4DJE

Crystal structure of folate-bound corrinoid iron-sulfur protein (CFeSP) in complex with its methyltransferase (MeTr), co-crystallized with folate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0008168	molecular_function	methyltransferase activity
A	0008705	molecular_function	methionine synthase activity
A	0009086	biological_process	methionine biosynthetic process
A	0015977	biological_process	carbon fixation
A	0031419	molecular_function	cobalamin binding
A	0032259	biological_process	methylation
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0044237	biological_process	cellular metabolic process
A	0046872	molecular_function	metal ion binding
A	0102036	molecular_function	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0008168	molecular_function	methyltransferase activity
B	0008705	molecular_function	methionine synthase activity
B	0009086	biological_process	methionine biosynthetic process
B	0015977	biological_process	carbon fixation
B	0031419	molecular_function	cobalamin binding
B	0032259	biological_process	methylation
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0044237	biological_process	cellular metabolic process
B	0046872	molecular_function	metal ion binding
B	0102036	molecular_function	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0008168	molecular_function	methyltransferase activity
C	0015977	biological_process	carbon fixation
C	0031419	molecular_function	cobalamin binding
C	0044237	biological_process	cellular metabolic process
C	0046356	biological_process	acetyl-CoA catabolic process
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0005515	molecular_function	protein binding
D	0006730	biological_process	one-carbon metabolic process
D	0015977	biological_process	carbon fixation
D	0031419	molecular_function	cobalamin binding
D	0044237	biological_process	cellular metabolic process
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0008168	molecular_function	methyltransferase activity
E	0015977	biological_process	carbon fixation
E	0031419	molecular_function	cobalamin binding
E	0044237	biological_process	cellular metabolic process
E	0046356	biological_process	acetyl-CoA catabolic process
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0005515	molecular_function	protein binding
F	0006730	biological_process	one-carbon metabolic process
F	0015977	biological_process	carbon fixation
F	0031419	molecular_function	cobalamin binding
F	0044237	biological_process	cellular metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE C2F A 300

Chain	Residue
A	GLU6
A	GLN202
A	ARG207
A	ILE227
A	MET11
A	PHE12
A	ASP75
A	ASN96
A	ASP160
A	GLY196
A	SER198
A	ASN199

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	GLY222
A	ASP224

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 301

Chain	Residue
B	GLY222
B	ASP224

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE C2F B 302

Chain	Residue
B	GLU6
B	MET11
B	PHE12
B	ASP43
B	ASP75
B	ASN96
B	ASP160
B	SER198
B	ASN199
B	GLN202
B	ARG207

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 C 501

Chain	Residue
C	ASN16
C	CYS17
C	GLY18
C	GLU19
C	CYS20
C	CYS25
C	CYS42
C	TYR44

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE B12 C 502

Chain	Residue
B	VAL168
B	ASN199
B	GLN202
B	ASN203
B	HOH403
C	PRO318
C	TYR338
C	VAL339
C	THR340
C	THR346
C	LEU371
C	SER372
C	VAL373
C	LEU374
C	THR375
C	ALA378
C	ASP379
C	PRO408
C	ALA410
C	PRO430
C	ARG431
C	ALA433

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 E 501

Chain	Residue
E	PRO13
E	LYS15
E	ASN16
E	CYS17
E	GLY18
E	GLU19
E	CYS20
E	CYS25
E	CYS42

---

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE B12 E 502

Chain	Residue
A	VAL168
A	ASN199
A	GLN202
A	ASN203
E	PRO318
E	VAL339
E	THR340
E	PHE343
E	LEU345
E	THR346
E	SER349
E	VAL350
E	GLY370
E	SER372
E	VAL373
E	LEU374
E	THR375
E	ILE406
E	ILE407
E	PRO408
E	PRO430
E	ARG431
E	ALA433

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22419154, ECO:0007744|PDB:4DJD

Chain	Residue	Details
D	PRO188
F	PRO188
C	CYS25
C	CYS42
E	CYS17
E	CYS20
E	CYS25
E	CYS42

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:22419154, ECO:0007744|PDB:4DJD

Chain	Residue	Details
C	THR340
C	THR346
C	GLY370
C	ALA433
E	THR340
E	THR346
E	GLY370
E	ALA433

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154, ECO:0007744|PDB:4DJF

Chain	Residue	Details
A	GLN202
B	GLN202

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	ASN199
B	ASN199

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