Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001516 | biological_process | prostaglandin biosynthetic process |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0036130 | molecular_function | prostaglandin H2 endoperoxidase reductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 301 |
| Chain | Residue |
| A | TRP24 |
| A | TYR53 |
| A | HIS111 |
| A | TRP112 |
| A | NAP302 |
| A | HOH562 |
| site_id | AC2 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE NAP A 302 |
| Chain | Residue |
| A | ASP48 |
| A | TYR53 |
| A | HIS111 |
| A | TRP112 |
| A | SER140 |
| A | ASN141 |
| A | GLN162 |
| A | TRP188 |
| A | SER189 |
| A | PRO190 |
| A | LEU191 |
| A | GLY192 |
| A | SER193 |
| A | GLY194 |
| A | LEU200 |
| A | ALA217 |
| A | ILE232 |
| A | PRO233 |
| A | LYS234 |
| A | SER235 |
| A | THR236 |
| A | ARG240 |
| A | GLU243 |
| A | ASN244 |
| A | ACT301 |
| A | HOH405 |
| A | HOH471 |
| A | HOH588 |
| A | HOH598 |
| A | HOH602 |
| A | HOH637 |
| A | HOH658 |
| A | HOH684 |
| A | HOH757 |
| A | HOH762 |
| A | GLY22 |
| A | VAL23 |
| A | TRP24 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LeklyeekkVRAIGVSNF |
| Chain | Residue | Details |
| A | LEU125-PHE142 | |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSTNkgRIqENfNV |
| Chain | Residue | Details |
| A | ILE232-VAL247 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAyiysnErgVG |
| Chain | Residue | Details |
| A | GLY43-GLY60 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR53 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL23 | |
| A | ASP48 | |
| A | HIS111 | |
| A | SER140 | |
| A | GLN162 | |
| A | TRP188 | |
| A | LYS234 | |
| A | ARG240 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS78 | |
