4BXF

60S ribosomal protein L27A histidine hydroxylase (MINA53 Y209C) in complex with MN(II), 2-oxoglutarate (2OG) and 60S ribosomal protein L27A (RPL27A G37C) peptide fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0016491	molecular_function	oxidoreductase activity
A	0018126	biological_process	protein hydroxylation
A	0032452	molecular_function	histone demethylase activity
A	0032453	molecular_function	histone H3K4 demethylase activity
A	0036139	molecular_function	peptidyl-histidine dioxygenase activity
A	0042254	biological_process	ribosome biogenesis
A	0042802	molecular_function	identical protein binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051864	molecular_function	histone H3K36 demethylase activity
B	0003714	molecular_function	transcription corepressor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005667	cellular_component	transcription regulator complex
B	0005730	cellular_component	nucleolus
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006351	biological_process	DNA-templated transcription
B	0016491	molecular_function	oxidoreductase activity
B	0018126	biological_process	protein hydroxylation
B	0032452	molecular_function	histone demethylase activity
B	0032453	molecular_function	histone H3K4 demethylase activity
B	0036139	molecular_function	peptidyl-histidine dioxygenase activity
B	0042254	biological_process	ribosome biogenesis
B	0042802	molecular_function	identical protein binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0051864	molecular_function	histone H3K36 demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 601

Chain	Residue
A	HIS179
A	ASP181
A	HIS240
A	AKG901
A	HOH2098

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AKG A 901

Chain	Residue
A	HIS240
A	HIS253
A	THR255
A	MN601
A	HOH2098
A	HOH2099
A	HOH2106
A	HOH2110
A	TYR167
A	HIS179
A	ASP181
A	LYS194

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 601

Chain	Residue
B	HIS179
B	ASP181
B	HIS240
B	AKG901
B	HOH2037

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AKG B 901

Chain	Residue
B	HIS179
B	ASP181
B	LYS194
B	HIS240
B	HIS253
B	THR255
B	MN601
B	HOH2037
B	HOH2038

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	264
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"(3S)-3-hydroxyhistidine","evidences":[{"source":"PubMed","id":"23103944","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---