4EDF
Dimeric hUGDH, K94E
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001702 | biological_process | gastrulation with mouth forming second |
A | 0003824 | molecular_function | catalytic activity |
A | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
A | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0034214 | biological_process | protein hexamerization |
A | 0042802 | molecular_function | identical protein binding |
A | 0048666 | biological_process | neuron development |
A | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
A | 0051287 | molecular_function | NAD binding |
A | 0070062 | cellular_component | extracellular exosome |
B | 0001702 | biological_process | gastrulation with mouth forming second |
B | 0003824 | molecular_function | catalytic activity |
B | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
B | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0034214 | biological_process | protein hexamerization |
B | 0042802 | molecular_function | identical protein binding |
B | 0048666 | biological_process | neuron development |
B | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
B | 0051287 | molecular_function | NAD binding |
B | 0070062 | cellular_component | extracellular exosome |
C | 0001702 | biological_process | gastrulation with mouth forming second |
C | 0003824 | molecular_function | catalytic activity |
C | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
C | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
C | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0034214 | biological_process | protein hexamerization |
C | 0042802 | molecular_function | identical protein binding |
C | 0048666 | biological_process | neuron development |
C | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
C | 0051287 | molecular_function | NAD binding |
C | 0070062 | cellular_component | extracellular exosome |
D | 0001702 | biological_process | gastrulation with mouth forming second |
D | 0003824 | molecular_function | catalytic activity |
D | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
D | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
D | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0034214 | biological_process | protein hexamerization |
D | 0042802 | molecular_function | identical protein binding |
D | 0048666 | biological_process | neuron development |
D | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
D | 0051287 | molecular_function | NAD binding |
D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE UPG A 501 |
Chain | Residue |
A | GLU161 |
A | LEU266 |
A | LYS267 |
A | SER269 |
A | PHE272 |
A | GLY273 |
A | CYS276 |
A | PHE277 |
A | PHE338 |
A | LYS339 |
A | ARG442 |
A | PHE162 |
A | HOH604 |
D | ARG260 |
D | HOH605 |
A | LEU163 |
A | ALA164 |
A | GLU165 |
A | LYS220 |
A | ASN224 |
A | ILE231 |
A | PHE265 |
site_id | AC2 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE UPG B 501 |
Chain | Residue |
B | GLU161 |
B | PHE162 |
B | LEU163 |
B | ALA164 |
B | GLU165 |
B | LYS220 |
B | ASN224 |
B | ILE231 |
B | PHE265 |
B | LEU266 |
B | LYS267 |
B | SER269 |
B | PHE272 |
B | GLY273 |
B | CYS276 |
B | PHE277 |
B | PHE338 |
B | LYS339 |
B | ARG442 |
B | HOH601 |
B | HOH604 |
C | ARG260 |
site_id | AC3 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE UPG C 501 |
Chain | Residue |
B | ARG260 |
C | GLU161 |
C | PHE162 |
C | LEU163 |
C | ALA164 |
C | GLU165 |
C | LYS220 |
C | ASN224 |
C | LEU227 |
C | ILE231 |
C | PHE265 |
C | LEU266 |
C | LYS267 |
C | SER269 |
C | PHE272 |
C | GLY273 |
C | CYS276 |
C | PHE277 |
C | PHE338 |
C | LYS339 |
C | ARG442 |
C | HOH603 |
site_id | AC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE UPG D 501 |
Chain | Residue |
A | ARG260 |
A | HOH607 |
D | GLU161 |
D | PHE162 |
D | LEU163 |
D | ALA164 |
D | GLU165 |
D | LYS220 |
D | ASN224 |
D | LEU227 |
D | ILE231 |
D | PHE265 |
D | LEU266 |
D | LYS267 |
D | SER269 |
D | PHE272 |
D | GLY273 |
D | CYS276 |
D | PHE277 |
D | PHE338 |
D | LYS339 |
D | ARG442 |
D | HOH627 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | Region: {"description":"Allosteric switch region","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21961565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30457329","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | Region: {"description":"Important for formation of active hexamer structure","evidences":[{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 40 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 60 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TJH","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |