4CCK

60S ribosomal protein L8 histidine hydroxylase (NO66) in complex with Mn(II) and N-oxalylglycine (NOG)

?

Functional Information from GO Data

ChainGOidnamespacecontents
A0005730cellular_componentnucleolus
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0016706molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
A0051864molecular_functionhistone demethylase activity (H3-K36 specific)
A0032453molecular_functionhistone demethylase activity (H3-K4 specific)
A0005506molecular_functioniron ion binding
A0070544biological_processhistone H3-K36 demethylation
A0034720biological_processhistone H3-K4 demethylation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045892biological_processnegative regulation of transcription, DNA-templated
B0005730cellular_componentnucleolus
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0016706molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
B0051864molecular_functionhistone demethylase activity (H3-K36 specific)
B0032453molecular_functionhistone demethylase activity (H3-K4 specific)
B0005506molecular_functioniron ion binding
B0070544biological_processhistone H3-K36 demethylation
B0034720biological_processhistone H3-K4 demethylation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045892biological_processnegative regulation of transcription, DNA-templated
C0005730cellular_componentnucleolus
C0005654cellular_componentnucleoplasm
C0005634cellular_componentnucleus
C0016706molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
C0051864molecular_functionhistone demethylase activity (H3-K36 specific)
C0032453molecular_functionhistone demethylase activity (H3-K4 specific)
C0005506molecular_functioniron ion binding
C0070544biological_processhistone H3-K36 demethylation
C0034720biological_processhistone H3-K4 demethylation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045892biological_processnegative regulation of transcription, DNA-templated
D0005730cellular_componentnucleolus
D0005654cellular_componentnucleoplasm
D0005634cellular_componentnucleus
D0016706molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
D0051864molecular_functionhistone demethylase activity (H3-K36 specific)
D0032453molecular_functionhistone demethylase activity (H3-K4 specific)
D0005506molecular_functioniron ion binding
D0070544biological_processhistone H3-K36 demethylation
D0034720biological_processhistone H3-K4 demethylation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045892biological_processnegative regulation of transcription, DNA-templated
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15BINDING SITE FOR RESIDUE MN A 901
ChainResidue
AHIS340
AASP342
AHIS405
AOGA902
AHOH2105

AC213BINDING SITE FOR RESIDUE OGA A 902
ChainResidue
ATYR328
APHE337
AHIS340
AASP342
ALYS355
ATRP357
AHIS405
AHIS417
ATHR419
AMN901
AHOH2105
AHOH2106
AHOH2109

AC36BINDING SITE FOR RESIDUE EDO A 903
ChainResidue
AGLY320
ASER321
AASN426
AARG501
AHOH2100
BPHE458

AC45BINDING SITE FOR RESIDUE MN B 901
ChainResidue
BHIS340
BASP342
BHIS405
BOGA902
BHOH2066

AC512BINDING SITE FOR RESIDUE OGA B 902
ChainResidue
BTYR328
BPHE337
BHIS340
BASP342
BLYS355
BHIS405
BHIS417
BTHR419
BMN901
BHOH2066
BHOH2067
BHOH2073

AC66BINDING SITE FOR RESIDUE EDO B 903
ChainResidue
APHE458
BGLY320
BSER321
BASN426
BARG501
BHOH2061

AC75BINDING SITE FOR RESIDUE MN C 901
ChainResidue
CHIS340
CASP342
CHIS405
COGA902
CHOH2090

AC810BINDING SITE FOR RESIDUE OGA C 902
ChainResidue
CTYR328
CHIS340
CASP342
CLYS355
CHIS405
CHIS417
CTHR419
CMN901
CHOH2091
CHOH2095

AC97BINDING SITE FOR RESIDUE EDO C 903
ChainResidue
CGLY320
CSER321
CASN426
CARG501
CPHE505
CHOH2085
DPHE458

BC15BINDING SITE FOR RESIDUE MN D 901
ChainResidue
DHIS340
DASP342
DHIS405
DOGA902
DHOH2054

BC211BINDING SITE FOR RESIDUE OGA D 902
ChainResidue
DTYR328
DPHE337
DHIS340
DASP342
DLYS355
DTRP357
DHIS405
DHIS417
DTHR419
DMN901
DHOH2056

BC37BINDING SITE FOR RESIDUE EDO D 903
ChainResidue
CPHE458
DGLY320
DSER321
DASN426
DARG501
DPHE505
DHOH2050

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
EDO_4cck_A_90391,2-ETHANEDIOL binding site
ChainResidueligand
AGLY320-MET322EDO: 1,2-ETHANEDIOL
AASN426EDO: 1,2-ETHANEDIOL
AARG501EDO: 1,2-ETHANEDIOL
APHE505EDO: 1,2-ETHANEDIOL
BLEU454EDO: 1,2-ETHANEDIOL
BPHE458-MET459EDO: 1,2-ETHANEDIOL

OGA_4cck_A_90213N-OXALYLGLYCINE binding site
ChainResidueligand
ATYR328OGA: N-OXALYLGLYCINE
ATHR330OGA: N-OXALYLGLYCINE
AGLY336-PHE337OGA: N-OXALYLGLYCINE
AHIS340OGA: N-OXALYLGLYCINE
AASP342OGA: N-OXALYLGLYCINE
AVAL348OGA: N-OXALYLGLYCINE
ALYS355OGA: N-OXALYLGLYCINE
ATRP357OGA: N-OXALYLGLYCINE
AHIS405OGA: N-OXALYLGLYCINE
AALA407OGA: N-OXALYLGLYCINE
AHIS417OGA: N-OXALYLGLYCINE
ATHR419OGA: N-OXALYLGLYCINE

EDO_4cck_B_90391,2-ETHANEDIOL binding site
ChainResidueligand
ALEU454EDO: 1,2-ETHANEDIOL
APHE458-MET459EDO: 1,2-ETHANEDIOL
BGLY320-SER321EDO: 1,2-ETHANEDIOL
BASN426EDO: 1,2-ETHANEDIOL
BARG501-ALA502EDO: 1,2-ETHANEDIOL
BPHE505EDO: 1,2-ETHANEDIOL

OGA_4cck_B_90213N-OXALYLGLYCINE binding site
ChainResidueligand
BTYR328OGA: N-OXALYLGLYCINE
BTHR330OGA: N-OXALYLGLYCINE
BGLY336-PHE337OGA: N-OXALYLGLYCINE
BHIS340OGA: N-OXALYLGLYCINE
BASP342OGA: N-OXALYLGLYCINE
BVAL348OGA: N-OXALYLGLYCINE
BLYS355OGA: N-OXALYLGLYCINE
BTRP357OGA: N-OXALYLGLYCINE
BHIS405OGA: N-OXALYLGLYCINE
BALA407OGA: N-OXALYLGLYCINE
BHIS417OGA: N-OXALYLGLYCINE
BTHR419OGA: N-OXALYLGLYCINE

EDO_4cck_C_90391,2-ETHANEDIOL binding site
ChainResidueligand
CGLY320-MET322EDO: 1,2-ETHANEDIOL
CASN426EDO: 1,2-ETHANEDIOL
CARG501EDO: 1,2-ETHANEDIOL
CPHE505EDO: 1,2-ETHANEDIOL
DLEU454EDO: 1,2-ETHANEDIOL
DPHE458-MET459EDO: 1,2-ETHANEDIOL

OGA_4cck_C_90214N-OXALYLGLYCINE binding site
ChainResidueligand
CTYR328OGA: N-OXALYLGLYCINE
CTHR330OGA: N-OXALYLGLYCINE
CGLY336-PHE337OGA: N-OXALYLGLYCINE
CHIS340OGA: N-OXALYLGLYCINE
CASP342OGA: N-OXALYLGLYCINE
CVAL348OGA: N-OXALYLGLYCINE
CLYS355OGA: N-OXALYLGLYCINE
CTRP357OGA: N-OXALYLGLYCINE
CPHE399OGA: N-OXALYLGLYCINE
CHIS405OGA: N-OXALYLGLYCINE
CALA407OGA: N-OXALYLGLYCINE
CHIS417OGA: N-OXALYLGLYCINE
CTHR419OGA: N-OXALYLGLYCINE

EDO_4cck_D_90391,2-ETHANEDIOL binding site
ChainResidueligand
CLEU454EDO: 1,2-ETHANEDIOL
CPHE458-MET459EDO: 1,2-ETHANEDIOL
DGLY320-MET322EDO: 1,2-ETHANEDIOL
DASN426EDO: 1,2-ETHANEDIOL
DARG501EDO: 1,2-ETHANEDIOL
DPHE505EDO: 1,2-ETHANEDIOL

OGA_4cck_D_90213N-OXALYLGLYCINE binding site
ChainResidueligand
DTYR328OGA: N-OXALYLGLYCINE
DTHR330OGA: N-OXALYLGLYCINE
DGLY336-PHE337OGA: N-OXALYLGLYCINE
DHIS340OGA: N-OXALYLGLYCINE
DASP342OGA: N-OXALYLGLYCINE
DVAL348OGA: N-OXALYLGLYCINE
DLYS355OGA: N-OXALYLGLYCINE
DTRP357OGA: N-OXALYLGLYCINE
DHIS405OGA: N-OXALYLGLYCINE
DALA407OGA: N-OXALYLGLYCINE
DHIS417OGA: N-OXALYLGLYCINE
DTHR419OGA: N-OXALYLGLYCINE

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails