4JUO

A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0005694	cellular_component	chromosome
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003916	molecular_function	DNA topoisomerase activity
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0005694	cellular_component	chromosome
C	0006265	biological_process	DNA topological change
C	0007059	biological_process	chromosome segregation
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 501

Chain	Residue
E	DT15
F	LFX101

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 701

Chain	Residue
C	ASP506
C	ASP508

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LFX F 101

Chain	Residue
F	DA5
G	DT15
H	DG1
H	DT4
H	DA5
A	SER79
A	MG501
E	DT15
F	DA1
F	DC4

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Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
C	LEU431-GLY439

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00939

Chain	Residue	Details
C	TYR11
C	ASN51
C	ASP78
C	GLY118
C	LYS344

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:20596531

Chain	Residue	Details
C	GLU433
C	ASP506
C	ASP508
A	ARG87
A	LYS93

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_00939

Chain	Residue	Details
C	LYS458
C	ASN461
C	HIS513
C	ARG629

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