4IW3
Crystal structure of a Pseudomonas putida prolyl-4-hydroxylase (P4H) in complex with elongation factor Tu (EF-Tu)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0031418 | molecular_function | L-ascorbic acid binding |
| A | 0031545 | molecular_function | peptidyl-proline 4-dioxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0071456 | biological_process | cellular response to hypoxia |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0097216 | molecular_function | guanosine tetraphosphate binding |
| J | 0005506 | molecular_function | iron ion binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0008198 | molecular_function | ferrous iron binding |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| J | 0031418 | molecular_function | L-ascorbic acid binding |
| J | 0031545 | molecular_function | peptidyl-proline 4-dioxygenase activity |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0051213 | molecular_function | dioxygenase activity |
| J | 0071456 | biological_process | cellular response to hypoxia |
| K | 0000166 | molecular_function | nucleotide binding |
| K | 0003746 | molecular_function | translation elongation factor activity |
| K | 0003924 | molecular_function | GTPase activity |
| K | 0005525 | molecular_function | GTP binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0005829 | cellular_component | cytosol |
| K | 0006412 | biological_process | translation |
| K | 0006414 | biological_process | translational elongation |
| K | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | HIS124 |
| A | ASP126 |
| A | HIS183 |
| A | OGA402 |
| A | HOH563 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE OGA A 402 |
| Chain | Residue |
| A | HIS183 |
| A | VAL185 |
| A | ARG192 |
| A | THR196 |
| A | TRP198 |
| A | MN401 |
| A | HOH504 |
| A | HOH540 |
| A | HOH563 |
| B | PRO54 |
| A | HIS124 |
| A | ASP126 |
| A | TYR141 |
| A | LEU154 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GDP B 501 |
| Chain | Residue |
| B | HIS20 |
| B | ASP22 |
| B | HIS23 |
| B | GLY24 |
| B | LYS25 |
| B | THR26 |
| B | THR27 |
| B | ASN136 |
| B | LYS137 |
| B | ASP139 |
| B | SER174 |
| B | ALA175 |
| B | ARG176 |
| B | ARG176 |
| B | MG502 |
| B | HOH616 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 502 |
| Chain | Residue |
| B | LYS25 |
| B | THR26 |
| B | CYS82 |
| B | GDP501 |
| B | HOH616 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG K 401 |
| Chain | Residue |
| K | THR26 |
| K | ASP81 |
| K | CYS82 |
| K | GDP402 |
| K | HOH525 |
| K | HOH536 |
| K | HOH537 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GDP K 402 |
| Chain | Residue |
| K | HIS20 |
| K | VAL21 |
| K | ASP22 |
| K | HIS23 |
| K | GLY24 |
| K | LYS25 |
| K | THR26 |
| K | THR27 |
| K | ASN136 |
| K | LYS137 |
| K | ASP139 |
| K | LEU140 |
| K | SER174 |
| K | ALA175 |
| K | ARG176 |
| K | ARG176 |
| K | MG401 |
| K | HOH525 |
| K | HOH537 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN J 401 |
| Chain | Residue |
| J | HIS124 |
| J | ASP126 |
| J | HIS183 |
| J | OGA402 |
| J | HOH532 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE OGA J 402 |
| Chain | Residue |
| J | TYR121 |
| J | HIS124 |
| J | ASP126 |
| J | VAL139 |
| J | TYR141 |
| J | LEU154 |
| J | HIS183 |
| J | VAL185 |
| J | ARG192 |
| J | THR196 |
| J | TRP198 |
| J | MN401 |
| J | HOH524 |
| J | HOH532 |
| J | HOH533 |
| K | PRO54 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DSapeEKaRGITIntA |
| Chain | Residue | Details |
| B | ASP51-ALA66 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00118 |
| Chain | Residue | Details |
| B | GLY19 | |
| B | ASP81 | |
| B | ASN136 | |
| K | GLY19 | |
| K | ASP81 | |
| K | ASN136 |
