4GYF

Crystal structure of histidinol phosphate phosphatase (HISK) from Lactococcus lactis subsp. lactis Il1403 complexed with ZN, L-histidinol and phosphate

Replaces:  3UMU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004401	molecular_function	histidinol-phosphatase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	GLU81
A	HIS109
A	HIS154
A	ZN303
A	PO4312
A	HOH619

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	PO4312
A	ASP17
A	HIS42
A	HIS230

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	HIS9
A	HIS11
A	GLU81
A	ASP228
A	ZN301
A	PO4312
A	HOH619

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 304

Chain	Residue
A	HIS32
A	HIS240
A	CL306
A	HSO314

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 305

Chain	Residue
A	HIS13
A	SER15
A	SER18
A	HOH421
A	HOH438
A	HOH627

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 306

Chain	Residue
A	HIS32
A	HIS240
A	ZN304
A	HSO314

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 307

Chain	Residue
A	ARG43
A	TYR46

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 308

Chain	Residue
A	ARG234
A	ASP235
A	HOH423

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 309

Chain	Residue
A	ASN93
A	PHE146
A	GLU147
A	HOH570

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 310

Chain	Residue
A	HIS230

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 311

Chain	Residue
A	LYS4
A	GLU253
A	LEU254
A	HOH611

---

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PO4 A 312

Chain	Residue
A	HIS11
A	ASP17
A	HIS42
A	GLU81
A	HIS109
A	TYR157
A	ARG160
A	ARG197
A	ASP228
A	HIS230
A	ZN301
A	ZN302
A	ZN303
A	HSO313
A	HOH619

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE HSO A 313

Chain	Residue
A	HIS109
A	GLU115
A	TYR157
A	TYR161
A	PO4312
A	HOH426
A	HOH485

---

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HSO A 314

Chain	Residue
A	LYS5
A	HIS32
A	TYR46
A	ARG87
A	ASP113
A	HIS240
A	ARG243
A	ZN304
A	CL306
A	HOH529

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 315

Chain	Residue
A	PHE60
A	LEU124

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 316

Chain	Residue
A	ARG183
A	ALA186
A	SER187
A	GLU189
A	HOH543

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 317

Chain	Residue
A	GLN206
A	SER209

---