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4EB6

Tubulin-Vinblastine: Stathmin-like complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0000793cellular_componentcondensed chromosome
A0001764biological_processneuron migration
A0001964biological_processstartle response
A0005200molecular_functionstructural constituent of cytoskeleton
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005879cellular_componentaxonemal microtubule
A0005881cellular_componentcytoplasmic microtubule
A0005886cellular_componentplasma membrane
A0006886biological_processintracellular protein transport
A0007017biological_processmicrotubule-based process
A0007098biological_processcentrosome cycle
A0007224biological_processsmoothened signaling pathway
A0007613biological_processmemory
A0007626biological_processlocomotory behavior
A0008344biological_processadult locomotory behavior
A0008542biological_processvisual learning
A0009612biological_processresponse to mechanical stimulus
A0010001biological_processglial cell differentiation
A0010467biological_processgene expression
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0021542biological_processdentate gyrus development
A0021696biological_processcerebellar cortex morphogenesis
A0021766biological_processhippocampus development
A0021859biological_processpyramidal neuron differentiation
A0021987biological_processcerebral cortex development
A0022008biological_processneurogenesis
A0030182biological_processneuron differentiation
A0030534biological_processadult behavior
A0031594cellular_componentneuromuscular junction
A0034612biological_processresponse to tumor necrosis factor
A0035641biological_processlocomotory exploration behavior
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042802molecular_functionidentical protein binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0046785biological_processmicrotubule polymerization
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0048853biological_processforebrain morphogenesis
A0048873biological_processhomeostasis of number of cells within a tissue
A0050807biological_processregulation of synapse organization
A0050808biological_processsynapse organization
A0051402biological_processneuron apoptotic process
A0055037cellular_componentrecycling endosome
A0061744biological_processmotor behavior
A0071277biological_processcellular response to calcium ion
A0072384biological_processorganelle transport along microtubule
A0140058biological_processneuron projection arborization
A1902065biological_processresponse to L-glutamate
B0000226biological_processmicrotubule cytoskeleton organization
B0000278biological_processmitotic cell cycle
B0003924molecular_functionGTPase activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0007017biological_processmicrotubule-based process
B0046872molecular_functionmetal ion binding
C0000226biological_processmicrotubule cytoskeleton organization
C0000278biological_processmitotic cell cycle
C0000793cellular_componentcondensed chromosome
C0001764biological_processneuron migration
C0001964biological_processstartle response
C0005200molecular_functionstructural constituent of cytoskeleton
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0005879cellular_componentaxonemal microtubule
C0005881cellular_componentcytoplasmic microtubule
C0005886cellular_componentplasma membrane
C0006886biological_processintracellular protein transport
C0007017biological_processmicrotubule-based process
C0007098biological_processcentrosome cycle
C0007224biological_processsmoothened signaling pathway
C0007613biological_processmemory
C0007626biological_processlocomotory behavior
C0008344biological_processadult locomotory behavior
C0008542biological_processvisual learning
C0009612biological_processresponse to mechanical stimulus
C0010001biological_processglial cell differentiation
C0010467biological_processgene expression
C0015630cellular_componentmicrotubule cytoskeleton
C0016787molecular_functionhydrolase activity
C0021542biological_processdentate gyrus development
C0021696biological_processcerebellar cortex morphogenesis
C0021766biological_processhippocampus development
C0021859biological_processpyramidal neuron differentiation
C0021987biological_processcerebral cortex development
C0022008biological_processneurogenesis
C0030182biological_processneuron differentiation
C0030534biological_processadult behavior
C0031594cellular_componentneuromuscular junction
C0034612biological_processresponse to tumor necrosis factor
C0035641biological_processlocomotory exploration behavior
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042802molecular_functionidentical protein binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0046785biological_processmicrotubule polymerization
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0048853biological_processforebrain morphogenesis
C0048873biological_processhomeostasis of number of cells within a tissue
C0050807biological_processregulation of synapse organization
C0050808biological_processsynapse organization
C0051402biological_processneuron apoptotic process
C0055037cellular_componentrecycling endosome
C0061744biological_processmotor behavior
C0071277biological_processcellular response to calcium ion
C0072384biological_processorganelle transport along microtubule
C0140058biological_processneuron projection arborization
C1902065biological_processresponse to L-glutamate
D0000226biological_processmicrotubule cytoskeleton organization
D0000278biological_processmitotic cell cycle
D0003924molecular_functionGTPase activity
D0005200molecular_functionstructural constituent of cytoskeleton
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0007017biological_processmicrotubule-based process
D0046872molecular_functionmetal ion binding
E0031110biological_processregulation of microtubule polymerization or depolymerization
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE GTP A 501
ChainResidue
AGLY10
ASER140
AGLY143
AGLY144
ATHR145
AVAL177
AGLU183
AASN206
ATYR224
AASN228
AMG502
AGLN11
AHOH601
AHOH602
AHOH603
BLYS254
AALA12
AGLN15
AILE16
AASP98
AALA99
AALA100
AASN101

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 502
ChainResidue
AGLN11
AGTP501
AHOH601
AHOH602
AHOH603
AHOH604

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 503
ChainResidue
APRO175
ALYS394
BASN349

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 504
ChainResidue
AVAL177
ASER178
AARG221
APRO222
ATYR224

site_idAC5
Number of Residues17
DetailsBINDING SITE FOR RESIDUE GDP B 501
ChainResidue
BGLY10
BGLN11
BCYS12
BILE16
BSER140
BGLY143
BGLY144
BTHR145
BGLY146
BPRO173
BVAL177
BSER178
BGLU183
BASN206
BTYR224
BASN228
BHOH601

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 502
ChainResidue
BTHR223
BGLY225
BASP226
BARG278

site_idAC7
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GTP C 501
ChainResidue
CGLY10
CGLN11
CALA12
CGLN15
CILE16
CASP98
CALA99
CALA100
CASN101
CSER140
CGLY143
CGLY144
CTHR145
CGLY146
CVAL177
CSER178
CTHR179
CGLU183
CASN206
CTYR224
CASN228
CMG502
CHOH602
CHOH603
CHOH606
DLYS254

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C 502
ChainResidue
CGLN11
CGTP501
CHOH602
CHOH603
CHOH605

site_idAC9
Number of Residues17
DetailsBINDING SITE FOR RESIDUE VLB C 503
ChainResidue
CPRO325
CASN329
CILE332
CLYS336
CPHE351
CVAL353
CILE355
BPRO175
BLYS176
BVAL177
BASP179
BTYR210
BTHR220
BTHR221
BPRO222
BTHR223
BTYR224

site_idBC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GDP D 501
ChainResidue
DGLY10
DGLN11
DCYS12
DASN101
DSER140
DGLY142
DGLY143
DGLY144
DTHR145
DGLY146
DPRO173
DVAL177
DGLU183
DASN206
DLEU209
DTYR224
DASN228
DHOH604

site_idBC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 D 502
ChainResidue
DGLU22
DHIS229
DARG278

site_idBC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 D 503
ChainResidue
DTHR223
DARG278
DPHE404

Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
BGLY142-GLY148
AGLY142-GLY148

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
BMET1-ILE4

site_idPS00563
Number of Residues10
DetailsSTATHMIN_1 Stathmin family signature 1. PRRRDpSLEE
ChainResidueDetails
EPRO40-GLU49

site_idPS01041
Number of Residues10
DetailsSTATHMIN_2 Stathmin family signature 2. AEKREHEREV
ChainResidueDetails
EALA73-VAL82

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ESER46

222624

PDB entries from 2024-07-17

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