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4DGL

Crystal Structure of the CK2 Tetrameric Holoenzyme

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0003682molecular_functionchromatin binding
A0004674molecular_functionprotein serine/threonine kinase activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005956cellular_componentprotein kinase CK2 complex
A0007165biological_processsignal transduction
A0008285biological_processnegative regulation of cell population proliferation
A0016055biological_processWnt signaling pathway
A0016605cellular_componentPML body
A0018107biological_processpeptidyl-threonine phosphorylation
A0019887molecular_functionprotein kinase regulator activity
A0019904molecular_functionprotein domain specific binding
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031519cellular_componentPcG protein complex
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032927biological_processpositive regulation of activin receptor signaling pathway
A0033211biological_processadiponectin-activated signaling pathway
A0034774cellular_componentsecretory granule lumen
A0042802molecular_functionidentical protein binding
A0043537biological_processnegative regulation of blood vessel endothelial cell migration
A0046872molecular_functionmetal ion binding
A0051101biological_processregulation of DNA binding
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0061154biological_processendothelial tube morphogenesis
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0065003biological_processprotein-containing complex assembly
A0070062cellular_componentextracellular exosome
A0075342biological_processsymbiont-mediated disruption of host cell PML body
A1903901biological_processnegative regulation of viral life cycle
A1904813cellular_componentficolin-1-rich granule lumen
B0000785cellular_componentchromatin
B0003682molecular_functionchromatin binding
B0004674molecular_functionprotein serine/threonine kinase activity
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005956cellular_componentprotein kinase CK2 complex
B0007165biological_processsignal transduction
B0008285biological_processnegative regulation of cell population proliferation
B0016055biological_processWnt signaling pathway
B0016605cellular_componentPML body
B0018107biological_processpeptidyl-threonine phosphorylation
B0019887molecular_functionprotein kinase regulator activity
B0019904molecular_functionprotein domain specific binding
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031519cellular_componentPcG protein complex
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032927biological_processpositive regulation of activin receptor signaling pathway
B0033211biological_processadiponectin-activated signaling pathway
B0034774cellular_componentsecretory granule lumen
B0042802molecular_functionidentical protein binding
B0043537biological_processnegative regulation of blood vessel endothelial cell migration
B0046872molecular_functionmetal ion binding
B0051101biological_processregulation of DNA binding
B0060391biological_processpositive regulation of SMAD protein signal transduction
B0061154biological_processendothelial tube morphogenesis
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0065003biological_processprotein-containing complex assembly
B0070062cellular_componentextracellular exosome
B0075342biological_processsymbiont-mediated disruption of host cell PML body
B1903901biological_processnegative regulation of viral life cycle
B1904813cellular_componentficolin-1-rich granule lumen
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 301
ChainResidue
ACYS109
ACYS114
ACYS137
ACYS140

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 301
ChainResidue
BCYS109
BCYS114
BCYS137
BCYS140

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK
ChainResidueDetails
CLEU45-LYS68

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
ChainResidueDetails
CILE152-ILE164

site_idPS01101
Number of Residues32
DetailsCK2_BETA Casein kinase II regulatory subunit signature. CPrVyCenqpmLPIGlsdipgeamVKlyCPkC
ChainResidueDetails
ACYS109-CYS140

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
CASP156
DASP156
ACYS137
ACYS140
BCYS109
BCYS114
BCYS137
BCYS140

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
CLEU45
CLYS68
DLEU45
DLYS68

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ASER8
ASER69
BSER8
BSER69

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR37
BTHR37

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER209
BSER209

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS212
BLYS212

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297
ChainResidueDetails
ALYS212
BLYS212

227344

PDB entries from 2024-11-13

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