4FLC

Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0003824	molecular_function	catalytic activity
A	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006167	biological_process	AMP biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0007584	biological_process	response to nutrient
A	0009060	biological_process	aerobic respiration
A	0009152	biological_process	purine ribonucleotide biosynthetic process
A	0014850	biological_process	response to muscle activity
A	0016829	molecular_function	lyase activity
A	0032991	cellular_component	protein-containing complex
A	0042594	biological_process	response to starvation
A	0042802	molecular_function	identical protein binding
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0044209	biological_process	AMP salvage
A	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
A	0097294	biological_process	'de novo' XMP biosynthetic process
B	0001666	biological_process	response to hypoxia
B	0003824	molecular_function	catalytic activity
B	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006167	biological_process	AMP biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0007584	biological_process	response to nutrient
B	0009060	biological_process	aerobic respiration
B	0009152	biological_process	purine ribonucleotide biosynthetic process
B	0014850	biological_process	response to muscle activity
B	0016829	molecular_function	lyase activity
B	0032991	cellular_component	protein-containing complex
B	0042594	biological_process	response to starvation
B	0042802	molecular_function	identical protein binding
B	0044208	biological_process	'de novo' AMP biosynthetic process
B	0044209	biological_process	AMP salvage
B	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
B	0097294	biological_process	'de novo' XMP biosynthetic process
C	0001666	biological_process	response to hypoxia
C	0003824	molecular_function	catalytic activity
C	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006167	biological_process	AMP biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0006189	biological_process	'de novo' IMP biosynthetic process
C	0007584	biological_process	response to nutrient
C	0009060	biological_process	aerobic respiration
C	0009152	biological_process	purine ribonucleotide biosynthetic process
C	0014850	biological_process	response to muscle activity
C	0016829	molecular_function	lyase activity
C	0032991	cellular_component	protein-containing complex
C	0042594	biological_process	response to starvation
C	0042802	molecular_function	identical protein binding
C	0044208	biological_process	'de novo' AMP biosynthetic process
C	0044209	biological_process	AMP salvage
C	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
C	0097294	biological_process	'de novo' XMP biosynthetic process
D	0001666	biological_process	response to hypoxia
D	0003824	molecular_function	catalytic activity
D	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006167	biological_process	AMP biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0006189	biological_process	'de novo' IMP biosynthetic process
D	0007584	biological_process	response to nutrient
D	0009060	biological_process	aerobic respiration
D	0009152	biological_process	purine ribonucleotide biosynthetic process
D	0014850	biological_process	response to muscle activity
D	0016829	molecular_function	lyase activity
D	0032991	cellular_component	protein-containing complex
D	0042594	biological_process	response to starvation
D	0042802	molecular_function	identical protein binding
D	0044208	biological_process	'de novo' AMP biosynthetic process
D	0044209	biological_process	AMP salvage
D	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
D	0097294	biological_process	'de novo' XMP biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00163
Number of Residues	10
Details	FUMARATE_LYASES Fumarate lyases signature. GSsaMpYKrN

Chain	Residue	Details
A	GLY288-ASN297

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22812634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"description":"in other chain"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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