Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4K7D

Crystal Structure of Parkin C-terminal RING domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0008270	molecular_function	zinc ion binding
C	0016567	biological_process	protein ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS150
A	CYS154
A	CYS212
A	HIS215

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS166
A	CYS169
A	CYS196
A	CYS201

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS241
A	CYS260
A	CYS263
A	CYS238

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 504

Chain	Residue
A	CYS253
A	HIS257
A	CYS289
A	CYS293

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 505

Chain	Residue
A	CYS332
A	CYS337
A	CYS352
A	CYS360

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 506

Chain	Residue
A	CYS365
A	CYS368
A	HIS373
A	CYS377

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	CYS418
A	CYS421
A	CYS436
A	CYS441

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 508

Chain	Residue
A	CYS446
A	CYS449
A	CYS457
A	HIS461

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI A 509

Chain	Residue
A	VAL186
A	LEU187
A	PRO189
A	ASN190
A	ALA206
A	PHE208

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	CYS150
B	CYS154
B	CYS212
B	HIS215

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS166
B	THR168
B	CYS169
B	CYS196
B	CYS201

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 503

Chain	Residue
B	CYS238
B	CYS241
B	CYS260
B	CYS263

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 504

Chain	Residue
B	CYS253
B	HIS257
B	CYS289
B	CYS293

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 505

Chain	Residue
B	CYS332
B	CYS337
B	CYS352
B	CYS360

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 506

Chain	Residue
B	CYS365
B	CYS368
B	HIS373
B	CYS377

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 507

Chain	Residue
B	CYS418
B	CYS421
B	CYS436
B	CYS441

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 508

Chain	Residue
B	CYS446
B	CYS449
B	CYS457
B	HIS461

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI B 509

Chain	Residue
B	VAL186
B	LEU187
B	ILE188
B	PRO189
B	ALA206
B	PHE208

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 501

Chain	Residue
C	CYS150
C	CYS154
C	CYS212
C	HIS215

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 502

Chain	Residue
C	CYS166
C	CYS169
C	CYS196
C	CYS201

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 503

Chain	Residue
C	CYS238
C	CYS241
C	CYS260
C	CYS263

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 504

Chain	Residue
C	CYS253
C	HIS257
C	CYS289
C	CYS293

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 505

Chain	Residue
C	CYS332
C	CYS337
C	CYS352
C	CYS360

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 506

Chain	Residue
C	HIS373
C	CYS377
C	CYS365
C	CYS368

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 507

Chain	Residue
C	CYS418
C	CYS421
C	CYS436
C	CYS441

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 508

Chain	Residue
C	CYS446
C	CYS449
C	CYS457
C	HIS461

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI C 509

Chain	Residue
C	VAL186
C	LEU187
C	PRO189
C	ASN190
C	ALA206
C	PHE208

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	Zinc finger: {"description":"RING-type 0; atypical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	165
Details	Zinc finger: {"description":"RING-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	192
Details	Zinc finger: {"description":"IBR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	93
Details	Zinc finger: {"description":"RING-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	102
Details	Region: {"description":"SYT11 binding 1","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	108
Details	Region: {"description":"SYT11 binding 2","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23661642","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine; by PINK1","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"UniProtKB","id":"O60260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)