4E9C
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG0 A 601 |
| Chain | Residue |
| A | TYR417 |
| A | TYR481 |
| A | PHE482 |
| A | TYR485 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PG0 A 602 |
| Chain | Residue |
| A | ASP376 |
| A | GLN380 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 101 |
| Chain | Residue |
| A | HIS538 |
| B | PRO74 |
| B | HIS76 |
| B | TPO78 |
| A | THR459 |
| A | GLU460 |
| A | PHE535 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR CHAIN B OF LDPPLHSPTA PHOSPHOPEPTIDE |
| Chain | Residue |
| A | LYS413 |
| A | TRP414 |
| A | VAL415 |
| A | ASP416 |
| A | THR459 |
| A | SER461 |
| A | TYR462 |
| A | TYR485 |
| A | HIS489 |
| A | LEU490 |
| A | LEU491 |
| A | ARG516 |
| A | THR517 |
| A | PHE535 |
| A | HIS538 |
| A | LYS540 |
| A | HOH702 |
| A | HOH738 |
| B | GOL101 |
| B | HOH201 |
| B | HOH202 |
| B | HOH203 |
| B | HOH204 |
| B | HOH205 |
| B | HOH207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Region: {"description":"Linker"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
