4EAJ
Co-crystal of AMPK core with AMP soaked with ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004679 | molecular_function | AMP-activated protein kinase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004679 | molecular_function | AMP-activated protein kinase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006110 | biological_process | regulation of glycolytic process |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016208 | molecular_function | AMP binding |
| C | 0019887 | molecular_function | protein kinase regulator activity |
| C | 0019901 | molecular_function | protein kinase binding |
| C | 0031588 | cellular_component | nucleotide-activated protein kinase complex |
| C | 0031669 | biological_process | cellular response to nutrient levels |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042149 | biological_process | cellular response to glucose starvation |
| C | 0043531 | molecular_function | ADP binding |
| C | 0044877 | molecular_function | protein-containing complex binding |
| C | 0045722 | biological_process | positive regulation of gluconeogenesis |
| C | 0050790 | biological_process | regulation of catalytic activity |
| C | 0051170 | biological_process | import into nucleus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ATP C 401 |
| Chain | Residue |
| C | ARG69 |
| C | GLY274 |
| C | VAL275 |
| C | LEU276 |
| C | VAL296 |
| C | HIS297 |
| C | ARG298 |
| C | ARG151 |
| C | LYS169 |
| C | ILE239 |
| C | SER241 |
| C | PHE243 |
| C | ASP244 |
| C | ARG268 |
| C | PHE272 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ATP C 402 |
| Chain | Residue |
| C | ARG69 |
| C | MET84 |
| C | THR86 |
| C | ILE87 |
| C | THR88 |
| C | ASP89 |
| C | PRO127 |
| C | VAL129 |
| C | HIS150 |
| C | ARG151 |
| C | PRO153 |
| C | SER225 |
| C | HOH507 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE AMP C 403 |
| Chain | Residue |
| C | HIS150 |
| C | THR199 |
| C | ASN202 |
| C | ILE203 |
| C | ALA204 |
| C | VAL224 |
| C | SER225 |
| C | ALA226 |
| C | PRO228 |
| C | HIS297 |
| C | SER313 |
| C | SER315 |
| C | ASP316 |
| C | HOH502 |
| C | HOH507 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q13131","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12764152","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Domain: {"description":"CBS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Motif: {"description":"AMPK pseudosubstrate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17851531","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V92","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17851531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21399626","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y8L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by ULK1","evidences":[{"source":"PubMed","id":"21460634","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by ULK1","evidences":[{"source":"PubMed","id":"21460634","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by ULK1","evidences":[{"source":"PubMed","id":"21460634","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
