4GTW
Crystal structure of mouse Enpp1 in complex with AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005044 | molecular_function | scavenger receptor activity |
| A | 0006955 | biological_process | immune response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030247 | molecular_function | polysaccharide binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0005044 | molecular_function | scavenger receptor activity |
| B | 0006955 | biological_process | immune response |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030247 | molecular_function | polysaccharide binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00524 |
| Number of Residues | 21 |
| Details | SMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvslgn.CClDFqetC |
| Chain | Residue | Details |
| A | CYS102-CYS122 | |
| A | CYS146-CYS166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5INH |
| Chain | Residue | Details |
| A | ASN53 | |
| B | ASN53 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: AMP-threonine intermediate => ECO:0000269|PubMed:11027689 |
| Chain | Residue | Details |
| A | THR238 | |
| B | THR238 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369, ECO:0000269|PubMed:30356045 |
| Chain | Residue | Details |
| A | ASP200 | |
| B | ASP405 | |
| B | HIS406 | |
| B | HIS517 | |
| A | ASP358 | |
| A | HIS362 | |
| A | ASP405 | |
| A | HIS406 | |
| A | HIS517 | |
| B | ASP200 | |
| B | ASP358 | |
| B | HIS362 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369 |
| Chain | Residue | Details |
| A | THR238 | |
| B | GLY785 | |
| B | TYR787 | |
| B | SER789 | |
| A | PHE781 | |
| A | TYR783 | |
| A | GLY785 | |
| A | TYR787 | |
| A | SER789 | |
| B | THR238 | |
| B | PHE781 | |
| B | TYR783 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23027977, ECO:0007744|PDB:4GTY |
| Chain | Residue | Details |
| A | ASN259 | |
| A | LEU272 | |
| A | LYS277 | |
| A | TYR322 | |
| B | ASN259 | |
| B | LEU272 | |
| B | LYS277 | |
| B | TYR322 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30356045 |
| Chain | Residue | Details |
| A | SER514 | |
| B | SER514 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6 |
| Chain | Residue | Details |
| A | THR896 | |
| B | THR896 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q924C3 |
| Chain | Residue | Details |
| A | THR238 | |
| B | THR238 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN161 | |
| B | ASN161 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23027977 |
| Chain | Residue | Details |
| A | ASN267 | |
| B | ASN267 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369 |
| Chain | Residue | Details |
| A | ASN323 | |
| B | ASN323 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23041369 |
| Chain | Residue | Details |
| A | ASN459 | |
| B | ASN459 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369 |
| Chain | Residue | Details |
| A | ASN567 | |
| B | ASN567 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23041369 |
| Chain | Residue | Details |
| A | ASN624 | |
| B | ASN624 |
