4I04
Structure of zymogen of cathepsin B1 from Schistosoma mansoni
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0050790 | biological_process | regulation of catalytic activity |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0050790 | biological_process | regulation of catalytic activity |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0050790 | biological_process | regulation of catalytic activity |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0050790 | biological_process | regulation of catalytic activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 401 |
| Chain | Residue |
| A | PHE76 |
| A | ASP77 |
| A | LYS80 |
| A | LYS81 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| C | ASN281 |
| C | LYS282 |
| A | VAL279 |
| A | ASN281 |
| A | LYS282 |
| C | VAL279 |
| C | GLU280 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 401 |
| Chain | Residue |
| B | ARG79 |
| B | TRP82 |
| B | CYS85 |
| B | LYS86 |
| B | ILE88 |
| B | ALA89 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 402 |
| Chain | Residue |
| B | ALA89 |
| B | THR90 |
| B | ILE91 |
| B | GLU294 |
| B | HOH548 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 403 |
| Chain | Residue |
| B | PHE76 |
| B | ASP77 |
| B | LYS81 |
| B | HOH579 |
| B | HOH637 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 401 |
| Chain | Residue |
| B | VAL279 |
| B | ASN281 |
| B | LYS282 |
| D | VAL279 |
| D | ASN281 |
| D | LYS282 |
| D | HOH592 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GGHAIRIIGWG |
| Chain | Residue | Details |
| A | GLY268-GLY278 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLiANSWnedWGenGYFrI |
| Chain | Residue | Details |
| A | TYR285-ILE304 |
