation of dopamine metabolic process
J0042415biological_processnorepinephrine metabolic process
J0042417biological_processdopamine metabolic process
J0042802molecular_functionidentical protein binding
J0042826molecular_functionhistone deacetylase binding
J0043005cellular_componentneuron projection
J0043025cellular_componentneuronal cell body
J0043065biological_processpositive regulation of apoptotic process
J0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
J0043130molecular_functionubiquitin binding
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0043195cellular_componentterminal bouton
J0043274molecular_functionphospholipase binding
J0043524biological_processnegative regulation of neuron apoptotic process
J0043653biological_processmitochondrial fragmentation involved in apoptotic process
J0044314biological_processprotein K27-linked ubiquitination
J0044828biological_processhost-mediated suppression of viral genome replication
J0044877molecular_functionprotein-containing complex binding
J0045202cellular_componentsynapse
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0046329biological_processnegative regulation of JNK cascade
J0046676biological_processnegative regulation of insulin secretion
J0046872molecular_functionmetal ion binding
J0046928biological_processregulation of neurotransmitter secretion
J0048471cellular_componentperinuclear region of cytoplasm
J0050804biological_processmodulation of chemical synaptic transmission
J0050821biological_processprotein stabilization
J0051087molecular_functionprotein-folding chaperone binding
J0051412biological_processresponse to corticosterone
J0051582biological_processpositive regulation of neurotransmitter uptake
J0051583biological_processdopamine uptake involved in synaptic transmission
J0051646biological_processmitochondrion localization
J0051865biological_processprotein autoubiquitination
J0051881biological_processregulation of mitochondrial membrane potential
J0051967biological_processnegative regulation of synaptic transmission, glutamatergic
J0061630molecular_functionubiquitin protein ligase activity
J0061734biological_processtype 2 mitophagy
J0070050biological_processneuron cellular homeostasis
J0070534biological_processprotein K63-linked ubiquitination
J0070585biological_processprotein localization to mitochondrion
J0070842biological_processaggresome assembly
J0070936biological_processprotein K48-linked ubiquitination
J0070979biological_processprotein K11-linked ubiquitination
J0071287biological_processcellular response to manganese ion
J0080090biological_processregulation of primary metabolic process
J0085020biological_processprotein K6-linked ubiquitination
J0090090biological_processnegative regulation of canonical Wnt signaling pathway
J0090141biological_processpositive regulation of mitochondrial fission
J0090201biological_processnegative regulation of release of cytochrome c from mitochondria
J0090258biological_processnegative regulation of mitochondrial fission
J0090394biological_processnegative regulation of excitatory postsynaptic potential
J0097237biological_processcellular response to toxic substance
J0097602molecular_functioncullin family protein binding
J0097708cellular_componentintracellular vesicle
J0098691cellular_componentdopaminergic synapse
J0098793cellular_componentpresynapse
J0098794cellular_componentpostsynapse
J0098978cellular_componentglutamatergic synapse
J0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
J0099073cellular_componentmitochondrion-derived vesicle
J0099074biological_processmitochondrion to lysosome vesicle-mediated transport
J0140251biological_processregulation protein catabolic process at presynapse
J1900242biological_processregulation of synaptic vesicle endocytosis
J1900407biological_processregulation of cellular response to oxidative stress
J1901526biological_processpositive regulation of mitophagy
J1901800biological_processpositive regulation of proteasomal protein catabolic process
J1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
J1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
J1902530biological_processpositive regulation of protein linear polyubiquitination
J1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
J1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
J1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
J1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
J1903530biological_processregulation of secretion by cell
J1903542biological_processnegative regulation of exosomal secretion
J1903861biological_processpositive regulation of dendrite extension
J1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
J1904643biological_processresponse to curcumin
J1904845biological_processcellular response to L-glutamine
J1904881biological_processcellular response to hydrogen sulfide
J1905091biological_processpositive regulation of type 2 mitophagy
J1905232biological_processcellular response to L-glutamate
J1905366biological_processnegative regulation of intralumenal vesicle formation
J1905477biological_processpositive regulation of protein localization to membrane
J1990381molecular_functionubiquitin-specific protease binding
J1990444molecular_functionF-box domain binding
J1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
J2000377biological_processregulation of reactive oxygen species metabolic process
J2000378biological_processnegative regulation of reactive oxygen species metabolic process
J2001171biological_processpositive regulation of ATP biosynthetic process
K0000122biological_processnegative regulation of transcription by RNA polymerase II
K0000139cellular_componentGolgi membrane
K0000151cellular_componentubiquitin ligase complex
K0000209biological_processprotein polyubiquitination
K0000266biological_processmitochondrial fission
K0000422biological_processautophagy of mitochondrion
K0000423biological_processmitophagy
K0001664molecular_functionG protein-coupled receptor binding
K0001963biological_processsynaptic transmission, dopaminergic
K0001964biological_processstartle response
K0003714molecular_functiontranscription corepressor activity
K0003779molecular_functionactin binding
K0004842molecular_functionubiquitin-protein transferase activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005741cellular_componentmitochondrial outer membrane
K0005783cellular_componentendoplasmic reticulum
K0005789cellular_componentendoplasmic reticulum membrane
K0005794cellular_componentGolgi apparatus
K0005829cellular_componentcytosol
K0006351biological_processDNA-templated transcription
K0006511biological_processubiquitin-dependent protein catabolic process
K0006513biological_processprotein monoubiquitination
K0006914biological_processautophagy
K0006979biological_processresponse to oxidative stress
K0006986biological_processresponse to unfolded protein
K0007005biological_processmitochondrion organization
K0007612biological_processlearning
K0007626biological_processlocomotory behavior
K0008013molecular_functionbeta-catenin binding
K0008021cellular_componentsynaptic vesicle
K0008270molecular_functionzinc ion binding
K0008344biological_processadult locomotory behavior
K0009410biological_processresponse to xenobiotic stimulus
K0009896biological_processpositive regulation of catabolic process
K0010498biological_processproteasomal protein catabolic process
K0010506biological_processregulation of autophagy
K0010628biological_processpositive regulation of gene expression
K0010629biological_processnegative regulation of gene expression
K0010636biological_processpositive regulation of mitochondrial fusion
K0010637biological_processnegative regulation of mitochondrial fusion
K0010821biological_processregulation of mitochondrion organization
K0010918biological_processpositive regulation of mitochondrial membrane potential
K0010994biological_processfree ubiquitin chain polymerization
K0014069cellular_componentpostsynaptic density
K0014850biological_processresponse to muscle activity
K0015631molecular_functiontubulin binding
K0016235cellular_componentaggresome
K0016567biological_processprotein ubiquitination
K0016607cellular_componentnuclear speck
K0016740molecular_functiontransferase activity
K0019005cellular_componentSCF ubiquitin ligase complex
K0019899molecular_functionenzyme binding
K0019900molecular_functionkinase binding
K0019901molecular_functionprotein kinase binding
K0022603biological_processregulation of anatomical structure morphogenesis
K0030163biological_processprotein catabolic process
K0030165molecular_functionPDZ domain binding
K0030424cellular_componentaxon
K0030544molecular_functionHsp70 protein binding
K0030672cellular_componentsynaptic vesicle membrane
K0031072molecular_functionheat shock protein binding
K0031396biological_processregulation of protein ubiquitination
K0031624molecular_functionubiquitin conjugating enzyme binding
K0031625molecular_functionubiquitin protein ligase binding
K0031647biological_processregulation of protein stability
K0031648biological_processprotein destabilization
K0032232biological_processnegative regulation of actin filament bundle assembly
K0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
K0032991cellular_componentprotein-containing complex
K0033132biological_processnegative regulation of glucokinase activity
K0034599biological_processcellular response to oxidative stress
K0034976biological_processresponse to endoplasmic reticulum stress
K0035249biological_processsynaptic transmission, glutamatergic
K0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
K0042053biological_processregulation of dopamine metabolic process
K0042415biological_processnorepinephrine metabolic process
K0042417biological_processdopamine metabolic process
K0042802molecular_functionidentical protein binding
K0042826molecular_functionhistone deacetylase binding
K0043005cellular_componentneuron projection
K0043025cellular_componentneuronal cell body
K0043065biological_processpositive regulation of apoptotic process
K0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
K0043130molecular_functionubiquitin binding
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0043195cellular_componentterminal bouton
K0043274molecular_functionphospholipase binding
K0043524biological_processnegative regulation of neuron apoptotic process
K0043653biological_processmitochondrial fragmentation involved in apoptotic process
K0044314biological_processprotein K27-linked ubiquitination
K0044828biological_processhost-mediated suppression of viral genome replication
K0044877molecular_functionprotein-containing complex binding
K0045202cellular_componentsynapse
K0045944biological_processpositive regulation of transcription by RNA polymerase II
K0046329biological_processnegative regulation of JNK cascade
K0046676biological_processnegative regulation of insulin secretion
K0046872molecular_functionmetal ion binding
K0046928biological_processregulation of neurotransmitter secretion
K0048471cellular_componentperinuclear region of cytoplasm
K0050804biological_processmodulation of chemical synaptic transmission
K0050821biological_processprotein stabilization
K0051087molecular_functionprotein-folding chaperone binding
K0051412biological_processresponse to corticosterone
K0051582biological_processpositive regulation of neurotransmitter uptake
K0051583biological_processdopamine uptake involved in synaptic transmission
K0051646biological_processmitochondrion localization
K0051865biological_processprotein autoubiquitination
K0051881biological_processregulation of mitochondrial membrane potential
K0051967biological_processnegative regulation of synaptic transmission, glutamatergic
K0061630molecular_functionubiquitin protein ligase activity
K0061734biological_processtype 2 mitophagy
K0070050biological_processneuron cellular homeostasis
K0070534biological_processprotein K63-linked ubiquitination
K0070585biological_processprotein localization to mitochondrion
K0070842biological_processaggresome assembly
K0070936biological_processprotein K48-linked ubiquitination
K0070979biological_processprotein K11-linked ubiquitination
K0071287biological_processcellular response to manganese ion
K0080090biological_processregulation of primary metabolic process
K0085020biological_processprotein K6-linked ubiquitination
K0090090biological_processnegative regulation of canonical Wnt signaling pathway
K0090141biological_processpositive regulation of mitochondrial fission
K0090201biological_processnegative regulation of release of cytochrome c from mitochondria
K0090258biological_processnegative regulation of mitochondrial fission
K0090394biological_processnegative regulation of excitatory postsynaptic potential
K0097237biological_processcellular response to toxic substance
K0097602molecular_functioncullin family protein binding
K0097708cellular_componentintracellular vesicle
K0098691cellular_componentdopaminergic synapse
K0098793cellular_componentpresynapse
K0098794cellular_componentpostsynapse
K0098978cellular_componentglutamatergic synapse
K0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
K0099073cellular_componentmitochondrion-derived vesicle
K0099074biological_processmitochondrion to lysosome vesicle-mediated transport
K0140251biological_processregulation protein catabolic process at presynapse
K1900242biological_processregulation of synaptic vesicle endocytosis
K1900407biological_processregulation of cellular response to oxidative stress
K1901526biological_processpositive regulation of mitophagy
K1901800biological_processpositive regulation of proteasomal protein catabolic process
K1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
K1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
K1902530biological_processpositive regulation of protein linear polyubiquitination
K1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
K1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
K1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
K1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
K1903530biological_processregulation of secretion by cell
K1903542biological_processnegative regulation of exosomal secretion
K1903861biological_processpositive regulation of dendrite extension
K1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
K1904643biological_processresponse to curcumin
K1904845biological_processcellular response to L-glutamine
K1904881biological_processcellular response to hydrogen sulfide
K1905091biological_processpositive regulation of type 2 mitophagy
K1905232biological_processcellular response to L-glutamate
K1905366biological_processnegative regulation of intralumenal vesicle formation
K1905477biological_processpositive regulation of protein localization to membrane
K1990381molecular_functionubiquitin-specific protease binding
K1990444molecular_functionF-box domain binding
K1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
K2000377biological_processregulation of reactive oxygen species metabolic process
K2000378biological_processnegative regulation of reactive oxygen species metabolic process
K2001171biological_processpositive regulation of ATP biosynthetic process
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0000139cellular_componentGolgi membrane
L0000151cellular_componentubiquitin ligase complex
L0000209biological_processprotein polyubiquitination
L0000266biological_processmitochondrial fission
L0000422biological_processautophagy of mitochondrion
L0000423biological_processmitophagy
L0001664molecular_functionG protein-coupled receptor binding
L0001963biological_processsynaptic transmission, dopaminergic
L0001964biological_processstartle response
L0003714molecular_functiontranscription corepressor activity
L0003779molecular_functionactin binding
L0004842molecular_functionubiquitin-protein transferase activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005741cellular_componentmitochondrial outer membrane
L0005783cellular_componentendoplasmic reticulum
L0005789cellular_componentendoplasmic reticulum membrane
L0005794cellular_componentGolgi apparatus
L0005829cellular_componentcytosol
L0006351biological_processDNA-templated transcription
L0006511biological_processubiquitin-dependent protein catabolic process
L0006513biological_processprotein monoubiquitination
L0006914biological_processautophagy
L0006979biological_processresponse to oxidative stress
L0006986biological_processresponse to unfolded protein
L0007005biological_processmitochondrion organization
L0007612biological_processlearning
L0007626biological_processlocomotory behavior
L0008013molecular_functionbeta-catenin binding
L0008021cellular_componentsynaptic vesicle
L0008270molecular_functionzinc ion binding
L0008344biological_processadult locomotory behavior
L0009410biological_processresponse to xenobiotic stimulus
L0009896biological_processpositive regulation of catabolic process
L0010498biological_processproteasomal protein catabolic process
L0010506biological_processregulation of autophagy
L0010628biological_processpositive regulation of gene expression
L0010629biological_processnegative regulation of gene expression
L0010636biological_processpositive regulation of mitochondrial fusion
L0010637biological_processnegative regulation of mitochondrial fusion
L0010821biological_processregulation of mitochondrion organization
L0010918biological_processpositive regulation of mitochondrial membrane potential
L0010994biological_processfree ubiquitin chain polymerization
L0014069cellular_componentpostsynaptic density
L0014850biological_processresponse to muscle activity
L0015631molecular_functiontubulin binding
L0016235cellular_componentaggresome
L0016567biological_processprotein ubiquitination
L0016607cellular_componentnuclear speck
L0016740molecular_functiontransferase activity
L0019005cellular_componentSCF ubiquitin ligase complex
L0019899molecular_functionenzyme binding
L0019900molecular_functionkinase binding
L0019901molecular_functionprotein kinase binding
L0022603biological_processregulation of anatomical structure morphogenesis
L0030163biological_processprotein catabolic process
L0030165molecular_functionPDZ domain binding
L0030424cellular_componentaxon
L0030544molecular_functionHsp70 protein binding
L0030672cellular_componentsynaptic vesicle membrane
L0031072molecular_functionheat shock protein binding
L0031396biological_processregulation of protein ubiquitination
L0031624molecular_functionubiquitin conjugating enzyme binding
L0031625molecular_functionubiquitin protein ligase binding
L0031647biological_processregulation of protein stability
L0031648biological_processprotein destabilization
L0032232biological_processnegative regulation of actin filament bundle assembly
L0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
L0032991cellular_componentprotein-containing complex
L0033132biological_processnegative regulation of glucokinase activity
L0034599biological_processcellular response to oxidative stress
L0034976biological_processresponse to endoplasmic reticulum stress
L0035249biological_processsynaptic transmission, glutamatergic
L0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
L0042053biological_processregulation of dopamine metabolic process
L0042415biological_processnorepinephrine metabolic process
L0042417biological_processdopamine metabolic process
L0042802molecular_functionidentical protein binding
L0042826molecular_functionhistone deacetylase binding
L0043005cellular_componentneuron projection
L0043025cellular_componentneuronal cell body
L0043065biological_processpositive regulation of apoptotic process
L0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
L0043130molecular_functionubiquitin binding
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0043195cellular_componentterminal bouton
L0043274molecular_functionphospholipase binding
L0043524biological_processnegative regulation of neuron apoptotic process
L0043653biological_processmitochondrial fragmentation involved in apoptotic process
L0044314biological_processprotein K27-linked ubiquitination
L0044828biological_processhost-mediated suppression of viral genome replication
L0044877molecular_functionprotein-containing complex binding
L0045202cellular_componentsynapse
L0045944biological_processpositive regulation of transcription by RNA polymerase II
L0046329biological_processnegative regulation of JNK cascade
L0046676biological_processnegative regulation of insulin secretion
L0046872molecular_functionmetal ion binding
L0046928biological_processregulation of neurotransmitter secretion
L0048471cellular_componentperinuclear region of cytoplasm
L0050804biological_processmodulation of chemical synaptic transmission
L0050821biological_processprotein stabilization
L0051087molecular_functionprotein-folding chaperone binding
L0051412biological_processresponse to corticosterone
L0051582biological_processpositive regulation of neurotransmitter uptake
L0051583biological_processdopamine uptake involved in synaptic transmission
L0051646biological_processmitochondrion localization
L0051865biological_processprotein autoubiquitination
L0051881biological_processregulation of mitochondrial membrane potential
L0051967biological_processnegative regulation of synaptic transmission, glutamatergic
L0061630molecular_functionubiquitin protein ligase activity
L0061734biological_processtype 2 mitophagy
L0070050biological_processneuron cellular homeostasis
L0070534biological_processprotein K63-linked ubiquitination
L0070585biological_processprotein localization to mitochondrion
L0070842biological_processaggresome assembly
L0070936biological_processprotein K48-linked ubiquitination
L0070979biological_processprotein K11-linked ubiquitination
L0071287biological_processcellular response to manganese ion
L0080090biological_processregulation of primary metabolic process
L0085020biological_processprotein K6-linked ubiquitination
L0090090biological_processnegative regulation of canonical Wnt signaling pathway
L0090141biological_processpositive regulation of mitochondrial fission
L0090201biological_processnegative regulation of release of cytochrome c from mitochondria
L0090258biological_processnegative regulation of mitochondrial fission
L0090394biological_processnegative regulation of excitatory postsynaptic potential
L0097237biological_processcellular response to toxic substance
L0097602molecular_functioncullin family protein binding
L0097708cellular_componentintracellular vesicle
L0098691cellular_componentdopaminergic synapse
L0098793cellular_componentpresynapse
L0098794cellular_componentpostsynapse
L0098978cellular_componentglutamatergic synapse
L0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
L0099073cellular_componentmitochondrion-derived vesicle
L0099074biological_processmitochondrion to lysosome vesicle-mediated transport
L0140251biological_processregulation protein catabolic process at presynapse
L1900242biological_processregulation of synaptic vesicle endocytosis
L1900407biological_processregulation of cellular response to oxidative stress
L1901526biological_processpositive regulation of mitophagy
L1901800biological_processpositive regulation of proteasomal protein catabolic process
L1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
L1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
L1902530biological_processpositive regulation of protein linear polyubiquitination
L1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
L1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
L1903382biological_processnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
L1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
L1903530biological_processregulation of secretion by cell
L1903542biological_processnegative regulation of exosomal secretion
L1903861biological_processpositive regulation of dendrite extension
L1904049biological_processnegative regulation of spontaneous neurotransmitter secretion
L1904643biological_processresponse to curcumin
L1904845biological_processcellular response to L-glutamine
L1904881biological_processcellular response to hydrogen sulfide
L1905091biological_processpositive regulation of type 2 mitophagy
L1905232biological_processcellular response to L-glutamate
L1905366biological_processnegative regulation of intralumenal vesicle formation
L1905477biological_processpositive regulation of protein localization to membrane
L1990381molecular_functionubiquitin-specific protease binding
L1990444molecular_functionF-box domain binding
L1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
L2000377biological_processregulation of reactive oxygen species metabolic process
L2000378biological_processnegative regulation of reactive oxygen species metabolic process
L2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 501
ChainResidue
ACYS150
ACYS154
ACYS212
AHIS215

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 502
ChainResidue
ACYS166
ACYS169
ACYS196
ACYS201

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 503
ChainResidue
ACYS241
ACYS260
ACYS263
ACYS238

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 504
ChainResidue
ACYS253
AHIS257
ACYS289
ACYS293

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 505
ChainResidue
ACYS332
ACYS337
ACYS352
ACYS360

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 506
ChainResidue
ACYS365
ACYS368
AHIS373
ACYS377

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 507
ChainResidue
ACYS418
ACYS421
ACYS436
ACYS441

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 508
ChainResidue
ACYS446
ACYS449
ACYS457
AHIS461

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 501
ChainResidue
BCYS150
BCYS154
BCYS212
BHIS215

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 502
ChainResidue
BCYS166
BCYS169
BCYS196
BCYS201

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 503
ChainResidue
BCYS238
BCYS241
BCYS260
BCYS263

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 504
ChainResidue
BCYS253
BHIS257
BCYS289
BCYS293

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 505
ChainResidue
BCYS332
BCYS337
BCYS352
BCYS360

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 506
ChainResidue
BCYS365
BCYS368
BHIS373
BCYS377

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 507
ChainResidue
BCYS418
BCYS421
BCYS436
BCYS441

site_idBC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 508
ChainResidue
BCYS446
BCYS449
BCYS457
BHIS461

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 501
ChainResidue
CCYS150
CCYS154
CCYS212
CHIS215

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 502
ChainResidue
CCYS166
CCYS169
CCYS196
CCYS201

site_idCC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 503
ChainResidue
CCYS238
CCYS241
CCYS260
CCYS263

site_idCC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 504
ChainResidue
CCYS253
CHIS257
CCYS289
CCYS293

site_idCC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 505
ChainResidue
CCYS332
CCYS337
CCYS352
CCYS360

site_idCC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 506
ChainResidue
CCYS365
CCYS368
CHIS373
CCYS377

site_idCC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 507
ChainResidue
CCYS418
CCYS421
CCYS436
CCYS441

site_idCC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 508
ChainResidue
CCYS446
CCYS449
CCYS457
CHIS461

site_idCC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 501
ChainResidue
DHIS215
DCYS150
DCYS154
DCYS212

site_idCC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 502
ChainResidue
DCYS166
DCYS169
DCYS196
DCYS201

site_idCC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 503
ChainResidue
DCYS238
DCYS241
DCYS260
DCYS263

site_idDC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 504
ChainResidue
DCYS253
DHIS257
DCYS289
DCYS293

site_idDC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 505
ChainResidue
DCYS332
DCYS337
DCYS352
DCYS360

site_idDC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 506
ChainResidue
DCYS365
DCYS368
DHIS373
DCYS377

site_idDC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 507
ChainResidue
DCYS418
DCYS421
DCYS436
DCYS441

site_idDC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 508
ChainResidue
DCYS446
DCYS449
DCYS457
DHIS461

site_idDC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 501
ChainResidue
ECYS150
ECYS154
ECYS212
EHIS215

site_idDC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 502
ChainResidue
ECYS166
ECYS169
ECYS196
ECYS201

site_idDC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 503
ChainResidue
ECYS238
ECYS241
ECYS260
ECYS263

site_idDC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 504
ChainResidue
ECYS253
EHIS257
ECYS289
ECYS293

site_idEC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 505
ChainResidue
ECYS332
ECYS337
ECYS352
ECYS360

site_idEC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 506
ChainResidue
ECYS365
ECYS368
EHIS373
ECYS377

site_idEC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 507
ChainResidue
ECYS418
ECYS421
ECYS436
ECYS441

site_idEC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 508
ChainResidue
ECYS446
ECYS449
ECYS457
EHIS461

site_idEC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 501
ChainResidue
FCYS150
FCYS154
FCYS212
FHIS215

site_idEC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 502
ChainResidue
FCYS166
FCYS169
FCYS196
FCYS201

site_idEC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 503
ChainResidue
FCYS238
FCYS241
FCYS260
FCYS263

site_idEC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 504
ChainResidue
FCYS253
FHIS257
FCYS289
FCYS293

site_idEC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 505
ChainResidue
FCYS332
FCYS337
FCYS352
FCYS360

site_idFC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 506
ChainResidue
FCYS365
FCYS368
FHIS373
FCYS377

site_idFC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 507
ChainResidue
FCYS418
FCYS421
FCYS436
FCYS441

site_idFC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 508
ChainResidue
FCYS446
FCYS449
FCYS457
FHIS461

site_idFC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 501
ChainResidue
GCYS150
GCYS154
GCYS212
GHIS215

site_idFC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 502
ChainResidue
GCYS166
GCYS169
GCYS196
GCYS201

site_idFC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 503
ChainResidue
GCYS238
GCYS241
GCYS260
GCYS263

site_idFC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 504
ChainResidue
GCYS253
GHIS257
GCYS289
GCYS293

site_idFC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 505
ChainResidue
GCYS332
GCYS337
GCYS352
GCYS360

site_idFC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 506
ChainResidue
GCYS365
GCYS368
GHIS373
GCYS377

site_idGC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 507
ChainResidue
GCYS418
GCYS421
GCYS436
GCYS441

site_idGC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN G 508
ChainResidue
GCYS446
GCYS449
GCYS457
GHIS461

site_idGC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 501
ChainResidue
HCYS150
HCYS154
HCYS212
HHIS215

site_idGC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 502
ChainResidue
HCYS166
HCYS169
HCYS196
HCYS201

site_idGC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 503
ChainResidue
HCYS238
HCYS241
HCYS260
HCYS263

site_idGC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 504
ChainResidue
HCYS253
HHIS257
HCYS289
HCYS293

site_idGC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 505
ChainResidue
HCYS332
HCYS337
HCYS352
HCYS360

site_idGC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 506
ChainResidue
HCYS365
HCYS368
HHIS373
HCYS377

site_idGC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 507
ChainResidue
HCYS418
HCYS421
HCYS436
HCYS441

site_idHC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 508
ChainResidue
HCYS446
HCYS449
HCYS457
HHIS461

site_idHC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 501
ChainResidue
ICYS150
ICYS154
ICYS212
IHIS215

site_idHC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 502
ChainResidue
ICYS166
ICYS169
ICYS196
ICYS201

site_idHC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 503
ChainResidue
ICYS238
ICYS241
ICYS260
ICYS263

site_idHC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 504
ChainResidue
ICYS253
IHIS257
ICYS289
ICYS293

site_idHC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 505
ChainResidue
ICYS332
ICYS337
ICYS352
ICYS360

site_idHC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 506
ChainResidue
ICYS365
ICYS368
IHIS373
ICYS377

site_idHC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 507
ChainResidue
ICYS418
ICYS421
ICYS436
ICYS441

site_idHC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 508
ChainResidue
ICYS446
ICYS449
ICYS457
IHIS461

site_idIC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 501
ChainResidue
JCYS150
JCYS154
JCYS212
JHIS215

site_idIC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 502
ChainResidue
JCYS166
JCYS169
JCYS196
JCYS201

site_idIC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 503
ChainResidue
JCYS238
JCYS241
JCYS260
JCYS263

site_idIC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 504
ChainResidue
JCYS253
JHIS257
JCYS289
JCYS293

site_idIC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 505
ChainResidue
JCYS332
JCYS337
JCYS352
JCYS360

site_idIC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 506
ChainResidue
JCYS365
JCYS368
JHIS373
JCYS377

site_idIC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 507
ChainResidue
JCYS418
JCYS421
JCYS436
JCYS441

site_idIC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 508
ChainResidue
JCYS446
JCYS449
JCYS457
JHIS461

site_idIC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 501
ChainResidue
KCYS150
KCYS154
KCYS212
KHIS215

site_idJC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 502
ChainResidue
KCYS166
KCYS169
KCYS196
KCYS201

site_idJC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 503
ChainResidue
KCYS238
KCYS241
KCYS260
KCYS263

site_idJC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 504
ChainResidue
KCYS253
KHIS257
KCYS289
KCYS293

site_idJC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 505
ChainResidue
KCYS332
KCYS337
KCYS352
KCYS360

site_idJC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 506
ChainResidue
KCYS365
KCYS368
KHIS373
KCYS377

site_idJC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 507
ChainResidue
KCYS418
KCYS421
KCYS436
KCYS441

site_idJC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN K 508
ChainResidue
KCYS446
KCYS449
KCYS457
KHIS461

site_idJC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 501
ChainResidue
LCYS150
LCYS154
LCYS212
LHIS215

site_idJC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 502
ChainResidue
LCYS166
LCYS169
LCYS196
LCYS201

site_idKC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 503
ChainResidue
LCYS238
LCYS241
LCYS260
LCYS263

site_idKC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 504
ChainResidue
LCYS253
LHIS257
LCYS289
LCYS293

site_idKC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 505
ChainResidue
LCYS332
LCYS337
LCYS352
LCYS360

site_idKC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 506
ChainResidue
LCYS365
LCYS368
LHIS373
LCYS377

site_idKC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 507
ChainResidue
LCYS418
LCYS421
LCYS436
LCYS441

site_idKC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 508
ChainResidue
LCYS446
LCYS449
LCYS457
LHIS461

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1008
DetailsZinc finger: {"description":"RING-type 0; atypical"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues660
DetailsZinc finger: {"description":"RING-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues768
DetailsZinc finger: {"description":"IBR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues372
DetailsZinc finger: {"description":"RING-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues408
DetailsRegion: {"description":"SYT11 binding 1","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues432
DetailsRegion: {"description":"SYT11 binding 2","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues12
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23661642","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues288
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine; by PINK1","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues36
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

250359

PDB entries from 2026-03-11

PDB statisticsPDBj update infoContact PDBjnumon