4F1H

Crystal structure of TDP2 from Danio rerio complexed with a single strand DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 C 101

Chain	Residue
C	DG5

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	HOH763
B	LEU178
A	GLN299
A	HIS301
A	CYS302
A	HIS342
A	MET343
A	HOH517
A	HOH670
A	HOH762

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	GLU161
A	HOH531
A	HOH678
C	DT1

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	GLY186
A	TYR187
A	PHE200
A	LEU201
A	MET213
A	MET214
A	HOH505
A	HOH560
A	HOH598
A	HOH772

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 401

Chain	Residue
B	ARG303
B	ARG323
B	ARG326
B	HOH675
B	HOH782

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 402

Chain	Residue
B	LEU138
B	ALA165
B	TYR166

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"UniProtKB","id":"Q9JJX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104058","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"O95551","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9JJX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23104058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FPV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"UniProtKB","id":"Q9JJX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104058","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---