4JUO
A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005694 | cellular_component | chromosome |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003916 | molecular_function | DNA topoisomerase activity |
| C | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005694 | cellular_component | chromosome |
| C | 0006265 | biological_process | DNA topological change |
| C | 0007059 | biological_process | chromosome segregation |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0034335 | molecular_function | DNA negative supercoiling activity |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| E | DT15 |
| F | LFX101 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C 701 |
| Chain | Residue |
| C | ASP506 |
| C | ASP508 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LFX F 101 |
| Chain | Residue |
| F | DA5 |
| G | DT15 |
| H | DG1 |
| H | DT4 |
| H | DA5 |
| A | SER79 |
| A | MG501 |
| E | DT15 |
| F | DA1 |
| F | DC4 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| C | LEU431-GLY439 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00937","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20596531","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Site: {"description":"Interaction with DNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00939","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00939","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20596531","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_00939","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
