4GGF

Crystal structure of Mn2+ bound calprotectin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002523	biological_process	leukocyte migration involved in inflammatory response
A	0002544	biological_process	chronic inflammatory response
A	0002790	biological_process	peptide secretion
A	0002793	biological_process	positive regulation of peptide secretion
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0008017	molecular_function	microtubule binding
A	0008270	molecular_function	zinc ion binding
A	0010043	biological_process	response to zinc ion
A	0014002	biological_process	astrocyte development
A	0018119	biological_process	peptidyl-cysteine S-nitrosylation
A	0030307	biological_process	positive regulation of cell growth
A	0030593	biological_process	neutrophil chemotaxis
A	0032119	biological_process	sequestering of zinc ion
A	0032496	biological_process	response to lipopolysaccharide
A	0034121	biological_process	regulation of toll-like receptor signaling pathway
A	0034774	cellular_component	secretory granule lumen
A	0035425	biological_process	autocrine signaling
A	0035662	molecular_function	Toll-like receptor 4 binding
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0045111	cellular_component	intermediate filament cytoskeleton
A	0045471	biological_process	response to ethanol
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050544	molecular_function	arachidonic acid binding
A	0050729	biological_process	positive regulation of inflammatory response
A	0050786	molecular_function	RAGE receptor binding
A	0050832	biological_process	defense response to fungus
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051493	biological_process	regulation of cytoskeleton organization
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
A	0070488	biological_process	neutrophil aggregation
A	1990660	cellular_component	calprotectin complex
A	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
C	0002523	biological_process	leukocyte migration involved in inflammatory response
C	0002544	biological_process	chronic inflammatory response
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0007267	biological_process	cell-cell signaling
C	0008017	molecular_function	microtubule binding
C	0008270	molecular_function	zinc ion binding
C	0010976	biological_process	positive regulation of neuron projection development
C	0014002	biological_process	astrocyte development
C	0016209	molecular_function	antioxidant activity
C	0030307	biological_process	positive regulation of cell growth
C	0030593	biological_process	neutrophil chemotaxis
C	0032119	biological_process	sequestering of zinc ion
C	0032496	biological_process	response to lipopolysaccharide
C	0034121	biological_process	regulation of toll-like receptor signaling pathway
C	0034774	cellular_component	secretory granule lumen
C	0035425	biological_process	autocrine signaling
C	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
C	0035662	molecular_function	Toll-like receptor 4 binding
C	0035821	biological_process	modulation of process of another organism
C	0042742	biological_process	defense response to bacterium
C	0043542	biological_process	endothelial cell migration
C	0045087	biological_process	innate immune response
C	0045113	biological_process	regulation of integrin biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050544	molecular_function	arachidonic acid binding
C	0050729	biological_process	positive regulation of inflammatory response
C	0050786	molecular_function	RAGE receptor binding
C	0050832	biological_process	defense response to fungus
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051493	biological_process	regulation of cytoskeleton organization
C	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
C	0070488	biological_process	neutrophil aggregation
C	0098869	biological_process	cellular oxidant detoxification
C	1990660	cellular_component	calprotectin complex
C	1990662	cellular_component	S100A9 complex
C	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
K	0002523	biological_process	leukocyte migration involved in inflammatory response
K	0002544	biological_process	chronic inflammatory response
K	0002790	biological_process	peptide secretion
K	0002793	biological_process	positive regulation of peptide secretion
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0006914	biological_process	autophagy
K	0006915	biological_process	apoptotic process
K	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
K	0006935	biological_process	chemotaxis
K	0006954	biological_process	inflammatory response
K	0008017	molecular_function	microtubule binding
K	0008270	molecular_function	zinc ion binding
K	0010043	biological_process	response to zinc ion
K	0014002	biological_process	astrocyte development
K	0018119	biological_process	peptidyl-cysteine S-nitrosylation
K	0030307	biological_process	positive regulation of cell growth
K	0030593	biological_process	neutrophil chemotaxis
K	0032119	biological_process	sequestering of zinc ion
K	0032496	biological_process	response to lipopolysaccharide
K	0034121	biological_process	regulation of toll-like receptor signaling pathway
K	0034774	cellular_component	secretory granule lumen
K	0035425	biological_process	autocrine signaling
K	0035662	molecular_function	Toll-like receptor 4 binding
K	0042742	biological_process	defense response to bacterium
K	0045087	biological_process	innate immune response
K	0045111	cellular_component	intermediate filament cytoskeleton
K	0045471	biological_process	response to ethanol
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0050544	molecular_function	arachidonic acid binding
K	0050729	biological_process	positive regulation of inflammatory response
K	0050786	molecular_function	RAGE receptor binding
K	0050832	biological_process	defense response to fungus
K	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
K	0051493	biological_process	regulation of cytoskeleton organization
K	0062023	cellular_component	collagen-containing extracellular matrix
K	0070062	cellular_component	extracellular exosome
K	0070488	biological_process	neutrophil aggregation
K	1990660	cellular_component	calprotectin complex
K	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
L	0002523	biological_process	leukocyte migration involved in inflammatory response
L	0002544	biological_process	chronic inflammatory response
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0006914	biological_process	autophagy
L	0006915	biological_process	apoptotic process
L	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
L	0006935	biological_process	chemotaxis
L	0006954	biological_process	inflammatory response
L	0007267	biological_process	cell-cell signaling
L	0008017	molecular_function	microtubule binding
L	0008270	molecular_function	zinc ion binding
L	0010976	biological_process	positive regulation of neuron projection development
L	0014002	biological_process	astrocyte development
L	0016209	molecular_function	antioxidant activity
L	0030307	biological_process	positive regulation of cell growth
L	0030593	biological_process	neutrophil chemotaxis
L	0032119	biological_process	sequestering of zinc ion
L	0032496	biological_process	response to lipopolysaccharide
L	0034121	biological_process	regulation of toll-like receptor signaling pathway
L	0034774	cellular_component	secretory granule lumen
L	0035425	biological_process	autocrine signaling
L	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
L	0035662	molecular_function	Toll-like receptor 4 binding
L	0035821	biological_process	modulation of process of another organism
L	0042742	biological_process	defense response to bacterium
L	0043542	biological_process	endothelial cell migration
L	0045087	biological_process	innate immune response
L	0045113	biological_process	regulation of integrin biosynthetic process
L	0046872	molecular_function	metal ion binding
L	0048306	molecular_function	calcium-dependent protein binding
L	0050544	molecular_function	arachidonic acid binding
L	0050729	biological_process	positive regulation of inflammatory response
L	0050786	molecular_function	RAGE receptor binding
L	0050832	biological_process	defense response to fungus
L	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
L	0051493	biological_process	regulation of cytoskeleton organization
L	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
L	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
L	0062023	cellular_component	collagen-containing extracellular matrix
L	0070062	cellular_component	extracellular exosome
L	0070488	biological_process	neutrophil aggregation
L	0098869	biological_process	cellular oxidant detoxification
L	1990660	cellular_component	calprotectin complex
L	1990662	cellular_component	S100A9 complex
L	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
S	0002523	biological_process	leukocyte migration involved in inflammatory response
S	0002544	biological_process	chronic inflammatory response
S	0002790	biological_process	peptide secretion
S	0002793	biological_process	positive regulation of peptide secretion
S	0005509	molecular_function	calcium ion binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005886	cellular_component	plasma membrane
S	0006914	biological_process	autophagy
S	0006915	biological_process	apoptotic process
S	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
S	0006935	biological_process	chemotaxis
S	0006954	biological_process	inflammatory response
S	0008017	molecular_function	microtubule binding
S	0008270	molecular_function	zinc ion binding
S	0010043	biological_process	response to zinc ion
S	0014002	biological_process	astrocyte development
S	0018119	biological_process	peptidyl-cysteine S-nitrosylation
S	0030307	biological_process	positive regulation of cell growth
S	0030593	biological_process	neutrophil chemotaxis
S	0032119	biological_process	sequestering of zinc ion
S	0032496	biological_process	response to lipopolysaccharide
S	0034121	biological_process	regulation of toll-like receptor signaling pathway
S	0034774	cellular_component	secretory granule lumen
S	0035425	biological_process	autocrine signaling
S	0035662	molecular_function	Toll-like receptor 4 binding
S	0042742	biological_process	defense response to bacterium
S	0045087	biological_process	innate immune response
S	0045111	cellular_component	intermediate filament cytoskeleton
S	0045471	biological_process	response to ethanol
S	0046872	molecular_function	metal ion binding
S	0048306	molecular_function	calcium-dependent protein binding
S	0050544	molecular_function	arachidonic acid binding
S	0050729	biological_process	positive regulation of inflammatory response
S	0050786	molecular_function	RAGE receptor binding
S	0050832	biological_process	defense response to fungus
S	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
S	0051493	biological_process	regulation of cytoskeleton organization
S	0062023	cellular_component	collagen-containing extracellular matrix
S	0070062	cellular_component	extracellular exosome
S	0070488	biological_process	neutrophil aggregation
S	1990660	cellular_component	calprotectin complex
S	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
T	0002523	biological_process	leukocyte migration involved in inflammatory response
T	0002544	biological_process	chronic inflammatory response
T	0005509	molecular_function	calcium ion binding
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005886	cellular_component	plasma membrane
T	0006914	biological_process	autophagy
T	0006915	biological_process	apoptotic process
T	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
T	0006935	biological_process	chemotaxis
T	0006954	biological_process	inflammatory response
T	0007267	biological_process	cell-cell signaling
T	0008017	molecular_function	microtubule binding
T	0008270	molecular_function	zinc ion binding
T	0010976	biological_process	positive regulation of neuron projection development
T	0014002	biological_process	astrocyte development
T	0016209	molecular_function	antioxidant activity
T	0030307	biological_process	positive regulation of cell growth
T	0030593	biological_process	neutrophil chemotaxis
T	0032119	biological_process	sequestering of zinc ion
T	0032496	biological_process	response to lipopolysaccharide
T	0034121	biological_process	regulation of toll-like receptor signaling pathway
T	0034774	cellular_component	secretory granule lumen
T	0035425	biological_process	autocrine signaling
T	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
T	0035662	molecular_function	Toll-like receptor 4 binding
T	0035821	biological_process	modulation of process of another organism
T	0042742	biological_process	defense response to bacterium
T	0043542	biological_process	endothelial cell migration
T	0045087	biological_process	innate immune response
T	0045113	biological_process	regulation of integrin biosynthetic process
T	0046872	molecular_function	metal ion binding
T	0048306	molecular_function	calcium-dependent protein binding
T	0050544	molecular_function	arachidonic acid binding
T	0050729	biological_process	positive regulation of inflammatory response
T	0050786	molecular_function	RAGE receptor binding
T	0050832	biological_process	defense response to fungus
T	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
T	0051493	biological_process	regulation of cytoskeleton organization
T	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
T	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
T	0062023	cellular_component	collagen-containing extracellular matrix
T	0070062	cellular_component	extracellular exosome
T	0070488	biological_process	neutrophil aggregation
T	0098869	biological_process	cellular oxidant detoxification
T	1990660	cellular_component	calprotectin complex
T	1990662	cellular_component	S100A9 complex
T	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
U	0002523	biological_process	leukocyte migration involved in inflammatory response
U	0002544	biological_process	chronic inflammatory response
U	0002790	biological_process	peptide secretion
U	0002793	biological_process	positive regulation of peptide secretion
U	0005509	molecular_function	calcium ion binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005615	cellular_component	extracellular space
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005856	cellular_component	cytoskeleton
U	0005886	cellular_component	plasma membrane
U	0006914	biological_process	autophagy
U	0006915	biological_process	apoptotic process
U	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
U	0006935	biological_process	chemotaxis
U	0006954	biological_process	inflammatory response
U	0008017	molecular_function	microtubule binding
U	0008270	molecular_function	zinc ion binding
U	0010043	biological_process	response to zinc ion
U	0014002	biological_process	astrocyte development
U	0018119	biological_process	peptidyl-cysteine S-nitrosylation
U	0030307	biological_process	positive regulation of cell growth
U	0030593	biological_process	neutrophil chemotaxis
U	0032119	biological_process	sequestering of zinc ion
U	0032496	biological_process	response to lipopolysaccharide
U	0034121	biological_process	regulation of toll-like receptor signaling pathway
U	0034774	cellular_component	secretory granule lumen
U	0035425	biological_process	autocrine signaling
U	0035662	molecular_function	Toll-like receptor 4 binding
U	0042742	biological_process	defense response to bacterium
U	0045087	biological_process	innate immune response
U	0045111	cellular_component	intermediate filament cytoskeleton
U	0045471	biological_process	response to ethanol
U	0046872	molecular_function	metal ion binding
U	0048306	molecular_function	calcium-dependent protein binding
U	0050544	molecular_function	arachidonic acid binding
U	0050729	biological_process	positive regulation of inflammatory response
U	0050786	molecular_function	RAGE receptor binding
U	0050832	biological_process	defense response to fungus
U	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
U	0051493	biological_process	regulation of cytoskeleton organization
U	0062023	cellular_component	collagen-containing extracellular matrix
U	0070062	cellular_component	extracellular exosome
U	0070488	biological_process	neutrophil aggregation
U	1990660	cellular_component	calprotectin complex
U	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
V	0002523	biological_process	leukocyte migration involved in inflammatory response
V	0002544	biological_process	chronic inflammatory response
V	0005509	molecular_function	calcium ion binding
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005615	cellular_component	extracellular space
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005856	cellular_component	cytoskeleton
V	0005886	cellular_component	plasma membrane
V	0006914	biological_process	autophagy
V	0006915	biological_process	apoptotic process
V	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
V	0006935	biological_process	chemotaxis
V	0006954	biological_process	inflammatory response
V	0007267	biological_process	cell-cell signaling
V	0008017	molecular_function	microtubule binding
V	0008270	molecular_function	zinc ion binding
V	0010976	biological_process	positive regulation of neuron projection development
V	0014002	biological_process	astrocyte development
V	0016209	molecular_function	antioxidant activity
V	0030307	biological_process	positive regulation of cell growth
V	0030593	biological_process	neutrophil chemotaxis
V	0032119	biological_process	sequestering of zinc ion
V	0032496	biological_process	response to lipopolysaccharide
V	0034121	biological_process	regulation of toll-like receptor signaling pathway
V	0034774	cellular_component	secretory granule lumen
V	0035425	biological_process	autocrine signaling
V	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
V	0035662	molecular_function	Toll-like receptor 4 binding
V	0035821	biological_process	modulation of process of another organism
V	0042742	biological_process	defense response to bacterium
V	0043542	biological_process	endothelial cell migration
V	0045087	biological_process	innate immune response
V	0045113	biological_process	regulation of integrin biosynthetic process
V	0046872	molecular_function	metal ion binding
V	0048306	molecular_function	calcium-dependent protein binding
V	0050544	molecular_function	arachidonic acid binding
V	0050729	biological_process	positive regulation of inflammatory response
V	0050786	molecular_function	RAGE receptor binding
V	0050832	biological_process	defense response to fungus
V	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
V	0051493	biological_process	regulation of cytoskeleton organization
V	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
V	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
V	0062023	cellular_component	collagen-containing extracellular matrix
V	0070062	cellular_component	extracellular exosome
V	0070488	biological_process	neutrophil aggregation
V	0098869	biological_process	cellular oxidant detoxification
V	1990660	cellular_component	calprotectin complex
V	1990662	cellular_component	S100A9 complex
V	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 101

Chain	Residue
A	ASP59
A	ASN61
A	ASP63
A	ALA65
A	GLU70
A	HOH203

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 201

Chain	Residue
C	HIS95
C	HIS103
C	HIS105
A	HIS17
A	HIS27
C	HIS91

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 202

Chain	Residue
A	HIS83
A	HIS87
C	HIS20
C	ASP30
C	HOH380

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 203

Chain	Residue
C	ASP67
C	ASN69
C	ASP71
C	GLN73
C	GLU78
C	HOH305

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 204

Chain	Residue
C	SER23
C	LEU26
C	HIS28
C	THR31
C	GLU36
C	HOH327

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 205

Chain	Residue
C	HIS91
C	GLU92
C	HIS95
C	HOH308
C	HOH349
C	HOH353
L	ASP65
L	ARG85

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 K 101

Chain	Residue
K	LYS35
K	GLY50
K	ALA51
K	ASP52
K	HOH245

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 102

Chain	Residue
K	ASP59
K	ASN61
K	ASP63
K	ALA65
K	GLU70
K	HOH240

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL K 103

Chain	Residue
A	GLU57
A	ILE73
A	HOH207
K	GLU57
K	ILE60
K	ILE73
K	LYS77
K	HOH255

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN L 201

Chain	Residue
K	HIS83
K	HIS87
L	HIS20
L	ASP30
L	HOH357

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN L 202

Chain	Residue
K	HIS17
K	HIS27
L	HIS91
L	HIS95
L	HIS103
L	HIS105

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 203

Chain	Residue
L	GLY27
L	HIS28
L	ASN33
L	GLN73
L	HOH317

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 204

Chain	Residue
L	ASP67
L	ASN69
L	ASP71
L	GLN73
L	GLU78
L	HOH354

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 205

Chain	Residue
L	SER23
L	LEU26
L	HIS28
L	THR31
L	GLU36
L	HOH317

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA S 101

Chain	Residue
S	ASP59
S	ASN61
S	ASP63
S	ALA65
S	GLU70
S	HOH235

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL S 102

Chain	Residue
S	LYS35
S	GLY50
S	ALA51
S	ASP52
S	HOH239

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL S 103

Chain	Residue
S	HOH201
S	HOH233
K	ASP32
K	HOH211
S	ARG31
S	GLY64

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN T 201

Chain	Residue
S	HIS17
S	HIS27
T	HIS91
T	HIS95
T	HIS103
T	HIS105

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN T 202

Chain	Residue
S	HIS83
S	HIS87
T	HIS20
T	ASP30
T	HOH370

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA T 203

Chain	Residue
T	SER23
T	LEU26
T	HIS28
T	THR31
T	GLU36
T	HOH317

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA T 204

Chain	Residue
T	ASP67
T	ASN69
T	ASP71
T	GLN73
T	GLU78
T	HOH343

---

site_id	CC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GOL T 205

Chain	Residue
S	HIS27
S	PHE68
S	GLN69
S	HOH255
T	TRP88
T	HIS91
T	GLU92
T	HIS95
T	HOH326
T	HOH375
V	ASP65
V	ARG85
V	HOH331

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL T 206

Chain	Residue
T	GLY27
T	HIS28
T	ASN33
T	GLN73

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA U 101

Chain	Residue
U	ASP59
U	ASN61
U	ASP63
U	ALA65
U	GLU70
U	HOH216

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN V 201

Chain	Residue
U	HIS17
U	HIS27
V	HIS91
V	HIS95
V	HIS103
V	HIS105

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 V 202

Chain	Residue
V	GLY27
V	HIS28
V	ASN33
V	GLN73
V	HOH316

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA V 203

Chain	Residue
V	ASP67
V	ASN69
V	ASP71
V	GLN73
V	GLU78
V	HOH327

---

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA V 204

Chain	Residue
V	SER23
V	LEU26
V	HIS28
V	THR31
V	GLU36
V	HOH316

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DINTDGAVNfqEF

Chain	Residue	Details
A	ASP59-PHE71
C	ASP67-PHE79

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. WFkeLDintDgavNFqEFliLV

Chain	Residue	Details
A	TRP54-VAL75
C	ILE62-MET83

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000305|PubMed:17553524

Chain	Residue	Details
C	HIS20
T	ASP30
T	HIS91
T	HIS95
V	HIS20
V	ASP30
V	HIS91
V	HIS95
U	HIS27
U	ASP33
U	HIS83
C	ASP30
U	HIS87
C	HIS91
C	HIS95
L	HIS20
L	ASP30
L	HIS91
L	HIS95
T	HIS20

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4

Chain	Residue	Details
C	SER23
L	GLU36
T	SER23
T	LEU26
T	HIS28
T	THR31
T	GLU36
V	SER23
V	LEU26
V	HIS28
V	THR31
C	LEU26
V	GLU36
C	HIS28
C	THR31
C	GLU36
L	SER23
L	LEU26
L	HIS28
L	THR31

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4

Chain	Residue	Details
C	ASP67
L	GLU78
T	ASP67
T	ASN69
T	ASP71
T	GLN73
T	GLU78
V	ASP67
V	ASN69
V	ASP71
V	GLN73
C	ASN69
V	GLU78
C	ASP71
C	GLN73
C	GLU78
L	ASP67
L	ASN69
L	ASP71
L	GLN73

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Blocked amino end (Thr)

Chain	Residue	Details
C	THR2
L	THR2
T	THR2
V	THR2

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine; transient => ECO:0000305|PubMed:25417112

Chain	Residue	Details
C	SER3
L	SER3
T	SER3
V	SER3

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Pros-methylhistidine => ECO:0000250|UniProtKB:P50116

Chain	Residue	Details
C	HIS105
L	HIS105
T	HIS105
V	HIS105

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:2478889, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	THR113
L	THR113
T	THR113
V	THR113

---