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4GMJ

Structure of human NOT1 MIF4G domain co-crystallized with CAF1

Functional Information from GO Data
ChainGOidnamespacecontents
A0017148biological_processnegative regulation of translation
A0030015cellular_componentCCR4-NOT core complex
B0000175molecular_function3'-5'-RNA exonuclease activity
B0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
B0000289biological_processnuclear-transcribed mRNA poly(A) tail shortening
B0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
B0000932cellular_componentP-body
B0003676molecular_functionnucleic acid binding
B0003714molecular_functiontranscription corepressor activity
B0003723molecular_functionRNA binding
B0004527molecular_functionexonuclease activity
B0004532molecular_functionRNA exonuclease activity
B0004535molecular_functionpoly(A)-specific ribonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006402biological_processmRNA catabolic process
B0006417biological_processregulation of translation
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0010629biological_processnegative regulation of gene expression
B0016020cellular_componentmembrane
B0016604cellular_componentnuclear body
B0016607cellular_componentnuclear speck
B0030014cellular_componentCCR4-NOT complex
B0030015cellular_componentCCR4-NOT core complex
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0033962biological_processP-body assembly
B0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
B0042509biological_processregulation of tyrosine phosphorylation of STAT protein
B0043232cellular_componentintracellular non-membrane-bounded organelle
B0045070biological_processpositive regulation of viral genome replication
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0051607biological_processdefense response to virus
B0060213biological_processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0061014biological_processpositive regulation of mRNA catabolic process
B0140297molecular_functionDNA-binding transcription factor binding
B1900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
C0017148biological_processnegative regulation of translation
C0030015cellular_componentCCR4-NOT core complex
D0000175molecular_function3'-5'-RNA exonuclease activity
D0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D0000289biological_processnuclear-transcribed mRNA poly(A) tail shortening
D0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
D0000932cellular_componentP-body
D0003676molecular_functionnucleic acid binding
D0003714molecular_functiontranscription corepressor activity
D0003723molecular_functionRNA binding
D0004527molecular_functionexonuclease activity
D0004532molecular_functionRNA exonuclease activity
D0004535molecular_functionpoly(A)-specific ribonuclease activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006402biological_processmRNA catabolic process
D0006417biological_processregulation of translation
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0010629biological_processnegative regulation of gene expression
D0016020cellular_componentmembrane
D0016604cellular_componentnuclear body
D0016607cellular_componentnuclear speck
D0030014cellular_componentCCR4-NOT complex
D0030015cellular_componentCCR4-NOT core complex
D0031047biological_processregulatory ncRNA-mediated gene silencing
D0033962biological_processP-body assembly
D0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
D0042509biological_processregulation of tyrosine phosphorylation of STAT protein
D0043232cellular_componentintracellular non-membrane-bounded organelle
D0045070biological_processpositive regulation of viral genome replication
D0045892biological_processnegative regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046872molecular_functionmetal ion binding
D0051607biological_processdefense response to virus
D0060213biological_processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
D0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
D0061014biological_processpositive regulation of mRNA catabolic process
D0140297molecular_functionDNA-binding transcription factor binding
D1900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
E0017148biological_processnegative regulation of translation
E0030015cellular_componentCCR4-NOT core complex
F0000175molecular_function3'-5'-RNA exonuclease activity
F0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
F0000289biological_processnuclear-transcribed mRNA poly(A) tail shortening
F0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
F0000932cellular_componentP-body
F0003676molecular_functionnucleic acid binding
F0003714molecular_functiontranscription corepressor activity
F0003723molecular_functionRNA binding
F0004527molecular_functionexonuclease activity
F0004532molecular_functionRNA exonuclease activity
F0004535molecular_functionpoly(A)-specific ribonuclease activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006402biological_processmRNA catabolic process
F0006417biological_processregulation of translation
F0008284biological_processpositive regulation of cell population proliferation
F0008285biological_processnegative regulation of cell population proliferation
F0010629biological_processnegative regulation of gene expression
F0016020cellular_componentmembrane
F0016604cellular_componentnuclear body
F0016607cellular_componentnuclear speck
F0030014cellular_componentCCR4-NOT complex
F0030015cellular_componentCCR4-NOT core complex
F0031047biological_processregulatory ncRNA-mediated gene silencing
F0033962biological_processP-body assembly
F0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
F0042509biological_processregulation of tyrosine phosphorylation of STAT protein
F0043232cellular_componentintracellular non-membrane-bounded organelle
F0045070biological_processpositive regulation of viral genome replication
F0045892biological_processnegative regulation of DNA-templated transcription
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046872molecular_functionmetal ion binding
F0051607biological_processdefense response to virus
F0060213biological_processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
F0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
F0061014biological_processpositive regulation of mRNA catabolic process
F0140297molecular_functionDNA-binding transcription factor binding
F1900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 301
ChainResidue
BASP40
BGLU278
BGOL303
BHOH407
BHOH408
BHOH409
BHOH410

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 302
ChainResidue
BASP230
BHOH409
BHOH411
BHOH412
BASP40
BGLU42

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 303
ChainResidue
BGLU42
BPHE43
BGLU278
BGLU280
BMG301
BHOH408

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL B 304
ChainResidue
BLYS73
BILE74
BLYS167

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 305
ChainResidue
BHOH401
BHOH402
BHOH403
BHOH404
BHOH405
BHOH406

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 301
ChainResidue
DGLU278
DHOH401
DHOH402
DHOH403
DHOH404

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 302
ChainResidue
DGLU42
DASP230
DHOH403
DHOH405
DHOH406

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL D 303
ChainResidue
DGLU42
DPHE43
DSER112
DGLU278

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL D 304
ChainResidue
DLYS73
DILE74
DLYS167

site_idBC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG F 301
ChainResidue
FASP40
FGLU278
FGOL303
FHOH407
FHOH408
FHOH409
FHOH410

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG F 302
ChainResidue
FASP40
FGLU42
FASP230
FHOH409
FHOH411
FHOH412

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL F 303
ChainResidue
FGLU42
FPHE43
FGLU278
FMG301

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL F 304
ChainResidue
FLYS73
FILE74
FLYS167

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG F 305
ChainResidue
FHOH401
FHOH402
FHOH403
FHOH404
FHOH405
FHOH406

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues15
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
BASP40
DGLU278
FASP40
FGLU42
FASP161
FASP230
FGLU278
BGLU42
BASP161
BASP230
BGLU278
DASP40
DGLU42
DASP161
DASP230

222415

PDB entries from 2024-07-10

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