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4GZM

Crystal structure of RAC1 F28L mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0001764biological_processneuron migration
A0001934biological_processpositive regulation of protein phosphorylation
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006954biological_processinflammatory response
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0007264biological_processsmall GTPase-mediated signal transduction
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0008361biological_processregulation of cell size
A0009611biological_processresponse to wounding
A0009653biological_processanatomical structure morphogenesis
A0010310biological_processregulation of hydrogen peroxide metabolic process
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0010595biological_processpositive regulation of endothelial cell migration
A0010764biological_processnegative regulation of fibroblast migration
A0010811biological_processpositive regulation of cell-substrate adhesion
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030032biological_processlamellipodium assembly
A0030036biological_processactin cytoskeleton organization
A0030041biological_processactin filament polymerization
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030667cellular_componentsecretory granule membrane
A0030865biological_processcortical cytoskeleton organization
A0031116biological_processpositive regulation of microtubule polymerization
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031996molecular_functionthioesterase binding
A0032587cellular_componentruffle membrane
A0032707biological_processnegative regulation of interleukin-23 production
A0032956biological_processregulation of actin cytoskeleton organization
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035025biological_processpositive regulation of Rho protein signal transduction
A0035556biological_processintracellular signal transduction
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0043020cellular_componentNADPH oxidase complex
A0043197cellular_componentdendritic spine
A0043652biological_processengulfment of apoptotic cell
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045428biological_processregulation of nitric oxide biosynthetic process
A0045730biological_processrespiratory burst
A0048012biological_processhepatocyte growth factor receptor signaling pathway
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048870biological_processcell motility
A0051022molecular_functionRho GDP-dissociation inhibitor binding
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051668biological_processlocalization within membrane
A0051894biological_processpositive regulation of focal adhesion assembly
A0055038cellular_componentrecycling endosome membrane
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060263biological_processregulation of respiratory burst
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0071526biological_processsemaphorin-plexin signaling pathway
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0097178biological_processruffle assembly
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0101003cellular_componentficolin-1-rich granule membrane
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902622biological_processregulation of neutrophil migration
B0001764biological_processneuron migration
B0001934biological_processpositive regulation of protein phosphorylation
B0003376biological_processsphingosine-1-phosphate receptor signaling pathway
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005802cellular_componenttrans-Golgi network
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006954biological_processinflammatory response
B0007015biological_processactin filament organization
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007163biological_processestablishment or maintenance of cell polarity
B0007264biological_processsmall GTPase-mediated signal transduction
B0008045biological_processmotor neuron axon guidance
B0008360biological_processregulation of cell shape
B0008361biological_processregulation of cell size
B0009611biological_processresponse to wounding
B0009653biological_processanatomical structure morphogenesis
B0010310biological_processregulation of hydrogen peroxide metabolic process
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0010595biological_processpositive regulation of endothelial cell migration
B0010764biological_processnegative regulation of fibroblast migration
B0010811biological_processpositive regulation of cell-substrate adhesion
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0016601biological_processRac protein signal transduction
B0016787molecular_functionhydrolase activity
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0030027cellular_componentlamellipodium
B0030031biological_processcell projection assembly
B0030032biological_processlamellipodium assembly
B0030036biological_processactin cytoskeleton organization
B0030041biological_processactin filament polymerization
B0030334biological_processregulation of cell migration
B0030425cellular_componentdendrite
B0030667cellular_componentsecretory granule membrane
B0030865biological_processcortical cytoskeleton organization
B0031116biological_processpositive regulation of microtubule polymerization
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031996molecular_functionthioesterase binding
B0032587cellular_componentruffle membrane
B0032707biological_processnegative regulation of interleukin-23 production
B0032956biological_processregulation of actin cytoskeleton organization
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035025biological_processpositive regulation of Rho protein signal transduction
B0035556biological_processintracellular signal transduction
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042470cellular_componentmelanosome
B0042995cellular_componentcell projection
B0043020cellular_componentNADPH oxidase complex
B0043197cellular_componentdendritic spine
B0043652biological_processengulfment of apoptotic cell
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0045428biological_processregulation of nitric oxide biosynthetic process
B0045730biological_processrespiratory burst
B0048012biological_processhepatocyte growth factor receptor signaling pathway
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0048870biological_processcell motility
B0051022molecular_functionRho GDP-dissociation inhibitor binding
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051668biological_processlocalization within membrane
B0051894biological_processpositive regulation of focal adhesion assembly
B0055038cellular_componentrecycling endosome membrane
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060263biological_processregulation of respiratory burst
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0071526biological_processsemaphorin-plexin signaling pathway
B0090023biological_processpositive regulation of neutrophil chemotaxis
B0097178biological_processruffle assembly
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0101003cellular_componentficolin-1-rich granule membrane
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1902622biological_processregulation of neutrophil migration
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GSP A 1000
ChainResidue
AASP11
APRO34
ATHR35
ATHR58
AGLY60
AASP118
ALEU119
ASER158
AALA159
ALEU160
AMG1001
AGLY12
AALA13
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
ATYR32

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 1001
ChainResidue
ATHR17
ATHR35
AASP57
AGSP1000

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE GSP B 1000
ChainResidue
BASP11
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BTYR32
BILE33
BPRO34
BTHR35
BASP118
BLEU119
BSER158
BALA159
BLEU160
BMG1001

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 1001
ChainResidue
BTHR17
BTHR35
BASP57
BTHR58
BGSP1000

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
AALA13
AGLY30
AGLY60
BALA13
BGLY30
BGLY60

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
ALYS116
AALA159
BLYS116
BALA159

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ATYR32
BTYR32

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR35
BTHR35

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
ASER71
BSER71

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32
BTYR32

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR35
BTHR35

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
ALYS147
BLYS147

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
ALYS166
BLYS166

226707

PDB entries from 2024-10-30

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