4F7Z

Conformational dynamics of exchange protein directly activated by cAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001750	cellular_component	photoreceptor outer segment
A	0001917	cellular_component	photoreceptor inner segment
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005903	cellular_component	brush border
A	0006887	biological_process	exocytosis
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0014069	cellular_component	postsynaptic density
A	0014911	biological_process	positive regulation of smooth muscle cell migration
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0017156	biological_process	calcium-ion regulated exocytosis
A	0017157	biological_process	regulation of exocytosis
A	0030073	biological_process	insulin secretion
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030426	cellular_component	growth cone
A	0030552	molecular_function	cAMP binding
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031267	molecular_function	small GTPase binding
A	0032991	cellular_component	protein-containing complex
A	0035556	biological_process	intracellular signal transduction
A	0043025	cellular_component	neuronal cell body
A	0043197	cellular_component	dendritic spine
A	0044316	cellular_component	cone cell pedicle
A	0044877	molecular_function	protein-containing complex binding
A	0046879	biological_process	hormone secretion
A	0050714	biological_process	positive regulation of protein secretion
A	0050773	biological_process	regulation of dendrite development
A	0050796	biological_process	regulation of insulin secretion
A	0050805	biological_process	negative regulation of synaptic transmission
A	0060076	cellular_component	excitatory synapse
A	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
A	0098693	biological_process	regulation of synaptic vesicle cycle
A	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099175	biological_process	regulation of postsynapse organization
A	1904457	biological_process	positive regulation of neuronal action potential

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1001

Chain	Residue
A	PHE71
A	GLY114
A	SER116
A	ARG123
A	HIS124
A	ALA125
A	GOL1004

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1002

Chain	Residue
A	MET243
A	GLY305
A	PRO306
A	HIS309
A	GLN239
A	GLY242

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1003

Chain	Residue
A	SER754
A	SER755
A	LYS828
A	LYS831

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1004

Chain	Residue
A	PHE113
A	GLY114
A	GLU115
A	SER116
A	HIS124
A	TYR162
A	VAL393
A	VAL394
A	GOL1001

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1005

Chain	Residue
A	ARG151
A	GLN152

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1006

Chain	Residue
A	PRO645
A	ARG647
A	ASN771
A	CYS772
A	VAL773
A	HIS774

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1007

Chain	Residue
A	HIS917
A	LYS921
A	THR922

---

Functional Information from PROSITE/UniProt

site_id	PS00720
Number of Residues	30
Details	RASGEF Ras Guanine-nucleotide exchange factors domain signature. IPFmPllIkDMtfthegnktfidnl.....................VNFeK

Chain	Residue	Details
A	ILE903-LYS932

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	75
Details	Domain: {"description":"DEP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O95398","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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