4HEL

Crystal structure analysis of apo-GroEL structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006457	biological_process	protein folding
A	0009408	biological_process	response to heat
A	0016853	molecular_function	isomerase activity
A	0032727	biological_process	positive regulation of interferon-alpha production
A	0032729	biological_process	positive regulation of type II interferon production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0034514	biological_process	mitochondrial unfolded protein response
A	0042026	biological_process	protein refolding
A	0045041	biological_process	protein import into mitochondrial intermembrane space
A	0046872	molecular_function	metal ion binding
A	0050870	biological_process	positive regulation of T cell activation
A	0051082	molecular_function	unfolded protein binding
A	0051085	biological_process	chaperone cofactor-dependent protein refolding
A	0051087	molecular_function	protein-folding chaperone binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
A	1990220	cellular_component	GroEL-GroES complex
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006457	biological_process	protein folding
B	0009408	biological_process	response to heat
B	0016853	molecular_function	isomerase activity
B	0032727	biological_process	positive regulation of interferon-alpha production
B	0032729	biological_process	positive regulation of type II interferon production
B	0032755	biological_process	positive regulation of interleukin-6 production
B	0034514	biological_process	mitochondrial unfolded protein response
B	0042026	biological_process	protein refolding
B	0045041	biological_process	protein import into mitochondrial intermembrane space
B	0046872	molecular_function	metal ion binding
B	0050870	biological_process	positive regulation of T cell activation
B	0051082	molecular_function	unfolded protein binding
B	0051085	biological_process	chaperone cofactor-dependent protein refolding
B	0051087	molecular_function	protein-folding chaperone binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone
B	1990220	cellular_component	GroEL-GroES complex
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006457	biological_process	protein folding
C	0009408	biological_process	response to heat
C	0016853	molecular_function	isomerase activity
C	0032727	biological_process	positive regulation of interferon-alpha production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032755	biological_process	positive regulation of interleukin-6 production
C	0034514	biological_process	mitochondrial unfolded protein response
C	0042026	biological_process	protein refolding
C	0045041	biological_process	protein import into mitochondrial intermembrane space
C	0046872	molecular_function	metal ion binding
C	0050870	biological_process	positive regulation of T cell activation
C	0051082	molecular_function	unfolded protein binding
C	0051085	biological_process	chaperone cofactor-dependent protein refolding
C	0051087	molecular_function	protein-folding chaperone binding
C	0140662	molecular_function	ATP-dependent protein folding chaperone
C	1990220	cellular_component	GroEL-GroES complex
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006457	biological_process	protein folding
D	0009408	biological_process	response to heat
D	0016853	molecular_function	isomerase activity
D	0032727	biological_process	positive regulation of interferon-alpha production
D	0032729	biological_process	positive regulation of type II interferon production
D	0032755	biological_process	positive regulation of interleukin-6 production
D	0034514	biological_process	mitochondrial unfolded protein response
D	0042026	biological_process	protein refolding
D	0045041	biological_process	protein import into mitochondrial intermembrane space
D	0046872	molecular_function	metal ion binding
D	0050870	biological_process	positive regulation of T cell activation
D	0051082	molecular_function	unfolded protein binding
D	0051085	biological_process	chaperone cofactor-dependent protein refolding
D	0051087	molecular_function	protein-folding chaperone binding
D	0140662	molecular_function	ATP-dependent protein folding chaperone
D	1990220	cellular_component	GroEL-GroES complex
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006457	biological_process	protein folding
E	0009408	biological_process	response to heat
E	0016853	molecular_function	isomerase activity
E	0032727	biological_process	positive regulation of interferon-alpha production
E	0032729	biological_process	positive regulation of type II interferon production
E	0032755	biological_process	positive regulation of interleukin-6 production
E	0034514	biological_process	mitochondrial unfolded protein response
E	0042026	biological_process	protein refolding
E	0045041	biological_process	protein import into mitochondrial intermembrane space
E	0046872	molecular_function	metal ion binding
E	0050870	biological_process	positive regulation of T cell activation
E	0051082	molecular_function	unfolded protein binding
E	0051085	biological_process	chaperone cofactor-dependent protein refolding
E	0051087	molecular_function	protein-folding chaperone binding
E	0140662	molecular_function	ATP-dependent protein folding chaperone
E	1990220	cellular_component	GroEL-GroES complex
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006457	biological_process	protein folding
F	0009408	biological_process	response to heat
F	0016853	molecular_function	isomerase activity
F	0032727	biological_process	positive regulation of interferon-alpha production
F	0032729	biological_process	positive regulation of type II interferon production
F	0032755	biological_process	positive regulation of interleukin-6 production
F	0034514	biological_process	mitochondrial unfolded protein response
F	0042026	biological_process	protein refolding
F	0045041	biological_process	protein import into mitochondrial intermembrane space
F	0046872	molecular_function	metal ion binding
F	0050870	biological_process	positive regulation of T cell activation
F	0051082	molecular_function	unfolded protein binding
F	0051085	biological_process	chaperone cofactor-dependent protein refolding
F	0051087	molecular_function	protein-folding chaperone binding
F	0140662	molecular_function	ATP-dependent protein folding chaperone
F	1990220	cellular_component	GroEL-GroES complex
G	0000166	molecular_function	nucleotide binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006457	biological_process	protein folding
G	0009408	biological_process	response to heat
G	0016853	molecular_function	isomerase activity
G	0032727	biological_process	positive regulation of interferon-alpha production
G	0032729	biological_process	positive regulation of type II interferon production
G	0032755	biological_process	positive regulation of interleukin-6 production
G	0034514	biological_process	mitochondrial unfolded protein response
G	0042026	biological_process	protein refolding
G	0045041	biological_process	protein import into mitochondrial intermembrane space
G	0046872	molecular_function	metal ion binding
G	0050870	biological_process	positive regulation of T cell activation
G	0051082	molecular_function	unfolded protein binding
G	0051085	biological_process	chaperone cofactor-dependent protein refolding
G	0051087	molecular_function	protein-folding chaperone binding
G	0140662	molecular_function	ATP-dependent protein folding chaperone
G	1990220	cellular_component	GroEL-GroES complex
H	0000166	molecular_function	nucleotide binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006457	biological_process	protein folding
H	0009408	biological_process	response to heat
H	0016853	molecular_function	isomerase activity
H	0032727	biological_process	positive regulation of interferon-alpha production
H	0032729	biological_process	positive regulation of type II interferon production
H	0032755	biological_process	positive regulation of interleukin-6 production
H	0034514	biological_process	mitochondrial unfolded protein response
H	0042026	biological_process	protein refolding
H	0045041	biological_process	protein import into mitochondrial intermembrane space
H	0046872	molecular_function	metal ion binding
H	0050870	biological_process	positive regulation of T cell activation
H	0051082	molecular_function	unfolded protein binding
H	0051085	biological_process	chaperone cofactor-dependent protein refolding
H	0051087	molecular_function	protein-folding chaperone binding
H	0140662	molecular_function	ATP-dependent protein folding chaperone
H	1990220	cellular_component	GroEL-GroES complex
I	0000166	molecular_function	nucleotide binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006457	biological_process	protein folding
I	0009408	biological_process	response to heat
I	0016853	molecular_function	isomerase activity
I	0032727	biological_process	positive regulation of interferon-alpha production
I	0032729	biological_process	positive regulation of type II interferon production
I	0032755	biological_process	positive regulation of interleukin-6 production
I	0034514	biological_process	mitochondrial unfolded protein response
I	0042026	biological_process	protein refolding
I	0045041	biological_process	protein import into mitochondrial intermembrane space
I	0046872	molecular_function	metal ion binding
I	0050870	biological_process	positive regulation of T cell activation
I	0051082	molecular_function	unfolded protein binding
I	0051085	biological_process	chaperone cofactor-dependent protein refolding
I	0051087	molecular_function	protein-folding chaperone binding
I	0140662	molecular_function	ATP-dependent protein folding chaperone
I	1990220	cellular_component	GroEL-GroES complex
J	0000166	molecular_function	nucleotide binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006457	biological_process	protein folding
J	0009408	biological_process	response to heat
J	0016853	molecular_function	isomerase activity
J	0032727	biological_process	positive regulation of interferon-alpha production
J	0032729	biological_process	positive regulation of type II interferon production
J	0032755	biological_process	positive regulation of interleukin-6 production
J	0034514	biological_process	mitochondrial unfolded protein response
J	0042026	biological_process	protein refolding
J	0045041	biological_process	protein import into mitochondrial intermembrane space
J	0046872	molecular_function	metal ion binding
J	0050870	biological_process	positive regulation of T cell activation
J	0051082	molecular_function	unfolded protein binding
J	0051085	biological_process	chaperone cofactor-dependent protein refolding
J	0051087	molecular_function	protein-folding chaperone binding
J	0140662	molecular_function	ATP-dependent protein folding chaperone
J	1990220	cellular_component	GroEL-GroES complex
K	0000166	molecular_function	nucleotide binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0006457	biological_process	protein folding
K	0009408	biological_process	response to heat
K	0016853	molecular_function	isomerase activity
K	0032727	biological_process	positive regulation of interferon-alpha production
K	0032729	biological_process	positive regulation of type II interferon production
K	0032755	biological_process	positive regulation of interleukin-6 production
K	0034514	biological_process	mitochondrial unfolded protein response
K	0042026	biological_process	protein refolding
K	0045041	biological_process	protein import into mitochondrial intermembrane space
K	0046872	molecular_function	metal ion binding
K	0050870	biological_process	positive regulation of T cell activation
K	0051082	molecular_function	unfolded protein binding
K	0051085	biological_process	chaperone cofactor-dependent protein refolding
K	0051087	molecular_function	protein-folding chaperone binding
K	0140662	molecular_function	ATP-dependent protein folding chaperone
K	1990220	cellular_component	GroEL-GroES complex
L	0000166	molecular_function	nucleotide binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0006457	biological_process	protein folding
L	0009408	biological_process	response to heat
L	0016853	molecular_function	isomerase activity
L	0032727	biological_process	positive regulation of interferon-alpha production
L	0032729	biological_process	positive regulation of type II interferon production
L	0032755	biological_process	positive regulation of interleukin-6 production
L	0034514	biological_process	mitochondrial unfolded protein response
L	0042026	biological_process	protein refolding
L	0045041	biological_process	protein import into mitochondrial intermembrane space
L	0046872	molecular_function	metal ion binding
L	0050870	biological_process	positive regulation of T cell activation
L	0051082	molecular_function	unfolded protein binding
L	0051085	biological_process	chaperone cofactor-dependent protein refolding
L	0051087	molecular_function	protein-folding chaperone binding
L	0140662	molecular_function	ATP-dependent protein folding chaperone
L	1990220	cellular_component	GroEL-GroES complex
M	0000166	molecular_function	nucleotide binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0006457	biological_process	protein folding
M	0009408	biological_process	response to heat
M	0016853	molecular_function	isomerase activity
M	0032727	biological_process	positive regulation of interferon-alpha production
M	0032729	biological_process	positive regulation of type II interferon production
M	0032755	biological_process	positive regulation of interleukin-6 production
M	0034514	biological_process	mitochondrial unfolded protein response
M	0042026	biological_process	protein refolding
M	0045041	biological_process	protein import into mitochondrial intermembrane space
M	0046872	molecular_function	metal ion binding
M	0050870	biological_process	positive regulation of T cell activation
M	0051082	molecular_function	unfolded protein binding
M	0051085	biological_process	chaperone cofactor-dependent protein refolding
M	0051087	molecular_function	protein-folding chaperone binding
M	0140662	molecular_function	ATP-dependent protein folding chaperone
M	1990220	cellular_component	GroEL-GroES complex
N	0000166	molecular_function	nucleotide binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0006457	biological_process	protein folding
N	0009408	biological_process	response to heat
N	0016853	molecular_function	isomerase activity
N	0032727	biological_process	positive regulation of interferon-alpha production
N	0032729	biological_process	positive regulation of type II interferon production
N	0032755	biological_process	positive regulation of interleukin-6 production
N	0034514	biological_process	mitochondrial unfolded protein response
N	0042026	biological_process	protein refolding
N	0045041	biological_process	protein import into mitochondrial intermembrane space
N	0046872	molecular_function	metal ion binding
N	0050870	biological_process	positive regulation of T cell activation
N	0051082	molecular_function	unfolded protein binding
N	0051085	biological_process	chaperone cofactor-dependent protein refolding
N	0051087	molecular_function	protein-folding chaperone binding
N	0140662	molecular_function	ATP-dependent protein folding chaperone
N	1990220	cellular_component	GroEL-GroES complex

Functional Information from PROSITE/UniProt

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGVVaGGG

Chain	Residue	Details
A	ALA405-GLY416

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