4I51

Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A

Replaces:  4H4H

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002039	molecular_function	p53 binding
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
A	0046974	molecular_function	histone H3K9 methyltransferase activity
B	0002039	molecular_function	p53 binding
B	0005634	cellular_component	nucleus
B	0008270	molecular_function	zinc ion binding
B	0016279	molecular_function	protein-lysine N-methyltransferase activity
B	0042054	molecular_function	histone methyltransferase activity
B	0046974	molecular_function	histone H3K9 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH A 3001

Chain	Residue
A	MET1105
A	HIS1170
A	PHE1215
A	LYS1219
A	PHE1223
A	CYS1225
A	ARG1226
A	HOH3151
A	HOH3173
A	HOH3215
A	HOH3314
A	GLY1106
C	LDH2009
A	TRP1107
A	SER1141
A	TYR1142
A	ARG1166
A	PHE1167
A	ILE1168
A	ASN1169

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3002

Chain	Residue
A	CYS1031
A	CYS1044
A	CYS1074
A	CYS1078

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3003

Chain	Residue
A	CYS1037
A	CYS1074
A	CYS1080
A	CYS1084

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3004

Chain	Residue
A	CYS1031
A	CYS1033
A	CYS1037
A	CYS1042

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3005

Chain	Residue
A	CYS1172
A	CYS1225
A	CYS1227
A	CYS1232

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 3006

Chain	Residue
A	ASN1013
A	ILE1021
A	ARG1023
B	HOH3266

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 3007

Chain	Residue
A	CYS1033
A	ILE1034
A	ASP1035
A	SER1039
A	ASN1041
A	HOH3365
B	LEU1047
B	LEU1070
B	PHE1072

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH B 3001

Chain	Residue
B	MET1105
B	GLY1106
B	TRP1107
B	SER1141
B	TYR1142
B	ARG1166
B	PHE1167
B	ASN1169
B	HIS1170
B	PHE1223
B	CYS1225
B	ARG1226
B	HOH3206
D	LDH2009

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 3002

Chain	Residue
B	CYS1031
B	CYS1044
B	CYS1074
B	CYS1078

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 3003

Chain	Residue
B	CYS1037
B	CYS1074
B	CYS1080
B	CYS1084

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 3004

Chain	Residue
B	CYS1031
B	CYS1033
B	CYS1037
B	CYS1042

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 3005

Chain	Residue
B	CYS1172
B	CYS1225
B	CYS1227
B	CYS1232

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 3006

Chain	Residue
A	ARG1023
A	HOH3123
B	ARG1023
B	LEU1128
B	HOH3155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	126
Details	Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	117
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	Region: {"description":"Interaction with histone H3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Histone H3K9me binding","evidences":[{"source":"PubMed","id":"18264113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"20228790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5; alternate","evidences":[{"source":"UniProtKB","id":"P68433","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---