4K95

Crystal Structure of Parkin

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
I	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
G	0098794	cellular_component	postsynapse
G	0098978	cellular_component	glutamatergic synapse
G	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
H	0098794	cellular_component	postsynapse
H	0098978	cellular_component	glutamatergic synapse
H	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
I	0098794	cellular_component	postsynapse
I	0098978	cellular_component	glutamatergic synapse
I	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
J	0098794	cellular_component	postsynapse
J	0098978	cellular_component	glutamatergic synapse
J	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
K	0098794	cellular_component	postsynapse
K	0098978	cellular_component	glutamatergic synapse
K	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
L	0098794	cellular_component	postsynapse
L	0098978	cellular_component	glutamatergic synapse
L	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
B	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
C	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
D	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
E	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
F	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
G	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
H	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
I	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
J	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
K	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
L	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
A	0061734	biological_process	type 2 mitophagy
A	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
B	0061734	biological_process	type 2 mitophagy
B	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
C	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
D	0061734	biological_process	type 2 mitophagy
D	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
E	0061734	biological_process	type 2 mitophagy
E	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
F	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
G	0061734	biological_process	type 2 mitophagy
G	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
H	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
I	0061734	biological_process	type 2 mitophagy
I	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
J	0061734	biological_process	type 2 mitophagy
J	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
K	0061734	biological_process	type 2 mitophagy
K	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
L	0098779	biological_process	obsolete positive regulation of mitophagy in response to mitochondrial depolarization
A	0098691	cellular_component	dopaminergic synapse
A	0140251	biological_process	regulation protein catabolic process at presynapse
A	1900242	biological_process	regulation of synaptic vesicle endocytosis
B	0098691	cellular_component	dopaminergic synapse
B	0140251	biological_process	regulation protein catabolic process at presynapse
B	1900242	biological_process	regulation of synaptic vesicle endocytosis
C	0098691	cellular_component	dopaminergic synapse
C	0140251	biological_process	regulation protein catabolic process at presynapse
C	1900242	biological_process	regulation of synaptic vesicle endocytosis
D	0098691	cellular_component	dopaminergic synapse
D	0140251	biological_process	regulation protein catabolic process at presynapse
D	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	0098691	cellular_component	dopaminergic synapse
E	0140251	biological_process	regulation protein catabolic process at presynapse
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	0098691	cellular_component	dopaminergic synapse
F	0140251	biological_process	regulation protein catabolic process at presynapse
F	1900242	biological_process	regulation of synaptic vesicle endocytosis
G	0098691	cellular_component	dopaminergic synapse
G	0140251	biological_process	regulation protein catabolic process at presynapse
G	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	0098691	cellular_component	dopaminergic synapse
H	0140251	biological_process	regulation protein catabolic process at presynapse
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
I	0098691	cellular_component	dopaminergic synapse
I	0140251	biological_process	regulation protein catabolic process at presynapse
I	1900242	biological_process	regulation of synaptic vesicle endocytosis
J	0098691	cellular_component	dopaminergic synapse
J	0140251	biological_process	regulation protein catabolic process at presynapse
J	1900242	biological_process	regulation of synaptic vesicle endocytosis
K	0098691	cellular_component	dopaminergic synapse
K	0140251	biological_process	regulation protein catabolic process at presynapse
K	1900242	biological_process	regulation of synaptic vesicle endocytosis
L	0098691	cellular_component	dopaminergic synapse
L	0140251	biological_process	regulation protein catabolic process at presynapse
L	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	0055069	biological_process	obsolete zinc ion homeostasis
J	0055069	biological_process	obsolete zinc ion homeostasis
K	0055069	biological_process	obsolete zinc ion homeostasis
A	0070936	biological_process	protein K48-linked ubiquitination
A	0034599	biological_process	cellular response to oxidative stress
B	0070936	biological_process	protein K48-linked ubiquitination
B	0034599	biological_process	cellular response to oxidative stress
C	0070936	biological_process	protein K48-linked ubiquitination
C	0034599	biological_process	cellular response to oxidative stress
D	0070936	biological_process	protein K48-linked ubiquitination
D	0034599	biological_process	cellular response to oxidative stress
E	0070936	biological_process	protein K48-linked ubiquitination
E	0034599	biological_process	cellular response to oxidative stress
F	0070936	biological_process	protein K48-linked ubiquitination
F	0034599	biological_process	cellular response to oxidative stress
G	0070936	biological_process	protein K48-linked ubiquitination
G	0034599	biological_process	cellular response to oxidative stress
H	0070936	biological_process	protein K48-linked ubiquitination
H	0034599	biological_process	cellular response to oxidative stress
I	0070936	biological_process	protein K48-linked ubiquitination
I	0034599	biological_process	cellular response to oxidative stress
J	0070936	biological_process	protein K48-linked ubiquitination
J	0034599	biological_process	cellular response to oxidative stress
K	0070936	biological_process	protein K48-linked ubiquitination
K	0034599	biological_process	cellular response to oxidative stress
L	0070936	biological_process	protein K48-linked ubiquitination
L	0034599	biological_process	cellular response to oxidative stress
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000151	cellular_component	ubiquitin ligase complex
A	0000209	biological_process	protein polyubiquitination
A	0000266	biological_process	mitochondrial fission
A	0000423	biological_process	mitophagy
A	0001664	molecular_function	G protein-coupled receptor binding
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001963	biological_process	synaptic transmission, dopaminergic
A	0001964	biological_process	startle response
A	0003714	molecular_function	transcription corepressor activity
A	0003779	molecular_function	actin binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005741	cellular_component	mitochondrial outer membrane
A	0005794	cellular_component	Golgi apparatus
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006914	biological_process	autophagy
A	0006979	biological_process	response to oxidative stress
A	0007005	biological_process	mitochondrion organization
A	0007612	biological_process	learning
A	0007626	biological_process	locomotory behavior
A	0008013	molecular_function	beta-catenin binding
A	0008344	biological_process	adult locomotory behavior
A	0010498	biological_process	proteasomal protein catabolic process
A	0010506	biological_process	regulation of autophagy
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0010636	biological_process	positive regulation of mitochondrial fusion
A	0010637	biological_process	negative regulation of mitochondrial fusion
A	0010821	biological_process	regulation of mitochondrion organization
A	0010994	biological_process	free ubiquitin chain polymerization
A	0015631	molecular_function	tubulin binding
A	0016235	cellular_component	aggresome
A	0016740	molecular_function	transferase activity
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0019899	molecular_function	enzyme binding
A	0019900	molecular_function	kinase binding
A	0030165	molecular_function	PDZ domain binding
A	0030544	molecular_function	Hsp70 protein binding
A	0031072	molecular_function	heat shock protein binding
A	0031396	biological_process	regulation of protein ubiquitination
A	0051087	molecular_function	protein-folding chaperone binding
A	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
A	0055069	biological_process	obsolete zinc ion homeostasis
A	0031624	molecular_function	ubiquitin conjugating enzyme binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031647	biological_process	regulation of protein stability
A	0031648	biological_process	protein destabilization
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0032232	biological_process	negative regulation of actin filament bundle assembly
A	0032991	cellular_component	protein-containing complex
A	0033132	biological_process	negative regulation of glucokinase activity
A	0035249	biological_process	synaptic transmission, glutamatergic
A	0042053	biological_process	regulation of dopamine metabolic process
A	0042415	biological_process	norepinephrine metabolic process
A	0042417	biological_process	dopamine metabolic process
A	0042802	molecular_function	identical protein binding
A	0042826	molecular_function	histone deacetylase binding
A	0042981	biological_process	regulation of apoptotic process
A	0042995	cellular_component	cell projection
A	0043130	molecular_function	ubiquitin binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043274	molecular_function	phospholipase binding
A	0043388	biological_process	positive regulation of DNA binding
A	0044828	biological_process	negative regulation by host of viral genome replication
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046329	biological_process	negative regulation of JNK cascade
A	0046676	biological_process	negative regulation of insulin secretion
A	0046872	molecular_function	metal ion binding
A	0046928	biological_process	regulation of neurotransmitter secretion
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050821	biological_process	protein stabilization
A	0051582	biological_process	positive regulation of neurotransmitter uptake
A	0051583	biological_process	dopamine uptake involved in synaptic transmission
A	0051865	biological_process	protein autoubiquitination
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070050	biological_process	neuron cellular homeostasis
A	0070534	biological_process	protein K63-linked ubiquitination
A	0070842	biological_process	aggresome assembly
A	0070979	biological_process	protein K11-linked ubiquitination
A	0085020	biological_process	protein K6-linked ubiquitination
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0090141	biological_process	positive regulation of mitochondrial fission
A	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
A	0097237	biological_process	cellular response to toxic substance
A	0097602	molecular_function	cullin family protein binding
A	0099073	cellular_component	mitochondrion-derived vesicle
A	1900407	biological_process	regulation of cellular response to oxidative stress
A	1901800	biological_process	positive regulation of proteasomal protein catabolic process
A	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
A	1902530	biological_process	positive regulation of protein linear polyubiquitination
A	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
A	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
A	1903542	biological_process	negative regulation of exosomal secretion
A	1903861	biological_process	positive regulation of dendrite extension
A	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
A	1905366	biological_process	negative regulation of intralumenal vesicle formation
A	1905477	biological_process	positive regulation of protein localization to membrane
A	1990381	molecular_function	ubiquitin-specific protease binding
A	1990444	molecular_function	F-box domain binding
A	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
A	2000377	biological_process	regulation of reactive oxygen species metabolic process
A	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000151	cellular_component	ubiquitin ligase complex
B	0000209	biological_process	protein polyubiquitination
B	0000266	biological_process	mitochondrial fission
B	0000423	biological_process	mitophagy
B	0001664	molecular_function	G protein-coupled receptor binding
B	0001933	biological_process	negative regulation of protein phosphorylation
B	0001963	biological_process	synaptic transmission, dopaminergic
B	0001964	biological_process	startle response
B	0003714	molecular_function	transcription corepressor activity
B	0003779	molecular_function	actin binding
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005741	cellular_component	mitochondrial outer membrane
B	0005794	cellular_component	Golgi apparatus
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006513	biological_process	protein monoubiquitination
B	0006914	biological_process	autophagy
B	0006979	biological_process	response to oxidative stress
B	0007005	biological_process	mitochondrion organization
B	0007612	biological_process	learning
B	0007626	biological_process	locomotory behavior
B	0008013	molecular_function	beta-catenin binding
B	0008344	biological_process	adult locomotory behavior
B	0010498	biological_process	proteasomal protein catabolic process
B	0010506	biological_process	regulation of autophagy
B	0010628	biological_process	positive regulation of gene expression
B	0010629	biological_process	negative regulation of gene expression
B	0010636	biological_process	positive regulation of mitochondrial fusion
B	0010637	biological_process	negative regulation of mitochondrial fusion
B	0010821	biological_process	regulation of mitochondrion organization
B	0010994	biological_process	free ubiquitin chain polymerization
B	0015631	molecular_function	tubulin binding
B	0016235	cellular_component	aggresome
B	0016740	molecular_function	transferase activity
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0019899	molecular_function	enzyme binding
B	0019900	molecular_function	kinase binding
B	0030165	molecular_function	PDZ domain binding
B	0030544	molecular_function	Hsp70 protein binding
B	0031072	molecular_function	heat shock protein binding
B	0031396	biological_process	regulation of protein ubiquitination
B	0031624	molecular_function	ubiquitin conjugating enzyme binding
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031647	biological_process	regulation of protein stability
B	0031648	biological_process	protein destabilization
B	0032232	biological_process	negative regulation of actin filament bundle assembly
B	0032991	cellular_component	protein-containing complex
B	0033132	biological_process	negative regulation of glucokinase activity
B	0035249	biological_process	synaptic transmission, glutamatergic
B	0042053	biological_process	regulation of dopamine metabolic process
B	0042415	biological_process	norepinephrine metabolic process
B	0042417	biological_process	dopamine metabolic process
B	0042802	molecular_function	identical protein binding
B	0042826	molecular_function	histone deacetylase binding
B	0042981	biological_process	regulation of apoptotic process
B	0042995	cellular_component	cell projection
B	0043130	molecular_function	ubiquitin binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043274	molecular_function	phospholipase binding
B	0043388	biological_process	positive regulation of DNA binding
B	0055069	biological_process	obsolete zinc ion homeostasis
B	0044828	biological_process	negative regulation by host of viral genome replication
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046329	biological_process	negative regulation of JNK cascade
B	0046676	biological_process	negative regulation of insulin secretion
B	0046872	molecular_function	metal ion binding
B	0046928	biological_process	regulation of neurotransmitter secretion
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0050821	biological_process	protein stabilization
B	0051582	biological_process	positive regulation of neurotransmitter uptake
B	0051583	biological_process	dopamine uptake involved in synaptic transmission
B	0051865	biological_process	protein autoubiquitination
B	0051881	biological_process	regulation of mitochondrial membrane potential
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0070050	biological_process	neuron cellular homeostasis
B	0070534	biological_process	protein K63-linked ubiquitination
B	0070842	biological_process	aggresome assembly
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0070979	biological_process	protein K11-linked ubiquitination
B	0085020	biological_process	protein K6-linked ubiquitination
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	0090141	biological_process	positive regulation of mitochondrial fission
B	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
B	0097237	biological_process	cellular response to toxic substance
B	0097602	molecular_function	cullin family protein binding
B	0099073	cellular_component	mitochondrion-derived vesicle
B	1900407	biological_process	regulation of cellular response to oxidative stress
B	1901800	biological_process	positive regulation of proteasomal protein catabolic process
B	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
B	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
B	1902530	biological_process	positive regulation of protein linear polyubiquitination
B	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
B	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
B	1903542	biological_process	negative regulation of exosomal secretion
B	1903861	biological_process	positive regulation of dendrite extension
B	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
B	1905366	biological_process	negative regulation of intralumenal vesicle formation
B	1905477	biological_process	positive regulation of protein localization to membrane
B	1990381	molecular_function	ubiquitin-specific protease binding
B	1990444	molecular_function	F-box domain binding
B	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
B	2000377	biological_process	regulation of reactive oxygen species metabolic process
B	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000151	cellular_component	ubiquitin ligase complex
C	0000209	biological_process	protein polyubiquitination
C	0000266	biological_process	mitochondrial fission
C	0000423	biological_process	mitophagy
B	0051087	molecular_function	protein-folding chaperone binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0001963	biological_process	synaptic transmission, dopaminergic
C	0001964	biological_process	startle response
C	0003714	molecular_function	transcription corepressor activity
C	0003779	molecular_function	actin binding
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005741	cellular_component	mitochondrial outer membrane
C	0005794	cellular_component	Golgi apparatus
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006914	biological_process	autophagy
C	0006979	biological_process	response to oxidative stress
C	0007005	biological_process	mitochondrion organization
C	0007612	biological_process	learning
C	0007626	biological_process	locomotory behavior
C	0008013	molecular_function	beta-catenin binding
C	0008344	biological_process	adult locomotory behavior
C	0010498	biological_process	proteasomal protein catabolic process
C	0010506	biological_process	regulation of autophagy
C	0010628	biological_process	positive regulation of gene expression
C	0010629	biological_process	negative regulation of gene expression
C	0010636	biological_process	positive regulation of mitochondrial fusion
C	0010637	biological_process	negative regulation of mitochondrial fusion
C	0010821	biological_process	regulation of mitochondrion organization
C	0010994	biological_process	free ubiquitin chain polymerization
C	0015631	molecular_function	tubulin binding
C	0016235	cellular_component	aggresome
C	0016740	molecular_function	transferase activity
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0019899	molecular_function	enzyme binding
C	0019900	molecular_function	kinase binding
C	0055069	biological_process	obsolete zinc ion homeostasis
C	0030165	molecular_function	PDZ domain binding
C	0030544	molecular_function	Hsp70 protein binding
C	0031072	molecular_function	heat shock protein binding
C	0031396	biological_process	regulation of protein ubiquitination
C	0031624	molecular_function	ubiquitin conjugating enzyme binding
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031647	biological_process	regulation of protein stability
C	0031648	biological_process	protein destabilization
C	0032232	biological_process	negative regulation of actin filament bundle assembly
C	0032991	cellular_component	protein-containing complex
C	0033132	biological_process	negative regulation of glucokinase activity
C	0035249	biological_process	synaptic transmission, glutamatergic
C	0042053	biological_process	regulation of dopamine metabolic process
C	0042415	biological_process	norepinephrine metabolic process
C	0042417	biological_process	dopamine metabolic process
C	0042802	molecular_function	identical protein binding
C	0042826	molecular_function	histone deacetylase binding
C	0042981	biological_process	regulation of apoptotic process
C	0042995	cellular_component	cell projection
C	0043130	molecular_function	ubiquitin binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043274	molecular_function	phospholipase binding
C	0043388	biological_process	positive regulation of DNA binding
C	0051087	molecular_function	protein-folding chaperone binding
C	0044828	biological_process	negative regulation by host of viral genome replication
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046329	biological_process	negative regulation of JNK cascade
C	0046676	biological_process	negative regulation of insulin secretion
C	0046872	molecular_function	metal ion binding
C	0046928	biological_process	regulation of neurotransmitter secretion
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0050821	biological_process	protein stabilization
C	0051582	biological_process	positive regulation of neurotransmitter uptake
C	0051583	biological_process	dopamine uptake involved in synaptic transmission
C	0051865	biological_process	protein autoubiquitination
C	0051881	biological_process	regulation of mitochondrial membrane potential
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061734	biological_process	type 2 mitophagy
C	0070050	biological_process	neuron cellular homeostasis
C	0070534	biological_process	protein K63-linked ubiquitination
C	0070842	biological_process	aggresome assembly
C	0070979	biological_process	protein K11-linked ubiquitination
C	0085020	biological_process	protein K6-linked ubiquitination
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0090141	biological_process	positive regulation of mitochondrial fission
C	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
C	0097237	biological_process	cellular response to toxic substance
C	0097602	molecular_function	cullin family protein binding
C	0099073	cellular_component	mitochondrion-derived vesicle
C	1900407	biological_process	regulation of cellular response to oxidative stress
C	1901800	biological_process	positive regulation of proteasomal protein catabolic process
C	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
C	1902530	biological_process	positive regulation of protein linear polyubiquitination
C	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
C	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
C	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
C	1903542	biological_process	negative regulation of exosomal secretion
C	1903861	biological_process	positive regulation of dendrite extension
C	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
C	1905366	biological_process	negative regulation of intralumenal vesicle formation
C	1905477	biological_process	positive regulation of protein localization to membrane
C	1990381	molecular_function	ubiquitin-specific protease binding
C	1990444	molecular_function	F-box domain binding
C	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
C	2000377	biological_process	regulation of reactive oxygen species metabolic process
C	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000151	cellular_component	ubiquitin ligase complex
D	0000209	biological_process	protein polyubiquitination
D	0000266	biological_process	mitochondrial fission
D	0000423	biological_process	mitophagy
D	0001664	molecular_function	G protein-coupled receptor binding
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0001963	biological_process	synaptic transmission, dopaminergic
D	0001964	biological_process	startle response
D	0003714	molecular_function	transcription corepressor activity
D	0003779	molecular_function	actin binding
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005741	cellular_component	mitochondrial outer membrane
D	0005794	cellular_component	Golgi apparatus
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006914	biological_process	autophagy
D	0006979	biological_process	response to oxidative stress
D	0007005	biological_process	mitochondrion organization
D	0007612	biological_process	learning
D	0007626	biological_process	locomotory behavior
D	0008013	molecular_function	beta-catenin binding
D	0008344	biological_process	adult locomotory behavior
D	0010498	biological_process	proteasomal protein catabolic process
D	0010506	biological_process	regulation of autophagy
D	0010628	biological_process	positive regulation of gene expression
D	0010629	biological_process	negative regulation of gene expression
D	0010636	biological_process	positive regulation of mitochondrial fusion
D	0010637	biological_process	negative regulation of mitochondrial fusion
D	0010821	biological_process	regulation of mitochondrion organization
D	0010994	biological_process	free ubiquitin chain polymerization
D	0015631	molecular_function	tubulin binding
D	0016235	cellular_component	aggresome
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019899	molecular_function	enzyme binding
D	0019900	molecular_function	kinase binding
D	0055069	biological_process	obsolete zinc ion homeostasis
D	0030165	molecular_function	PDZ domain binding
D	0030544	molecular_function	Hsp70 protein binding
D	0031072	molecular_function	heat shock protein binding
D	0031396	biological_process	regulation of protein ubiquitination
D	0031624	molecular_function	ubiquitin conjugating enzyme binding
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031647	biological_process	regulation of protein stability
D	0031648	biological_process	protein destabilization
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0032232	biological_process	negative regulation of actin filament bundle assembly
D	0032991	cellular_component	protein-containing complex
D	0033132	biological_process	negative regulation of glucokinase activity
D	0035249	biological_process	synaptic transmission, glutamatergic
D	0042053	biological_process	regulation of dopamine metabolic process
D	0042415	biological_process	norepinephrine metabolic process
D	0042417	biological_process	dopamine metabolic process
D	0042802	molecular_function	identical protein binding
D	0042826	molecular_function	histone deacetylase binding
D	0042981	biological_process	regulation of apoptotic process
D	0042995	cellular_component	cell projection
D	0043130	molecular_function	ubiquitin binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043274	molecular_function	phospholipase binding
D	0043388	biological_process	positive regulation of DNA binding
D	0051087	molecular_function	protein-folding chaperone binding
D	0044828	biological_process	negative regulation by host of viral genome replication
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046329	biological_process	negative regulation of JNK cascade
D	0046676	biological_process	negative regulation of insulin secretion
D	0046872	molecular_function	metal ion binding
D	0046928	biological_process	regulation of neurotransmitter secretion
D	0050804	biological_process	modulation of chemical synaptic transmission
D	0050821	biological_process	protein stabilization
D	0051582	biological_process	positive regulation of neurotransmitter uptake
D	0051583	biological_process	dopamine uptake involved in synaptic transmission
D	0051865	biological_process	protein autoubiquitination
D	0051881	biological_process	regulation of mitochondrial membrane potential
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0070050	biological_process	neuron cellular homeostasis
D	0070534	biological_process	protein K63-linked ubiquitination
D	0070842	biological_process	aggresome assembly
D	0070979	biological_process	protein K11-linked ubiquitination
D	0085020	biological_process	protein K6-linked ubiquitination
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090141	biological_process	positive regulation of mitochondrial fission
D	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
D	0097237	biological_process	cellular response to toxic substance
D	0097602	molecular_function	cullin family protein binding
D	0099073	cellular_component	mitochondrion-derived vesicle
D	1900407	biological_process	regulation of cellular response to oxidative stress
D	1901800	biological_process	positive regulation of proteasomal protein catabolic process
D	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
D	1902530	biological_process	positive regulation of protein linear polyubiquitination
D	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
D	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
D	1903542	biological_process	negative regulation of exosomal secretion
D	1903861	biological_process	positive regulation of dendrite extension
D	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
D	1905366	biological_process	negative regulation of intralumenal vesicle formation
D	1905477	biological_process	positive regulation of protein localization to membrane
D	1990381	molecular_function	ubiquitin-specific protease binding
D	1990444	molecular_function	F-box domain binding
D	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
D	2000377	biological_process	regulation of reactive oxygen species metabolic process
D	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000151	cellular_component	ubiquitin ligase complex
E	0000209	biological_process	protein polyubiquitination
E	0000266	biological_process	mitochondrial fission
E	0000423	biological_process	mitophagy
E	0001664	molecular_function	G protein-coupled receptor binding
E	0001933	biological_process	negative regulation of protein phosphorylation
E	0001963	biological_process	synaptic transmission, dopaminergic
E	0001964	biological_process	startle response
E	0003714	molecular_function	transcription corepressor activity
E	0003779	molecular_function	actin binding
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005741	cellular_component	mitochondrial outer membrane
E	0005794	cellular_component	Golgi apparatus
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006513	biological_process	protein monoubiquitination
E	0006914	biological_process	autophagy
E	0006979	biological_process	response to oxidative stress
E	0007005	biological_process	mitochondrion organization
E	0007612	biological_process	learning
E	0007626	biological_process	locomotory behavior
E	0008013	molecular_function	beta-catenin binding
E	0008344	biological_process	adult locomotory behavior
E	0010498	biological_process	proteasomal protein catabolic process
E	0010506	biological_process	regulation of autophagy
E	0010628	biological_process	positive regulation of gene expression
E	0010629	biological_process	negative regulation of gene expression
E	0010636	biological_process	positive regulation of mitochondrial fusion
E	0010637	biological_process	negative regulation of mitochondrial fusion
E	0010821	biological_process	regulation of mitochondrion organization
E	0010994	biological_process	free ubiquitin chain polymerization
E	0015631	molecular_function	tubulin binding
E	0016235	cellular_component	aggresome
E	0016740	molecular_function	transferase activity
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0019899	molecular_function	enzyme binding
E	0019900	molecular_function	kinase binding
E	0030165	molecular_function	PDZ domain binding
E	0030544	molecular_function	Hsp70 protein binding
E	0031072	molecular_function	heat shock protein binding
E	0031396	biological_process	regulation of protein ubiquitination
E	0031624	molecular_function	ubiquitin conjugating enzyme binding
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0031647	biological_process	regulation of protein stability
E	0031648	biological_process	protein destabilization
E	0032232	biological_process	negative regulation of actin filament bundle assembly
E	0032991	cellular_component	protein-containing complex
E	0033132	biological_process	negative regulation of glucokinase activity
E	0035249	biological_process	synaptic transmission, glutamatergic
E	0042053	biological_process	regulation of dopamine metabolic process
E	0042415	biological_process	norepinephrine metabolic process
E	0042417	biological_process	dopamine metabolic process
E	0042802	molecular_function	identical protein binding
E	0042826	molecular_function	histone deacetylase binding
E	0042981	biological_process	regulation of apoptotic process
E	0042995	cellular_component	cell projection
E	0043130	molecular_function	ubiquitin binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043274	molecular_function	phospholipase binding
E	0043388	biological_process	positive regulation of DNA binding
E	0055069	biological_process	obsolete zinc ion homeostasis
E	0044828	biological_process	negative regulation by host of viral genome replication
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046329	biological_process	negative regulation of JNK cascade
E	0046676	biological_process	negative regulation of insulin secretion
E	0046872	molecular_function	metal ion binding
E	0046928	biological_process	regulation of neurotransmitter secretion
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0050821	biological_process	protein stabilization
E	0051582	biological_process	positive regulation of neurotransmitter uptake
E	0051583	biological_process	dopamine uptake involved in synaptic transmission
E	0051865	biological_process	protein autoubiquitination
E	0051881	biological_process	regulation of mitochondrial membrane potential
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0070050	biological_process	neuron cellular homeostasis
E	0070534	biological_process	protein K63-linked ubiquitination
E	0070842	biological_process	aggresome assembly
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0070979	biological_process	protein K11-linked ubiquitination
E	0085020	biological_process	protein K6-linked ubiquitination
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0090141	biological_process	positive regulation of mitochondrial fission
E	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
E	0097237	biological_process	cellular response to toxic substance
E	0097602	molecular_function	cullin family protein binding
E	0099073	cellular_component	mitochondrion-derived vesicle
E	1900407	biological_process	regulation of cellular response to oxidative stress
E	1901800	biological_process	positive regulation of proteasomal protein catabolic process
E	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
E	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
E	1902530	biological_process	positive regulation of protein linear polyubiquitination
E	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
E	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
E	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
E	1903542	biological_process	negative regulation of exosomal secretion
E	1903861	biological_process	positive regulation of dendrite extension
E	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
E	1905366	biological_process	negative regulation of intralumenal vesicle formation
E	1905477	biological_process	positive regulation of protein localization to membrane
E	1990381	molecular_function	ubiquitin-specific protease binding
E	1990444	molecular_function	F-box domain binding
E	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
E	2000377	biological_process	regulation of reactive oxygen species metabolic process
E	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000151	cellular_component	ubiquitin ligase complex
F	0000209	biological_process	protein polyubiquitination
F	0000266	biological_process	mitochondrial fission
F	0000423	biological_process	mitophagy
F	0001664	molecular_function	G protein-coupled receptor binding
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0001963	biological_process	synaptic transmission, dopaminergic
F	0001964	biological_process	startle response
F	0003714	molecular_function	transcription corepressor activity
F	0003779	molecular_function	actin binding
E	0051087	molecular_function	protein-folding chaperone binding
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005741	cellular_component	mitochondrial outer membrane
F	0005794	cellular_component	Golgi apparatus
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006513	biological_process	protein monoubiquitination
F	0006914	biological_process	autophagy
F	0006979	biological_process	response to oxidative stress
F	0007005	biological_process	mitochondrion organization
F	0007612	biological_process	learning
F	0007626	biological_process	locomotory behavior
F	0008013	molecular_function	beta-catenin binding
F	0008344	biological_process	adult locomotory behavior
F	0010498	biological_process	proteasomal protein catabolic process
F	0010506	biological_process	regulation of autophagy
F	0010628	biological_process	positive regulation of gene expression
F	0010629	biological_process	negative regulation of gene expression
F	0010636	biological_process	positive regulation of mitochondrial fusion
F	0010637	biological_process	negative regulation of mitochondrial fusion
F	0010821	biological_process	regulation of mitochondrion organization
F	0010994	biological_process	free ubiquitin chain polymerization
F	0015631	molecular_function	tubulin binding
F	0016235	cellular_component	aggresome
F	0016740	molecular_function	transferase activity
F	0019005	cellular_component	SCF ubiquitin ligase complex
F	0019899	molecular_function	enzyme binding
F	0019900	molecular_function	kinase binding
F	0051087	molecular_function	protein-folding chaperone binding
F	0030165	molecular_function	PDZ domain binding
F	0030544	molecular_function	Hsp70 protein binding
F	0031072	molecular_function	heat shock protein binding
F	0031396	biological_process	regulation of protein ubiquitination
F	0031624	molecular_function	ubiquitin conjugating enzyme binding
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031647	biological_process	regulation of protein stability
F	0031648	biological_process	protein destabilization
F	0032232	biological_process	negative regulation of actin filament bundle assembly
F	0032991	cellular_component	protein-containing complex
F	0033132	biological_process	negative regulation of glucokinase activity
F	0035249	biological_process	synaptic transmission, glutamatergic
F	0042053	biological_process	regulation of dopamine metabolic process
F	0042415	biological_process	norepinephrine metabolic process
F	0042417	biological_process	dopamine metabolic process
F	0042802	molecular_function	identical protein binding
F	0042826	molecular_function	histone deacetylase binding
F	0042981	biological_process	regulation of apoptotic process
F	0042995	cellular_component	cell projection
F	0043130	molecular_function	ubiquitin binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043274	molecular_function	phospholipase binding
F	0043388	biological_process	positive regulation of DNA binding
F	0044828	biological_process	negative regulation by host of viral genome replication
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046329	biological_process	negative regulation of JNK cascade
F	0046676	biological_process	negative regulation of insulin secretion
F	0046872	molecular_function	metal ion binding
F	0046928	biological_process	regulation of neurotransmitter secretion
F	0050804	biological_process	modulation of chemical synaptic transmission
F	0050821	biological_process	protein stabilization
F	0051582	biological_process	positive regulation of neurotransmitter uptake
F	0051583	biological_process	dopamine uptake involved in synaptic transmission
F	0051865	biological_process	protein autoubiquitination
F	0051881	biological_process	regulation of mitochondrial membrane potential
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0061734	biological_process	type 2 mitophagy
F	0070050	biological_process	neuron cellular homeostasis
F	0070534	biological_process	protein K63-linked ubiquitination
F	0070842	biological_process	aggresome assembly
F	0070979	biological_process	protein K11-linked ubiquitination
F	0085020	biological_process	protein K6-linked ubiquitination
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0090141	biological_process	positive regulation of mitochondrial fission
F	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
F	0097237	biological_process	cellular response to toxic substance
F	0097602	molecular_function	cullin family protein binding
F	0099073	cellular_component	mitochondrion-derived vesicle
F	1900407	biological_process	regulation of cellular response to oxidative stress
F	1901800	biological_process	positive regulation of proteasomal protein catabolic process
F	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
F	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
F	1902530	biological_process	positive regulation of protein linear polyubiquitination
F	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
F	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
F	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
F	1903542	biological_process	negative regulation of exosomal secretion
F	1903861	biological_process	positive regulation of dendrite extension
F	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
F	1905366	biological_process	negative regulation of intralumenal vesicle formation
F	1905477	biological_process	positive regulation of protein localization to membrane
F	1990381	molecular_function	ubiquitin-specific protease binding
F	1990444	molecular_function	F-box domain binding
F	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
F	2000377	biological_process	regulation of reactive oxygen species metabolic process
F	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000151	cellular_component	ubiquitin ligase complex
G	0000209	biological_process	protein polyubiquitination
G	0000266	biological_process	mitochondrial fission
G	0000423	biological_process	mitophagy
G	0001664	molecular_function	G protein-coupled receptor binding
G	0001933	biological_process	negative regulation of protein phosphorylation
G	0001963	biological_process	synaptic transmission, dopaminergic
G	0001964	biological_process	startle response
G	0003714	molecular_function	transcription corepressor activity
G	0003779	molecular_function	actin binding
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005741	cellular_component	mitochondrial outer membrane
G	0005794	cellular_component	Golgi apparatus
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006513	biological_process	protein monoubiquitination
G	0006914	biological_process	autophagy
G	0006979	biological_process	response to oxidative stress
G	0007005	biological_process	mitochondrion organization
G	0007612	biological_process	learning
G	0007626	biological_process	locomotory behavior
G	0008013	molecular_function	beta-catenin binding
G	0008344	biological_process	adult locomotory behavior
G	0010498	biological_process	proteasomal protein catabolic process
G	0010506	biological_process	regulation of autophagy
G	0010628	biological_process	positive regulation of gene expression
G	0010629	biological_process	negative regulation of gene expression
G	0010636	biological_process	positive regulation of mitochondrial fusion
G	0010637	biological_process	negative regulation of mitochondrial fusion
G	0010821	biological_process	regulation of mitochondrion organization
G	0010994	biological_process	free ubiquitin chain polymerization
G	0015631	molecular_function	tubulin binding
G	0016235	cellular_component	aggresome
G	0016740	molecular_function	transferase activity
G	0019005	cellular_component	SCF ubiquitin ligase complex
G	0019899	molecular_function	enzyme binding
G	0019900	molecular_function	kinase binding
G	0055069	biological_process	obsolete zinc ion homeostasis
G	0030165	molecular_function	PDZ domain binding
G	0030544	molecular_function	Hsp70 protein binding
G	0031072	molecular_function	heat shock protein binding
G	0031396	biological_process	regulation of protein ubiquitination
G	0031624	molecular_function	ubiquitin conjugating enzyme binding
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0031647	biological_process	regulation of protein stability
G	0031648	biological_process	protein destabilization
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0032232	biological_process	negative regulation of actin filament bundle assembly
G	0032991	cellular_component	protein-containing complex
G	0033132	biological_process	negative regulation of glucokinase activity
G	0035249	biological_process	synaptic transmission, glutamatergic
G	0042053	biological_process	regulation of dopamine metabolic process
G	0042415	biological_process	norepinephrine metabolic process
G	0042417	biological_process	dopamine metabolic process
G	0042802	molecular_function	identical protein binding
G	0042826	molecular_function	histone deacetylase binding
G	0042981	biological_process	regulation of apoptotic process
G	0042995	cellular_component	cell projection
G	0043130	molecular_function	ubiquitin binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043274	molecular_function	phospholipase binding
G	0043388	biological_process	positive regulation of DNA binding
G	0051087	molecular_function	protein-folding chaperone binding
G	0044828	biological_process	negative regulation by host of viral genome replication
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046329	biological_process	negative regulation of JNK cascade
G	0046676	biological_process	negative regulation of insulin secretion
G	0046872	molecular_function	metal ion binding
G	0046928	biological_process	regulation of neurotransmitter secretion
G	0050804	biological_process	modulation of chemical synaptic transmission
G	0050821	biological_process	protein stabilization
G	0051582	biological_process	positive regulation of neurotransmitter uptake
G	0051583	biological_process	dopamine uptake involved in synaptic transmission
G	0051865	biological_process	protein autoubiquitination
G	0051881	biological_process	regulation of mitochondrial membrane potential
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0070050	biological_process	neuron cellular homeostasis
G	0070534	biological_process	protein K63-linked ubiquitination
G	0070842	biological_process	aggresome assembly
G	0070979	biological_process	protein K11-linked ubiquitination
G	0085020	biological_process	protein K6-linked ubiquitination
G	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
G	0090141	biological_process	positive regulation of mitochondrial fission
G	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
G	0097237	biological_process	cellular response to toxic substance
G	0097602	molecular_function	cullin family protein binding
G	0099073	cellular_component	mitochondrion-derived vesicle
G	1900407	biological_process	regulation of cellular response to oxidative stress
G	1901800	biological_process	positive regulation of proteasomal protein catabolic process
G	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
G	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
G	1902530	biological_process	positive regulation of protein linear polyubiquitination
G	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
G	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
G	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
G	1903542	biological_process	negative regulation of exosomal secretion
G	1903861	biological_process	positive regulation of dendrite extension
G	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
G	1905366	biological_process	negative regulation of intralumenal vesicle formation
G	1905477	biological_process	positive regulation of protein localization to membrane
G	1990381	molecular_function	ubiquitin-specific protease binding
G	1990444	molecular_function	F-box domain binding
G	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
G	2000377	biological_process	regulation of reactive oxygen species metabolic process
G	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000151	cellular_component	ubiquitin ligase complex
H	0000209	biological_process	protein polyubiquitination
H	0000266	biological_process	mitochondrial fission
H	0000423	biological_process	mitophagy
H	0001664	molecular_function	G protein-coupled receptor binding
H	0001933	biological_process	negative regulation of protein phosphorylation
H	0001963	biological_process	synaptic transmission, dopaminergic
H	0001964	biological_process	startle response
H	0003714	molecular_function	transcription corepressor activity
H	0003779	molecular_function	actin binding
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005741	cellular_component	mitochondrial outer membrane
H	0005794	cellular_component	Golgi apparatus
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0006914	biological_process	autophagy
H	0006979	biological_process	response to oxidative stress
H	0007005	biological_process	mitochondrion organization
H	0007612	biological_process	learning
H	0007626	biological_process	locomotory behavior
H	0008013	molecular_function	beta-catenin binding
H	0008344	biological_process	adult locomotory behavior
H	0010498	biological_process	proteasomal protein catabolic process
H	0010506	biological_process	regulation of autophagy
H	0010628	biological_process	positive regulation of gene expression
H	0010629	biological_process	negative regulation of gene expression
H	0010636	biological_process	positive regulation of mitochondrial fusion
H	0010637	biological_process	negative regulation of mitochondrial fusion
H	0010821	biological_process	regulation of mitochondrion organization
H	0010994	biological_process	free ubiquitin chain polymerization
H	0015631	molecular_function	tubulin binding
H	0016235	cellular_component	aggresome
H	0016740	molecular_function	transferase activity
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0019899	molecular_function	enzyme binding
H	0019900	molecular_function	kinase binding
H	0030165	molecular_function	PDZ domain binding
H	0030544	molecular_function	Hsp70 protein binding
H	0031072	molecular_function	heat shock protein binding
H	0031396	biological_process	regulation of protein ubiquitination
H	0031624	molecular_function	ubiquitin conjugating enzyme binding
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0031647	biological_process	regulation of protein stability
H	0031648	biological_process	protein destabilization
H	0032232	biological_process	negative regulation of actin filament bundle assembly
H	0032991	cellular_component	protein-containing complex
H	0033132	biological_process	negative regulation of glucokinase activity
H	0035249	biological_process	synaptic transmission, glutamatergic
H	0042053	biological_process	regulation of dopamine metabolic process
H	0042415	biological_process	norepinephrine metabolic process
H	0042417	biological_process	dopamine metabolic process
H	0042802	molecular_function	identical protein binding
H	0042826	molecular_function	histone deacetylase binding
H	0042981	biological_process	regulation of apoptotic process
H	0042995	cellular_component	cell projection
H	0043130	molecular_function	ubiquitin binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0043274	molecular_function	phospholipase binding
H	0043388	biological_process	positive regulation of DNA binding
H	0055069	biological_process	obsolete zinc ion homeostasis
H	0044828	biological_process	negative regulation by host of viral genome replication
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046329	biological_process	negative regulation of JNK cascade
H	0046676	biological_process	negative regulation of insulin secretion
H	0046872	molecular_function	metal ion binding
H	0046928	biological_process	regulation of neurotransmitter secretion
H	0050804	biological_process	modulation of chemical synaptic transmission
H	0050821	biological_process	protein stabilization
H	0051582	biological_process	positive regulation of neurotransmitter uptake
H	0051583	biological_process	dopamine uptake involved in synaptic transmission
H	0051865	biological_process	protein autoubiquitination
H	0051881	biological_process	regulation of mitochondrial membrane potential
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0061734	biological_process	type 2 mitophagy
H	0070050	biological_process	neuron cellular homeostasis
H	0070534	biological_process	protein K63-linked ubiquitination
H	0070842	biological_process	aggresome assembly
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0070979	biological_process	protein K11-linked ubiquitination
H	0085020	biological_process	protein K6-linked ubiquitination
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0090141	biological_process	positive regulation of mitochondrial fission
H	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
H	0097237	biological_process	cellular response to toxic substance
H	0097602	molecular_function	cullin family protein binding
H	0099073	cellular_component	mitochondrion-derived vesicle
H	1900407	biological_process	regulation of cellular response to oxidative stress
H	1901800	biological_process	positive regulation of proteasomal protein catabolic process
H	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
H	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
H	1902530	biological_process	positive regulation of protein linear polyubiquitination
H	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
H	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
H	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
H	1903542	biological_process	negative regulation of exosomal secretion
H	1903861	biological_process	positive regulation of dendrite extension
H	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
H	1905366	biological_process	negative regulation of intralumenal vesicle formation
H	1905477	biological_process	positive regulation of protein localization to membrane
H	1990381	molecular_function	ubiquitin-specific protease binding
H	1990444	molecular_function	F-box domain binding
H	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
H	2000377	biological_process	regulation of reactive oxygen species metabolic process
H	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000151	cellular_component	ubiquitin ligase complex
I	0000209	biological_process	protein polyubiquitination
I	0000266	biological_process	mitochondrial fission
I	0000423	biological_process	mitophagy
I	0001664	molecular_function	G protein-coupled receptor binding
I	0001933	biological_process	negative regulation of protein phosphorylation
H	0051087	molecular_function	protein-folding chaperone binding
I	0001963	biological_process	synaptic transmission, dopaminergic
I	0001964	biological_process	startle response
I	0003714	molecular_function	transcription corepressor activity
I	0003779	molecular_function	actin binding
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005741	cellular_component	mitochondrial outer membrane
I	0005794	cellular_component	Golgi apparatus
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006513	biological_process	protein monoubiquitination
I	0006914	biological_process	autophagy
I	0006979	biological_process	response to oxidative stress
I	0007005	biological_process	mitochondrion organization
I	0007612	biological_process	learning
I	0007626	biological_process	locomotory behavior
I	0008013	molecular_function	beta-catenin binding
I	0008344	biological_process	adult locomotory behavior
I	0010498	biological_process	proteasomal protein catabolic process
I	0010506	biological_process	regulation of autophagy
I	0010628	biological_process	positive regulation of gene expression
I	0010629	biological_process	negative regulation of gene expression
I	0010636	biological_process	positive regulation of mitochondrial fusion
I	0010637	biological_process	negative regulation of mitochondrial fusion
I	0010821	biological_process	regulation of mitochondrion organization
I	0010994	biological_process	free ubiquitin chain polymerization
I	0015631	molecular_function	tubulin binding
I	0016235	cellular_component	aggresome
I	0016740	molecular_function	transferase activity
I	0019005	cellular_component	SCF ubiquitin ligase complex
I	0019899	molecular_function	enzyme binding
I	0019900	molecular_function	kinase binding
I	0055069	biological_process	obsolete zinc ion homeostasis
I	0030165	molecular_function	PDZ domain binding
I	0030544	molecular_function	Hsp70 protein binding
I	0031072	molecular_function	heat shock protein binding
I	0031396	biological_process	regulation of protein ubiquitination
I	0031624	molecular_function	ubiquitin conjugating enzyme binding
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0031647	biological_process	regulation of protein stability
I	0031648	biological_process	protein destabilization
I	0032232	biological_process	negative regulation of actin filament bundle assembly
I	0032991	cellular_component	protein-containing complex
I	0033132	biological_process	negative regulation of glucokinase activity
I	0035249	biological_process	synaptic transmission, glutamatergic
I	0042053	biological_process	regulation of dopamine metabolic process
I	0042415	biological_process	norepinephrine metabolic process
I	0042417	biological_process	dopamine metabolic process
I	0042802	molecular_function	identical protein binding
I	0042826	molecular_function	histone deacetylase binding
I	0042981	biological_process	regulation of apoptotic process
I	0042995	cellular_component	cell projection
I	0043130	molecular_function	ubiquitin binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0043274	molecular_function	phospholipase binding
I	0043388	biological_process	positive regulation of DNA binding
I	0051087	molecular_function	protein-folding chaperone binding
I	0044828	biological_process	negative regulation by host of viral genome replication
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046329	biological_process	negative regulation of JNK cascade
I	0046676	biological_process	negative regulation of insulin secretion
I	0046872	molecular_function	metal ion binding
I	0046928	biological_process	regulation of neurotransmitter secretion
I	0050804	biological_process	modulation of chemical synaptic transmission
I	0050821	biological_process	protein stabilization
I	0051582	biological_process	positive regulation of neurotransmitter uptake
I	0051583	biological_process	dopamine uptake involved in synaptic transmission
I	0051865	biological_process	protein autoubiquitination
I	0051881	biological_process	regulation of mitochondrial membrane potential
I	0061630	molecular_function	ubiquitin protein ligase activity
I	0070050	biological_process	neuron cellular homeostasis
I	0070534	biological_process	protein K63-linked ubiquitination
I	0070842	biological_process	aggresome assembly
I	0070979	biological_process	protein K11-linked ubiquitination
I	0085020	biological_process	protein K6-linked ubiquitination
I	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
I	0090141	biological_process	positive regulation of mitochondrial fission
I	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
I	0097237	biological_process	cellular response to toxic substance
I	0097602	molecular_function	cullin family protein binding
I	0099073	cellular_component	mitochondrion-derived vesicle
I	1900407	biological_process	regulation of cellular response to oxidative stress
I	1901800	biological_process	positive regulation of proteasomal protein catabolic process
I	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
I	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
I	1902530	biological_process	positive regulation of protein linear polyubiquitination
I	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
I	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
I	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
I	1903542	biological_process	negative regulation of exosomal secretion
I	1903861	biological_process	positive regulation of dendrite extension
I	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
I	1905366	biological_process	negative regulation of intralumenal vesicle formation
I	1905477	biological_process	positive regulation of protein localization to membrane
I	1990381	molecular_function	ubiquitin-specific protease binding
I	1990444	molecular_function	F-box domain binding
I	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
I	2000377	biological_process	regulation of reactive oxygen species metabolic process
I	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000151	cellular_component	ubiquitin ligase complex
J	0000209	biological_process	protein polyubiquitination
J	0000266	biological_process	mitochondrial fission
J	0000423	biological_process	mitophagy
J	0001664	molecular_function	G protein-coupled receptor binding
J	0001933	biological_process	negative regulation of protein phosphorylation
J	0001963	biological_process	synaptic transmission, dopaminergic
J	0001964	biological_process	startle response
J	0003714	molecular_function	transcription corepressor activity
J	0003779	molecular_function	actin binding
J	0004842	molecular_function	ubiquitin-protein transferase activity
J	0005741	cellular_component	mitochondrial outer membrane
J	0005794	cellular_component	Golgi apparatus
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0006513	biological_process	protein monoubiquitination
J	0006914	biological_process	autophagy
J	0006979	biological_process	response to oxidative stress
J	0007005	biological_process	mitochondrion organization
J	0007612	biological_process	learning
J	0007626	biological_process	locomotory behavior
J	0008013	molecular_function	beta-catenin binding
J	0008344	biological_process	adult locomotory behavior
J	0010498	biological_process	proteasomal protein catabolic process
J	0010506	biological_process	regulation of autophagy
J	0010628	biological_process	positive regulation of gene expression
J	0010629	biological_process	negative regulation of gene expression
J	0010636	biological_process	positive regulation of mitochondrial fusion
J	0010637	biological_process	negative regulation of mitochondrial fusion
J	0010821	biological_process	regulation of mitochondrion organization
J	0010994	biological_process	free ubiquitin chain polymerization
J	0015631	molecular_function	tubulin binding
J	0016235	cellular_component	aggresome
J	0016740	molecular_function	transferase activity
J	0019005	cellular_component	SCF ubiquitin ligase complex
J	0019899	molecular_function	enzyme binding
J	0019900	molecular_function	kinase binding
J	0030165	molecular_function	PDZ domain binding
J	0030544	molecular_function	Hsp70 protein binding
J	0031072	molecular_function	heat shock protein binding
J	0031396	biological_process	regulation of protein ubiquitination
J	0031624	molecular_function	ubiquitin conjugating enzyme binding
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0031647	biological_process	regulation of protein stability
J	0031648	biological_process	protein destabilization
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0032232	biological_process	negative regulation of actin filament bundle assembly
J	0032991	cellular_component	protein-containing complex
J	0033132	biological_process	negative regulation of glucokinase activity
J	0035249	biological_process	synaptic transmission, glutamatergic
J	0042053	biological_process	regulation of dopamine metabolic process
J	0042415	biological_process	norepinephrine metabolic process
J	0042417	biological_process	dopamine metabolic process
J	0042802	molecular_function	identical protein binding
J	0042826	molecular_function	histone deacetylase binding
J	0042981	biological_process	regulation of apoptotic process
J	0042995	cellular_component	cell projection
J	0043130	molecular_function	ubiquitin binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043274	molecular_function	phospholipase binding
J	0043388	biological_process	positive regulation of DNA binding
J	0044828	biological_process	negative regulation by host of viral genome replication
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046329	biological_process	negative regulation of JNK cascade
J	0046676	biological_process	negative regulation of insulin secretion
J	0046872	molecular_function	metal ion binding
J	0046928	biological_process	regulation of neurotransmitter secretion
J	0050804	biological_process	modulation of chemical synaptic transmission
J	0050821	biological_process	protein stabilization
J	0051582	biological_process	positive regulation of neurotransmitter uptake
J	0051583	biological_process	dopamine uptake involved in synaptic transmission
J	0051865	biological_process	protein autoubiquitination
J	0051881	biological_process	regulation of mitochondrial membrane potential
J	0051087	molecular_function	protein-folding chaperone binding
J	0061630	molecular_function	ubiquitin protein ligase activity
J	0070050	biological_process	neuron cellular homeostasis
J	0070534	biological_process	protein K63-linked ubiquitination
J	0070842	biological_process	aggresome assembly
J	0070979	biological_process	protein K11-linked ubiquitination
J	0085020	biological_process	protein K6-linked ubiquitination
J	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
J	0090141	biological_process	positive regulation of mitochondrial fission
J	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
J	0097237	biological_process	cellular response to toxic substance
J	0097602	molecular_function	cullin family protein binding
J	0099073	cellular_component	mitochondrion-derived vesicle
J	1900407	biological_process	regulation of cellular response to oxidative stress
J	1901800	biological_process	positive regulation of proteasomal protein catabolic process
J	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
J	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
J	1902530	biological_process	positive regulation of protein linear polyubiquitination
J	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
J	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
J	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
J	1903542	biological_process	negative regulation of exosomal secretion
J	1903861	biological_process	positive regulation of dendrite extension
J	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
J	1905366	biological_process	negative regulation of intralumenal vesicle formation
J	1905477	biological_process	positive regulation of protein localization to membrane
J	1990381	molecular_function	ubiquitin-specific protease binding
J	1990444	molecular_function	F-box domain binding
J	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
J	2000377	biological_process	regulation of reactive oxygen species metabolic process
J	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000151	cellular_component	ubiquitin ligase complex
K	0000209	biological_process	protein polyubiquitination
K	0000266	biological_process	mitochondrial fission
K	0000423	biological_process	mitophagy
K	0001664	molecular_function	G protein-coupled receptor binding
K	0001933	biological_process	negative regulation of protein phosphorylation
K	0001963	biological_process	synaptic transmission, dopaminergic
K	0001964	biological_process	startle response
K	0003714	molecular_function	transcription corepressor activity
K	0003779	molecular_function	actin binding
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005741	cellular_component	mitochondrial outer membrane
K	0005794	cellular_component	Golgi apparatus
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006513	biological_process	protein monoubiquitination
K	0006914	biological_process	autophagy
K	0006979	biological_process	response to oxidative stress
K	0007005	biological_process	mitochondrion organization
K	0007612	biological_process	learning
K	0007626	biological_process	locomotory behavior
K	0008013	molecular_function	beta-catenin binding
K	0008344	biological_process	adult locomotory behavior
K	0010498	biological_process	proteasomal protein catabolic process
K	0010506	biological_process	regulation of autophagy
K	0010628	biological_process	positive regulation of gene expression
K	0010629	biological_process	negative regulation of gene expression
K	0010636	biological_process	positive regulation of mitochondrial fusion
K	0010637	biological_process	negative regulation of mitochondrial fusion
K	0010821	biological_process	regulation of mitochondrion organization
K	0010994	biological_process	free ubiquitin chain polymerization
K	0015631	molecular_function	tubulin binding
K	0016235	cellular_component	aggresome
K	0016740	molecular_function	transferase activity
K	0019005	cellular_component	SCF ubiquitin ligase complex
K	0019899	molecular_function	enzyme binding
K	0019900	molecular_function	kinase binding
K	0051087	molecular_function	protein-folding chaperone binding
K	0030165	molecular_function	PDZ domain binding
K	0030544	molecular_function	Hsp70 protein binding
K	0031072	molecular_function	heat shock protein binding
K	0031396	biological_process	regulation of protein ubiquitination
K	0031624	molecular_function	ubiquitin conjugating enzyme binding
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0031647	biological_process	regulation of protein stability
K	0031648	biological_process	protein destabilization
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0032232	biological_process	negative regulation of actin filament bundle assembly
K	0032991	cellular_component	protein-containing complex
K	0033132	biological_process	negative regulation of glucokinase activity
K	0035249	biological_process	synaptic transmission, glutamatergic
K	0042053	biological_process	regulation of dopamine metabolic process
K	0042415	biological_process	norepinephrine metabolic process
K	0042417	biological_process	dopamine metabolic process
K	0042802	molecular_function	identical protein binding
K	0042826	molecular_function	histone deacetylase binding
K	0042981	biological_process	regulation of apoptotic process
K	0042995	cellular_component	cell projection
K	0043130	molecular_function	ubiquitin binding
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043274	molecular_function	phospholipase binding
K	0043388	biological_process	positive regulation of DNA binding
K	0044828	biological_process	negative regulation by host of viral genome replication
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046329	biological_process	negative regulation of JNK cascade
K	0046676	biological_process	negative regulation of insulin secretion
K	0046872	molecular_function	metal ion binding
K	0046928	biological_process	regulation of neurotransmitter secretion
K	0050804	biological_process	modulation of chemical synaptic transmission
K	0050821	biological_process	protein stabilization
K	0051582	biological_process	positive regulation of neurotransmitter uptake
K	0051583	biological_process	dopamine uptake involved in synaptic transmission
K	0051865	biological_process	protein autoubiquitination
K	0051881	biological_process	regulation of mitochondrial membrane potential
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0070050	biological_process	neuron cellular homeostasis
K	0070534	biological_process	protein K63-linked ubiquitination
K	0070842	biological_process	aggresome assembly
K	0070979	biological_process	protein K11-linked ubiquitination
K	0085020	biological_process	protein K6-linked ubiquitination
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	0090141	biological_process	positive regulation of mitochondrial fission
K	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
K	0097237	biological_process	cellular response to toxic substance
K	0097602	molecular_function	cullin family protein binding
K	0099073	cellular_component	mitochondrion-derived vesicle
K	1900407	biological_process	regulation of cellular response to oxidative stress
K	1901800	biological_process	positive regulation of proteasomal protein catabolic process
K	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
K	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
K	1902530	biological_process	positive regulation of protein linear polyubiquitination
K	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
K	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
K	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
K	1903542	biological_process	negative regulation of exosomal secretion
K	1903861	biological_process	positive regulation of dendrite extension
K	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
K	1905366	biological_process	negative regulation of intralumenal vesicle formation
K	1905477	biological_process	positive regulation of protein localization to membrane
K	1990381	molecular_function	ubiquitin-specific protease binding
K	1990444	molecular_function	F-box domain binding
K	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
K	2000377	biological_process	regulation of reactive oxygen species metabolic process
K	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000151	cellular_component	ubiquitin ligase complex
L	0000209	biological_process	protein polyubiquitination
L	0000266	biological_process	mitochondrial fission
L	0000423	biological_process	mitophagy
L	0001664	molecular_function	G protein-coupled receptor binding
L	0001933	biological_process	negative regulation of protein phosphorylation
L	0001963	biological_process	synaptic transmission, dopaminergic
L	0001964	biological_process	startle response
L	0003714	molecular_function	transcription corepressor activity
L	0003779	molecular_function	actin binding
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005741	cellular_component	mitochondrial outer membrane
L	0005794	cellular_component	Golgi apparatus
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0006914	biological_process	autophagy
L	0006979	biological_process	response to oxidative stress
L	0007005	biological_process	mitochondrion organization
L	0007612	biological_process	learning
L	0007626	biological_process	locomotory behavior
L	0008013	molecular_function	beta-catenin binding
L	0008344	biological_process	adult locomotory behavior
L	0010498	biological_process	proteasomal protein catabolic process
L	0010506	biological_process	regulation of autophagy
L	0010628	biological_process	positive regulation of gene expression
L	0010629	biological_process	negative regulation of gene expression
L	0010636	biological_process	positive regulation of mitochondrial fusion
L	0010637	biological_process	negative regulation of mitochondrial fusion
L	0010821	biological_process	regulation of mitochondrion organization
L	0010994	biological_process	free ubiquitin chain polymerization
L	0015631	molecular_function	tubulin binding
L	0016235	cellular_component	aggresome
L	0016740	molecular_function	transferase activity
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019899	molecular_function	enzyme binding
L	0019900	molecular_function	kinase binding
L	0055069	biological_process	obsolete zinc ion homeostasis
L	0030165	molecular_function	PDZ domain binding
L	0030544	molecular_function	Hsp70 protein binding
L	0031072	molecular_function	heat shock protein binding
L	0031396	biological_process	regulation of protein ubiquitination
L	0031624	molecular_function	ubiquitin conjugating enzyme binding
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0031647	biological_process	regulation of protein stability
L	0031648	biological_process	protein destabilization
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0032232	biological_process	negative regulation of actin filament bundle assembly
L	0032991	cellular_component	protein-containing complex
L	0033132	biological_process	negative regulation of glucokinase activity
L	0035249	biological_process	synaptic transmission, glutamatergic
L	0042053	biological_process	regulation of dopamine metabolic process
L	0042415	biological_process	norepinephrine metabolic process
L	0042417	biological_process	dopamine metabolic process
L	0042802	molecular_function	identical protein binding
L	0042826	molecular_function	histone deacetylase binding
L	0042981	biological_process	regulation of apoptotic process
L	0042995	cellular_component	cell projection
L	0043130	molecular_function	ubiquitin binding
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043274	molecular_function	phospholipase binding
L	0043388	biological_process	positive regulation of DNA binding
L	0051087	molecular_function	protein-folding chaperone binding
L	0044828	biological_process	negative regulation by host of viral genome replication
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046329	biological_process	negative regulation of JNK cascade
L	0046676	biological_process	negative regulation of insulin secretion
L	0046872	molecular_function	metal ion binding
L	0046928	biological_process	regulation of neurotransmitter secretion
L	0050804	biological_process	modulation of chemical synaptic transmission
L	0050821	biological_process	protein stabilization
L	0051582	biological_process	positive regulation of neurotransmitter uptake
L	0051583	biological_process	dopamine uptake involved in synaptic transmission
L	0051865	biological_process	protein autoubiquitination
L	0051881	biological_process	regulation of mitochondrial membrane potential
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0061734	biological_process	type 2 mitophagy
L	0070050	biological_process	neuron cellular homeostasis
L	0070534	biological_process	protein K63-linked ubiquitination
L	0070842	biological_process	aggresome assembly
L	0070979	biological_process	protein K11-linked ubiquitination
L	0085020	biological_process	protein K6-linked ubiquitination
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0090141	biological_process	positive regulation of mitochondrial fission
L	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
L	0097237	biological_process	cellular response to toxic substance
L	0097602	molecular_function	cullin family protein binding
L	0099073	cellular_component	mitochondrion-derived vesicle
L	1900407	biological_process	regulation of cellular response to oxidative stress
L	1901800	biological_process	positive regulation of proteasomal protein catabolic process
L	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
L	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
L	1902530	biological_process	positive regulation of protein linear polyubiquitination
L	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
L	1903377	biological_process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
L	1903382	biological_process	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
L	1903542	biological_process	negative regulation of exosomal secretion
L	1903861	biological_process	positive regulation of dendrite extension
L	1904049	biological_process	negative regulation of spontaneous neurotransmitter secretion
L	1905366	biological_process	negative regulation of intralumenal vesicle formation
L	1905477	biological_process	positive regulation of protein localization to membrane
L	1990381	molecular_function	ubiquitin-specific protease binding
L	1990444	molecular_function	F-box domain binding
L	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
L	2000377	biological_process	regulation of reactive oxygen species metabolic process
L	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
B	0030424	cellular_component	axon
B	0005737	cellular_component	cytoplasm
A	0030424	cellular_component	axon
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0000139	cellular_component	Golgi membrane
A	0097708	cellular_component	intracellular vesicle
A	0005739	cellular_component	mitochondrion
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0005634	cellular_component	nucleus
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0014069	cellular_component	postsynaptic density
A	0098793	cellular_component	presynapse
A	0045202	cellular_component	synapse
A	0008021	cellular_component	synaptic vesicle
A	0030672	cellular_component	synaptic vesicle membrane
A	0043195	cellular_component	terminal bouton
A	0019901	molecular_function	protein kinase binding
A	0044877	molecular_function	protein-containing complex binding
A	0000422	biological_process	autophagy of mitochondrion
A	1904881	biological_process	cellular response to hydrogen sulfide
A	1905232	biological_process	cellular response to L-glutamate
A	1904845	biological_process	cellular response to L-glutamine
A	0071287	biological_process	cellular response to manganese ion
A	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
A	0051646	biological_process	mitochondrion localization
A	0090394	biological_process	negative regulation of excitatory postsynaptic potential
A	0090258	biological_process	negative regulation of mitochondrial fission
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
A	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
A	0043065	biological_process	positive regulation of apoptotic process
A	2001171	biological_process	positive regulation of ATP biosynthetic process
A	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
A	0010918	biological_process	positive regulation of mitochondrial membrane potential
A	1901526	biological_process	positive regulation of mitophagy
A	0070585	biological_process	protein localization to mitochondrion
A	0016567	biological_process	protein ubiquitination
A	0051412	biological_process	response to corticosterone
A	1904643	biological_process	response to curcumin
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0014850	biological_process	response to muscle activity
A	0006986	biological_process	response to unfolded protein
B	0005829	cellular_component	cytosol
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0000139	cellular_component	Golgi membrane
B	0097708	cellular_component	intracellular vesicle
B	0005739	cellular_component	mitochondrion
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0005634	cellular_component	nucleus
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0014069	cellular_component	postsynaptic density
B	0098793	cellular_component	presynapse
B	0045202	cellular_component	synapse
B	0008021	cellular_component	synaptic vesicle
B	0030672	cellular_component	synaptic vesicle membrane
B	0043195	cellular_component	terminal bouton
B	0019901	molecular_function	protein kinase binding
B	0044877	molecular_function	protein-containing complex binding
B	0000422	biological_process	autophagy of mitochondrion
B	1904881	biological_process	cellular response to hydrogen sulfide
B	1905232	biological_process	cellular response to L-glutamate
B	1904845	biological_process	cellular response to L-glutamine
B	0071287	biological_process	cellular response to manganese ion
B	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
B	0051646	biological_process	mitochondrion localization
B	0090394	biological_process	negative regulation of excitatory postsynaptic potential
B	0090258	biological_process	negative regulation of mitochondrial fission
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
B	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
B	0043065	biological_process	positive regulation of apoptotic process
B	2001171	biological_process	positive regulation of ATP biosynthetic process
B	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
B	0010918	biological_process	positive regulation of mitochondrial membrane potential
B	1901526	biological_process	positive regulation of mitophagy
B	0070585	biological_process	protein localization to mitochondrion
B	0016567	biological_process	protein ubiquitination
B	0051412	biological_process	response to corticosterone
B	1904643	biological_process	response to curcumin
B	0034976	biological_process	response to endoplasmic reticulum stress
B	0014850	biological_process	response to muscle activity
B	0006986	biological_process	response to unfolded protein
C	0030424	cellular_component	axon
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0000139	cellular_component	Golgi membrane
C	0097708	cellular_component	intracellular vesicle
C	0005739	cellular_component	mitochondrion
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0005634	cellular_component	nucleus
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0014069	cellular_component	postsynaptic density
C	0098793	cellular_component	presynapse
C	0045202	cellular_component	synapse
C	0008021	cellular_component	synaptic vesicle
C	0030672	cellular_component	synaptic vesicle membrane
C	0043195	cellular_component	terminal bouton
C	0019901	molecular_function	protein kinase binding
C	0044877	molecular_function	protein-containing complex binding
C	0000422	biological_process	autophagy of mitochondrion
C	1904881	biological_process	cellular response to hydrogen sulfide
C	1905232	biological_process	cellular response to L-glutamate
C	1904845	biological_process	cellular response to L-glutamine
C	0071287	biological_process	cellular response to manganese ion
C	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
C	0051646	biological_process	mitochondrion localization
C	0090394	biological_process	negative regulation of excitatory postsynaptic potential
C	0090258	biological_process	negative regulation of mitochondrial fission
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
C	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
C	0043065	biological_process	positive regulation of apoptotic process
C	2001171	biological_process	positive regulation of ATP biosynthetic process
C	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
C	0010918	biological_process	positive regulation of mitochondrial membrane potential
C	1901526	biological_process	positive regulation of mitophagy
C	0070585	biological_process	protein localization to mitochondrion
C	0016567	biological_process	protein ubiquitination
C	0051412	biological_process	response to corticosterone
C	1904643	biological_process	response to curcumin
C	0034976	biological_process	response to endoplasmic reticulum stress
C	0014850	biological_process	response to muscle activity
C	0006986	biological_process	response to unfolded protein
D	0030424	cellular_component	axon
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0000139	cellular_component	Golgi membrane
D	0097708	cellular_component	intracellular vesicle
D	0005739	cellular_component	mitochondrion
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0005634	cellular_component	nucleus
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0014069	cellular_component	postsynaptic density
D	0098793	cellular_component	presynapse
D	0045202	cellular_component	synapse
D	0008021	cellular_component	synaptic vesicle
D	0030672	cellular_component	synaptic vesicle membrane
D	0043195	cellular_component	terminal bouton
D	0019901	molecular_function	protein kinase binding
D	0044877	molecular_function	protein-containing complex binding
D	0000422	biological_process	autophagy of mitochondrion
D	1904881	biological_process	cellular response to hydrogen sulfide
D	1905232	biological_process	cellular response to L-glutamate
D	1904845	biological_process	cellular response to L-glutamine
D	0071287	biological_process	cellular response to manganese ion
D	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
D	0051646	biological_process	mitochondrion localization
D	0090394	biological_process	negative regulation of excitatory postsynaptic potential
D	0090258	biological_process	negative regulation of mitochondrial fission
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
D	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
D	0043065	biological_process	positive regulation of apoptotic process
D	2001171	biological_process	positive regulation of ATP biosynthetic process
D	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
D	0010918	biological_process	positive regulation of mitochondrial membrane potential
D	1901526	biological_process	positive regulation of mitophagy
D	0070585	biological_process	protein localization to mitochondrion
D	0016567	biological_process	protein ubiquitination
D	0051412	biological_process	response to corticosterone
D	1904643	biological_process	response to curcumin
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0014850	biological_process	response to muscle activity
D	0006986	biological_process	response to unfolded protein
E	0030424	cellular_component	axon
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0000139	cellular_component	Golgi membrane
E	0097708	cellular_component	intracellular vesicle
E	0005739	cellular_component	mitochondrion
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0005634	cellular_component	nucleus
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0014069	cellular_component	postsynaptic density
E	0098793	cellular_component	presynapse
E	0045202	cellular_component	synapse
E	0008021	cellular_component	synaptic vesicle
E	0030672	cellular_component	synaptic vesicle membrane
E	0043195	cellular_component	terminal bouton
E	0019901	molecular_function	protein kinase binding
E	0044877	molecular_function	protein-containing complex binding
E	0000422	biological_process	autophagy of mitochondrion
E	1904881	biological_process	cellular response to hydrogen sulfide
E	1905232	biological_process	cellular response to L-glutamate
E	1904845	biological_process	cellular response to L-glutamine
E	0071287	biological_process	cellular response to manganese ion
E	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
E	0051646	biological_process	mitochondrion localization
E	0090394	biological_process	negative regulation of excitatory postsynaptic potential
E	0090258	biological_process	negative regulation of mitochondrial fission
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
E	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
E	0043065	biological_process	positive regulation of apoptotic process
E	2001171	biological_process	positive regulation of ATP biosynthetic process
E	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
E	0010918	biological_process	positive regulation of mitochondrial membrane potential
E	1901526	biological_process	positive regulation of mitophagy
E	0070585	biological_process	protein localization to mitochondrion
E	0016567	biological_process	protein ubiquitination
E	0051412	biological_process	response to corticosterone
E	1904643	biological_process	response to curcumin
E	0034976	biological_process	response to endoplasmic reticulum stress
E	0014850	biological_process	response to muscle activity
E	0006986	biological_process	response to unfolded protein
F	0030424	cellular_component	axon
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0000139	cellular_component	Golgi membrane
F	0097708	cellular_component	intracellular vesicle
F	0005739	cellular_component	mitochondrion
F	0043005	cellular_component	neuron projection
F	0043025	cellular_component	neuronal cell body
F	0005634	cellular_component	nucleus
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0014069	cellular_component	postsynaptic density
F	0098793	cellular_component	presynapse
F	0045202	cellular_component	synapse
F	0008021	cellular_component	synaptic vesicle
F	0030672	cellular_component	synaptic vesicle membrane
F	0043195	cellular_component	terminal bouton
F	0019901	molecular_function	protein kinase binding
F	0044877	molecular_function	protein-containing complex binding
F	0000422	biological_process	autophagy of mitochondrion
F	1904881	biological_process	cellular response to hydrogen sulfide
F	1905232	biological_process	cellular response to L-glutamate
F	1904845	biological_process	cellular response to L-glutamine
F	0071287	biological_process	cellular response to manganese ion
F	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
F	0051646	biological_process	mitochondrion localization
F	0090394	biological_process	negative regulation of excitatory postsynaptic potential
F	0090258	biological_process	negative regulation of mitochondrial fission
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
F	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
F	0043065	biological_process	positive regulation of apoptotic process
F	2001171	biological_process	positive regulation of ATP biosynthetic process
F	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
F	0010918	biological_process	positive regulation of mitochondrial membrane potential
F	1901526	biological_process	positive regulation of mitophagy
F	0070585	biological_process	protein localization to mitochondrion
F	0016567	biological_process	protein ubiquitination
F	0051412	biological_process	response to corticosterone
F	1904643	biological_process	response to curcumin
F	0034976	biological_process	response to endoplasmic reticulum stress
F	0014850	biological_process	response to muscle activity
F	0006986	biological_process	response to unfolded protein
G	0030424	cellular_component	axon
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0000139	cellular_component	Golgi membrane
G	0097708	cellular_component	intracellular vesicle
G	0005739	cellular_component	mitochondrion
G	0043005	cellular_component	neuron projection
G	0043025	cellular_component	neuronal cell body
G	0005634	cellular_component	nucleus
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0014069	cellular_component	postsynaptic density
G	0098793	cellular_component	presynapse
G	0045202	cellular_component	synapse
G	0008021	cellular_component	synaptic vesicle
G	0030672	cellular_component	synaptic vesicle membrane
G	0043195	cellular_component	terminal bouton
G	0019901	molecular_function	protein kinase binding
G	0044877	molecular_function	protein-containing complex binding
G	0000422	biological_process	autophagy of mitochondrion
G	1904881	biological_process	cellular response to hydrogen sulfide
G	1905232	biological_process	cellular response to L-glutamate
G	1904845	biological_process	cellular response to L-glutamine
G	0071287	biological_process	cellular response to manganese ion
G	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
G	0051646	biological_process	mitochondrion localization
G	0090394	biological_process	negative regulation of excitatory postsynaptic potential
G	0090258	biological_process	negative regulation of mitochondrial fission
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
G	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
G	0043065	biological_process	positive regulation of apoptotic process
G	2001171	biological_process	positive regulation of ATP biosynthetic process
G	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
G	0010918	biological_process	positive regulation of mitochondrial membrane potential
G	1901526	biological_process	positive regulation of mitophagy
G	0070585	biological_process	protein localization to mitochondrion
G	0016567	biological_process	protein ubiquitination
G	0051412	biological_process	response to corticosterone
G	1904643	biological_process	response to curcumin
G	0034976	biological_process	response to endoplasmic reticulum stress
G	0014850	biological_process	response to muscle activity
G	0006986	biological_process	response to unfolded protein
H	0030424	cellular_component	axon
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0000139	cellular_component	Golgi membrane
H	0097708	cellular_component	intracellular vesicle
H	0005739	cellular_component	mitochondrion
H	0043005	cellular_component	neuron projection
H	0043025	cellular_component	neuronal cell body
H	0005634	cellular_component	nucleus
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0014069	cellular_component	postsynaptic density
H	0098793	cellular_component	presynapse
H	0045202	cellular_component	synapse
H	0008021	cellular_component	synaptic vesicle
H	0030672	cellular_component	synaptic vesicle membrane
H	0043195	cellular_component	terminal bouton
H	0019901	molecular_function	protein kinase binding
H	0044877	molecular_function	protein-containing complex binding
H	0000422	biological_process	autophagy of mitochondrion
H	1904881	biological_process	cellular response to hydrogen sulfide
H	1905232	biological_process	cellular response to L-glutamate
H	1904845	biological_process	cellular response to L-glutamine
H	0071287	biological_process	cellular response to manganese ion
H	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
H	0051646	biological_process	mitochondrion localization
H	0090394	biological_process	negative regulation of excitatory postsynaptic potential
H	0090258	biological_process	negative regulation of mitochondrial fission
H	0043524	biological_process	negative regulation of neuron apoptotic process
H	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
H	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
H	0043065	biological_process	positive regulation of apoptotic process
H	2001171	biological_process	positive regulation of ATP biosynthetic process
H	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
H	0010918	biological_process	positive regulation of mitochondrial membrane potential
H	1901526	biological_process	positive regulation of mitophagy
H	0070585	biological_process	protein localization to mitochondrion
H	0016567	biological_process	protein ubiquitination
H	0051412	biological_process	response to corticosterone
H	1904643	biological_process	response to curcumin
H	0034976	biological_process	response to endoplasmic reticulum stress
H	0014850	biological_process	response to muscle activity
H	0006986	biological_process	response to unfolded protein
I	0030424	cellular_component	axon
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0000139	cellular_component	Golgi membrane
I	0097708	cellular_component	intracellular vesicle
I	0005739	cellular_component	mitochondrion
I	0043005	cellular_component	neuron projection
I	0043025	cellular_component	neuronal cell body
I	0005634	cellular_component	nucleus
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0014069	cellular_component	postsynaptic density
I	0098793	cellular_component	presynapse
I	0045202	cellular_component	synapse
I	0008021	cellular_component	synaptic vesicle
I	0030672	cellular_component	synaptic vesicle membrane
I	0043195	cellular_component	terminal bouton
I	0019901	molecular_function	protein kinase binding
I	0044877	molecular_function	protein-containing complex binding
I	0000422	biological_process	autophagy of mitochondrion
I	1904881	biological_process	cellular response to hydrogen sulfide
I	1905232	biological_process	cellular response to L-glutamate
I	1904845	biological_process	cellular response to L-glutamine
I	0071287	biological_process	cellular response to manganese ion
I	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
I	0051646	biological_process	mitochondrion localization
I	0090394	biological_process	negative regulation of excitatory postsynaptic potential
I	0090258	biological_process	negative regulation of mitochondrial fission
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
I	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
I	0043065	biological_process	positive regulation of apoptotic process
I	2001171	biological_process	positive regulation of ATP biosynthetic process
I	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
I	0010918	biological_process	positive regulation of mitochondrial membrane potential
I	1901526	biological_process	positive regulation of mitophagy
I	0070585	biological_process	protein localization to mitochondrion
I	0016567	biological_process	protein ubiquitination
I	0051412	biological_process	response to corticosterone
I	1904643	biological_process	response to curcumin
I	0034976	biological_process	response to endoplasmic reticulum stress
I	0014850	biological_process	response to muscle activity
I	0006986	biological_process	response to unfolded protein
J	0030424	cellular_component	axon
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0000139	cellular_component	Golgi membrane
J	0097708	cellular_component	intracellular vesicle
J	0005739	cellular_component	mitochondrion
J	0043005	cellular_component	neuron projection
J	0043025	cellular_component	neuronal cell body
J	0005634	cellular_component	nucleus
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0014069	cellular_component	postsynaptic density
J	0098793	cellular_component	presynapse
J	0045202	cellular_component	synapse
J	0008021	cellular_component	synaptic vesicle
J	0030672	cellular_component	synaptic vesicle membrane
J	0043195	cellular_component	terminal bouton
J	0019901	molecular_function	protein kinase binding
J	0044877	molecular_function	protein-containing complex binding
J	0000422	biological_process	autophagy of mitochondrion
J	1904881	biological_process	cellular response to hydrogen sulfide
J	1905232	biological_process	cellular response to L-glutamate
J	1904845	biological_process	cellular response to L-glutamine
J	0071287	biological_process	cellular response to manganese ion
J	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
J	0051646	biological_process	mitochondrion localization
J	0090394	biological_process	negative regulation of excitatory postsynaptic potential
J	0090258	biological_process	negative regulation of mitochondrial fission
J	0043524	biological_process	negative regulation of neuron apoptotic process
J	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
J	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
J	0043065	biological_process	positive regulation of apoptotic process
J	2001171	biological_process	positive regulation of ATP biosynthetic process
J	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
J	0010918	biological_process	positive regulation of mitochondrial membrane potential
J	1901526	biological_process	positive regulation of mitophagy
J	0070585	biological_process	protein localization to mitochondrion
J	0016567	biological_process	protein ubiquitination
J	0051412	biological_process	response to corticosterone
J	1904643	biological_process	response to curcumin
J	0034976	biological_process	response to endoplasmic reticulum stress
J	0014850	biological_process	response to muscle activity
J	0006986	biological_process	response to unfolded protein
K	0030424	cellular_component	axon
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0000139	cellular_component	Golgi membrane
K	0097708	cellular_component	intracellular vesicle
K	0005739	cellular_component	mitochondrion
K	0043005	cellular_component	neuron projection
K	0043025	cellular_component	neuronal cell body
K	0005634	cellular_component	nucleus
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0014069	cellular_component	postsynaptic density
K	0098793	cellular_component	presynapse
K	0045202	cellular_component	synapse
K	0008021	cellular_component	synaptic vesicle
K	0030672	cellular_component	synaptic vesicle membrane
K	0043195	cellular_component	terminal bouton
K	0019901	molecular_function	protein kinase binding
K	0044877	molecular_function	protein-containing complex binding
K	0000422	biological_process	autophagy of mitochondrion
K	1904881	biological_process	cellular response to hydrogen sulfide
K	1905232	biological_process	cellular response to L-glutamate
K	1904845	biological_process	cellular response to L-glutamine
K	0071287	biological_process	cellular response to manganese ion
K	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
K	0051646	biological_process	mitochondrion localization
K	0090394	biological_process	negative regulation of excitatory postsynaptic potential
K	0090258	biological_process	negative regulation of mitochondrial fission
K	0043524	biological_process	negative regulation of neuron apoptotic process
K	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
K	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
K	0043065	biological_process	positive regulation of apoptotic process
K	2001171	biological_process	positive regulation of ATP biosynthetic process
K	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
K	0010918	biological_process	positive regulation of mitochondrial membrane potential
K	1901526	biological_process	positive regulation of mitophagy
K	0070585	biological_process	protein localization to mitochondrion
K	0016567	biological_process	protein ubiquitination
K	0051412	biological_process	response to corticosterone
K	1904643	biological_process	response to curcumin
K	0034976	biological_process	response to endoplasmic reticulum stress
K	0014850	biological_process	response to muscle activity
K	0006986	biological_process	response to unfolded protein
L	0030424	cellular_component	axon
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0000139	cellular_component	Golgi membrane
L	0097708	cellular_component	intracellular vesicle
L	0005739	cellular_component	mitochondrion
L	0043005	cellular_component	neuron projection
L	0043025	cellular_component	neuronal cell body
L	0005634	cellular_component	nucleus
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0014069	cellular_component	postsynaptic density
L	0098793	cellular_component	presynapse
L	0045202	cellular_component	synapse
L	0008021	cellular_component	synaptic vesicle
L	0030672	cellular_component	synaptic vesicle membrane
L	0043195	cellular_component	terminal bouton
L	0019901	molecular_function	protein kinase binding
L	0044877	molecular_function	protein-containing complex binding
L	0000422	biological_process	autophagy of mitochondrion
L	1904881	biological_process	cellular response to hydrogen sulfide
L	1905232	biological_process	cellular response to L-glutamate
L	1904845	biological_process	cellular response to L-glutamine
L	0071287	biological_process	cellular response to manganese ion
L	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
L	0051646	biological_process	mitochondrion localization
L	0090394	biological_process	negative regulation of excitatory postsynaptic potential
L	0090258	biological_process	negative regulation of mitochondrial fission
L	0043524	biological_process	negative regulation of neuron apoptotic process
L	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
L	0051967	biological_process	negative regulation of synaptic transmission, glutamatergic
L	0043065	biological_process	positive regulation of apoptotic process
L	2001171	biological_process	positive regulation of ATP biosynthetic process
L	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
L	0010918	biological_process	positive regulation of mitochondrial membrane potential
L	1901526	biological_process	positive regulation of mitophagy
L	0070585	biological_process	protein localization to mitochondrion
L	0016567	biological_process	protein ubiquitination
L	0051412	biological_process	response to corticosterone
L	1904643	biological_process	response to curcumin
L	0034976	biological_process	response to endoplasmic reticulum stress
L	0014850	biological_process	response to muscle activity
L	0006986	biological_process	response to unfolded protein
A	0005515	molecular_function	protein binding
B	0005515	molecular_function	protein binding
C	0005515	molecular_function	protein binding
D	0005515	molecular_function	protein binding
E	0005515	molecular_function	protein binding
F	0005515	molecular_function	protein binding
G	0005515	molecular_function	protein binding
H	0005515	molecular_function	protein binding
I	0005515	molecular_function	protein binding
J	0005515	molecular_function	protein binding
K	0005515	molecular_function	protein binding
L	0005515	molecular_function	protein binding
A	0009410	biological_process	response to xenobiotic stimulus
B	0009410	biological_process	response to xenobiotic stimulus
C	0009410	biological_process	response to xenobiotic stimulus
D	0009410	biological_process	response to xenobiotic stimulus
E	0009410	biological_process	response to xenobiotic stimulus
F	0009410	biological_process	response to xenobiotic stimulus
G	0009410	biological_process	response to xenobiotic stimulus
H	0009410	biological_process	response to xenobiotic stimulus
I	0009410	biological_process	response to xenobiotic stimulus
J	0009410	biological_process	response to xenobiotic stimulus
K	0009410	biological_process	response to xenobiotic stimulus
L	0009410	biological_process	response to xenobiotic stimulus
G	0008270	molecular_function	zinc ion binding
H	0008270	molecular_function	zinc ion binding
I	0008270	molecular_function	zinc ion binding
J	0008270	molecular_function	zinc ion binding
K	0008270	molecular_function	zinc ion binding
L	0008270	molecular_function	zinc ion binding
A	0030163	biological_process	protein catabolic process
B	0030163	biological_process	protein catabolic process
C	0030163	biological_process	protein catabolic process
D	0030163	biological_process	protein catabolic process
E	0030163	biological_process	protein catabolic process
F	0030163	biological_process	protein catabolic process
G	0030163	biological_process	protein catabolic process
H	0030163	biological_process	protein catabolic process
I	0030163	biological_process	protein catabolic process
J	0030163	biological_process	protein catabolic process
K	0030163	biological_process	protein catabolic process
L	0030163	biological_process	protein catabolic process
A	0008270	molecular_function	zinc ion binding
B	0008270	molecular_function	zinc ion binding
C	0008270	molecular_function	zinc ion binding
D	0008270	molecular_function	zinc ion binding
E	0008270	molecular_function	zinc ion binding
F	0008270	molecular_function	zinc ion binding
A	0009893	biological_process	positive regulation of metabolic process
B	0009893	biological_process	positive regulation of metabolic process
C	0009893	biological_process	positive regulation of metabolic process
D	0009893	biological_process	positive regulation of metabolic process
E	0009893	biological_process	positive regulation of metabolic process
F	0009893	biological_process	positive regulation of metabolic process
G	0009893	biological_process	positive regulation of metabolic process
H	0009893	biological_process	positive regulation of metabolic process
I	0009893	biological_process	positive regulation of metabolic process
J	0009893	biological_process	positive regulation of metabolic process
K	0009893	biological_process	positive regulation of metabolic process
L	0009893	biological_process	positive regulation of metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS150
A	CYS154
A	CYS212
A	HIS215

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS166
A	CYS169
A	CYS196
A	CYS201

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS241
A	CYS260
A	CYS263
A	CYS238

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 504

Chain	Residue
A	CYS253
A	HIS257
A	CYS289
A	CYS293

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 505

Chain	Residue
A	CYS332
A	CYS337
A	CYS352
A	CYS360

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 506

Chain	Residue
A	CYS365
A	CYS368
A	HIS373
A	CYS377

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	CYS418
A	CYS421
A	CYS436
A	CYS441

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 508

Chain	Residue
A	CYS446
A	CYS449
A	CYS457
A	HIS461

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	CYS150
B	CYS154
B	CYS212
B	HIS215

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS166
B	CYS169
B	CYS196
B	CYS201

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 503

Chain	Residue
B	CYS238
B	CYS241
B	CYS260
B	CYS263

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 504

Chain	Residue
B	CYS253
B	HIS257
B	CYS289
B	CYS293

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 505

Chain	Residue
B	CYS332
B	CYS337
B	CYS352
B	CYS360

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 506

Chain	Residue
B	CYS365
B	CYS368
B	HIS373
B	CYS377

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 507

Chain	Residue
B	CYS418
B	CYS421
B	CYS436
B	CYS441

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 508

Chain	Residue
B	CYS446
B	CYS449
B	CYS457
B	HIS461

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 501

Chain	Residue
C	CYS150
C	CYS154
C	CYS212
C	HIS215

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 502

Chain	Residue
C	CYS166
C	CYS169
C	CYS196
C	CYS201

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 503

Chain	Residue
C	CYS238
C	CYS241
C	CYS260
C	CYS263

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 504

Chain	Residue
C	CYS253
C	HIS257
C	CYS289
C	CYS293

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 505

Chain	Residue
C	CYS332
C	CYS337
C	CYS352
C	CYS360

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 506

Chain	Residue
C	CYS365
C	CYS368
C	HIS373
C	CYS377

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 507

Chain	Residue
C	CYS418
C	CYS421
C	CYS436
C	CYS441

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 508

Chain	Residue
C	CYS446
C	CYS449
C	CYS457
C	HIS461

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 501

Chain	Residue
D	HIS215
D	CYS150
D	CYS154
D	CYS212

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 502

Chain	Residue
D	CYS166
D	CYS169
D	CYS196
D	CYS201

---

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 503

Chain	Residue
D	CYS238
D	CYS241
D	CYS260
D	CYS263

---

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 504

Chain	Residue
D	CYS253
D	HIS257
D	CYS289
D	CYS293

---

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 505

Chain	Residue
D	CYS332
D	CYS337
D	CYS352
D	CYS360

---

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 506

Chain	Residue
D	CYS365
D	CYS368
D	HIS373
D	CYS377

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 507

Chain	Residue
D	CYS418
D	CYS421
D	CYS436
D	CYS441

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 508

Chain	Residue
D	CYS446
D	CYS449
D	CYS457
D	HIS461

---

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 501

Chain	Residue
E	CYS150
E	CYS154
E	CYS212
E	HIS215

---

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 502

Chain	Residue
E	CYS166
E	CYS169
E	CYS196
E	CYS201

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 503

Chain	Residue
E	CYS238
E	CYS241
E	CYS260
E	CYS263

---

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 504

Chain	Residue
E	CYS253
E	HIS257
E	CYS289
E	CYS293

---

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 505

Chain	Residue
E	CYS332
E	CYS337
E	CYS352
E	CYS360

---

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 506

Chain	Residue
E	CYS365
E	CYS368
E	HIS373
E	CYS377

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 507

Chain	Residue
E	CYS418
E	CYS421
E	CYS436
E	CYS441

---

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 508

Chain	Residue
E	CYS446
E	CYS449
E	CYS457
E	HIS461

---

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 501

Chain	Residue
F	CYS150
F	CYS154
F	CYS212
F	HIS215

---

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 502

Chain	Residue
F	CYS166
F	CYS169
F	CYS196
F	CYS201

---

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 503

Chain	Residue
F	CYS238
F	CYS241
F	CYS260
F	CYS263

---

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 504

Chain	Residue
F	CYS253
F	HIS257
F	CYS289
F	CYS293

---

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 505

Chain	Residue
F	CYS332
F	CYS337
F	CYS352
F	CYS360

---

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 506

Chain	Residue
F	CYS365
F	CYS368
F	HIS373
F	CYS377

---

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 507

Chain	Residue
F	CYS418
F	CYS421
F	CYS436
F	CYS441

---

site_id	FC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 508

Chain	Residue
F	CYS446
F	CYS449
F	CYS457
F	HIS461

---

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 501

Chain	Residue
G	CYS150
G	CYS154
G	CYS212
G	HIS215

---

site_id	FC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 502

Chain	Residue
G	CYS166
G	CYS169
G	CYS196
G	CYS201

---

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 503

Chain	Residue
G	CYS238
G	CYS241
G	CYS260
G	CYS263

---

site_id	FC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 504

Chain	Residue
G	CYS253
G	HIS257
G	CYS289
G	CYS293

---

site_id	FC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 505

Chain	Residue
G	CYS332
G	CYS337
G	CYS352
G	CYS360

---

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 506

Chain	Residue
G	CYS365
G	CYS368
G	HIS373
G	CYS377

---

site_id	GC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 507

Chain	Residue
G	CYS418
G	CYS421
G	CYS436
G	CYS441

---

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 508

Chain	Residue
G	CYS446
G	CYS449
G	CYS457
G	HIS461

---

site_id	GC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 501

Chain	Residue
H	CYS150
H	CYS154
H	CYS212
H	HIS215

---

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 502

Chain	Residue
H	CYS166
H	CYS169
H	CYS196
H	CYS201

---

site_id	GC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 503

Chain	Residue
H	CYS238
H	CYS241
H	CYS260
H	CYS263

---

site_id	GC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 504

Chain	Residue
H	CYS253
H	HIS257
H	CYS289
H	CYS293

---

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 505

Chain	Residue
H	CYS332
H	CYS337
H	CYS352
H	CYS360

---

site_id	GC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 506

Chain	Residue
H	CYS365
H	CYS368
H	HIS373
H	CYS377

---

site_id	GC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 507

Chain	Residue
H	CYS418
H	CYS421
H	CYS436
H	CYS441

---

site_id	HC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 508

Chain	Residue
H	CYS446
H	CYS449
H	CYS457
H	HIS461

---

site_id	HC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 501

Chain	Residue
I	CYS150
I	CYS154
I	CYS212
I	HIS215

---

site_id	HC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 502

Chain	Residue
I	CYS166
I	CYS169
I	CYS196
I	CYS201

---

site_id	HC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 503

Chain	Residue
I	CYS238
I	CYS241
I	CYS260
I	CYS263

---

site_id	HC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 504

Chain	Residue
I	CYS253
I	HIS257
I	CYS289
I	CYS293

---

site_id	HC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 505

Chain	Residue
I	CYS332
I	CYS337
I	CYS352
I	CYS360

---

site_id	HC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 506

Chain	Residue
I	CYS365
I	CYS368
I	HIS373
I	CYS377

---

site_id	HC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 507

Chain	Residue
I	CYS418
I	CYS421
I	CYS436
I	CYS441

---

site_id	HC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 508

Chain	Residue
I	CYS446
I	CYS449
I	CYS457
I	HIS461

---

site_id	IC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 501

Chain	Residue
J	CYS150
J	CYS154
J	CYS212
J	HIS215

---

site_id	IC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 502

Chain	Residue
J	CYS166
J	CYS169
J	CYS196
J	CYS201

---

site_id	IC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 503

Chain	Residue
J	CYS238
J	CYS241
J	CYS260
J	CYS263

---

site_id	IC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 504

Chain	Residue
J	CYS253
J	HIS257
J	CYS289
J	CYS293

---

site_id	IC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 505

Chain	Residue
J	CYS332
J	CYS337
J	CYS352
J	CYS360

---

site_id	IC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 506

Chain	Residue
J	CYS365
J	CYS368
J	HIS373
J	CYS377

---

site_id	IC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 507

Chain	Residue
J	CYS418
J	CYS421
J	CYS436
J	CYS441

---

site_id	IC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 508

Chain	Residue
J	CYS446
J	CYS449
J	CYS457
J	HIS461

---

site_id	IC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 501

Chain	Residue
K	CYS150
K	CYS154
K	CYS212
K	HIS215

---

site_id	JC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 502

Chain	Residue
K	CYS166
K	CYS169
K	CYS196
K	CYS201

---

site_id	JC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 503

Chain	Residue
K	CYS238
K	CYS241
K	CYS260
K	CYS263

---

site_id	JC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 504

Chain	Residue
K	CYS253
K	HIS257
K	CYS289
K	CYS293

---

site_id	JC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 505

Chain	Residue
K	CYS332
K	CYS337
K	CYS352
K	CYS360

---

site_id	JC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 506

Chain	Residue
K	CYS365
K	CYS368
K	HIS373
K	CYS377

---

site_id	JC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 507

Chain	Residue
K	CYS418
K	CYS421
K	CYS436
K	CYS441

---

site_id	JC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 508

Chain	Residue
K	CYS446
K	CYS449
K	CYS457
K	HIS461

---

site_id	JC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 501

Chain	Residue
L	CYS150
L	CYS154
L	CYS212
L	HIS215

---

site_id	JC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 502

Chain	Residue
L	CYS166
L	CYS169
L	CYS196
L	CYS201

---

site_id	KC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 503

Chain	Residue
L	CYS238
L	CYS241
L	CYS260
L	CYS263

---

site_id	KC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 504

Chain	Residue
L	CYS253
L	HIS257
L	CYS289
L	CYS293

---

site_id	KC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 505

Chain	Residue
L	CYS332
L	CYS337
L	CYS352
L	CYS360

---

site_id	KC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 506

Chain	Residue
L	CYS365
L	CYS368
L	HIS373
L	CYS377

---

site_id	KC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 507

Chain	Residue
L	CYS418
L	CYS421
L	CYS436
L	CYS441

---

site_id	KC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 508

Chain	Residue
L	CYS446
L	CYS449
L	CYS457
L	HIS461

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1008
Details	ZN_FING: RING-type 0; atypical

Chain	Residue	Details
A	PRO141-ALA225
J	PRO141-ALA225
K	PRO141-ALA225
L	PRO141-ALA225
B	PRO141-ALA225
C	PRO141-ALA225
D	PRO141-ALA225
E	PRO141-ALA225
F	PRO141-ALA225
G	PRO141-ALA225
H	PRO141-ALA225
I	PRO141-ALA225

---

site_id	SWS_FT_FI2
Number of Residues	660
Details	ZN_FING: RING-type 1 => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238-CYS293
J	CYS238-CYS293
K	CYS238-CYS293
L	CYS238-CYS293
B	CYS238-CYS293
C	CYS238-CYS293
D	CYS238-CYS293
E	CYS238-CYS293
F	CYS238-CYS293
G	CYS238-CYS293
H	CYS238-CYS293
I	CYS238-CYS293

---

site_id	SWS_FT_FI3
Number of Residues	768
Details	ZN_FING: IBR-type => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	ASN313-CYS377
J	ASN313-CYS377
K	ASN313-CYS377
L	ASN313-CYS377
B	ASN313-CYS377
C	ASN313-CYS377
D	ASN313-CYS377
E	ASN313-CYS377
F	ASN313-CYS377
G	ASN313-CYS377
H	ASN313-CYS377
I	ASN313-CYS377

---

site_id	SWS_FT_FI4
Number of Residues	372
Details	ZN_FING: RING-type 2; atypical => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS418-CYS449
J	CYS418-CYS449
K	CYS418-CYS449
L	CYS418-CYS449
B	CYS418-CYS449
C	CYS418-CYS449
D	CYS418-CYS449
E	CYS418-CYS449
F	CYS418-CYS449
G	CYS418-CYS449
H	CYS418-CYS449
I	CYS418-CYS449

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23661642

Chain	Residue	Details
A	CYS431
J	CYS431
K	CYS431
L	CYS431
B	CYS431
C	CYS431
D	CYS431
E	CYS431
F	CYS431
G	CYS431
H	CYS431
I	CYS431

---

site_id	SWS_FT_FI6
Number of Residues	288
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238
A	CYS337
E	HIS257
E	CYS260
E	CYS263
E	CYS289
E	CYS293
E	CYS332
E	CYS337
E	CYS352
E	CYS360
E	CYS365
A	CYS352
E	CYS368
E	HIS373
E	CYS377
E	CYS418
E	CYS421
E	CYS436
E	CYS441
E	CYS446
E	CYS449
E	CYS457
A	CYS360
E	HIS461
F	CYS238
F	CYS241
F	CYS253
F	HIS257
F	CYS260
F	CYS263
F	CYS289
F	CYS293
F	CYS332
A	CYS365
F	CYS337
F	CYS352
F	CYS360
F	CYS365
F	CYS368
F	HIS373
F	CYS377
F	CYS418
F	CYS421
F	CYS436
A	CYS368
F	CYS441
F	CYS446
F	CYS449
F	CYS457
F	HIS461
G	CYS238
G	CYS241
G	CYS253
G	HIS257
G	CYS260
A	HIS373
G	CYS263
G	CYS289
G	CYS293
G	CYS332
G	CYS337
G	CYS352
G	CYS360
G	CYS365
G	CYS368
G	HIS373
A	CYS377
G	CYS377
G	CYS418
G	CYS421
G	CYS436
G	CYS441
G	CYS446
G	CYS449
G	CYS457
G	HIS461
H	CYS238
A	CYS418
H	CYS241
H	CYS253
H	HIS257
H	CYS260
H	CYS263
H	CYS289
H	CYS293
H	CYS332
H	CYS337
H	CYS352
A	CYS421
H	CYS360
H	CYS365
H	CYS368
H	HIS373
H	CYS377
H	CYS418
H	CYS421
H	CYS436
H	CYS441
H	CYS446
A	CYS436
H	CYS449
H	CYS457
H	HIS461
I	CYS238
I	CYS241
I	CYS253
I	HIS257
I	CYS260
I	CYS263
I	CYS289
A	CYS241
A	CYS441
I	CYS293
I	CYS332
I	CYS337
I	CYS352
I	CYS360
I	CYS365
I	CYS368
I	HIS373
I	CYS377
I	CYS418
A	CYS446
I	CYS421
I	CYS436
I	CYS441
I	CYS446
I	CYS449
I	CYS457
I	HIS461
J	CYS238
J	CYS241
J	CYS253
A	CYS449
J	HIS257
J	CYS260
J	CYS263
J	CYS289
J	CYS293
J	CYS332
J	CYS337
J	CYS352
J	CYS360
J	CYS365
A	CYS457
J	CYS368
J	HIS373
J	CYS377
J	CYS418
J	CYS421
J	CYS436
J	CYS441
J	CYS446
J	CYS449
J	CYS457
A	HIS461
J	HIS461
K	CYS238
K	CYS241
K	CYS253
K	HIS257
K	CYS260
K	CYS263
K	CYS289
K	CYS293
K	CYS332
B	CYS238
K	CYS337
K	CYS352
K	CYS360
K	CYS365
K	CYS368
K	HIS373
K	CYS377
K	CYS418
K	CYS421
K	CYS436
B	CYS241
K	CYS441
K	CYS446
K	CYS449
K	CYS457
K	HIS461
L	CYS238
L	CYS241
L	CYS253
L	HIS257
L	CYS260
B	CYS253
L	CYS263
L	CYS289
L	CYS293
L	CYS332
L	CYS337
L	CYS352
L	CYS360
L	CYS365
L	CYS368
L	HIS373
B	HIS257
L	CYS377
L	CYS418
L	CYS421
L	CYS436
L	CYS441
L	CYS446
L	CYS449
L	CYS457
L	HIS461
B	CYS260
A	CYS253
B	CYS263
B	CYS289
B	CYS293
B	CYS332
B	CYS337
B	CYS352
B	CYS360
B	CYS365
B	CYS368
B	HIS373
A	HIS257
B	CYS377
B	CYS418
B	CYS421
B	CYS436
B	CYS441
B	CYS446
B	CYS449
B	CYS457
B	HIS461
C	CYS238
A	CYS260
C	CYS241
C	CYS253
C	HIS257
C	CYS260
C	CYS263
C	CYS289
C	CYS293
C	CYS332
C	CYS337
C	CYS352
A	CYS263
C	CYS360
C	CYS365
C	CYS368
C	HIS373
C	CYS377
C	CYS418
C	CYS421
C	CYS436
C	CYS441
C	CYS446
A	CYS289
C	CYS449
C	CYS457
C	HIS461
D	CYS238
D	CYS241
D	CYS253
D	HIS257
D	CYS260
D	CYS263
D	CYS289
A	CYS293
D	CYS293
D	CYS332
D	CYS337
D	CYS352
D	CYS360
D	CYS365
D	CYS368
D	HIS373
D	CYS377
D	CYS418
A	CYS332
D	CYS421
D	CYS436
D	CYS441
D	CYS446
D	CYS449
D	CYS457
D	HIS461
E	CYS238
E	CYS241
E	CYS253

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	SER65
J	SER65
K	SER65
L	SER65
B	SER65
C	SER65
D	SER65
E	SER65
F	SER65
G	SER65
H	SER65
I	SER65

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9WVS6

Chain	Residue	Details
A	THR80
J	THR80
K	THR80
L	THR80
B	THR80
C	THR80
D	THR80
E	THR80
F	THR80
G	THR80
H	THR80
I	THR80

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by PINK1 => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	THR175
J	THR175
K	THR175
L	THR175
B	THR175
C	THR175
D	THR175
E	THR175
F	THR175
G	THR175
H	THR175
I	THR175

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	THR217
J	THR217
K	THR217
L	THR217
B	THR217
C	THR217
D	THR217
E	THR217
F	THR217
G	THR217
H	THR217
I	THR217

---

site_id	SWS_FT_FI11
Number of Residues	36
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	LYS349
D	LYS349
D	LYS369
E	LYS349
E	LYS369
F	LYS349
F	LYS369
G	LYS349
G	LYS369
H	LYS349
H	LYS369
I	LYS349
I	LYS369
J	LYS349
A	LYS369
J	LYS369
K	LYS349
K	LYS369
L	LYS349
L	LYS369
B	LYS349
B	LYS369
C	LYS349
C	LYS369

---