4K7D

Crystal Structure of Parkin C-terminal RING domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0008270	molecular_function	zinc ion binding
C	0016567	biological_process	protein ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS150
A	CYS154
A	CYS212
A	HIS215

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS166
A	CYS169
A	CYS196
A	CYS201

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS241
A	CYS260
A	CYS263
A	CYS238

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 504

Chain	Residue
A	CYS253
A	HIS257
A	CYS289
A	CYS293

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 505

Chain	Residue
A	CYS332
A	CYS337
A	CYS352
A	CYS360

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 506

Chain	Residue
A	CYS365
A	CYS368
A	HIS373
A	CYS377

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	CYS418
A	CYS421
A	CYS436
A	CYS441

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 508

Chain	Residue
A	CYS446
A	CYS449
A	CYS457
A	HIS461

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI A 509

Chain	Residue
A	VAL186
A	LEU187
A	PRO189
A	ASN190
A	ALA206
A	PHE208

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	CYS150
B	CYS154
B	CYS212
B	HIS215

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS166
B	THR168
B	CYS169
B	CYS196
B	CYS201

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 503

Chain	Residue
B	CYS238
B	CYS241
B	CYS260
B	CYS263

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 504

Chain	Residue
B	CYS253
B	HIS257
B	CYS289
B	CYS293

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 505

Chain	Residue
B	CYS332
B	CYS337
B	CYS352
B	CYS360

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 506

Chain	Residue
B	CYS365
B	CYS368
B	HIS373
B	CYS377

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 507

Chain	Residue
B	CYS418
B	CYS421
B	CYS436
B	CYS441

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 508

Chain	Residue
B	CYS446
B	CYS449
B	CYS457
B	HIS461

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI B 509

Chain	Residue
B	VAL186
B	LEU187
B	ILE188
B	PRO189
B	ALA206
B	PHE208

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 501

Chain	Residue
C	CYS150
C	CYS154
C	CYS212
C	HIS215

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 502

Chain	Residue
C	CYS166
C	CYS169
C	CYS196
C	CYS201

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 503

Chain	Residue
C	CYS238
C	CYS241
C	CYS260
C	CYS263

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 504

Chain	Residue
C	CYS253
C	HIS257
C	CYS289
C	CYS293

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 505

Chain	Residue
C	CYS332
C	CYS337
C	CYS352
C	CYS360

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 506

Chain	Residue
C	HIS373
C	CYS377
C	CYS365
C	CYS368

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 507

Chain	Residue
C	CYS418
C	CYS421
C	CYS436
C	CYS441

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 508

Chain	Residue
C	CYS446
C	CYS449
C	CYS457
C	HIS461

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI C 509

Chain	Residue
C	VAL186
C	LEU187
C	PRO189
C	ASN190
C	ALA206
C	PHE208

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	ZN_FING: RING-type 0; atypical

Chain	Residue	Details
A	PRO141-ALA225
B	PRO141-ALA225
C	PRO141-ALA225

---

site_id	SWS_FT_FI2
Number of Residues	165
Details	ZN_FING: RING-type 1 => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238-CYS293
B	CYS238-CYS293
C	CYS238-CYS293

---

site_id	SWS_FT_FI3
Number of Residues	192
Details	ZN_FING: IBR-type => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	ASN313-CYS377
B	ASN313-CYS377
C	ASN313-CYS377

---

site_id	SWS_FT_FI4
Number of Residues	93
Details	ZN_FING: RING-type 2; atypical => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS418-CYS449
B	CYS418-CYS449
C	CYS418-CYS449

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23661642

Chain	Residue	Details
A	CYS431
B	CYS431
C	CYS431

---

site_id	SWS_FT_FI6
Number of Residues	72
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238
A	CYS337
A	CYS352
A	CYS360
A	CYS365
A	CYS368
A	HIS373
A	CYS377
A	CYS418
A	CYS421
A	CYS436
A	CYS241
A	CYS441
A	CYS446
A	CYS449
A	CYS457
A	HIS461
B	CYS238
B	CYS241
B	CYS253
B	HIS257
B	CYS260
A	CYS253
B	CYS263
B	CYS289
B	CYS293
B	CYS332
B	CYS337
B	CYS352
B	CYS360
B	CYS365
B	CYS368
B	HIS373
A	HIS257
B	CYS377
B	CYS418
B	CYS421
B	CYS436
B	CYS441
B	CYS446
B	CYS449
B	CYS457
B	HIS461
C	CYS238
A	CYS260
C	CYS241
C	CYS253
C	HIS257
C	CYS260
C	CYS263
C	CYS289
C	CYS293
C	CYS332
C	CYS337
C	CYS352
A	CYS263
C	CYS360
C	CYS365
C	CYS368
C	HIS373
C	CYS377
C	CYS418
C	CYS421
C	CYS436
C	CYS441
C	CYS446
A	CYS289
C	CYS449
C	CYS457
C	HIS461
A	CYS293
A	CYS332

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphothreonine; by PINK1 => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	THR175
B	THR175
C	THR175

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	THR217
B	THR217
C	THR217

---

site_id	SWS_FT_FI9
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000250|UniProtKB:O60260

Chain	Residue	Details
A	LYS349
A	LYS369
B	LYS349
B	LYS369
C	LYS349
C	LYS369

---