4GDL

Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0005737	cellular_component	cytoplasm
B	0000045	biological_process	autophagosome assembly
B	0000423	biological_process	mitophagy
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005776	cellular_component	autophagosome
B	0005829	cellular_component	cytosol
B	0005930	cellular_component	axoneme
B	0006914	biological_process	autophagy
B	0006915	biological_process	apoptotic process
B	0006995	biological_process	cellular response to nitrogen starvation
B	0010040	biological_process	response to iron(II) ion
B	0010508	biological_process	positive regulation of autophagy
B	0016020	cellular_component	membrane
B	0016236	biological_process	macroautophagy
B	0019776	molecular_function	Atg8-family ligase activity
B	0030424	cellular_component	axon
B	0030670	cellular_component	phagocytic vesicle membrane
B	0032480	biological_process	negative regulation of type I interferon production
B	0032991	cellular_component	protein-containing complex
B	0034045	cellular_component	phagophore assembly site membrane
B	0034274	cellular_component	Atg12-Atg5-Atg16 complex
B	0034727	biological_process	piecemeal microautophagy of the nucleus
B	0035973	biological_process	aggrephagy
B	0043066	biological_process	negative regulation of apoptotic process
B	0043069	biological_process	negative regulation of programmed cell death
B	0043687	biological_process	post-translational protein modification
B	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
B	0045202	cellular_component	synapse
B	0045824	biological_process	negative regulation of innate immune response
B	0050687	biological_process	negative regulation of defense response to virus
B	0061684	biological_process	chaperone-mediated autophagy
B	0061908	cellular_component	phagophore
B	0062029	biological_process	positive regulation of stress granule assembly
B	0071500	biological_process	cellular response to nitrosative stress
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098794	cellular_component	postsynapse
B	0098930	biological_process	axonal transport
B	0098978	cellular_component	glutamatergic synapse
B	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
B	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
B	1901096	biological_process	regulation of autophagosome maturation
B	1902017	biological_process	regulation of cilium assembly
B	1902617	biological_process	response to fluoride
B	1904093	biological_process	negative regulation of autophagic cell death
B	1904973	biological_process	positive regulation of viral translation
B	1990234	cellular_component	transferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 301

Chain	Residue
B	ALA95
B	PRO97
B	ASN99

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-130 in ATG5)","evidences":[{"source":"PubMed","id":"23202584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Region: {"description":"Interaction with ATG5","evidences":[{"source":"PubMed","id":"25484072","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---