4C2A
Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CAC A 2468 |
| Chain | Residue |
| A | LEU1267 |
| A | HIS1268 |
| A | ARG1450 |
| A | HOH2009 |
| B | THR145 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 2469 |
| Chain | Residue |
| A | SER1273 |
| A | ARG1308 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 2470 |
| Chain | Residue |
| A | HOH2025 |
| A | HOH2026 |
| A | HOH2027 |
| A | HOH2105 |
| A | ASP1302 |
| A | HOH2024 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 1267 |
| Chain | Residue |
| B | ASP106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:12087105 |
| Chain | Residue | Details |
| B | TYR276 | |
| B | TYR278 | |
| B | TYR279 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:3497398, ECO:0000269|PubMed:36740532 |
| Chain | Residue | Details |
| B | ARG21 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3497398 |
| Chain | Residue | Details |
| B | ARG159 |
