4CH2
Low-salt crystal structure of a thrombin-GpIbalpha peptide complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0007596 | biological_process | blood coagulation |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0007596 | biological_process | blood coagulation |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0006508 | biological_process | proteolysis |
| D | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 3001 |
| Chain | Residue |
| B | ARG553 |
| B | LYS556 |
| B | HOH2170 |
| B | HOH2172 |
| B | HOH2187 |
| B | HOH2205 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 3001 |
| Chain | Residue |
| D | HOH2144 |
| D | HOH2150 |
| D | HOH2167 |
| D | ARG553 |
| D | LYS556 |
| D | HOH2142 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1317 |
| Chain | Residue |
| A | SER288 |
| A | GLY289 |
| A | GLU290 |
| A | ALA291 |
| A | HOH2005 |
| A | HOH2031 |
| B | TYR540 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL D 1579 |
| Chain | Residue |
| D | ILE329 |
| D | GLY330 |
| D | MET331 |
| D | SER332 |
| D | PRO333 |
| D | LYS385 |
| D | HIS386 |
| D | HOH2016 |
| D | HOH2045 |
| D | HOH2095 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 1580 |
| Chain | Residue |
| D | VAL488 |
| D | ARG490 |
| D | CYS493 |
| D | PHE506 |
| D | CYS507 |
| D | HOH2121 |
| D | HOH2174 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 1579 |
| Chain | Residue |
| B | GLU328 |
| B | GLY330 |
| B | MET331 |
| B | SER332 |
| B | PRO333 |
| B | GLY384 |
| B | LYS385 |
| B | HIS386 |
| B | HOH2014 |
| B | HOH2101 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | Binding site for Ligand 0G6 B1001 bound to SER B 525 |
| Chain | Residue |
| B | HIS363 |
| B | LEU416 |
| B | ILE499 |
| B | ASP519 |
| B | ALA520 |
| B | GLY523 |
| B | SER525 |
| B | SER546 |
| B | TRP547 |
| B | GLY548 |
| B | GLY550 |
| B | GLY558 |
| B | HOH2189 |
| B | HOH2190 |
| B | HOH2191 |
| B | HOH2192 |
| B | HOH2201 |
| B | HOH4001 |
| B | HOH4002 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | Binding site for Ligand 0G6 D1001 bound to SER D 525 |
| Chain | Residue |
| D | HIS363 |
| D | TYR367 |
| D | LEU416 |
| D | ILE499 |
| D | ASP519 |
| D | ALA520 |
| D | GLY523 |
| D | SER525 |
| D | SER546 |
| D | TRP547 |
| D | GLY548 |
| D | GLY550 |
| D | GLY558 |
| D | HOH2022 |
| D | HOH2153 |
| D | HOH2155 |
| D | HOH2156 |
| D | HOH2162 |
| D | HOH4001 |
| D | HOH4002 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| B | LEU359-CYS364 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| B | ASP519-VAL530 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 254 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
