4HBN

Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CMP A 801

Chain	Residue
A	VAL642
A	ARG710
A	ARG713
A	HOH948
A	THR650
A	PHE658
A	GLY659
A	GLU660
A	ILE661
A	CYS662
A	ARG669
A	THR670

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 802

Chain	Residue
A	SER568
A	GLU572

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGTiGKkMYFIqhG

Chain	Residue	Details
A	ILE622-GLY638

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24776929","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23103389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HBN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9TV66","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23103389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HBN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---