4C9Z

Crystal structure of Siah1 at 1.95 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007275	biological_process	multicellular organism development
A	0008270	molecular_function	zinc ion binding
B	0005737	cellular_component	cytoplasm
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0007275	biological_process	multicellular organism development
B	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 283

Chain	Residue
A	CYS128
A	CYS135
A	HIS147
A	HIS152

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 284

Chain	Residue
A	CYS98
A	CYS105
A	HIS117
A	CYS121

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 283

Chain	Residue
B	CYS135
B	HIS147
B	HIS152
B	CYS128

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 284

Chain	Residue
B	CYS98
B	CYS105
B	HIS117
B	CYS121

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1283

Chain	Residue
A	ARG224

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 1286

Chain	Residue
B	ARG224

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1285

Chain	Residue
A	HIS230
A	ARG232

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TRS B 1283

Chain	Residue
A	GLU237
A	ALA238
A	HOH2106
A	HOH2142
B	ARG231
B	ARG232
B	ARG233
B	HOH2057

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1286

Chain	Residue
A	ARG231
A	ARG232
A	ARG233
A	HOH2143
B	ALA222

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1287

Chain	Residue
A	GLU161
A	CYS184
A	PHE185
A	GLY186
A	PHE187
A	HOH2144
A	HOH2145

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1284

Chain	Residue
A	THR239
A	ARG241
A	HOH2080
B	ARG231
B	ARG232

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1285

Chain	Residue
A	HIS244
B	PRO146
B	HIS147
B	HIS150
B	GLN151
B	HOH2013

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1288

Chain	Residue
A	CYS130
A	HIS152
A	LYS153
A	SER154

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1289

Chain	Residue
A	GLU119
A	ARG124
A	THR214
A	ARG215
A	HIS244
A	HOH2076
A	HOH2078
A	HOH2110

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TRS A 1290

Chain	Residue
A	GLU219
A	ASN220
A	CYS282
A	CYS282
A	HOH2083
A	HOH2140
A	HOH2146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Zinc finger: {"description":"SIAH-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00455","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	192
Details	Region: {"description":"SBD","evidences":[{"source":"UniProtKB","id":"P61092","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28546513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16085652","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28546513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A25","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---