4BXF
60S ribosomal protein L27A histidine hydroxylase (MINA53 Y209C) in complex with MN(II), 2-oxoglutarate (2OG) and 60S ribosomal protein L27A (RPL27A G37C) peptide fragment
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005667 | cellular_component | transcription regulator complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0018126 | biological_process | protein hydroxylation |
| A | 0032452 | molecular_function | histone demethylase activity |
| A | 0032453 | molecular_function | histone H3K4 demethylase activity |
| A | 0036139 | molecular_function | peptidyl-histidine dioxygenase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0051864 | molecular_function | histone H3K36 demethylase activity |
| B | 0003714 | molecular_function | transcription corepressor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005667 | cellular_component | transcription regulator complex |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0018126 | biological_process | protein hydroxylation |
| B | 0032452 | molecular_function | histone demethylase activity |
| B | 0032453 | molecular_function | histone H3K4 demethylase activity |
| B | 0036139 | molecular_function | peptidyl-histidine dioxygenase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0051864 | molecular_function | histone H3K36 demethylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 601 |
| Chain | Residue |
| A | HIS179 |
| A | ASP181 |
| A | HIS240 |
| A | AKG901 |
| A | HOH2098 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE AKG A 901 |
| Chain | Residue |
| A | HIS240 |
| A | HIS253 |
| A | THR255 |
| A | MN601 |
| A | HOH2098 |
| A | HOH2099 |
| A | HOH2106 |
| A | HOH2110 |
| A | TYR167 |
| A | HIS179 |
| A | ASP181 |
| A | LYS194 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 601 |
| Chain | Residue |
| B | HIS179 |
| B | ASP181 |
| B | HIS240 |
| B | AKG901 |
| B | HOH2037 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AKG B 901 |
| Chain | Residue |
| B | HIS179 |
| B | ASP181 |
| B | LYS194 |
| B | HIS240 |
| B | HIS253 |
| B | THR255 |
| B | MN601 |
| B | HOH2037 |
| B | HOH2038 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 264 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(3S)-3-hydroxyhistidine","evidences":[{"source":"PubMed","id":"23103944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
