4I04

Structure of zymogen of cathepsin B1 from Schistosoma mansoni

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
A	0050790	biological_process	regulation of catalytic activity
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005615	cellular_component	extracellular space
B	0005764	cellular_component	lysosome
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
B	0050790	biological_process	regulation of catalytic activity
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0005615	cellular_component	extracellular space
C	0005764	cellular_component	lysosome
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
C	0050790	biological_process	regulation of catalytic activity
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0005615	cellular_component	extracellular space
D	0005764	cellular_component	lysosome
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
D	0050790	biological_process	regulation of catalytic activity
D	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 401

Chain	Residue
A	PHE76
A	ASP77
A	LYS80
A	LYS81

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 402

Chain	Residue
C	ASN281
C	LYS282
A	VAL279
A	ASN281
A	LYS282
C	VAL279
C	GLU280

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 401

Chain	Residue
B	ARG79
B	TRP82
B	CYS85
B	LYS86
B	ILE88
B	ALA89

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 402

Chain	Residue
B	ALA89
B	THR90
B	ILE91
B	GLU294
B	HOH548

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 403

Chain	Residue
B	PHE76
B	ASP77
B	LYS81
B	HOH579
B	HOH637

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site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 401

Chain	Residue
B	VAL279
B	ASN281
B	LYS282
D	VAL279
D	ASN281
D	LYS282
D	HOH592

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Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GGHAIRIIGWG

Chain	Residue	Details
A	GLY268-GLY278

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site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLiANSWnedWGenGYFrI

Chain	Residue	Details
A	TYR285-ILE304

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