4E18

Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0005198	molecular_function	structural molecule activity
A	0007155	biological_process	cell adhesion
A	0015629	cellular_component	actin cytoskeleton
A	0051015	molecular_function	actin filament binding
B	0007155	biological_process	cell adhesion
B	0051015	molecular_function	actin filament binding

Functional Information from PROSITE/UniProt

site_id	PS00663
Number of Residues	21
Details	VINCULIN_1 Vinculin family talin-binding region signature. KnLgpgMtkMakmideRQQEL

Chain	Residue	Details
A	LYS162-LEU182

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Region: {"description":"Talin-interaction","evidences":[{"source":"PubMed","id":"2512301","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15229287","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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