4F7Z
Conformational dynamics of exchange protein directly activated by cAMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006887 | biological_process | exocytosis |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0007265 | biological_process | Ras protein signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0017156 | biological_process | calcium-ion regulated exocytosis |
| A | 0017157 | biological_process | regulation of exocytosis |
| A | 0030073 | biological_process | insulin secretion |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0046879 | biological_process | hormone secretion |
| A | 0050714 | biological_process | positive regulation of protein secretion |
| A | 0050796 | biological_process | regulation of insulin secretion |
| A | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
| A | 0098693 | biological_process | regulation of synaptic vesicle cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1001 |
| Chain | Residue |
| A | PHE71 |
| A | GLY114 |
| A | SER116 |
| A | ARG123 |
| A | HIS124 |
| A | ALA125 |
| A | GOL1004 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1002 |
| Chain | Residue |
| A | MET243 |
| A | GLY305 |
| A | PRO306 |
| A | HIS309 |
| A | GLN239 |
| A | GLY242 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1003 |
| Chain | Residue |
| A | SER754 |
| A | SER755 |
| A | LYS828 |
| A | LYS831 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1004 |
| Chain | Residue |
| A | PHE113 |
| A | GLY114 |
| A | GLU115 |
| A | SER116 |
| A | HIS124 |
| A | TYR162 |
| A | VAL393 |
| A | VAL394 |
| A | GOL1001 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1005 |
| Chain | Residue |
| A | ARG151 |
| A | GLN152 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1006 |
| Chain | Residue |
| A | PRO645 |
| A | ARG647 |
| A | ASN771 |
| A | CYS772 |
| A | VAL773 |
| A | HIS774 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1007 |
| Chain | Residue |
| A | HIS917 |
| A | LYS921 |
| A | THR922 |
Functional Information from PROSITE/UniProt
| site_id | PS00720 |
| Number of Residues | 30 |
| Details | RASGEF Ras Guanine-nucleotide exchange factors domain signature. IPFmPllIkDMtfthegnktfidnl.....................VNFeK |
| Chain | Residue | Details |
| A | ILE903-LYS932 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O95398 |
| Chain | Residue | Details |
| A | GLU422 | |
| A | LYS432 |
