4H8J
Structure of GluA2-LBD in complex with MES
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MES A 301 |
| Chain | Residue |
| A | GLU13 |
| A | HOH633 |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLU193 |
| A | MET196 |
| A | TYR220 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | THR143 |
| A | LEU192 |
| A | GLU193 |
| A | HOH455 |
| A | HOH475 |
| A | HOH549 |
| A | HOH593 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 303 |
| Chain | Residue |
| A | LYS50 |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
| A | HOH617 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 304 |
| Chain | Residue |
| A | ASP139 |
| A | SER140 |
| A | LYS144 |
| A | ARG148 |
| B | ARG172 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | LYS116 |
| A | LYS185 |
| A | GLY186 |
| A | HOH462 |
| D | ILE70 |
| D | TYR80 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 306 |
| Chain | Residue |
| A | PRO167 |
| A | HOH417 |
| B | PRO167 |
| B | HOH417 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLU193 |
| B | EDO304 |
| B | HOH586 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | ARG148 |
| B | TRP159 |
| B | ARG163 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 303 |
| Chain | Residue |
| A | ARG172 |
| B | ASP139 |
| B | LYS144 |
| B | ARG148 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 304 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | GLU193 |
| B | MET196 |
| B | TYR220 |
| B | SO4301 |
| B | HOH464 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MES C 301 |
| Chain | Residue |
| C | GLU13 |
| C | TYR61 |
| C | PRO89 |
| C | THR91 |
| C | ARG96 |
| C | GLU193 |
| C | TYR220 |
| C | HOH507 |
| C | HOH655 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 302 |
| Chain | Residue |
| C | THR143 |
| C | LEU192 |
| C | GLU193 |
| C | HOH407 |
| C | HOH434 |
| C | HOH438 |
| C | HOH572 |
| C | HOH602 |
| C | HOH624 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | ARG148 |
| C | TRP159 |
| C | ARG163 |
| D | LYS50 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 304 |
| Chain | Residue |
| C | ASP139 |
| C | SER140 |
| C | LYS144 |
| C | ARG148 |
| D | ARG172 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 305 |
| Chain | Residue |
| C | PRO167 |
| C | HOH453 |
| D | PRO167 |
| D | HOH410 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 301 |
| Chain | Residue |
| D | TYR61 |
| D | PRO89 |
| D | THR91 |
| D | ARG96 |
| D | EDO304 |
| D | HOH664 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| D | ARG148 |
| D | HOH674 |
| C | ARG172 |
| D | ASP139 |
| D | LYS144 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| D | ARG148 |
| D | TRP159 |
| D | ARG163 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 304 |
| Chain | Residue |
| D | TYR61 |
| D | PRO89 |
| D | GLU193 |
| D | MET196 |
| D | TYR220 |
| D | SO4301 |
| D | HOH456 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
