4FK5
Structure of the SAGA Ubp8(S144N)/Sgf11/Sus1/Sgf73 DUB module
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000124 | cellular_component | SAGA complex |
A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
A | 0006508 | biological_process | proteolysis |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008380 | biological_process | RNA splicing |
A | 0016579 | biological_process | protein deubiquitination |
A | 0046695 | cellular_component | SLIK (SAGA-like) complex |
A | 0046872 | molecular_function | metal ion binding |
A | 0060090 | molecular_function | molecular adaptor activity |
A | 0071819 | cellular_component | DUBm complex |
B | 0000124 | cellular_component | SAGA complex |
B | 0000932 | cellular_component | P-body |
B | 0000973 | biological_process | post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery |
B | 0003682 | molecular_function | chromatin binding |
B | 0003713 | molecular_function | transcription coactivator activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005643 | cellular_component | nuclear pore |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0006325 | biological_process | chromatin organization |
B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
B | 0006406 | biological_process | mRNA export from nucleus |
B | 0008047 | molecular_function | enzyme activator activity |
B | 0015031 | biological_process | protein transport |
B | 0016973 | biological_process | poly(A)+ mRNA export from nucleus |
B | 0032880 | biological_process | regulation of protein localization |
B | 0043229 | cellular_component | intracellular organelle |
B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
B | 0046695 | cellular_component | SLIK (SAGA-like) complex |
B | 0051028 | biological_process | mRNA transport |
B | 0070390 | cellular_component | transcription export complex 2 |
B | 0071028 | biological_process | nuclear mRNA surveillance |
B | 0071819 | cellular_component | DUBm complex |
C | 0000124 | cellular_component | SAGA complex |
C | 0003713 | molecular_function | transcription coactivator activity |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0006325 | biological_process | chromatin organization |
C | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
C | 0008047 | molecular_function | enzyme activator activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
C | 0046695 | cellular_component | SLIK (SAGA-like) complex |
C | 0046872 | molecular_function | metal ion binding |
C | 0070461 | cellular_component | SAGA-type complex |
C | 0071819 | cellular_component | DUBm complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 501 |
Chain | Residue |
A | CYS4 |
A | HIS6 |
A | CYS96 |
A | CYS99 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 502 |
Chain | Residue |
A | CYS46 |
A | CYS49 |
A | CYS68 |
A | HIS73 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 503 |
Chain | Residue |
A | CYS63 |
A | HIS77 |
A | HIS83 |
A | CYS60 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 504 |
Chain | Residue |
A | HIS170 |
A | CYS174 |
A | CYS182 |
A | CYS185 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 505 |
Chain | Residue |
A | HIS250 |
A | CYS271 |
A | CYS273 |
A | HIS276 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 506 |
Chain | Residue |
A | CYS289 |
A | CYS292 |
A | CYS336 |
A | CYS339 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 507 |
Chain | Residue |
A | ASN387 |
A | ASN390 |
A | HOH608 |
A | HOH839 |
A | HOH841 |
B | GLN35 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 508 |
Chain | Residue |
A | ASN25 |
A | ALA26 |
A | HOH760 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 101 |
Chain | Residue |
C | CYS73 |
C | CYS76 |
C | HIS88 |
C | CYS92 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL C 102 |
Chain | Residue |
A | GLY104 |
C | THR33 |
C | GLN34 |
C | LEU37 |
C | HOH245 |
E | LYS71 |
E | HOH253 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN E 101 |
Chain | Residue |
E | CYS78 |
E | CYS81 |
E | HIS93 |
Functional Information from PROSITE/UniProt
site_id | PS00972 |
Number of Residues | 16 |
Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLinmGNtCFMSSiLQ |
Chain | Residue | Details |
A | GLY138-GLN153 |
site_id | PS00973 |
Number of Residues | 18 |
Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YeLiGIvsHkGtvne..GHY |
Chain | Residue | Details |
A | TYR411-TYR428 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 21 |
Details | ZN_FING: SGF11-type => ECO:0000255|HAMAP-Rule:MF_03047 |
Chain | Residue | Details |
C | ILE71-CYS92 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | CYS146 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093 |
Chain | Residue | Details |
A | HIS427 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00502 |
Chain | Residue | Details |
A | CYS46 | |
A | CYS49 | |
A | CYS60 | |
A | CYS63 | |
A | CYS68 | |
A | HIS73 | |
A | HIS77 | |
A | HIS83 |