Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4CAD

Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004175	molecular_function	endopeptidase activity
C	0004222	molecular_function	metalloendopeptidase activity
C	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0016020	cellular_component	membrane
C	0016485	biological_process	protein processing
C	0071586	biological_process	CAAX-box protein processing
C	0080120	biological_process	CAAX-box protein maturation
F	0004175	molecular_function	endopeptidase activity
F	0004222	molecular_function	metalloendopeptidase activity
F	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
F	0005886	cellular_component	plasma membrane
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity
F	0016020	cellular_component	membrane
F	0016485	biological_process	protein processing
F	0071586	biological_process	CAAX-box protein processing
F	0080120	biological_process	CAAX-box protein maturation
I	0004175	molecular_function	endopeptidase activity
I	0004222	molecular_function	metalloendopeptidase activity
I	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
I	0005886	cellular_component	plasma membrane
I	0006508	biological_process	proteolysis
I	0008233	molecular_function	peptidase activity
I	0016020	cellular_component	membrane
I	0016485	biological_process	protein processing
I	0071586	biological_process	CAAX-box protein processing
I	0080120	biological_process	CAAX-box protein maturation
L	0004175	molecular_function	endopeptidase activity
L	0004222	molecular_function	metalloendopeptidase activity
L	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
L	0005886	cellular_component	plasma membrane
L	0006508	biological_process	proteolysis
L	0008233	molecular_function	peptidase activity
L	0016020	cellular_component	membrane
L	0016485	biological_process	protein processing
L	0071586	biological_process	CAAX-box protein processing
L	0080120	biological_process	CAAX-box protein maturation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
A	TYR192-HIS198

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	MET1-PRO9
F	LYS264-GLY271
I	MET1-PRO9
I	ALA60-ASN82
I	ASP150-PHE159
I	LEU214-SER219
I	LYS264-GLY271
L	MET1-PRO9
L	ALA60-ASN82
L	ASP150-PHE159
L	LEU214-SER219
C	ALA60-ASN82
L	LYS264-GLY271
C	ASP150-PHE159
C	LEU214-SER219
C	LYS264-GLY271
F	MET1-PRO9
F	ALA60-ASN82
F	ASP150-PHE159
F	LEU214-SER219

site_id	SWS_FT_FI2
Number of Residues	80
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	LYS10-LEU30
F	LYS10-LEU30
I	LYS10-LEU30
L	LYS10-LEU30

site_id	SWS_FT_FI3
Number of Residues	172
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	SER31-GLY38
I	PRO106-ASP125
I	ASN180-ILE192
I	ALA238-THR243
L	SER31-GLY38
L	PRO106-ASP125
L	ASN180-ILE192
L	ALA238-THR243
C	PRO106-ASP125
C	ASN180-ILE192
C	ALA238-THR243
F	SER31-GLY38
F	PRO106-ASP125
F	ASN180-ILE192
F	ALA238-THR243
I	SER31-GLY38

site_id	SWS_FT_FI4
Number of Residues	80
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	ILE39-ILE59
F	ILE39-ILE59
I	ILE39-ILE59
L	ILE39-ILE59

site_id	SWS_FT_FI5
Number of Residues	88
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	LEU83-ILE105
F	LEU83-ILE105
I	LEU83-ILE105
L	LEU83-ILE105

site_id	SWS_FT_FI6
Number of Residues	92
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	PHE126-PHE149
F	PHE126-PHE149
I	PHE126-PHE149
L	PHE126-PHE149

site_id	SWS_FT_FI7
Number of Residues	76
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	LYS160-VAL179
F	LYS160-VAL179
I	LYS160-VAL179
L	LYS160-VAL179

site_id	SWS_FT_FI8
Number of Residues	80
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	TRP193-CYS213
F	TRP193-CYS213
I	TRP193-CYS213
L	TRP193-CYS213

site_id	SWS_FT_FI9
Number of Residues	68
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	ILE220-LEU237
F	ILE220-LEU237
I	ILE220-LEU237
L	ILE220-LEU237

site_id	SWS_FT_FI10
Number of Residues	76
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	LYS244-LYS263
F	LYS244-LYS263
I	LYS244-LYS263
L	LYS244-LYS263

site_id	SWS_FT_FI11
Number of Residues	8
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	GLU140
C	HIS173
F	GLU140
F	HIS173
I	GLU140
I	HIS173
L	GLU140
L	HIS173

site_id	SWS_FT_FI12
Number of Residues	8
Details	SITE: Transition state stabilizer => ECO:0000269\|PubMed:24291792

Chain	Residue	Details
C	HIS227
C	ASN231
F	HIS227
F	ASN231
I	HIS227
I	ASN231
L	HIS227
L	ASN231

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)