Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4IHF

Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016410	molecular_function	N-acyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0042802	molecular_function	identical protein binding
A	0046677	biological_process	response to antibiotic
A	0103118	molecular_function	UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016020	cellular_component	membrane
B	0016410	molecular_function	N-acyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0042802	molecular_function	identical protein binding
B	0046677	biological_process	response to antibiotic
B	0103118	molecular_function	UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016020	cellular_component	membrane
C	0016410	molecular_function	N-acyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0042802	molecular_function	identical protein binding
C	0046677	biological_process	response to antibiotic
C	0103118	molecular_function	UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016020	cellular_component	membrane
D	0016410	molecular_function	N-acyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0042802	molecular_function	identical protein binding
D	0046677	biological_process	response to antibiotic
D	0103118	molecular_function	UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0009245	biological_process	lipid A biosynthetic process
E	0016020	cellular_component	membrane
E	0016410	molecular_function	N-acyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0042802	molecular_function	identical protein binding
E	0046677	biological_process	response to antibiotic
E	0103118	molecular_function	UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0009245	biological_process	lipid A biosynthetic process
F	0016020	cellular_component	membrane
F	0016410	molecular_function	N-acyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0042802	molecular_function	identical protein binding
F	0046677	biological_process	response to antibiotic
F	0103118	molecular_function	UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity
G	0006633	biological_process	fatty acid biosynthetic process
H	0006633	biological_process	fatty acid biosynthetic process
I	0006633	biological_process	fatty acid biosynthetic process
J	0006633	biological_process	fatty acid biosynthetic process
K	0006633	biological_process	fatty acid biosynthetic process
L	0006633	biological_process	fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 401

Chain	Residue
A	HOH647
A	HOH648
B	HOH532
B	HOH533
C	HOH546
C	HOH547

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL D 401

Chain	Residue
F	HOH533
F	HOH538
F	HOH539
D	HOH659
E	HOH539
E	HOH540

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 1F7 G 101

Chain	Residue
D	ASP232
D	GLY269
D	THR286
E	PHE183
E	GLN236
E	ALA238
E	ILE254
E	GLY257
E	VAL272
E	ASN274
E	MET290
E	VAL291
E	MET292
F	ASN310
F	TRP313
F	ARG314
G	SER36
G	HOH201
G	HOH202
G	HOH203
G	HOH204
G	HOH209

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1F7 H 101

Chain	Residue
D	GLN236
D	ALA238
D	ILE254
D	GLY257
D	VAL272
D	ASN274
D	VAL291
D	MET292
E	ASN310
E	ARG314
F	ASP232
F	GLY251
F	GLY268
F	GLY269
F	THR286
F	GLY287
H	SER36
H	HOH201

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 1F7 I 101

Chain	Residue
A	ASN310
A	ARG314
B	ASP232
B	GLY268
B	GLY269
B	THR286
B	GLY287
C	GLN236
C	ALA238
C	ILE254
C	GLY257
C	VAL272
C	MET290
C	VAL291
C	HOH402
I	SER36

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1F7 J 101

Chain	Residue
A	ASP232
A	GLY251
A	GLY268
A	GLY269
A	THR286
A	GLY287
B	PHE183
B	GLN236
B	ALA238
B	ILE254
B	ALA256
B	GLY257
B	VAL272
B	ASN274
B	VAL291
B	MET292
C	ASN310
C	ARG314
J	SER36
J	HOH202
J	HOH203

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1F7 K 101

Chain	Residue
F	ALA238
F	ILE254
F	GLY257
F	ASN274
F	MET292
K	SER36
K	HOH210
D	ASN310
D	ARG314
E	ASP232
E	GLY251
E	GLY268
E	GLY269
E	THR286
E	GLY287
F	PHE183
F	GLN236

site_id	AC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1F7 L 101

Chain	Residue
A	PHE183
A	GLN236
A	ALA238
A	ILE254
A	ALA256
A	GLY257
A	VAL272
A	ASN274
A	MET290
A	VAL291
A	MET292
B	ASN310
B	ARG314
C	ASP232
C	GLY251
C	GLY268
C	GLY269
C	THR286
C	GLY287
L	SER36
L	HOH201

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL

Chain	Residue	Details
G	ASP31-LEU46

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV

Chain	Residue	Details
A	ILE100-VAL128
A	ILE106-VAL134
A	LEU130-VAL158
A	ILE225-VAL253

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"18422345","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Involved in determining the hydroxyacyl-ACP selectivity"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)