4HN1
Crystal Structure of H60N/Y130F double mutant of ChmJ, a 3'-monoepimerase from Streptomyces bikiniensis in complex with dTDP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0017000 | biological_process | antibiotic biosynthetic process |
B | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0017000 | biological_process | antibiotic biosynthetic process |
C | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
C | 0016853 | molecular_function | isomerase activity |
C | 0017000 | biological_process | antibiotic biosynthetic process |
D | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
D | 0016853 | molecular_function | isomerase activity |
D | 0017000 | biological_process | antibiotic biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 301 |
Chain | Residue |
A | THR62 |
A | TYR136 |
A | ALA137 |
A | PRO138 |
A | HOH473 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 302 |
Chain | Residue |
A | ARG23 |
A | SER24 |
B | ARG57 |
B | TYD304 |
A | HIS17 |
A | ASP19 |
A | ARG21 |
A | GLY22 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 303 |
Chain | Residue |
A | GLN12 |
A | PHE28 |
A | ARG29 |
A | SER32 |
A | TYR71 |
A | HOH401 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 304 |
Chain | Residue |
A | MET1 |
A | TRP10 |
A | ALA36 |
A | HOH518 |
D | ASN169 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TYD A 305 |
Chain | Residue |
A | GLN45 |
A | ARG57 |
A | TYR136 |
A | HOH450 |
A | HOH486 |
A | HOH487 |
A | HOH509 |
B | HIS17 |
B | ARG21 |
B | GLU26 |
B | EDO301 |
B | HOH512 |
D | VAL15 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE THM A 306 |
Chain | Residue |
A | ARG95 |
A | TRP96 |
A | HOH415 |
A | HOH525 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 301 |
Chain | Residue |
A | ARG57 |
A | TYD305 |
B | HIS17 |
B | ASP19 |
B | ARG21 |
B | GLY22 |
B | SER24 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 302 |
Chain | Residue |
B | GLN12 |
B | PHE28 |
B | ARG29 |
B | SER32 |
B | TYR71 |
B | HOH414 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 303 |
Chain | Residue |
B | THR62 |
B | GLN68 |
B | TYR136 |
B | ALA137 |
B | PRO138 |
B | HOH467 |
site_id | BC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TYD B 304 |
Chain | Residue |
A | HIS17 |
A | ARG21 |
A | GLU26 |
A | EDO302 |
A | HOH503 |
B | GLN45 |
B | ARG57 |
B | TYR136 |
B | ARG166 |
B | HOH448 |
B | HOH493 |
B | HOH506 |
C | VAL15 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE THM B 305 |
Chain | Residue |
B | ARG95 |
B | TRP96 |
B | HOH423 |
B | HOH487 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO C 301 |
Chain | Residue |
C | HIS17 |
C | ASP19 |
C | GLY22 |
C | SER24 |
C | TYD303 |
D | ARG57 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO C 302 |
Chain | Residue |
C | GLN12 |
C | PHE28 |
C | ARG29 |
C | PHE33 |
C | TYR71 |
site_id | BC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TYD C 303 |
Chain | Residue |
D | ARG166 |
D | HOH428 |
A | VAL15 |
A | HIS17 |
C | HIS17 |
C | ARG21 |
C | GLU26 |
C | EDO301 |
C | HOH424 |
C | HOH428 |
D | GLN45 |
D | ARG57 |
D | TYR136 |
site_id | BC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TYD C 304 |
Chain | Residue |
B | VAL15 |
B | HIS17 |
C | GLN45 |
C | ARG57 |
C | TYR136 |
C | ARG166 |
C | HOH438 |
C | HOH441 |
C | HOH442 |
D | HIS17 |
D | ARG21 |
D | GLU26 |
D | EDO302 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE TDR C 305 |
Chain | Residue |
C | ARG95 |
C | TRP96 |
C | HOH475 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO D 301 |
Chain | Residue |
D | GLN12 |
D | PHE28 |
D | ARG29 |
D | SER32 |
D | PHE33 |
D | TYR71 |
site_id | BC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO D 302 |
Chain | Residue |
C | ARG57 |
C | TYD304 |
D | HIS17 |
D | ASP19 |
D | ARG21 |
D | GLY22 |
D | SER24 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE TDR D 303 |
Chain | Residue |
D | ARG95 |
D | TRP96 |
D | HOH437 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:23116432 |
Chain | Residue | Details |
A | ASN60 | |
B | ASN60 | |
C | ASN60 | |
D | ASN60 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:23116432 |
Chain | Residue | Details |
A | PHE130 | |
B | PHE130 | |
C | PHE130 | |
D | PHE130 |
site_id | SWS_FT_FI3 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23116432, ECO:0007744|PDB:4HN1 |
Chain | Residue | Details |
A | ARG21 | |
B | LYS70 | |
B | ARG117 | |
B | GLU141 | |
C | ARG21 | |
C | GLU26 | |
C | ARG57 | |
C | LYS70 | |
C | ARG117 | |
C | GLU141 | |
D | ARG21 | |
A | GLU26 | |
D | GLU26 | |
D | ARG57 | |
D | LYS70 | |
D | ARG117 | |
D | GLU141 | |
A | ARG57 | |
A | LYS70 | |
A | ARG117 | |
A | GLU141 | |
B | ARG21 | |
B | GLU26 | |
B | ARG57 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23116432, ECO:0007744|PDB:4HMZ, ECO:0007744|PDB:4HN1 |
Chain | Residue | Details |
A | GLN45 | |
B | GLN45 | |
C | GLN45 | |
D | GLN45 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9HU21 |
Chain | Residue | Details |
A | ARG166 | |
B | ARG166 | |
C | ARG166 | |
D | ARG166 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose => ECO:0000269|PubMed:23116432, ECO:0007744|PDB:4HN1 |
Chain | Residue | Details |
A | TYR136 | |
B | TYR136 | |
C | TYR136 | |
D | TYR136 |