4CAD
Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004175 | molecular_function | endopeptidase activity |
| C | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0071586 | biological_process | CAAX-box protein processing |
| C | 0080120 | biological_process | CAAX-box protein maturation |
| F | 0004175 | molecular_function | endopeptidase activity |
| F | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0016020 | cellular_component | membrane |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0071586 | biological_process | CAAX-box protein processing |
| F | 0080120 | biological_process | CAAX-box protein maturation |
| I | 0004175 | molecular_function | endopeptidase activity |
| I | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006508 | biological_process | proteolysis |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0016020 | cellular_component | membrane |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0071586 | biological_process | CAAX-box protein processing |
| I | 0080120 | biological_process | CAAX-box protein maturation |
| L | 0004175 | molecular_function | endopeptidase activity |
| L | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0006508 | biological_process | proteolysis |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0016020 | cellular_component | membrane |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0071586 | biological_process | CAAX-box protein processing |
| L | 0080120 | biological_process | CAAX-box protein maturation |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| A | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 96 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 92 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 76 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 76 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"24291792","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
