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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4DGL

Crystal Structure of the CK2 Tetrameric Holoenzyme

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0001650cellular_componentfibrillar center
A0003682molecular_functionchromatin binding
A0004674molecular_functionprotein serine/threonine kinase activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005956cellular_componentprotein kinase CK2 complex
A0007165biological_processsignal transduction
A0008285biological_processnegative regulation of cell population proliferation
A0016055biological_processWnt signaling pathway
A0016605cellular_componentPML body
A0019887molecular_functionprotein kinase regulator activity
A0019904molecular_functionprotein domain specific binding
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031519cellular_componentPcG protein complex
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032927biological_processpositive regulation of activin receptor signaling pathway
A0033011cellular_componentperinuclear theca
A0033211biological_processadiponectin-activated signaling pathway
A0034774cellular_componentsecretory granule lumen
A0042802molecular_functionidentical protein binding
A0043537biological_processnegative regulation of blood vessel endothelial cell migration
A0046872molecular_functionmetal ion binding
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0061154biological_processendothelial tube morphogenesis
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0065003biological_processprotein-containing complex assembly
A0070062cellular_componentextracellular exosome
A0075342biological_processsymbiont-mediated disruption of host cell PML body
A0097225cellular_componentsperm midpiece
A0120238cellular_componentsperm glycocalyx
A1903901biological_processnegative regulation of viral life cycle
A1904813cellular_componentficolin-1-rich granule lumen
B0000785cellular_componentchromatin
B0001650cellular_componentfibrillar center
B0003682molecular_functionchromatin binding
B0004674molecular_functionprotein serine/threonine kinase activity
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005956cellular_componentprotein kinase CK2 complex
B0007165biological_processsignal transduction
B0008285biological_processnegative regulation of cell population proliferation
B0016055biological_processWnt signaling pathway
B0016605cellular_componentPML body
B0019887molecular_functionprotein kinase regulator activity
B0019904molecular_functionprotein domain specific binding
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031519cellular_componentPcG protein complex
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032927biological_processpositive regulation of activin receptor signaling pathway
B0033011cellular_componentperinuclear theca
B0033211biological_processadiponectin-activated signaling pathway
B0034774cellular_componentsecretory granule lumen
B0042802molecular_functionidentical protein binding
B0043537biological_processnegative regulation of blood vessel endothelial cell migration
B0046872molecular_functionmetal ion binding
B0060391biological_processpositive regulation of SMAD protein signal transduction
B0061154biological_processendothelial tube morphogenesis
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0065003biological_processprotein-containing complex assembly
B0070062cellular_componentextracellular exosome
B0075342biological_processsymbiont-mediated disruption of host cell PML body
B0097225cellular_componentsperm midpiece
B0120238cellular_componentsperm glycocalyx
B1903901biological_processnegative regulation of viral life cycle
B1904813cellular_componentficolin-1-rich granule lumen
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 301
ChainResidue
ACYS109
ACYS114
ACYS137
ACYS140
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 301
ChainResidue
BCYS109
BCYS114
BCYS137
BCYS140
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK
ChainResidueDetails
CLEU45-LYS68
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
ChainResidueDetails
CILE152-ILE164
site_idPS01101
Number of Residues32
DetailsCK2_BETA Casein kinase II regulatory subunit signature. CPrVyCenqpmLPIGlsdipgeamVKlyCPkC
ChainResidueDetails
ACYS109-CYS140
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsRegion: {"description":"Interaction with alpha subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues6
DetailsMotif: {"description":"KSSR motif","evidences":[{"source":"PubMed","id":"24216761","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues570
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsRegion: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-11-19

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