4E4V
The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0061608 | molecular_function | nuclear import signal receptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | ARG101 |
| A | LYS102 |
| A | SER105 |
| B | TRP399 |
| B | ASP442 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | ILE116 |
| B | HIS376 |
| B | HOH724 |
| B | HOH763 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 603 |
| Chain | Residue |
| A | PRO174 |
| A | HIS175 |
| A | ALA176 |
| A | HIS177 |
| B | GLU480 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 604 |
| Chain | Residue |
| A | ASP217 |
| A | MET218 |
| A | ARG258 |
| A | HIS262 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 605 |
| Chain | Residue |
| A | GLN372 |
| A | HIS376 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 606 |
| Chain | Residue |
| A | VAL374 |
| A | GLY377 |
| A | GOL608 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 607 |
| Chain | Residue |
| A | THR131 |
| A | GLN137 |
| A | SER169 |
| A | HOH714 |
| A | HOH752 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 608 |
| Chain | Residue |
| A | GLN371 |
| A | VAL374 |
| A | GLU411 |
| A | GLN412 |
| A | TYR415 |
| A | GOL606 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DTT A 609 |
| Chain | Residue |
| A | LEU454 |
| A | GLU456 |
| A | LYS459 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 601 |
| Chain | Residue |
| A | ALA431 |
| A | LYS432 |
| B | CYS223 |
| B | GLY224 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 602 |
| Chain | Residue |
| B | GLN371 |
| B | GLU411 |
| B | GLN412 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 603 |
| Chain | Residue |
| B | LYS353 |
| B | GLU354 |
| B | GLU396 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 604 |
| Chain | Residue |
| A | HOH753 |
| B | ALA431 |
| B | LYS432 |
| B | ASP433 |
| B | HOH722 |
| B | HOH745 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL B 605 |
| Chain | Residue |
| B | ASN228 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DTT B 606 |
| Chain | Residue |
| B | HIS418 |
| B | GLU456 |
| B | HOH712 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"ARM 1; truncated"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | Repeat: {"description":"ARM 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 10; atypical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 192 |
| Details | Region: {"description":"NLS binding site (major)","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 176 |
| Details | Region: {"description":"NLS binding site (minor)","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
