4C68
Plasmodium vivax N-myristoyltransferase in complex with a peptidomimetic inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006499 | biological_process | N-terminal protein myristoylation |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006499 | biological_process | N-terminal protein myristoylation |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006499 | biological_process | N-terminal protein myristoylation |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE FMT A 997 |
| Chain | Residue |
| A | TYR211 |
| A | HOH2459 |
| A | TYR315 |
| A | TYR334 |
| A | LEU367 |
| A | LEU388 |
| A | VAL408 |
| A | LEU409 |
| A | HOH2284 |
| A | HOH2408 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 999 |
| Chain | Residue |
| A | ILE144 |
| A | GLU159 |
| A | TRP289 |
| A | HOH2412 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE EN5 A 1000 |
| Chain | Residue |
| A | VAL96 |
| A | ASP98 |
| A | ASP99 |
| A | ASP100 |
| A | THR197 |
| A | ALA198 |
| A | TYR211 |
| A | HIS213 |
| A | SER215 |
| A | PHE226 |
| A | SER227 |
| A | TYR242 |
| A | GLY382 |
| A | GLY384 |
| A | ASP385 |
| A | GLY386 |
| A | LEU388 |
| A | NHW1411 |
| A | DMS1415 |
| A | HOH2167 |
| A | HOH2240 |
| A | HOH2473 |
| site_id | AC4 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE NHW A 1411 |
| Chain | Residue |
| A | TYR28 |
| A | LYS29 |
| A | PHE30 |
| A | TRP31 |
| A | ASN94 |
| A | TYR95 |
| A | VAL96 |
| A | ASN161 |
| A | PHE162 |
| A | LEU163 |
| A | CYS164 |
| A | VAL165 |
| A | ARG170 |
| A | SER171 |
| A | LYS172 |
| A | ARG173 |
| A | LEU174 |
| A | ALA175 |
| A | PRO176 |
| A | THR183 |
| A | TRP192 |
| A | GLN193 |
| A | ALA194 |
| A | TYR196 |
| A | THR197 |
| A | ALA198 |
| A | LEU202 |
| A | TYR393 |
| A | EN51000 |
| A | MG1413 |
| A | HOH2001 |
| A | HOH2251 |
| A | HOH2257 |
| A | HOH2474 |
| A | HOH2475 |
| A | HOH2476 |
| A | HOH2477 |
| A | HOH2478 |
| A | HOH2479 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1412 |
| Chain | Residue |
| A | LYS180 |
| A | THR247 |
| A | LEU248 |
| A | ARG358 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1413 |
| Chain | Residue |
| A | LEU169 |
| A | SER171 |
| A | LYS172 |
| A | ARG173 |
| A | LEU174 |
| A | NHW1411 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1414 |
| Chain | Residue |
| A | ARG210 |
| A | LYS373 |
| B | ARG210 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 1415 |
| Chain | Residue |
| A | PHE105 |
| A | HIS213 |
| A | TYR334 |
| A | EN51000 |
| A | HOH2397 |
| A | HOH2407 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 999 |
| Chain | Residue |
| B | GLU159 |
| B | PHE281 |
| B | TRP289 |
| B | HOH2396 |
| site_id | BC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE EN5 B 1000 |
| Chain | Residue |
| B | ASP98 |
| B | ASP100 |
| B | PHE105 |
| B | ASN161 |
| B | THR197 |
| B | TYR211 |
| B | HIS213 |
| B | SER215 |
| B | PHE226 |
| B | SER227 |
| B | TYR242 |
| B | GLY382 |
| B | GLY384 |
| B | ASP385 |
| B | GLY386 |
| B | LEU410 |
| B | NHW1411 |
| B | DMS1414 |
| B | HOH2145 |
| B | HOH2153 |
| B | HOH2154 |
| B | VAL96 |
| site_id | BC2 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE NHW B 1411 |
| Chain | Residue |
| B | TYR28 |
| B | LYS29 |
| B | PHE30 |
| B | TRP31 |
| B | ASN94 |
| B | TYR95 |
| B | VAL96 |
| B | ASN161 |
| B | PHE162 |
| B | LEU163 |
| B | CYS164 |
| B | VAL165 |
| B | ARG170 |
| B | SER171 |
| B | LYS172 |
| B | ARG173 |
| B | LEU174 |
| B | ALA175 |
| B | PRO176 |
| B | THR183 |
| B | ILE186 |
| B | ASN187 |
| B | TRP192 |
| B | GLN193 |
| B | TYR196 |
| B | THR197 |
| B | LEU202 |
| B | TYR393 |
| B | EN51000 |
| B | MG1413 |
| B | HOH2002 |
| B | HOH2003 |
| B | HOH2229 |
| B | HOH2235 |
| B | HOH2236 |
| B | HOH2444 |
| B | HOH2445 |
| B | HOH2446 |
| B | HOH2447 |
| B | HOH2448 |
| B | HOH2449 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1412 |
| Chain | Residue |
| B | LYS180 |
| B | LEU248 |
| B | ARG358 |
| B | HOH2085 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1413 |
| Chain | Residue |
| B | LEU169 |
| B | SER171 |
| B | LYS172 |
| B | ARG173 |
| B | LEU174 |
| B | NHW1411 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 1414 |
| Chain | Residue |
| B | PHE105 |
| B | TYR211 |
| B | HIS213 |
| B | TYR334 |
| B | EN51000 |
| B | HOH2267 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 999 |
| Chain | Residue |
| C | GLU159 |
| C | PHE281 |
| C | TRP289 |
| C | HOH2309 |
| site_id | BC7 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NHW C 1411 |
| Chain | Residue |
| C | TYR28 |
| C | LYS29 |
| C | PHE30 |
| C | TRP31 |
| C | ASN94 |
| C | TYR95 |
| C | VAL96 |
| C | ASN161 |
| C | PHE162 |
| C | LEU163 |
| C | CYS164 |
| C | VAL165 |
| C | ARG170 |
| C | SER171 |
| C | LYS172 |
| C | ARG173 |
| C | LEU174 |
| C | ALA175 |
| C | PRO176 |
| C | THR183 |
| C | ILE186 |
| C | TRP192 |
| C | GLN193 |
| C | ALA194 |
| C | THR197 |
| C | LEU202 |
| C | TYR393 |
| C | MG1415 |
| C | HOH2001 |
| C | HOH2171 |
| C | HOH2177 |
| C | HOH2352 |
| C | HOH2353 |
| C | HOH2354 |
| C | HOH2355 |
| C | HOH2356 |
| C | HOH2357 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 1412 |
| Chain | Residue |
| C | LYS180 |
| C | THR247 |
| C | LEU248 |
| C | ARG358 |
| C | HOH2234 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 1413 |
| Chain | Residue |
| C | GLN350 |
| C | HOH2320 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 1414 |
| Chain | Residue |
| C | HIS213 |
| C | ARG214 |
| C | SER215 |
| C | LYS380 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1415 |
| Chain | Residue |
| C | LEU169 |
| C | SER171 |
| C | LYS172 |
| C | ARG173 |
| C | LEU174 |
| C | NHW1411 |
Functional Information from PROSITE/UniProt
